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Protein

Probable nucleoporin Nup58

Gene

Nup58

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.By similarity

GO - Molecular functioni

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • neuron projection morphogenesis Source: FlyBase
  • nucleocytoplasmic transport Source: UniProtKB
  • protein import into nucleus Source: GO_Central

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-DME-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-DME-191859. snRNP Assembly.
R-DME-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-DME-3371453. Regulation of HSF1-mediated heat shock response.
R-DME-4551638. SUMOylation of chromatin organization proteins.
R-DME-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nucleoporin Nup58
Gene namesi
Name:Nup58
ORF Names:CG7360
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0038722. Nup58.

Subcellular locationi

  • Nucleusnuclear pore complex By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048911 – 546Probable nucleoporin Nup58Add BLAST546

Proteomic databases

PaxDbiQ9VDV3.
PRIDEiQ9VDV3.

Expressioni

Gene expression databases

BgeeiFBgn0038722.
GenevisibleiQ9VDV3. DM.

Interactioni

Protein-protein interaction databases

BioGridi67334. 7 interactors.
IntActiQ9VDV3. 2 interactors.
MINTiMINT-979671.
STRINGi7227.FBpp0083195.

Structurei

3D structure databases

ProteinModelPortaliQ9VDV3.
SMRiQ9VDV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 2312
Repeati36 – 3722
Repeati45 – 4632
Repeati64 – 6542
Repeati73 – 7452
Repeati82 – 8362
Repeati92 – 9372
Repeati101 – 10282
Repeati110 – 11192
Repeati119 – 120102
Repeati128 – 129112
Repeati137 – 138122
Repeati146 – 147132
Repeati155 – 156142
Repeati166 – 167152
Repeati197 – 198162
Repeati199 – 200172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 20017 X 2 AA repeats of F-GAdd BLAST179

Domaini

Contains FG repeats.

Sequence similaritiesi

Belongs to the NUP58 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIR3. Eukaryota.
ENOG410ZJAM. LUCA.
GeneTreeiENSGT00730000111111.
InParanoidiQ9VDV3.
KOiK14307.
OMAiFFPSQSS.
OrthoDBiEOG091G0KUR.
PhylomeDBiQ9VDV3.

Family and domain databases

InterProiView protein in InterPro
IPR024882. Nucleoporin_p58/p45.
IPR024945. Spt5_C_dom.
PANTHERiPTHR13437. PTHR13437. 1 hit.
SMARTiView protein in SMART
SM01104. CTD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VDV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTPTTNNAI GGATAATGAF AFGARPATTT APPPSFGAAT STPTFGAAPA
60 70 80 90 100
TTSLFAAPAA TPAFGAPAAT PAFGAPASTP GFGATSTAAP AFGTAAATPA
110 120 130 140 150
FGIPAATSAF GAPAATPAFG AAAATPAFGA PAATPAFGAP AATSAFGAPA
160 170 180 190 200
ATTAFGAPAS TQASAFGAPA PAVGTVAPTF SFATPATSAP TTAPPAFGFG
210 220 230 240 250
TTATTAAAAM PASLSSGIGS FSFPKPQATT AASLNFNTTT TTATAQPFNT
260 270 280 290 300
GLKLGTTNAT TTLGGGGIFS KPAGQAAAPA ASTFVGLGGI DVTATQPKLG
310 320 330 340 350
DNKQDGIKIK ETQVPDEIIK TVDGLKAYIK QQKTISSDIG RTSTSKFTNV
360 370 380 390 400
SHEITNLKWA LQNMATLVEG SNQQIRLMRQ ETVKAIQSLE MAQRTQDTPA
410 420 430 440 450
GLQFENNAPF QYFQCLVAKY EQDLIAFRQQ IALTERHMHA ISNPQSISPD
460 470 480 490 500
DLKRGFRQLN ESFISLAGRL HEVHQRVEEH KEHYLNLRRY RLRDTTNVFE
510 520 530 540
RIDNPPLPTV EPQRISSGPT PFSNISALMN KSYAAAASSA SNATGN
Length:546
Mass (Da):55,528
Last modified:May 1, 2000 - v1
Checksum:iEBA7C812DDBEEACE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267Missing in AAL49062 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF55687.1.
AY071440 mRNA. Translation: AAL49062.1.
RefSeqiNP_650821.2. NM_142564.4.
UniGeneiDm.5932.

Genome annotation databases

EnsemblMetazoaiFBtr0083781; FBpp0083195; FBgn0038722.
GeneIDi42342.
KEGGidme:Dmel_CG7360.

Similar proteinsi

Entry informationi

Entry nameiNUP58_DROME
AccessioniPrimary (citable) accession number: Q9VDV3
Secondary accession number(s): Q8SYM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families