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Q9VD23

- Q9VD23_DROME

UniProt

Q9VD23 - Q9VD23_DROME

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Protein

Pyruvate kinase

Gene

CG7069

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. potassium ion binding Source: InterPro
  3. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
ORF Names:CG7069Imported, Dmel_CG7069Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0038952. CG7069.

PTM / Processingi

Proteomic databases

PRIDEiQ9VD23.

Expressioni

Gene expression databases

BgeeiQ9VD23.
ExpressionAtlasiQ9VD23. differential.

Interactioni

Protein-protein interaction databases

IntActiQ9VD23. 1 interaction.
MINTiMINT-764253.

Structurei

3D structure databases

ProteinModelPortaliQ9VD23.
SMRiQ9VD23. Positions 1-444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000008859.
InParanoidiQ9VD23.
KOiK00873.
OMAiVICQVEN.
OrthoDBiEOG78M01Q.
PhylomeDBiQ9VD23.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VD23-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVVRMNFSH GSHEYHCQTI QAARKAIAMY VEQTGLPRTL AIALDTKGPE
60 70 80 90 100
IRTGKLAGGN DRAEIELKTG DKVTLSTKKE MADKSNKDNI YVDYQRLPQL
110 120 130 140 150
VKPGNRVFVD DGLIALIVKE SKGDEVICQV ENGGKLGSHK GINLPGVPVD
160 170 180 190 200
LPSVTEKDKQ DLKFGAEQKV DMIFASFIRD ANALKEIRQV LGPAGACIKI
210 220 230 240 250
ISKIENHQGL VNIDDIIRES DGIMVARGDM GIEIPTEDVP LAQKSIVAKC
260 270 280 290 300
NKVGKPVICA TQMMESMTNK PRPTRAEASD VANAIFDGCD AVMLSGETAK
310 320 330 340 350
GKYPVECVQC MARICAKVEA VLWYESLQNS LKREIRTSAA DHISAVTTAI
360 370 380 390 400
AEAATVGQAR AIVVASPCSM VAQMVSHMRP PCPIVMLTGN ESEAAQSLLF
410 420 430 440 450
RGIYPLLVEE MVIGSFNFRR IMQSGLKLMG KMDILEPGQK GSVVLVNAMS
460 470 480 490 500
AEKITFRLFT IRQQTKEERD QDERCRKLAL EQSCKERAEK EECRKLQQAE
510 520 530 540 550
ECQKQKLAKK CKQFEEKQKV CPKKNDTPKN DCPKKDCPKK ECPKQDDEIS
560 570 580 590 600
KCRQMQEAEA EERKCKEEFE QMCKLAEEKR KEAEKCRKAD EERRKEEAEK
610 620 630 640 650
CRKLEEDRKC KLAEEKKRNE EELKIIEAEV AKLEAAEKAK RLKEEEKKKE
660 670 680 690 700
ELMKCKQRNE AKKKREEAER CKRKEREREL AEMENKWKQV AEKRKRKKAA
710 720 730 740
EMCRKIEDAK EKAAAESADK ILKAVCEKLK QSLSDPDKSK KGKK
Length:744
Mass (Da):83,997
Last modified:March 1, 2001 - v2
Checksum:i27AAD998D07E17B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAF55980.2.
RefSeqiNP_651030.1. NM_142773.1.
UniGeneiDm.14821.

Genome annotation databases

EnsemblMetazoaiFBtr0084215; FBpp0083612; FBgn0038952.
GeneIDi42621.
KEGGidme:Dmel_CG7069.
UCSCiCG7069-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAF55980.2 .
RefSeqi NP_651030.1. NM_142773.1.
UniGenei Dm.14821.

3D structure databases

ProteinModelPortali Q9VD23.
SMRi Q9VD23. Positions 1-444.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9VD23. 1 interaction.
MINTi MINT-764253.

Proteomic databases

PRIDEi Q9VD23.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0084215 ; FBpp0083612 ; FBgn0038952 .
GeneIDi 42621.
KEGGi dme:Dmel_CG7069.
UCSCi CG7069-RA. d. melanogaster.

Organism-specific databases

FlyBasei FBgn0038952. CG7069.

Phylogenomic databases

GeneTreei ENSGT00390000008859.
InParanoidi Q9VD23.
KOi K00873.
OMAi VICQVEN.
OrthoDBi EOG78M01Q.
PhylomeDBi Q9VD23.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Miscellaneous databases

GenomeRNAii 42621.
NextBioi 829736.

Gene expression databases

Bgeei Q9VD23.
ExpressionAtlasi Q9VD23. differential.

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.

Entry informationi

Entry nameiQ9VD23_DROME
AccessioniPrimary (citable) accession number: Q9VD23
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3