Reviewed, UniProtKB/Swiss-Prot Q9VCZ8 (PFD5_DROME)

Names and origin

Protein names

Recommended name:
    Probable prefoldin subunit 5

Gene names

ORF Names:

CG7048

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins By similarity.
Subunit structure	Heterohexamer of two PFD-alpha type and four PFD-beta type subunits By similarity.
Sequence similarities	Belongs to the prefoldin subunit alpha family.

Ontologies

Keywords
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: InterPro
Cellular component	prefoldin complex Inferred from electronic annotation. Source: InterPro
Molecular function	unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9VDE2	1	EBI-100243,EBI-139859
	Q9VW56	1	EBI-100243,EBI-162978
Aats-met	Q9VFL5	1	EBI-100243,EBI-182711

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 168	168	Probable prefoldin subunit 5		PRO_0000153665

Sequences

	Sequence		Length	Mass (Da)
	Q9VCZ8-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 047C81F16AD59194	FASTA	168	19,078
	10 20 30 40 50 60 MAATPSAPAK SEMIDLTKLS PEQLIQIKQE FEQEITNVQD SLSTLHGCQA KYAGSKEALG 70 80 90 100 110 120 TFQPNWENRQ ILVPLTSSMY VPGRVKDLNR FVIDIGTGYY IEKDLEGSKD YFKRRVEYVQ 130 140 150 160 EQIEKIEKIH LQKTRFYNSV MSVLEMKQAA AAKLQSQQQS QPAVTQSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Head.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014297 Genomic DNA. Translation: AAF56007.1. AY051649 mRNA. Translation: AAK93073.1.
RefSeq	NP_651053.1.
UniGene	Dm.4526
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:20776N.
IntAct	Q9VCZ8. 10 interactions.
STRING	Q9VCZ8.
Proteomic databases
PRIDE	Q9VCZ8.
Genome annotation databases
Ensembl	FBtr0084257; FBpp0083650; FBgn0038976; Drosophila melanogaster. [Genome view]
GeneID	42647.
KEGG	dme:Dmel_CG7048.
NMPDR	fig|7227.3.peg.14078.
UCSC	CG7048-RA. d. melanogaster.
Organism-specific databases
FlyBase	FBgn0038976. CG7048.
Phylogenomic databases
HOGENOM	Q9VCZ8.
OMA	KRRTRAY
OrthoDB	EOG9V6ZQJ
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-012829-MON.
Gene expression databases
ArrayExpress	Q9VCZ8.
GermOnline	CG7048. Drosophila melanogaster.
Family and domain databases
InterPro	IPR011599. PFD_alpha. IPR004127. PFD_alpha-like. IPR009053. Prefoldin. [Graphical view]
Pfam	PF02996. Prefoldin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00293. PFD_alpha. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	829861.

Entry information

Entry name

PFD5_DROME

Accession

Primary (citable) accession number: Q9VCZ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 2000
Last modified:	November 24, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project