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Q9VCE6

- MTA70_DROME

UniProt

Q9VCE6 - MTA70_DROME

Protein

Probable N6-adenosine-methyltransferase MT-A70-like protein

Gene

Ime4

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Probable N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites in mRNA isolated, may play a role in the efficiency of mRNA splicing, transport or translation By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + m7G(5')pppAm = S-adenosyl-L-homocysteine + m7G(5')pppm6Am.

    GO - Molecular functioni

    1. mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity Source: UniProtKB
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. germarium-derived female germ-line cyst encapsulation Source: FlyBase
    2. mRNA methylation Source: GOC
    3. ovarian follicle cell development Source: FlyBase
    4. regulation of gene silencing Source: FlyBase
    5. regulation of Notch signaling pathway Source: FlyBase
    6. RNA methylation Source: UniProtKB

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    ReactomeiREACT_207945. Processing of Capped Intron-Containing Pre-mRNA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable N6-adenosine-methyltransferase MT-A70-like protein (EC:2.1.1.62)
    Alternative name(s):
    Inducer of meiosis 4
    Gene namesi
    Name:Ime4
    ORF Names:CG5933
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0039139. Ime4.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 608608Probable N6-adenosine-methyltransferase MT-A70-like proteinPRO_0000207633Add
    BLAST

    Proteomic databases

    PaxDbiQ9VCE6.
    PRIDEiQ9VCE6.

    Expressioni

    Gene expression databases

    BgeeiQ9VCE6.

    Interactioni

    Protein-protein interaction databases

    BioGridi67779. 16 interactions.
    DIPiDIP-17384N.
    IntActiQ9VCE6. 3 interactions.
    MINTiMINT-308015.
    STRINGi7227.FBpp0083917.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VCE6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MT-A70-like family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG4725.
    GeneTreeiENSGT00550000075058.
    InParanoidiQ9VCE6.
    KOiK05925.
    OMAiCDLRFLD.
    OrthoDBiEOG7PZRWV.
    PhylomeDBiQ9VCE6.

    Family and domain databases

    InterProiIPR025848. MT-A70.
    IPR007757. MT-A70-like.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF05063. MT-A70. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51143. MT_A70. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9VCE6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADAWDIKSL KTKRNTLREK LEKRKKERIE ILSDIQEDLT NPKKELVEAD    50
    LEVQKEVLQA LSSCSLALPI VSTQVVEKIA GSSLEMVNFI LGKLANQGAI 100
    VIRNVTIGTE AGCEIISVQP KELKEILEDT NDTCQQKEEE AKRKLEVDDV 150
    DQPQEKTIKL ESTVARKEST SLDAPDDIMM LLSMPSTREK QSKQVGEEIL 200
    ELLTKPTAKE RSVAEKFKSH GGAQVMEFCS HGTKVECLKA QQATAEMAAK 250
    KKQERRDEKE LRPDVDAGEN VTGKVPKTES AAEDGEIIAE VINNCEAESQ 300
    ESTDGSDTCS SETTDKCTKL HFKKIIQAHT DESLGDCSFL NTCFHMATCK 350
    YVHYEVDTLP HINTNKPTDV KTKLSLKRSV DSSCTLYPPQ WIQCDLRFLD 400
    MTVLGKFAVV MADPPWDIHM ELPYGTMSDD EMRALGVPAL QDDGLIFLWV 450
    TGRAMELGRD CLKLWGYERV DELIWVKTNQ LQRIIRTGRT GHWLNHGKEH 500
    CLVGMKGNPT NLNRGLDCDV IVAEVRATSH KPDEIYGIIE RLSPGTRKIE 550
    LFGRPHNIQP NWITLGNQLD GIRLVDPELI TQFQKRYPDG NCMSPASANA 600
    ASINGIQK 608
    Length:608
    Mass (Da):68,101
    Last modified:May 1, 2000 - v1
    Checksum:i00A2E06082E7FD2F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAF56221.1.
    AY113286 mRNA. Translation: AAM29291.1.
    RefSeqiNP_651204.1. NM_142947.3.
    UniGeneiDm.13317.

    Genome annotation databases

    EnsemblMetazoaiFBtr0084532; FBpp0083917; FBgn0039139.
    GeneIDi42844.
    KEGGidme:Dmel_CG5933.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAF56221.1 .
    AY113286 mRNA. Translation: AAM29291.1 .
    RefSeqi NP_651204.1. NM_142947.3.
    UniGenei Dm.13317.

    3D structure databases

    ProteinModelPortali Q9VCE6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 67779. 16 interactions.
    DIPi DIP-17384N.
    IntActi Q9VCE6. 3 interactions.
    MINTi MINT-308015.
    STRINGi 7227.FBpp0083917.

    Proteomic databases

    PaxDbi Q9VCE6.
    PRIDEi Q9VCE6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0084532 ; FBpp0083917 ; FBgn0039139 .
    GeneIDi 42844.
    KEGGi dme:Dmel_CG5933.

    Organism-specific databases

    CTDi 42844.
    FlyBasei FBgn0039139. Ime4.

    Phylogenomic databases

    eggNOGi COG4725.
    GeneTreei ENSGT00550000075058.
    InParanoidi Q9VCE6.
    KOi K05925.
    OMAi CDLRFLD.
    OrthoDBi EOG7PZRWV.
    PhylomeDBi Q9VCE6.

    Enzyme and pathway databases

    Reactomei REACT_207945. Processing of Capped Intron-Containing Pre-mRNA.

    Miscellaneous databases

    GenomeRNAii 42844.
    NextBioi 830874.
    PROi Q9VCE6.

    Gene expression databases

    Bgeei Q9VCE6.

    Family and domain databases

    InterProi IPR025848. MT-A70.
    IPR007757. MT-A70-like.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF05063. MT-A70. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51143. MT_A70. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Testis.

    Entry informationi

    Entry nameiMTA70_DROME
    AccessioniPrimary (citable) accession number: Q9VCE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3