SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9VCE6

- MTA70_DROME

UniProt

Q9VCE6 - MTA70_DROME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable N6-adenosine-methyltransferase MT-A70-like protein
Gene
Ime4, CG5933
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites in mRNA isolated, may play a role in the efficiency of mRNA splicing, transport or translation By similarity.

Catalytic activityi

S-adenosyl-L-methionine + m7G(5')pppAm = S-adenosyl-L-homocysteine + m7G(5')pppm6Am.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity Source: UniProtKB

GO - Biological processi

  1. RNA methylation Source: UniProtKB
  2. germarium-derived female germ-line cyst encapsulation Source: FlyBase
  3. mRNA methylation Source: GOC
  4. ovarian follicle cell development Source: FlyBase
  5. regulation of Notch signaling pathway Source: FlyBase
  6. regulation of gene silencing Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiREACT_207945. Processing of Capped Intron-Containing Pre-mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N6-adenosine-methyltransferase MT-A70-like protein (EC:2.1.1.62)
Alternative name(s):
Inducer of meiosis 4
Gene namesi
Name:Ime4
ORF Names:CG5933
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0039139. Ime4.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 608608Probable N6-adenosine-methyltransferase MT-A70-like protein
PRO_0000207633Add
BLAST

Proteomic databases

PaxDbiQ9VCE6.
PRIDEiQ9VCE6.

Expressioni

Gene expression databases

BgeeiQ9VCE6.

Interactioni

Protein-protein interaction databases

BioGridi67779. 16 interactions.
DIPiDIP-17384N.
IntActiQ9VCE6. 3 interactions.
MINTiMINT-308015.
STRINGi7227.FBpp0083917.

Structurei

3D structure databases

ProteinModelPortaliQ9VCE6.

Family & Domainsi

Sequence similaritiesi

Belongs to the MT-A70-like family.

Phylogenomic databases

eggNOGiCOG4725.
GeneTreeiENSGT00550000075058.
InParanoidiQ9VCE6.
KOiK05925.
OMAiCDLRFLD.
OrthoDBiEOG7PZRWV.
PhylomeDBiQ9VCE6.

Family and domain databases

InterProiIPR025848. MT-A70.
IPR007757. MT-A70-like.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF05063. MT-A70. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51143. MT_A70. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VCE6-1 [UniParc]FASTAAdd to Basket

« Hide

MADAWDIKSL KTKRNTLREK LEKRKKERIE ILSDIQEDLT NPKKELVEAD    50
LEVQKEVLQA LSSCSLALPI VSTQVVEKIA GSSLEMVNFI LGKLANQGAI 100
VIRNVTIGTE AGCEIISVQP KELKEILEDT NDTCQQKEEE AKRKLEVDDV 150
DQPQEKTIKL ESTVARKEST SLDAPDDIMM LLSMPSTREK QSKQVGEEIL 200
ELLTKPTAKE RSVAEKFKSH GGAQVMEFCS HGTKVECLKA QQATAEMAAK 250
KKQERRDEKE LRPDVDAGEN VTGKVPKTES AAEDGEIIAE VINNCEAESQ 300
ESTDGSDTCS SETTDKCTKL HFKKIIQAHT DESLGDCSFL NTCFHMATCK 350
YVHYEVDTLP HINTNKPTDV KTKLSLKRSV DSSCTLYPPQ WIQCDLRFLD 400
MTVLGKFAVV MADPPWDIHM ELPYGTMSDD EMRALGVPAL QDDGLIFLWV 450
TGRAMELGRD CLKLWGYERV DELIWVKTNQ LQRIIRTGRT GHWLNHGKEH 500
CLVGMKGNPT NLNRGLDCDV IVAEVRATSH KPDEIYGIIE RLSPGTRKIE 550
LFGRPHNIQP NWITLGNQLD GIRLVDPELI TQFQKRYPDG NCMSPASANA 600
ASINGIQK 608
Length:608
Mass (Da):68,101
Last modified:May 1, 2000 - v1
Checksum:i00A2E06082E7FD2F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAF56221.1.
AY113286 mRNA. Translation: AAM29291.1.
RefSeqiNP_651204.1. NM_142947.3.
UniGeneiDm.13317.

Genome annotation databases

EnsemblMetazoaiFBtr0084532; FBpp0083917; FBgn0039139.
GeneIDi42844.
KEGGidme:Dmel_CG5933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAF56221.1 .
AY113286 mRNA. Translation: AAM29291.1 .
RefSeqi NP_651204.1. NM_142947.3.
UniGenei Dm.13317.

3D structure databases

ProteinModelPortali Q9VCE6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 67779. 16 interactions.
DIPi DIP-17384N.
IntActi Q9VCE6. 3 interactions.
MINTi MINT-308015.
STRINGi 7227.FBpp0083917.

Proteomic databases

PaxDbi Q9VCE6.
PRIDEi Q9VCE6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0084532 ; FBpp0083917 ; FBgn0039139 .
GeneIDi 42844.
KEGGi dme:Dmel_CG5933.

Organism-specific databases

CTDi 42844.
FlyBasei FBgn0039139. Ime4.

Phylogenomic databases

eggNOGi COG4725.
GeneTreei ENSGT00550000075058.
InParanoidi Q9VCE6.
KOi K05925.
OMAi CDLRFLD.
OrthoDBi EOG7PZRWV.
PhylomeDBi Q9VCE6.

Enzyme and pathway databases

Reactomei REACT_207945. Processing of Capped Intron-Containing Pre-mRNA.

Miscellaneous databases

GenomeRNAii 42844.
NextBioi 830874.
PROi Q9VCE6.

Gene expression databases

Bgeei Q9VCE6.

Family and domain databases

InterProi IPR025848. MT-A70.
IPR007757. MT-A70-like.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF05063. MT-A70. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51143. MT_A70. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Testis.

Entry informationi

Entry nameiMTA70_DROME
AccessioniPrimary (citable) accession number: Q9VCE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi