Reviewed, UniProtKB/Swiss-Prot Q9VCW0 (CCAP_DROME)

Names and origin

Protein names

Recommended name:
    Cardioactive peptide
Alternative name(s):
    Crustacean cardioactive peptide
      Short name=CCAP
    Cardioacceleratory peptide 2a

Gene names

Name:	Ccap
ORF Names:	CG4910

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	151 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Cardioregulatory neurohormone that increases heart beat rate during adult wing inflation; has no effect on beat amplitude. The effect of CCAP is both ino- and chronotropic By similarity. UniProtKB Q8WRC7
Subcellular location	Secreted By similarity. UniProtKB Q8WRC7
Tissue specificity	Central nervous system; most neurons exhibit coexpression with burs. Ref.3

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone Neuropeptide
PTM	Amidation Cleavage on pair of basic residues Disulfide bond
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	neuropeptide hormone activity Non-traceable author statement. Source: FlyBase
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CG5890-RA	Q9VBL2	1	EBI-158635,EBI-105608

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 19

19

Potential

Propeptide

20 – 45

26

By similarity

PRO_0000020851

Peptide

48 – 56

9

Cardioactive peptide By similarity UniProtKB Q8WRC7

PRO_0000020852

Propeptide

60 – 151

92

By similarity UniProtKB Q8WRC7

PRO_0000020853

Amino acid modifications

Modified residue

56

1

Cysteine amide By similarity UniProtKB Q8WRC7

Disulfide bond

50 ↔ 56

By similarity UniProtKB Q8WRC7

Secondary structure

1

.

.

.

151

Helix Strand Turn

Details...

Beta strand

50 – 54

5

Sequences

	Sequence		Length	Mass (Da)
	Q9VCW0-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: A038C56A5AA367C4	FASTA	151	17,568
	10 20 30 40 50 60 MRISLRLLAL LACAICSQAS LERENNEGTN MANHKLSGVI QWKYEKRPFC NAFTGCGRKR 70 80 90 100 110 120 TYPSYPPFSL FKRNEVEEKP YNNEYLSEGL SDLIDINAEP AVENVQKQIM SQAKIFEAIK 130 140 150 EASKEIFRQK NKQKMLQNEK EMQQLEERES K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"Identification of the gene encoding bursicon, an insect neuropeptide responsible for cuticle sclerotization and wing spreading." Dewey E.M., McNabb S.L., Ewer J., Kuo G.R., Takanishi C.L., Truman J.W., Honegger H.-W. Curr. Biol. 14:1208-1213(2004) [PubMed: 15242619] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AE014297 Genomic DNA. Translation: AAF56045.1.

RefSeq

NP_651083.2.

UniGene

Dm.31330

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1Y49	NMR	-	A	48-56	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9VCW0. 1 interaction.

Proteomic databases

PRIDE

Q9VCW0.

Genome annotation databases

Ensembl

FBgn0039007. Drosophila melanogaster. [Contig view]

GeneID

42683.

KEGG

dme:Dmel_CG4910.

NMPDR

fig|7227.3.peg.14124.

Organism-specific databases

FlyBase

FBgn0039007. Ccap.

Phylogenomic databases

OMA

Q9VCW0. EASKEIF.

Gene expression databases

ArrayExpress

Q9VCW0.

GermOnline

CG4910. Drosophila melanogaster.

Family and domain databases

ProtoNet

Search...

Other Resources

NextBio

830042.

Entry information

Entry name

CCAP_DROME

Accession

Primary (citable) accession number: Q9VCW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project