Reviewed,
UniProtKB/Swiss-Prot Q9VCR6 (SAV_DROME)
Last modified
June 16, 2009.
Version 62.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Scaffold protein salvador Alternative name(s): Shar-pei | ||||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) [Complete proteome] | ||||||
| Taxonomic identifier | 7227 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 608 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Required for cell cycle exit in eye imaginal disk and hid-induced apoptotic cell deaths that are part of normal retinal development. Activation of Ice in eye imaginal disk by either Hid or Rpr is almost completely blocked by Sav expression. Probably part of a same tumor suppression pathway with Sav and Wts. Ref.1 Ref.5 Ref.6 |
| Subunit structure | Interacts with Wts via its WW domains. Ref.1 |
| Tissue specificity | Third instar larvae eye disk, expressed in a stripe in the morphogenetic furrow, decreases in the region of the second mitotic wave (SMW) and increases once again posterior to the SMW. Ref.1 |
| Post-translational modification | |
| Sequence similarities | Contains 1 SARAH domain. Contains 2 WW domains. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CG15423-RA | Q9VQW5 | 1 | EBI-145004,EBI-153446 | |
| hpo | Q8T0S6 | 1 | EBI-145004,EBI-101858 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 608 | 608 | Scaffold protein salvador | PRO_0000076062 | |||||
Regions | |||||||||
| Domain | 423 – 456 | 34 | WW 1 | ||||||
| Domain | 458 – 491 | 34 | WW 2 | ||||||
| Domain | 552 – 599 | 48 | SARAH | ||||||
| Coiled coil | 274 – 294 | 21 | Potential | ||||||
| Compositional bias | 107 – 132 | 26 | His-rich | ||||||
| Compositional bias | 231 – 234 | 4 | Poly-Gln | ||||||
| Compositional bias | 275 – 289 | 15 | Poly-Gln | ||||||
Amino acid modifications | |||||||||
| Modified residue | 413 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 416 | 1 | Phosphoserine Ref.8 | ||||||
Experimental info | |||||||||
| Sequence conflict | 119 | 1 | S → A in AAL39999. Ref.4 | ||||||
| Sequence conflict | 194 | 1 | L → M in AAM97280. Ref.1 | ||||||
| Sequence conflict | 275 | 1 | Missing in AAL39999. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines." Tapon N., Harvey K.F., Bell D.W., Wahrer D.C.R., Schiripo T.A., Haber D.A., Hariharan I.K. Cell 110:467-478(2002) [PubMed: 12202036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE, FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH WTS. |
| [2] | "The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. Venter J.C.Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley. |
| [3] | "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. Lewis S.E.Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. |
| [4] | "A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo. |
| [5] | "Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila." Kango-Singh M., Nolo R., Tao C., Verstreken P., Hiesinger P.R., Bellen H.J., Halder G. Development 129:5719-5730(2002) [PubMed: 12421711] [Abstract] Cited for: FUNCTION. |
| [6] | "The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis." Harvey K.F., Pfleger C.M., Hariharan I.K. Cell 114:457-467(2003) [PubMed: 12941274] [Abstract] Cited for: FUNCTION WITH HPO. |
| [7] | "hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts." Wu S., Huang J., Dong J., Pan D. Cell 114:445-456(2003) [PubMed: 12941273] [Abstract] Cited for: PHOSPHORYLATION BY HPO. |
| [8] | "Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413 AND SER-416, MASS SPECTROMETRY. Tissue: Embryo. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AY131211 mRNA. Translation: AAM97280.1. AE014297 Genomic DNA. Translation: AAF56090.3. AY069854 mRNA. Translation: AAL39999.1. | |
| RefSeq | NP_788721.1. |
| UniGene | Dm.1289 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:18696N. |
| IntAct | Q9VCR6. 31 interactions. |
Genome annotation databases | |
| Ensembl | FBgn0053193. Drosophila melanogaster. [Contig view] |
| GeneID | 252554. |
| KEGG | dme:Dmel_CG33193. |
| NMPDR | fig|7227.3.peg.14174. |
Organism-specific databases | |
| FlyBase | FBgn0053193. sav. |
Phylogenomic databases | |
| HOGENOM | Q9VCR6. |
Enzyme and pathway databases | |
| BioCyc | DMEL-XXX-02:DMEL-XXX-02-012925-MON. |
Gene expression databases | |
| ArrayExpress | Q9VCR6. |
| GermOnline | CG33193. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR011524. SARAH. IPR001202. WW_Rsp5_WWP. [Graphical view] |
| Pfam | PF00397. WW. 2 hits. [Graphical view] |
| SMART | SM00456. WW. 2 hits. [Graphical view] |
| PROSITE | PS50951. SARAH. 1 hit. PS01159. WW_DOMAIN_1. False negative. PS50020. WW_DOMAIN_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 843605. |
Entry information
| Entry name | SAV_DROME | ||||||||
| Accession | Primary (citable) accession number: Q9VCR6 Secondary accession number(s): Q8MQH6, Q8T9A6, Q9VCR5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with


