Unreviewed, UniProtKB/TrEMBL Q9VDE3 (Q9VDE3_DROME)

Names and origin

Protein names

Submitted name:
    Supernumerary limbs EMBL AAF55853.1
    EC=6.3.2.19 EMBL AAF55853.1
Submitted name:
    LD08669p EMBL AAM50758.1
    Slimb EMBL AAF63214.1

Gene names

Name:	slmb EMBL AAF55853.1 FlyBase FBgn0023423
ORF Names:	CG3412 FlyBase FBgn0023423, Dmel_CG3412 EMBL AAF55853.1

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 F-box domain.

Ontologies

Keywords
Domain	Repeat RuleBase RU003532V3 WD repeat RuleBase RU000362V4
Molecular function	Ligase EMBL AAF55853.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	border follicle cell migration Inferred from mutant phenotype. Source: FlyBase dorsal appendage formation Inferred from mutant phenotype. Source: FlyBase germarium-derived female germ-line cyst encapsulation Inferred from mutant phenotype. Source: FlyBase germarium-derived female germ-line cyst formation Inferred from mutant phenotype. Source: FlyBase locomotor rhythm Inferred from mutant phenotype. Source: FlyBase negative regulation of Wnt receptor signaling pathway Non-traceable author statement. Source: FlyBase negative regulation of nurse cell apoptosis Inferred from mutant phenotype. Source: FlyBase negative regulation of smoothened signaling pathway Inferred from mutant phenotype. Source: FlyBase negative regulation of transforming growth factor beta receptor signaling pathway Non-traceable author statement. Source: FlyBase olfactory learning Inferred from mutant phenotype. Source: FlyBase oocyte localization during germarium-derived egg chamber formation Inferred from mutant phenotype. Source: FlyBase ovarian follicle cell stalk formation Inferred from mutant phenotype. Source: FlyBase proteolysis Inferred from mutant phenotype. Source: FlyBase regulation of mitosis Inferred from mutant phenotype. Source: FlyBase regulation of proteolysis Traceable author statement. Source: FlyBase release of cytoplasmic sequestered NF-kappaB Inferred from mutant phenotype. Source: FlyBase
Cellular component	SCF ubiquitin ligase complex Non-traceable author statement. Source: FlyBase
Molecular function	phosphoprotein binding Inferred from physical interaction. Source: FlyBase ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VDE3-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: F4D5DF126F58A012	FASTA	510	58,952
	10 20 30 40 50 60 MMKMETDKIM DETNSNAQAF TTTMLYDPVR KKDSSPTYQT ERELCFQYFT QWSESGQVDF 70 80 90 100 110 120 VEHLLSRMCH YQHGQINAYL KPMLQRDFIT LLPIKGLDHI AENILSYLDA ESLKSSELVC 130 140 150 160 170 180 KEWLRVISEG MLWKKLIERK VRTDSLWRGL AERRNWMQYL FKPRPGQTQR PHSFHRELFP 190 200 210 220 230 240 KIMNDIDSIE NNWRTGRHML RRINCRSENS KGVYCLQYDD GKIVSGLRDN TIKIWDRTDL 250 260 270 280 290 300 QCVKTLMGHT GSVLCLQYDD KVIISGSSDS TVRVWDVNTG EMVNTLIHHC EAVLHLRFNN 310 320 330 340 350 360 GMMVTCSKDR SIAVWDMTSP SEITLRRVLV GHRAAVNVVD FDEKYIVSAS GDRTIKVWST 370 380 390 400 410 420 SSCEFVRTLN GHKRGIACLQ YRDRLVVSGS SDNSIRLWDI ECGACLRVLE GHEELVRCIR 430 440 450 460 470 480 FDTKRIVSGA YDGKIKVWDL VAALDPRAAS NTLCLNTLVE HTGRVFRLQF DEFQIVSSSH 490 500 510 DDTILIWDFL NFTPNENKTG RTPSPALMEH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. , Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAM50758.1.
[4]	"Drosophila null slimb clones transiently deregulate Hedgehog-independent transcription of wingless in all limb discs, and induce decapentaplegic transcription linked to imaginal disc regeneration." Miletich I., Limbourg-Bouchon B. Mech. Dev. 93:15-26(2000) [PubMed: 10781936] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Ovary EMBL AAF63214.1 and Imaginal disc EMBL AAF63213.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014297 Genomic DNA. Translation: AAF55853.1. AF222923 mRNA. Translation: AAF63213.1. AF222924 mRNA. Translation: AAF63214.1. AY118898 mRNA. Translation: AAM50758.1.
RefSeq	NP_524430.1.
UniGene	Dm.2387
3D structure databases
HSSP	HSSP built from PDB template 1P22 based on UniProtKB Q9Y297.
SMR	Q9VDE3. Positions 35-85, 83-488.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VDE3. 32 interactions.
STRING	Q9VDE3.
Proteomic databases
PRIDE	Q9VDE3.
Genome annotation databases
Ensembl	FBtr0084032; FBpp0083434; FBgn0023423; Drosophila melanogaster. [Genome view]
GeneID	42504.
KEGG	dme:Dmel_CG3412.
NMPDR	fig|7227.3.peg.13855.
UCSC	CG3412-RA. d. melanogaster.
Organism-specific databases
CTD	42504.
FlyBase	FBgn0023423. slmb.
Phylogenomic databases
InParanoid	Q9VDE3.
OMA	TIKVWSM.
OrthoDB	EOG9F1X91.
PhylomeDB	Q9VDE3.
Gene expression databases
ArrayExpress	Q9VDE3.
Family and domain databases
InterPro	IPR001810. F-box. IPR020472. G-protein_beta_WD-40_rep_reg. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019782. WD40_repeat_2. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 7 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00256. FBOX. 1 hit. SM00320. WD40. 7 hits. [Graphical view]
PROSITE	PS50181. FBOX. 1 hit. PS00678. WD_REPEATS_1. 5 hits. PS50082. WD_REPEATS_2. 7 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	829138.

Entry information

Entry name

Q9VDE3_DROME

Accession

Primary (citable) accession number: Q9VDE3

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	February 9, 2010
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)