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Protein
Submitted name:

Myoblast city

Gene

mbc

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • Rac guanyl-nucleotide exchange factor activity Source: FlyBase

GO - Biological processi

  • actin cytoskeleton organization Source: FlyBase
  • activation of GTPase activity Source: FlyBase
  • anterior Malpighian tubule development Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • cell competition in a multicellular organism Source: FlyBase
  • cell morphogenesis Source: FlyBase
  • central nervous system development Source: FlyBase
  • cytoskeleton organization Source: FlyBase
  • dorsal closure Source: FlyBase
  • larval visceral muscle development Source: FlyBase
  • muscle attachment Source: FlyBase
  • myoblast fusion Source: FlyBase
  • skeletal muscle tissue development Source: FlyBase
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-418885. DCC mediated attractive signaling.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
R-DME-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Submitted name:
Myoblast cityImported
Submitted name:
Myoblast city, isoform AImported
Gene namesi
Name:mbcImported
ORF Names:CG10379Imported, Dmel_CG10379Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0015513. mbc.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • extrinsic component of plasma membrane Source: FlyBase
  • ruffle Source: FlyBase
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ9VCH4. differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Ced-12Q9VKB26EBI-177001,EBI-147069
CrkQ9XYM03EBI-177001,EBI-99477

Protein-protein interaction databases

DIPiDIP-18141N.
IntActiQ9VCH4. 20 interactions.
MINTiMINT-930590.
STRINGi7227.FBpp0293271.

Structurei

3D structure databases

SMRiQ9VCH4. Positions 1-165, 444-625, 1236-1660.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 7263SH3InterPro annotationAdd
BLAST
Domaini444 – 623180DHR-1InterPro annotationAdd
BLAST
Domaini1251 – 1664414DHR-2InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1998. Eukaryota.
ENOG410XQH7. LUCA.
GeneTreeiENSGT00610000085806.
PhylomeDBiQ9VCH4.

Family and domain databases

InterProiIPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR031057. DOCK1_homologue.
IPR010703. DOCK_C.
IPR032376. DOCK_N.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 2 hits.
PTHR23317:SF69. PTHR23317:SF69. 2 hits.
PfamiPF06920. DHR-2. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF16172. DOCK_N. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VCH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVWSDCNAK QAEFGIAKCN FDQESKPHRL NLDVGDAVII LKETTHWYYG
60 70 80 90 100
YRQKAKEIRG IFPKSYIHLC EYNIVNGEYC IQRTDIVEEI TKVLLEWGSI
110 120 130 140 150
AKDYFLTTNP SFPKIRRKMN ELNNNRAALI SGNLPLDEVR KVKLLATNQI
160 170 180 190 200
DTGNKLLGLD MVVRDESGDI LDTNAICTTE LYEQHMHAVQ RIDKANRLSS
210 220 230 240 250
ERGTTRTPNK YSHNILLHVN AFVCKFQEDS DLLFTLFDGE THKPISENYV
260 270 280 290 300
VKWSRTGIAR DTDQIDNNRV LFTDLSKSDL AIAKMYLVCY AIRIGSMEFK
310 320 330 340 350
DSAESKRTSM SIANSMLNAS SRKASQLSVS SSGSSSSNGE YIIRRPFGVA
360 370 380 390 400
CKDLTPFINK SDDFRGNIDL PFIMCEKETL DGTLRKLIAN KDIGKIDSKM
410 420 430 440 450
AVTIEVLRGD IKQIKEEFPR LMHTNVPVAR KMGFPEVILP GDVRNDLYLT
460 470 480 490 500
ICSGEFARIA KTSEKNVEVS VCVANEQGYL MPGVLSIGAG HQPIDEYKSV
510 520 530 540 550
VYYHDDKPKW QETFKIHVPI EDFKQCHLRF VLKHRSSNEQ KDRTEKPFGL
560 570 580 590 600
AYVRLMQANG TTITQGQHIL AVYKIDHKKY DKTVANCYLE LPATVAELQG
610 620 630 640 650
AKPSIGGLTL LPKDQLSIGV NLCSTKLTQS VSLLGLLNWS AHKETLEQSL
660 670 680 690 700
NALSTVPGEE VVKFLQDILD ALFNILVEND HPEKYDQLVF MSIIHLIETV
710 720 730 740 750
SDLKYQHFLS VLDVYINESF SFTLAYTKLM DVLQKNISEA ISPKEKSADG
760 770 780 790 800
NDLEESPEVR RLYKTTRYLH YVMKFVIRSR VLYAEMNCNT DYMDFATRLQ
810 820 830 840 850
ELLRMFIDMI GCPSNLLKSE GALLKNLHII ATDLMQVFEH VRLSISIVEI
860 870 880 890 900
LEKFPPRRLT QSKMGCIKDF VETKLFTLPK CRAILLPVFC KHIKDHLESK
910 920 930 940 950
EEIAECINIM NNILKLLFRS DVGSTHNDIR DIMIILFRTV MKAAHALDRD
960 970 980 990 1000
TGLVGKFFAI MLGILQRMDA QHYEYFVKDL HQSGELKHFV IEILLVFEEL
1010 1020 1030 1040 1050
VSPHQKAVFP RDWMDMIMHQ NTVILGALKH LTVVITDYFL CPFEKQIWSN
1060 1070 1080 1090 1100
FFQCSIAFLV QSPLQLNDFN DNKRQIVFAR YRDIRKDTAM EIRKMWFQLG
1110 1120 1130 1140 1150
QHKPKFVPQL VEPILEMSMI PEKELRQETI PIFFDMMQCE YYSSRLEHES
1160 1170 1180 1190 1200
YGDTKFNNAH HKGNFSDFKT AMIEKLDILI GAGKGDAEYK HLFETIMLER
1210 1220 1230 1240 1250
CAAHNTLNVD GTAFVQMVTR LMDKLLEYRF IIQDESKENR MACTFSLLQF
1260 1270 1280 1290 1300
YSEVDLKEMY IRYVNKLCAL HMEFENYTEA AFTLKLHTEL LRWTDTELSH
1310 1320 1330 1340 1350
QLRSYRHNNC RTHRQLKEAL YFEIMEYFDK GKQWECAIDM CRVLARQYEE
1360 1370 1380 1390 1400
EIFDYLKLAE LLNRMALFYE KIIKELRHNS EYFRVCFYGR GFPRFLQNRV
1410 1420 1430 1440 1450
YIFRGKEYER HSDFCARMLV QHPQAELMQT LEAPGDDITN SDGQYIQVNK
1460 1470 1480 1490 1500
VEPIMGQAFN KFNDKIINNE IVKYFTANNV QKFQFSRPFR DSTNGGDRDD
1510 1520 1530 1540 1550
VRNLWLERTE LRISYPLPGI LRWFPVVETN TFKISPLERA VEIMKDTNRD
1560 1570 1580 1590 1600
IRQLVILHKS DETLHINPLS MKLNGIVDPA VMGGFAKYEE AFLTDDYLEQ
1610 1620 1630 1640 1650
NPDDKELVEE LKELIANQIP LLDLAIQLHR LRAPDSLKAL QEHLERCFAD
1660 1670 1680 1690 1700
MQQHVEQRYG RKSCDLKIER DSVVMRRPNS FLPSLFDGSN NRHSETSMGS
1710 1720 1730 1740 1750
SDSGLSKSTF LPRPQTNSIK NPFSGLSFNT RPSLGHSPSI KSNKSKDKTP
1760 1770 1780 1790 1800
SKRRTKDGKV KEREAHSLSS SQWYTPPLST ITSTPEKEIN TSIASLASTS
1810 1820 1830 1840 1850
NSSLSGPKTP DPHVLTEELT PKRPLRSEME KERRLSRPAS IATPTASIKN
1860 1870 1880 1890 1900
FPDTRSLSES SNRNSVETTD STSEEDIRPP PLPAKARDST DFTSLSQNMD
1910 1920 1930 1940 1950
WTPNGYAMLS TISNTSSMST TSTLTKTSIT NTTYEYLETT NFSLVGAIDG
1960 1970
NKPRPPTPPP KPSRHSKHIP
Length:1,970
Mass (Da):226,460
Last modified:October 1, 2002 - v2
Checksum:i8E38CA72FDD3A656
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007805 mRNA. Translation: AAB69648.1.
AE014297 Genomic DNA. Translation: AAF56191.2.
PIRiT03284.
RefSeqiNP_477144.1. NM_057796.4.
UniGeneiDm.3480.

