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Q9VE01 (C12A5_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome P450 12a5, mitochondrial
EC=1.14.-.-
Alternative name(s):
CYPXIIA5
Gene names
Name:Cyp12a5
ORF Names:CG11821
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length536 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Mitochondrion membrane Potential.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 536Probable cytochrome P450 12a5, mitochondrialPRO_0000003609

Sites

Metal binding4821Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict661G → S in AAM76202. Ref.4
Sequence conflict721L → M in AAR88135. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9VE01 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 231BFD7E6284A1F6

FASTA53661,355
        10         20         30         40         50         60 
MLKGRIALNI LQSQKPIVFS ASQQRWQTNV PTAEIRNDPE WLQAKPFEEI PKANILSLFA 

        70         80         90        100        110        120 
KSALPGGKYK NLEMMEMIDA LRQDYGNIIF LPGMMGRDGL VMTHNPKDFE VVFRNEGVWP 

       130        140        150        160        170        180 
FRPGSDILRY HRTVYRKDFF DGVQGIIPSQ GKSWGDFRSI VNPVLMQPKN VRLYFKKMSQ 

       190        200        210        220        230        240 
VNQEFVELIK EIRDASTQEV PGNFLETINR WTLESVSVVA LDKQLGLLRE SGKNSEATKL 

       250        260        270        280        290        300 
FKYLDEFFLH SADLEMKPSL WRYFKTPLLK KMLRTMDSVQ EVTLKYVDEA IERLEKEAKE 

       310        320        330        340        350        360 
GVVRPEHEQS VLEKLLKVDK KVATVMAMDM LMAGVDTTSS TFTALLLCLA KNPEKQARLR 

       370        380        390        400        410        420 
EEVMKVLPNK DSEFTEASMK NVPYLRACIK ESQRVYPLVI GNARGLTRDS VISGYRVPAG 

       430        440        450        460        470        480 
TIVSMIPINS LYSEEYFPKP TEFLPERWLR NASDSAGKCP ANDLKTKNPF VFLPFGFGPR 

       490        500        510        520        530 
MCVGKRIVEM ELELGTARLI RNFNVEFNHS TKNAFRSALI NLPNIPLKFK FTDVPN

« Hide

References

« Hide 'large scale' references
[1]"Expression of Cyp6g1 and Cyp12d1 in DDT resistant and susceptible strains of Drosophila melanogaster."
Festucci-Buselli R.A., Carvalho-Dias A.S., de Oliveira-Andrade M., Caixeta-Nunes C., Li H.-M., Stuart J.J., Muir W., Scharf M.E., Pittendrigh B.R.
Insect Mol. Biol. 14:69-77(2005) [PubMed: 15663776] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Head.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY459354 mRNA. Translation: AAR88135.1.
AE014297 Genomic DNA. Translation: AAF55635.1.
AY129460 mRNA. Translation: AAM76202.1.
RefSeqNP_650782.1. NM_142525.2.
UniGeneDm.36852.

3D structure databases

ProteinModelPortalQ9VE01.
SMRQ9VE01. Positions 44-535.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-20196N.
MINTMINT-964513.
STRINGQ9VE01.

Proteomic databases

PRIDEQ9VE01.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0083730; FBpp0083144; FBgn0038680.
GeneID42293.
KEGGdme:Dmel_CG11821.
NMPDRfig|7227.3.peg.13557.
UCSCCG11821-RA. d. melanogaster.

Organism-specific databases

CTD42293.
FlyBaseFBgn0038680. Cyp12a5.

Phylogenomic databases

eggNOGinNOG08324.
GeneTreeEMGT00050000001200.
InParanoidQ9VE01.
OMAVATIMAM.
OrthoDBEOG4S7H56.
PhylomeDBQ9VE01.

Gene expression databases

BgeeQ9VE01.
GermOnlineCG11821. Drosophila melanogaster.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
KOK15004.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. Cytochrome_P450. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio828077.

Entry information

Entry nameC12A5_DROME
AccessionPrimary (citable) accession number: Q9VE01
Secondary accession number(s): Q6SEI2, Q8MQI5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents