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Q9VCE6

- MTA70_DROME

UniProt

Q9VCE6 - MTA70_DROME

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Protein

Probable N6-adenosine-methyltransferase MT-A70-like protein

Gene

Ime4

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Probable N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites in mRNA isolated, may play a role in the efficiency of mRNA splicing, transport or translation (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + m7G(5')pppAm = S-adenosyl-L-homocysteine + m7G(5')pppm6Am.

GO - Molecular functioni

  1. mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity Source: UniProtKB
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. germarium-derived female germ-line cyst encapsulation Source: FlyBase
  2. mRNA methylation Source: GOC
  3. ovarian follicle cell development Source: FlyBase
  4. regulation of gene silencing Source: FlyBase
  5. regulation of Notch signaling pathway Source: FlyBase
  6. RNA methylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiREACT_207945. Processing of Capped Intron-Containing Pre-mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N6-adenosine-methyltransferase MT-A70-like protein (EC:2.1.1.62)
Alternative name(s):
Inducer of meiosis 4
Gene namesi
Name:Ime4
ORF Names:CG5933
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0039139. Ime4.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 608608Probable N6-adenosine-methyltransferase MT-A70-like proteinPRO_0000207633Add
BLAST

Proteomic databases

PaxDbiQ9VCE6.
PRIDEiQ9VCE6.

Expressioni

Gene expression databases

BgeeiQ9VCE6.

Interactioni

Protein-protein interaction databases

BioGridi67779. 16 interactions.
DIPiDIP-17384N.
IntActiQ9VCE6. 3 interactions.
MINTiMINT-308015.
STRINGi7227.FBpp0083917.

Structurei

3D structure databases

ProteinModelPortaliQ9VCE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MT-A70-like family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG4725.
GeneTreeiENSGT00550000075058.
InParanoidiQ9VCE6.
KOiK05925.
OMAiCDLRFLD.
OrthoDBiEOG7PZRWV.
PhylomeDBiQ9VCE6.

Family and domain databases

InterProiIPR025848. MT-A70.
IPR007757. MT-A70-like.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF05063. MT-A70. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51143. MT_A70. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VCE6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADAWDIKSL KTKRNTLREK LEKRKKERIE ILSDIQEDLT NPKKELVEAD
60 70 80 90 100
LEVQKEVLQA LSSCSLALPI VSTQVVEKIA GSSLEMVNFI LGKLANQGAI
110 120 130 140 150
VIRNVTIGTE AGCEIISVQP KELKEILEDT NDTCQQKEEE AKRKLEVDDV
160 170 180 190 200
DQPQEKTIKL ESTVARKEST SLDAPDDIMM LLSMPSTREK QSKQVGEEIL
210 220 230 240 250
ELLTKPTAKE RSVAEKFKSH GGAQVMEFCS HGTKVECLKA QQATAEMAAK
260 270 280 290 300
KKQERRDEKE LRPDVDAGEN VTGKVPKTES AAEDGEIIAE VINNCEAESQ
310 320 330 340 350
ESTDGSDTCS SETTDKCTKL HFKKIIQAHT DESLGDCSFL NTCFHMATCK
360 370 380 390 400
YVHYEVDTLP HINTNKPTDV KTKLSLKRSV DSSCTLYPPQ WIQCDLRFLD
410 420 430 440 450
MTVLGKFAVV MADPPWDIHM ELPYGTMSDD EMRALGVPAL QDDGLIFLWV
460 470 480 490 500
TGRAMELGRD CLKLWGYERV DELIWVKTNQ LQRIIRTGRT GHWLNHGKEH
510 520 530 540 550
CLVGMKGNPT NLNRGLDCDV IVAEVRATSH KPDEIYGIIE RLSPGTRKIE
560 570 580 590 600
LFGRPHNIQP NWITLGNQLD GIRLVDPELI TQFQKRYPDG NCMSPASANA

ASINGIQK
Length:608
Mass (Da):68,101
Last modified:May 1, 2000 - v1
Checksum:i00A2E06082E7FD2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56221.1.
AY113286 mRNA. Translation: AAM29291.1.
RefSeqiNP_651204.1. NM_142947.4.
UniGeneiDm.13317.

Genome annotation databases

EnsemblMetazoaiFBtr0084532; FBpp0083917; FBgn0039139.
GeneIDi42844.
KEGGidme:Dmel_CG5933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56221.1 .
AY113286 mRNA. Translation: AAM29291.1 .
RefSeqi NP_651204.1. NM_142947.4.
UniGenei Dm.13317.

3D structure databases

ProteinModelPortali Q9VCE6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 67779. 16 interactions.
DIPi DIP-17384N.
IntActi Q9VCE6. 3 interactions.
MINTi MINT-308015.
STRINGi 7227.FBpp0083917.

Proteomic databases

PaxDbi Q9VCE6.
PRIDEi Q9VCE6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0084532 ; FBpp0083917 ; FBgn0039139 .
GeneIDi 42844.
KEGGi dme:Dmel_CG5933.

Organism-specific databases

CTDi 42844.
FlyBasei FBgn0039139. Ime4.

Phylogenomic databases

eggNOGi COG4725.
GeneTreei ENSGT00550000075058.
InParanoidi Q9VCE6.
KOi K05925.
OMAi CDLRFLD.
OrthoDBi EOG7PZRWV.
PhylomeDBi Q9VCE6.

Enzyme and pathway databases

Reactomei REACT_207945. Processing of Capped Intron-Containing Pre-mRNA.

Miscellaneous databases

GenomeRNAii 42844.
NextBioi 830874.
PROi Q9VCE6.

Gene expression databases

Bgeei Q9VCE6.

Family and domain databases

InterProi IPR025848. MT-A70.
IPR007757. MT-A70-like.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF05063. MT-A70. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51143. MT_A70. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Testis.

Entry informationi

Entry nameiMTA70_DROME
AccessioniPrimary (citable) accession number: Q9VCE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3