Genome annotation databases

EnsemblMetazoaiFBtr0084459; FBpp0083850; FBgn0015513.
GeneIDi42817.
UCSCiCG10379-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007805 mRNA. Translation: AAB69648.1.
AE014297 Genomic DNA. Translation: AAF56191.2.
PIRiT03284.
RefSeqiNP_477144.1. NM_057796.4.
UniGeneiDm.3480.

3D structure databases

SMRiQ9VCH4. Positions 1-165, 444-625, 1236-1660.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-18141N.
IntActiQ9VCH4. 20 interactions.
MINTiMINT-930590.
STRINGi7227.FBpp0293271.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0084459; FBpp0083850; FBgn0015513.
GeneIDi42817.
UCSCiCG10379-RA. d. melanogaster.

Organism-specific databases

CTDi42817.
FlyBaseiFBgn0015513. mbc.

Phylogenomic databases

eggNOGiKOG1998. Eukaryota.
ENOG410XQH7. LUCA.
GeneTreeiENSGT00610000085806.
PhylomeDBiQ9VCH4.

Enzyme and pathway databases

ReactomeiR-DME-418885. DCC mediated attractive signaling.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
R-DME-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

GenomeRNAii42817.

Gene expression databases

ExpressionAtlasiQ9VCH4. differential.

Family and domain databases

InterProiIPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR031057. DOCK1_homologue.
IPR010703. DOCK_C.
IPR032376. DOCK_N.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 2 hits.
PTHR23317:SF69. PTHR23317:SF69. 2 hits.
PfamiPF06920. DHR-2. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF16172. DOCK_N. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization."
    Erickson M.R., Galletta B.J., Abmayr S.M.
    J. Cell Biol. 138:589-603(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Erickson M.R.S., Galletta B.J., Abmayr S.M.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  6. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  9. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  11. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  13. FlyBase
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9VCH4_DROME
AccessioniPrimary (citable) accession number: Q9VCH4
Secondary accession number(s): O16103
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.