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Protein

Pyruvate kinase

Gene

Dmel\CG7069

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase 1 (Gapdh1), Glyceraldehyde-3-phosphate dehydrogenase 2 (Gapdh2), Glyceraldehyde-3-phosphate dehydrogenase (Gapdh2), Glyceraldehyde-3-phosphate dehydrogenase (CG9010)
  2. Phosphoglycerate kinase (Pgk), Phosphoglycerate kinase, Phosphoglycerate kinase (Dmel\CG9961), Phosphoglycerate kinase (Dmel\CG9961), Phosphoglycerate kinase (Pgk), Phosphoglycerate kinase (CG9961)
  3. no protein annotated in this organism
  4. Enolase (Eno)
  5. Pyruvate kinase (CG7362), Pyruvate kinase (PyK), Pyruvate kinase (Dmel\CG2964), Pyruvate kinase (Dmel\CG7069), Pyruvate kinase (CG7069), Pyruvate kinase (CG2964)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation

Enzyme and pathway databases

ReactomeiR-DME-6798695 Neutrophil degranulation
R-DME-70171 Glycolysis
UniPathwayiUPA00109; UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:Dmel\CG7069Imported
ORF Names:CG7069Imported, Dmel_CG7069Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0038952 CG7069

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiQ9VD23
PRIDEiQ9VD23

Expressioni

Gene expression databases

BgeeiFBgn0038952
ExpressionAtlasiQ9VD23 differential
GenevisibleiQ9VD23 DM

Interactioni

Protein-protein interaction databases

IntActiQ9VD23, 6 interactors
STRINGi7227.FBpp0083612

Structurei

3D structure databases

ProteinModelPortaliQ9VD23
SMRiQ9VD23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 324PKInterPro annotationAdd BLAST324
Domaini345 – 449PK_CInterPro annotationAdd BLAST105

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili497 – 517Sequence analysisAdd BLAST21
Coiled coili555 – 614Sequence analysisAdd BLAST60
Coiled coili616 – 719Sequence analysisAdd BLAST104

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2323 Eukaryota
COG0469 LUCA
GeneTreeiENSGT00390000008859
InParanoidiQ9VD23
KOiK00873
OMAiEEFEQMC
OrthoDBiEOG091G0597
PhylomeDBiQ9VD23

Family and domain databases

Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00110 PYRUVATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VD23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVVRMNFSH GSHEYHCQTI QAARKAIAMY VEQTGLPRTL AIALDTKGPE
60 70 80 90 100
IRTGKLAGGN DRAEIELKTG DKVTLSTKKE MADKSNKDNI YVDYQRLPQL
110 120 130 140 150
VKPGNRVFVD DGLIALIVKE SKGDEVICQV ENGGKLGSHK GINLPGVPVD
160 170 180 190 200
LPSVTEKDKQ DLKFGAEQKV DMIFASFIRD ANALKEIRQV LGPAGACIKI
210 220 230 240 250
ISKIENHQGL VNIDDIIRES DGIMVARGDM GIEIPTEDVP LAQKSIVAKC
260 270 280 290 300
NKVGKPVICA TQMMESMTNK PRPTRAEASD VANAIFDGCD AVMLSGETAK
310 320 330 340 350
GKYPVECVQC MARICAKVEA VLWYESLQNS LKREIRTSAA DHISAVTTAI
360 370 380 390 400
AEAATVGQAR AIVVASPCSM VAQMVSHMRP PCPIVMLTGN ESEAAQSLLF
410 420 430 440 450
RGIYPLLVEE MVIGSFNFRR IMQSGLKLMG KMDILEPGQK GSVVLVNAMS
460 470 480 490 500
AEKITFRLFT IRQQTKEERD QDERCRKLAL EQSCKERAEK EECRKLQQAE
510 520 530 540 550
ECQKQKLAKK CKQFEEKQKV CPKKNDTPKN DCPKKDCPKK ECPKQDDEIS
560 570 580 590 600
KCRQMQEAEA EERKCKEEFE QMCKLAEEKR KEAEKCRKAD EERRKEEAEK
610 620 630 640 650
CRKLEEDRKC KLAEEKKRNE EELKIIEAEV AKLEAAEKAK RLKEEEKKKE
660 670 680 690 700
ELMKCKQRNE AKKKREEAER CKRKEREREL AEMENKWKQV AEKRKRKKAA
710 720 730 740
EMCRKIEDAK EKAAAESADK ILKAVCEKLK QSLSDPDKSK KGKK
Length:744
Mass (Da):83,997
Last modified:March 1, 2001 - v2
Checksum:i27AAD998D07E17B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55980.2
RefSeqiNP_651030.1, NM_142773.1
UniGeneiDm.14821

Genome annotation databases

EnsemblMetazoaiFBtr0084215; FBpp0083612; FBgn0038952
GeneIDi42621
KEGGidme:Dmel_CG7069
UCSCiCG7069-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9VD23_DROME
AccessioniPrimary (citable) accession number: Q9VD23
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health