##gff-version 3 Q9VCU9 UniProtKB Chain 1 2249 . . . ID=PRO_0000180474;Note=Endoribonuclease Dcr-1 Q9VCU9 UniProtKB Domain 485 648 . . . Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542 Q9VCU9 UniProtKB Domain 825 920 . . . Note=Dicer dsRNA-binding fold;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00657 Q9VCU9 UniProtKB Domain 1100 1246 . . . Note=PAZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00142 Q9VCU9 UniProtKB Domain 1698 1919 . . . Note=RNase III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00177 Q9VCU9 UniProtKB Domain 1993 2150 . . . Note=RNase III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00177 Q9VCU9 UniProtKB Domain 2175 2241 . . . Note=DRBM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00266 Q9VCU9 UniProtKB Region 1 1042 . . . Note=Necessary for processing certain pre-miRNas%2C such as pre-let 7 and pre-bantam;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17666393;Dbxref=PMID:17666393 Q9VCU9 UniProtKB Region 1 761 . . . Note=Helicase domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A1ZAW0 Q9VCU9 UniProtKB Region 1 690 . . . Note=Important for interaction with loqs isoform PB (loqs-PB);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17666393;Dbxref=PMID:17666393 Q9VCU9 UniProtKB Region 1 371 . . . Note=Essential for miRNA substrate recognition;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21926993;Dbxref=PMID:21926993 Q9VCU9 UniProtKB Region 371 491 . . . Note=Dispensable for activity and substrate recognition;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21926993;Dbxref=PMID:21926993 Q9VCU9 UniProtKB Region 436 486 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9VCU9 UniProtKB Region 496 606 . . . Note=Essential for miRNA substrate recognition;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21926993;Dbxref=PMID:21926993 Q9VCU9 UniProtKB Region 617 761 . . . Note=Dispensable for activity and substrate recognition;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21926993;Dbxref=PMID:21926993 Q9VCU9 UniProtKB Region 640 665 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9VCU9 UniProtKB Region 705 757 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9VCU9 UniProtKB Region 924 957 . . . Note=Wing domain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:36182693;Dbxref=PMID:36182693 Q9VCU9 UniProtKB Region 963 1108 . . . Note=Platform domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A1ZAW0 Q9VCU9 UniProtKB Region 1147 2249 . . . Note=Essential for production of mature miRNAs from pre-miRNAs. Also important for proper formation of the siRISC complex but is dispensable for biogenesis of siRNAs;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15066283;Dbxref=PMID:15066283 Q9VCU9 UniProtKB Region 1314 1351 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9VCU9 UniProtKB Region 1426 1477 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9VCU9 UniProtKB Compositional bias 649 665 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9VCU9 UniProtKB Compositional bias 1426 1448 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9VCU9 UniProtKB Binding site 37 44 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9VCU9 UniProtKB Binding site 1745 1745 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:36182693,ECO:0007744|PDB:8DG7;Dbxref=PMID:36182693 Q9VCU9 UniProtKB Binding site 1749 1749 . . . Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:36182693,ECO:0007744|PDB:8DG5,ECO:0007744|PDB:8DG7;Dbxref=PMID:36182693 Q9VCU9 UniProtKB Binding site 1905 1905 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:36182693,ECO:0007744|PDB:8DG7;Dbxref=PMID:36182693 Q9VCU9 UniProtKB Binding site 1908 1908 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:36182693,ECO:0007744|PDB:8DG7;Dbxref=PMID:36182693 Q9VCU9 UniProtKB Binding site 1908 1908 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:36182693,ECO:0007744|PDB:8DG7;Dbxref=PMID:36182693 Q9VCU9 UniProtKB Binding site 2032 2032 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9UPY3 Q9VCU9 UniProtKB Binding site 2136 2136 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9UPY3 Q9VCU9 UniProtKB Binding site 2139 2139 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9UPY3 Q9VCU9 UniProtKB Site 2132 2132 . . . Note=Important for activity;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9VCU9 UniProtKB Modified residue 1423 1423 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18327897;Dbxref=PMID:18327897 Q9VCU9 UniProtKB Modified residue 1877 1877 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18327897;Dbxref=PMID:18327897 Q9VCU9 UniProtKB Modified residue 1880 1880 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18327897;Dbxref=PMID:18327897 Q9VCU9 UniProtKB Mutagenesis 1749 1749 . . . Note=Cleaves the 5' (top) strand but not the 3' (bottom) strand of pre-miRNA. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17666393;Dbxref=PMID:17666393 Q9VCU9 UniProtKB Mutagenesis 1908 1908 . . . Note=Cleaves the 5' (top) strand but not the 3' (bottom) strand of pre-miRNA. Abolishes cleavage of pre-miRNA%3B when associated with A-2139. E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17666393,ECO:0000269|PubMed:21926993;Dbxref=PMID:17666393,PMID:21926993 Q9VCU9 UniProtKB Mutagenesis 2036 2036 . . . Note=Cleaves the 3' (bottom) strand but not the 5' (top) strand of pre-miRNA. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17666393;Dbxref=PMID:17666393 Q9VCU9 UniProtKB Mutagenesis 2139 2139 . . . Note=Cleaves the 3' (bottom) strand but not the 5' (top) strand of pre-miRNA. Abolishes cleavage of pre-miRNA%3B when associated with A-1908. E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17666393,ECO:0000269|PubMed:21926993;Dbxref=PMID:17666393,PMID:21926993 Q9VCU9 UniProtKB Mutagenesis 2186 2249 . . . Note=No effect on processing of the pre-miRNas%2C pre-let 7 and pre-bantam. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17666393;Dbxref=PMID:17666393 Q9VCU9 UniProtKB Sequence conflict 1338 1339 . . . Note=PT->AI;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9VCU9 UniProtKB Sequence conflict 1345 1345 . . . Note=L->I;Ontology_term=ECO:0000305;evidence=ECO:0000305