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Protein
Submitted name:

IP09655p

Gene

Mdh2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • L-malate dehydrogenase activity Source: FlyBase
  • malate dehydrogenase activity Source: FlyBase

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: FlyBase
  • carbohydrate metabolic process Source: InterPro
  • larval midgut cell programmed cell death Source: FlyBase
  • malate metabolic process Source: InterPro
  • positive regulation of programmed cell death Source: FlyBase
  • pupal development Source: FlyBase
  • regulation of programmed cell death Source: FlyBase
  • salivary gland cell autophagic cell death Source: FlyBase
  • salivary gland histolysis Source: FlyBase
  • tricarboxylic acid cycle Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Enzyme and pathway databases

ReactomeiR-DME-70263. Gluconeogenesis.
R-DME-71403. Citric acid cycle (TCA cycle).

Names & Taxonomyi

Protein namesi
Submitted name:
IP09655pImported
Submitted name:
Malate dehydrogenase 2Imported (EC:1.1.1.37Imported)
Submitted name:
RE60471pImported
Gene namesi
Name:Mdh2Imported
Synonyms:l(3)psg7Imported
ORF Names:CG7998Imported, Dmel_CG7998Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0262559. Mdh2.

Subcellular locationi

GO - Cellular componenti

  • lipid particle Source: FlyBase
  • mitochondrial matrix Source: FlyBase
  • mitochondrion Source: FlyBase
Complete GO annotation...

Interactioni

Protein-protein interaction databases

IntActiQ9VEB1. 24 interactions.
STRINGi7227.FBpp0082985.

Structurei

3D structure databases

SMRiQ9VEB1. Positions 24-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 168143Ldh_1_NInterPro annotationAdd
BLAST
Domaini171 – 333163Ldh_1_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1494. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00390000016686.
KOiK00026.
OMAiSQQNNYK.
OrthoDBiEOG74R1R7.
PhylomeDBiQ9VEB1.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VEB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKQVTKQLA LQGVRTFSVG QQNNYKVTVC GAAGGIGQPL SLLLKQNPLV
60 70 80 90 100
TDLALYDIVH TPGVAADLSH IDTKSKTAGF IGADQLGDSL KGSDVVVIPA
110 120 130 140 150
GVPRKPGMTR DDLFNVNAGI IKDISNSIAK NCPKALVAII TNPVNTCVPI
160 170 180 190 200
AAEILKKAGV YDPKRLFGVS TLDVVRARAF IGHALGVDPQ TVQIPVIGGH
210 220 230 240 250
SGVTILPVLS QSQPLFKGNQ DTIEKLTVRI QEAGTEVVKA KAGAGSATLS
260 270 280 290 300
MAYAGARFAG SLLKGLNGEK NVIECSYVQS TVTEATFFST PLVLGKNGVQ
310 320 330
ENLGLPKLND YEKKLLEAAI PELKKNIQKG IDFANA
Length:336
Mass (Da):35,318
Last modified:May 1, 2000 - v1
Checksum:i6E9FFC5744541383
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF55516.1.
AY119152 mRNA. Translation: AAM51012.1.
BT029274 mRNA. Translation: ABK30911.1.
RefSeqiNP_650696.1. NM_142439.3.
UniGeneiDm.7212.

Genome annotation databases

EnsemblMetazoaiFBtr0083563; FBpp0082985; FBgn0262559.
GeneIDi42185.
KEGGidme:Dmel_CG7998.
UCSCiCG7998-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF55516.1.
AY119152 mRNA. Translation: AAM51012.1.
BT029274 mRNA. Translation: ABK30911.1.
RefSeqiNP_650696.1. NM_142439.3.
UniGeneiDm.7212.

3D structure databases

SMRiQ9VEB1. Positions 24-333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9VEB1. 24 interactions.
STRINGi7227.FBpp0082985.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0083563; FBpp0082985; FBgn0262559.
GeneIDi42185.
KEGGidme:Dmel_CG7998.
UCSCiCG7998-RA. d. melanogaster.

Organism-specific databases

CTDi4191.
FlyBaseiFBgn0262559. Mdh2.

Phylogenomic databases

eggNOGiKOG1494. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00390000016686.
KOiK00026.
OMAiSQQNNYK.
OrthoDBiEOG74R1R7.
PhylomeDBiQ9VEB1.

Enzyme and pathway databases

ReactomeiR-DME-70263. Gluconeogenesis.
R-DME-71403. Citric acid cycle (TCA cycle).

Miscellaneous databases

ChiTaRSiMdh2. fly.
GenomeRNAii42185.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. Stapleton M., Carlson J., Frise E., Kapadia B., Park S., Wan K., Yu C., Celniker S.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  11. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  13. FlyBase
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9VEB1_DROME
AccessioniPrimary (citable) accession number: Q9VEB1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.