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Protein

Sensory neuron membrane protein 1

Gene

Snmp1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an olfactory role that is not restricted to pheromone sensitivity. Has a role in detection and signal transduction of the fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA). Not required for sensitivity to general odorants. Acts in concert with Or67d and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Essential for the electrophysiological responses of these olfactory sensory neurons (OSNs) to cVA. Not required for the development of trichoid OSNs and support cells.2 Publications

GO - Biological processi

  • cell surface receptor signaling pathway Source: FlyBase
  • cellular response to pheromone Source: FlyBase
  • detection of chemical stimulus involved in sensory perception of smell Source: FlyBase
  • lipid homeostasis Source: FlyBase
  • pupariation Source: FlyBase
  • response to pheromone Source: FlyBase

Keywordsi

Molecular functionReceptor
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-DME-114608. Platelet degranulation.
R-DME-1236973. Cross-presentation of particulate exogenous antigens (phagosomes).
R-DME-3000471. Scavenging by Class B Receptors.
R-DME-5686938. Regulation of TLR by endogenous ligand.
R-DME-6798695. Neutrophil degranulation.
R-DME-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-DME-8856828. Clathrin-mediated endocytosis.

Protein family/group databases

TCDBi9.B.39.1.6. the long chain fatty acid translocase (lcfat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sensory neuron membrane protein 13 PublicationsImported
Short name:
SNMP1Dmel1 Publication
Gene namesi
Name:Snmp11 Publication
ORF Names:CG7000
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0260004. Snmp1.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 459ExtracellularSequence analysisAdd BLAST431
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Topological domaini481 – 551CytoplasmicSequence analysisAdd BLAST71

GO - Cellular componenti

  • cilium Source: FlyBase
  • dendrite Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: FlyBase
  • plasma membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutants are viable and fertile with no gross morphological or locomotor defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004082391 – 551Sensory neuron membrane protein 1Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi265 ↔ 330By similarity
Disulfide bondi294 ↔ 352By similarity
Disulfide bondi332 ↔ 341By similarity
Glycosylationi440N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9VDD3.
PRIDEiQ9VDD3.

Expressioni

Tissue specificityi

Selectively expressed in antenna. Expressed in lateral-distal population of OSNs that coexpress Orco, in non-neuronal support cells that surround these OSNs, in support cells elsewhere in the antenna and chemosensory organs on the proboscis. Expressed in trichoid sensory cilia (at protein level).1 Publication

Developmental stagei

In L3 instar larvae, expression increases with development. Expressed in the ring gland. Ubiquitously expressed in the testis whereas in the ovary expression appears to be restricted to one pole. Weak expression in the Garland cells, salivary glands and the central nervous system.1 Publication

Gene expression databases

BgeeiFBgn0260004.
ExpressionAtlasiQ9VDD3. differential.
GenevisibleiQ9VDD3. DM.

Interactioni

Protein-protein interaction databases

BioGridi67484. 1 interactor.
IntActiQ9VDD3. 1 interactor.
MINTiMINT-774289.
STRINGi7227.FBpp0306056.

Structurei

3D structure databases

ProteinModelPortaliQ9VDD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD36 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3776. Eukaryota.
ENOG410XS17. LUCA.
GeneTreeiENSGT00530000062927.
InParanoidiQ9VDD3.
OMAiMISKQVT.
OrthoDBiEOG091G0ALW.
PhylomeDBiQ9VDD3.

Family and domain databases

InterProiView protein in InterPro
IPR005428. CD36/SCARB1/SNMP1.
IPR002159. CD36_fam.
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiView protein in Pfam
PF01130. CD36. 1 hit.
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.

Sequencei

Sequence statusi: Complete.

Q9VDD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVPRVKLLM GSGAMFVFAI IYGWVIFPKI LKFMISKQVT LKPGSDVREL
60 70 80 90 100
WSNTPFPLHF YIYVFNVTNP DEVSEGAKPR LQEVGPFVFD EWKDKYDLED
110 120 130 140 150
DVVEDTVSFT MRNTFIFNPK ESLPLTGEEE IILPHPIMLP GGISVQREKA
160 170 180 190 200
AMMELVSKGL SIVFPDAKAF LKAKFMDLFF RGINVDCSSE EFSAKALCTV
210 220 230 240 250
FYTGEIKQAK QVNQTHFLFS FMGQANHSDS GRFTVCRGVK NNKKLGKVVK
260 270 280 290 300
FADEPEQDIW PDGECNTFVG TDSTVFAPGL KKEDGLWAFT PDLCRSLGAY
310 320 330 340 350
YQHKSSYHGM PSMRYTLDLG DIRADEKLHC FCEDPEDLDT CPPKGTMNLA
360 370 380 390 400
ACVGGPLMAS MPHFYLGDPK LVADVDGLNP NEKDHAVYID FELMSGTPFQ
410 420 430 440 450
AAKRLQFNLD MEPVEGIEPM KNLPKLILPM FWVEEGVQLN KTYTNLVKYT
460 470 480 490 500
LFLGLKINSV LRWSLITFSL VGLMFSAYLF YHKSDSLDIN SILKDNNKVD
510 520 530 540 550
DVASTKEPLP SANPKQSSTV HPVQLPNTLI PGTNPATNPA THHKMEHRER

Y
Length:551
Mass (Da):62,117
Last modified:October 1, 2002 - v2
Checksum:iEB58ECD3B5A7158C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF55863.2.
BT024286 mRNA. Translation: ABC86348.1.
EF560170 mRNA. Translation: ABQ42604.1.
EF560171 mRNA. Translation: ABQ42605.1.
EF596938 Genomic DNA. Translation: ABQ96635.1.
RefSeqiNP_001262803.1. NM_001275874.1.
NP_650953.1. NM_142696.3.
UniGeneiDm.27587.

Genome annotation databases

EnsemblMetazoaiFBtr0084027; FBpp0083430; FBgn0260004.
FBtr0333928; FBpp0306056; FBgn0260004.
GeneIDi42514.
KEGGidme:Dmel_CG7000.
UCSCiCG7000-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiSNMP1_DROME
AccessioniPrimary (citable) accession number: Q9VDD3
Secondary accession number(s): A5JS49, A5JS50, A5YWL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: October 1, 2002
Last modified: August 30, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families