Q9VCE6 (MTA70_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable N6-adenosine-methyltransferase MT-A70-like protein
EC=2.1.1.62

Gene names

ORF Names:

CG5933

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	608 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites in mRNA isolated, may play a role in the efficiency of mRNA splicing, transport or translation By similarity.
Catalytic activity	S-adenosyl-L-methionine + m7G(5')pppAm = S-adenosyl-L-homocysteine + m7G(5')pppm6Am.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the MT-A70-like family.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	germarium-derived female germ-line cyst encapsulation Inferred from mutant phenotype PubMed 21873203. Source: FlyBase regulation of Notch signaling pathway Inferred from mutant phenotype PubMed 21873203. Source: FlyBase regulation of gene silencing Inferred from mutant phenotype PubMed 20838586. Source: FlyBase
Cellular_component	nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 608	608	Probable N6-adenosine-methyltransferase MT-A70-like protein		PRO_0000207633

Sequences

	Sequence		Length	Mass (Da)
	Q9VCE6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 00A2E06082E7FD2F	FASTA	608	68,101
	10 20 30 40 50 60 MADAWDIKSL KTKRNTLREK LEKRKKERIE ILSDIQEDLT NPKKELVEAD LEVQKEVLQA 70 80 90 100 110 120 LSSCSLALPI VSTQVVEKIA GSSLEMVNFI LGKLANQGAI VIRNVTIGTE AGCEIISVQP 130 140 150 160 170 180 KELKEILEDT NDTCQQKEEE AKRKLEVDDV DQPQEKTIKL ESTVARKEST SLDAPDDIMM 190 200 210 220 230 240 LLSMPSTREK QSKQVGEEIL ELLTKPTAKE RSVAEKFKSH GGAQVMEFCS HGTKVECLKA 250 260 270 280 290 300 QQATAEMAAK KKQERRDEKE LRPDVDAGEN VTGKVPKTES AAEDGEIIAE VINNCEAESQ 310 320 330 340 350 360 ESTDGSDTCS SETTDKCTKL HFKKIIQAHT DESLGDCSFL NTCFHMATCK YVHYEVDTLP 370 380 390 400 410 420 HINTNKPTDV KTKLSLKRSV DSSCTLYPPQ WIQCDLRFLD MTVLGKFAVV MADPPWDIHM 430 440 450 460 470 480 ELPYGTMSDD EMRALGVPAL QDDGLIFLWV TGRAMELGRD CLKLWGYERV DELIWVKTNQ 490 500 510 520 530 540 LQRIIRTGRT GHWLNHGKEH CLVGMKGNPT NLNRGLDCDV IVAEVRATSH KPDEIYGIIE 550 560 570 580 590 600 RLSPGTRKIE LFGRPHNIQP NWITLGNQLD GIRLVDPELI TQFQKRYPDG NCMSPASANA ASINGIQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014297 Genomic DNA. Translation: AAF56221.1. AY113286 mRNA. Translation: AAM29291.1.
RefSeq	NP_651204.1. NM_142947.3.
UniGene	Dm.13317.
3D structure databases
ProteinModelPortal	Q9VCE6.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-17384N.
IntAct	Q9VCE6. 3 interactions.
MINT	MINT-308015.
STRING	7227.FBpp0083917.
Proteomic databases
PaxDb	Q9VCE6.
PRIDE	Q9VCE6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0084532; FBpp0083917; FBgn0039139.
GeneID	42844.
KEGG	dme:Dmel_CG5933.
Organism-specific databases
CTD	42844.
FlyBase	FBgn0039139. CG5933.
Phylogenomic databases
eggNOG	COG4725.
GeneTree	ENSGT00550000075058.
InParanoid	Q9VCE6.
KO	K05925.
OMA	CDLRFLD.
OrthoDB	EOG4J9KF1.
PhylomeDB	Q9VCE6.
Gene expression databases
Bgee	Q9VCE6.
GermOnline	CG5933. Drosophila melanogaster.
Family and domain databases
InterPro	IPR025848. MT-A70. IPR007757. MT-A70-like. [Graphical view]
Pfam	PF05063. MT-A70. 1 hit. [Graphical view]
PROSITE	PS51143. MT_A70. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	42844.
NextBio	830874.

Entry information

Entry name

MTA70_DROME

Accession

Primary (citable) accession number: Q9VCE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project