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Protein

Sensory neuron membrane protein 1

Gene

Snmp1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an olfactory role that is not restricted to pheromone sensitivity. Has a role in detection and signal transduction of the fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA). Not required for sensitivity to general odorants. Acts in concert with Or67d and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Essential for the electrophysiological responses of these olfactory sensory neurons (OSNs) to cVA. Not required for the development of trichoid OSNs and support cells.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: FlyBase
  • defense response Source: FlyBase
  • detection of chemical stimulus involved in sensory perception of smell Source: FlyBase
  • lipid homeostasis Source: FlyBase
  • pupariation Source: FlyBase
  • receptor-mediated endocytosis Source: GOC
  • response to pheromone Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Sensory neuron membrane protein 13 PublicationsImported
Short name:
SNMP1Dmel1 Publication
Gene namesi
Name:Snmp11 Publication
ORF Names:CG7000
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0260004. Snmp1.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence analysis
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Topological domaini29 – 459431ExtracellularSequence analysisAdd
BLAST
Transmembranei460 – 48021HelicalSequence analysisAdd
BLAST
Topological domaini481 – 55171CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • dendrite Source: FlyBase
  • integral component of plasma membrane Source: FlyBase
  • neuronal cell body Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutants are viable and fertile with no gross morphological or locomotor defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Sensory neuron membrane protein 1PRO_0000408239Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence analysis
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence analysis
Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence analysis
Disulfide bondi265 ↔ 330By similarity
Disulfide bondi294 ↔ 352By similarity
Disulfide bondi332 ↔ 341By similarity
Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9VDD3.

Expressioni

Tissue specificityi

Selectively expressed in antenna. Expressed in lateral-distal population of OSNs that coexpress Orco, in non-neuronal support cells that surround these OSNs, in support cells elsewhere in the antenna and chemosensory organs on the proboscis. Expressed in trichoid sensory cilia (at protein level).1 Publication

Gene expression databases

BgeeiQ9VDD3.
GenevisibleiQ9VDD3. DM.

Interactioni

Protein-protein interaction databases

BioGridi67484. 1 interaction.
IntActiQ9VDD3. 1 interaction.
MINTiMINT-774289.
STRINGi7227.FBpp0306056.

Structurei

3D structure databases

ProteinModelPortaliQ9VDD3.
SMRiQ9VDD3. Positions 35-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD36 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3776. Eukaryota.
ENOG410XS17. LUCA.
GeneTreeiENSGT00530000062927.
InParanoidiQ9VDD3.
OMAiFDEWKDK.
OrthoDBiEOG7ZWD1Q.
PhylomeDBiQ9VDD3.

Family and domain databases

InterProiIPR005428. CD36/SCARB1/SNMP1.
IPR002159. CD36_fam.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.

Sequencei

Sequence statusi: Complete.

Q9VDD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVPRVKLLM GSGAMFVFAI IYGWVIFPKI LKFMISKQVT LKPGSDVREL
60 70 80 90 100
WSNTPFPLHF YIYVFNVTNP DEVSEGAKPR LQEVGPFVFD EWKDKYDLED
110 120 130 140 150
DVVEDTVSFT MRNTFIFNPK ESLPLTGEEE IILPHPIMLP GGISVQREKA
160 170 180 190 200
AMMELVSKGL SIVFPDAKAF LKAKFMDLFF RGINVDCSSE EFSAKALCTV
210 220 230 240 250
FYTGEIKQAK QVNQTHFLFS FMGQANHSDS GRFTVCRGVK NNKKLGKVVK
260 270 280 290 300
FADEPEQDIW PDGECNTFVG TDSTVFAPGL KKEDGLWAFT PDLCRSLGAY
310 320 330 340 350
YQHKSSYHGM PSMRYTLDLG DIRADEKLHC FCEDPEDLDT CPPKGTMNLA
360 370 380 390 400
ACVGGPLMAS MPHFYLGDPK LVADVDGLNP NEKDHAVYID FELMSGTPFQ
410 420 430 440 450
AAKRLQFNLD MEPVEGIEPM KNLPKLILPM FWVEEGVQLN KTYTNLVKYT
460 470 480 490 500
LFLGLKINSV LRWSLITFSL VGLMFSAYLF YHKSDSLDIN SILKDNNKVD
510 520 530 540 550
DVASTKEPLP SANPKQSSTV HPVQLPNTLI PGTNPATNPA THHKMEHRER

Y
Length:551
Mass (Da):62,117
Last modified:October 1, 2002 - v2
Checksum:iEB58ECD3B5A7158C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF55863.2.
BT024286 mRNA. Translation: ABC86348.1.
EF560170 mRNA. Translation: ABQ42604.1.
EF560171 mRNA. Translation: ABQ42605.1.
EF596938 Genomic DNA. Translation: ABQ96635.1.
RefSeqiNP_001262803.1. NM_001275874.1.
NP_650953.1. NM_142696.3.
UniGeneiDm.27587.

Genome annotation databases

EnsemblMetazoaiFBtr0084027; FBpp0083430; FBgn0260004.
FBtr0333928; FBpp0306056; FBgn0260004.
GeneIDi42514.
KEGGidme:Dmel_CG7000.
UCSCiCG7000-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF55863.2.
BT024286 mRNA. Translation: ABC86348.1.
EF560170 mRNA. Translation: ABQ42604.1.
EF560171 mRNA. Translation: ABQ42605.1.
EF596938 Genomic DNA. Translation: ABQ96635.1.
RefSeqiNP_001262803.1. NM_001275874.1.
NP_650953.1. NM_142696.3.
UniGeneiDm.27587.

3D structure databases

ProteinModelPortaliQ9VDD3.
SMRiQ9VDD3. Positions 35-448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi67484. 1 interaction.
IntActiQ9VDD3. 1 interaction.
MINTiMINT-774289.
STRINGi7227.FBpp0306056.

Proteomic databases

PaxDbiQ9VDD3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0084027; FBpp0083430; FBgn0260004.
FBtr0333928; FBpp0306056; FBgn0260004.
GeneIDi42514.
KEGGidme:Dmel_CG7000.
UCSCiCG7000-RA. d. melanogaster.

Organism-specific databases

CTDi42514.
FlyBaseiFBgn0260004. Snmp1.

Phylogenomic databases

eggNOGiKOG3776. Eukaryota.
ENOG410XS17. LUCA.
GeneTreeiENSGT00530000062927.
InParanoidiQ9VDD3.
OMAiFDEWKDK.
OrthoDBiEOG7ZWD1Q.
PhylomeDBiQ9VDD3.

Miscellaneous databases

GenomeRNAii42514.
NextBioi829187.
PROiQ9VDD3.

Gene expression databases

BgeeiQ9VDD3.
GenevisibleiQ9VDD3. DM.

Family and domain databases

InterProiIPR005428. CD36/SCARB1/SNMP1.
IPR002159. CD36_fam.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J., Park S., Wan K., Yu C., Celniker S.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 190-367.
    Strain: W1118Imported.
    Tissue: HeadImported, LimbImported and WingImported.
  5. "An essential role for a CD36-related receptor in pheromone detection in Drosophila."
    Benton R., Vannice K.S., Vosshall L.B.
    Nature 450:289-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  6. "SNMP is a signaling component required for pheromone sensitivity in Drosophila."
    Jin X., Ha T.S., Smith D.P.
    Proc. Natl. Acad. Sci. U.S.A. 105:10996-11001(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSNMP1_DROME
AccessioniPrimary (citable) accession number: Q9VDD3
Secondary accession number(s): A5JS49, A5JS50, A5YWL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.