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Protein
Submitted name:

IP09655p

Gene

Mdh2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei110SubstrateUniRule annotation1
Binding sitei142SubstrateUniRule annotation1
Binding sitei176SubstrateUniRule annotation1
Active sitei200Proton acceptorUniRule annotation1

GO - Molecular functioni

  • L-malate dehydrogenase activity Source: FlyBase
  • malate dehydrogenase activity Source: FlyBase

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: FlyBase
  • carbohydrate metabolic process Source: InterPro
  • larval midgut cell programmed cell death Source: FlyBase
  • oxidation-reduction process Source: FlyBase
  • positive regulation of programmed cell death Source: FlyBase
  • pupal development Source: FlyBase
  • regulation of programmed cell death Source: FlyBase
  • salivary gland cell autophagic cell death Source: FlyBase
  • salivary gland histolysis Source: FlyBase
  • tricarboxylic acid cycle Source: FlyBase

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported

Enzyme and pathway databases

ReactomeiR-DME-70263 Gluconeogenesis
R-DME-71403 Citric acid cycle (TCA cycle)

Names & Taxonomyi

Protein namesi
Submitted name:
IP09655pImported
Submitted name:
Malate dehydrogenase 2Imported (EC:1.1.1.37Imported)
Submitted name:
RE60471pImported
Gene namesi
Name:Mdh2Imported
Synonyms:CG 7998Imported, Dmel\CG7998Imported, l(3)psg7Imported, MdhImported, MDH-2Imported, mdh2Imported, mMdhImported, psg7Imported
ORF Names:CG7998Imported, Dmel_CG7998Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0262559 Mdh2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0262559

Interactioni

Protein-protein interaction databases

IntActiQ9VEB1, 22 interactors
STRINGi7227.FBpp0082985

Structurei

3D structure databases

SMRiQ9VEB1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 168Ldh_1_NInterPro annotationAdd BLAST144
Domaini171 – 333Ldh_1_CInterPro annotationAdd BLAST163

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1494 Eukaryota
COG0039 LUCA
GeneTreeiENSGT00390000016686
KOiK00026
OMAiQCTPKVE
OrthoDBiEOG091G0AVO

Family and domain databases

Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR010097 Malate_DH_type1
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01772 MDH_euk_gproteo, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VEB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKQVTKQLA LQGVRTFSVG QQNNYKVTVC GAAGGIGQPL SLLLKQNPLV
60 70 80 90 100
TDLALYDIVH TPGVAADLSH IDTKSKTAGF IGADQLGDSL KGSDVVVIPA
110 120 130 140 150
GVPRKPGMTR DDLFNVNAGI IKDISNSIAK NCPKALVAII TNPVNTCVPI
160 170 180 190 200
AAEILKKAGV YDPKRLFGVS TLDVVRARAF IGHALGVDPQ TVQIPVIGGH
210 220 230 240 250
SGVTILPVLS QSQPLFKGNQ DTIEKLTVRI QEAGTEVVKA KAGAGSATLS
260 270 280 290 300
MAYAGARFAG SLLKGLNGEK NVIECSYVQS TVTEATFFST PLVLGKNGVQ
310 320 330
ENLGLPKLND YEKKLLEAAI PELKKNIQKG IDFANA
Length:336
Mass (Da):35,318
Last modified:May 1, 2000 - v1
Checksum:i6E9FFC5744541383
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55516.1
AY119152 mRNA Translation: AAM51012.1
BT029274 mRNA Translation: ABK30911.1
RefSeqiNP_650696.1, NM_142439.3
UniGeneiDm.7212

Genome annotation databases

EnsemblMetazoaiFBtr0083563; FBpp0082985; FBgn0262559
GeneIDi42185
KEGGidme:Dmel_CG7998
UCSCiCG7998-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9VEB1_DROME
AccessioniPrimary (citable) accession number: Q9VEB1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health