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Protein

Organic cation transporter protein

Gene

Orct

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably transports organic cations.By similarity

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB
  • ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi2.A.1.19.36. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Organic cation transporter protein
Gene namesi
Name:Orct
ORF Names:CG6331
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0019952. Orct.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence analysisAdd
BLAST
Transmembranei23 – 4321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini44 – 12784ExtracellularSequence analysisAdd
BLAST
Transmembranei128 – 14821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini149 – 15810CytoplasmicSequence analysis
Transmembranei159 – 17921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini180 – 18910ExtracellularSequence analysis
Transmembranei190 – 21021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini211 – 2199CytoplasmicSequence analysis
Transmembranei220 – 24021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini241 – 2444ExtracellularSequence analysis
Transmembranei245 – 26521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini266 – 33772CytoplasmicSequence analysisAdd
BLAST
Transmembranei338 – 35821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini359 – 3668ExtracellularSequence analysis
Transmembranei367 – 38721Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini388 – 3958CytoplasmicSequence analysis
Transmembranei396 – 41621Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini417 – 4193ExtracellularSequence analysis
Transmembranei420 – 44021Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini441 – 45313CytoplasmicSequence analysisAdd
BLAST
Transmembranei454 – 47421Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini475 – 4828ExtracellularSequence analysis
Transmembranei483 – 50321Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini504 – 54845CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Organic cation transporter proteinPRO_0000220514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence analysis
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence analysis
Glycosylationi97 – 971N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9VCA2.
PRIDEiQ9VCA2.

Expressioni

Tissue specificityi

Expressed in embryos and adults at low level. Expressed at higher level in third instar larvae.

Gene expression databases

BgeeiQ9VCA2.
ExpressionAtlasiQ9VCA2. differential.
GenevisibleiQ9VCA2. DM.

Interactioni

Protein-protein interaction databases

BioGridi67819. 1 interaction.
IntActiQ9VCA2. 1 interaction.
MINTiMINT-1673907.
STRINGi7227.FBpp0083983.

Structurei

3D structure databases

ProteinModelPortaliQ9VCA2.
SMRiQ9VCA2. Positions 127-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
InParanoidiQ9VCA2.
KOiK08202.
OMAiNKVEVPN.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ9VCA2.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VCA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYDDVITHL GEFGPYQKRI YYLLCLPAIV CAFHKLAGVF LLAKPDFRCA
60 70 80 90 100
LPYENGSIYE LSPHLWNLSY PENERCSYYD VDYTEEYLNG SIPRSSNETK
110 120 130 140 150
TCSSYVYDRS KYLNSAVTEW NLVCSRSLLS ATSDSLFMLG VLLGSLIFGQ
160 170 180 190 200
MSDKLGRKPT FFASLVLQLI FGVLAAVAPE YFSYTISRMI VGATTSGVFL
210 220 230 240 250
VAYVIALEMV GSSYRLFAGV AMQMFFSVGF MLTAGFAYFI HDWRWLQIAI
260 270 280 290 300
TLPGLLFLCY YWIIPESARW LLMKGRKDEA FVIIEKAAKE NKVEVPNEIY
310 320 330 340 350
EQLVDEVAEK KKQDEMAASQ PAATVFDLLR YPNLRRKTLL IFFDWFVNSG
360 370 380 390 400
VYYGLSWNTN NLGGNQLVNF MISGAVEIPG YTLLLFTLNR WGRRSILCGT
410 420 430 440 450
MMVAGISLLA TIFVPSDMNW LIVACAMIGK LAITSSYGTI YIFSAEQFPT
460 470 480 490 500
VVRNVGLGAS SMVARVGGIL APYLKLLGEI WRPLPLIICG ALSLTAGLLS
510 520 530 540
LLLPETLNKP MPETIEDGEN FGKKPAPQET AEEGGTQELS GMLNGKSG
Length:548
Mass (Da):61,003
Last modified:May 1, 2000 - v1
Checksum:i08D7F97599B477AF
GO

Sequence cautioni

The sequence CAA73030.1 differs from that shown.Chimeric cDNA.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti375 – 3751A → P in CAA73031 (PubMed:9409773).Curated
Sequence conflicti385 – 3851L → F in CAA73031 (PubMed:9409773).Curated
Sequence conflicti501 – 5011L → R in CAA73031 (PubMed:9409773).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12399 mRNA. Translation: CAA73030.1. Sequence problems.
Y12400 mRNA. Translation: CAA73031.1.
AE014297 Genomic DNA. Translation: AAF56271.1.
AY058437 mRNA. Translation: AAL13666.1.
RefSeqiNP_001262908.1. NM_001275979.1.
NP_524479.1. NM_079755.2.
UniGeneiDm.2997.

Genome annotation databases

EnsemblMetazoaiFBtr0084599; FBpp0083983; FBgn0019952.
FBtr0334870; FBpp0306893; FBgn0019952.
GeneIDi42891.
KEGGidme:Dmel_CG6331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12399 mRNA. Translation: CAA73030.1. Sequence problems.
Y12400 mRNA. Translation: CAA73031.1.
AE014297 Genomic DNA. Translation: AAF56271.1.
AY058437 mRNA. Translation: AAL13666.1.
RefSeqiNP_001262908.1. NM_001275979.1.
NP_524479.1. NM_079755.2.
UniGeneiDm.2997.

3D structure databases

ProteinModelPortaliQ9VCA2.
SMRiQ9VCA2. Positions 127-506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi67819. 1 interaction.
IntActiQ9VCA2. 1 interaction.
MINTiMINT-1673907.
STRINGi7227.FBpp0083983.

Protein family/group databases

TCDBi2.A.1.19.36. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiQ9VCA2.
PRIDEiQ9VCA2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0084599; FBpp0083983; FBgn0019952.
FBtr0334870; FBpp0306893; FBgn0019952.
GeneIDi42891.
KEGGidme:Dmel_CG6331.

Organism-specific databases

CTDi42891.
FlyBaseiFBgn0019952. Orct.

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
InParanoidiQ9VCA2.
KOiK08202.
OMAiNKVEVPN.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ9VCA2.

Miscellaneous databases

ChiTaRSiOrct. fly.
GenomeRNAii42891.
NextBioi831124.
PROiQ9VCA2.

Gene expression databases

BgeeiQ9VCA2.
ExpressionAtlasiQ9VCA2. differential.
GenevisibleiQ9VCA2. DM.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Orct gene of Drosophila melanogaster codes for a putative organic cation transporter with six or 12 transmembrane domains."
    Taylor C.A.M., Stanley K., Shirras A.D.
    Gene 201:69-74(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Larva.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.
  5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-97, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiORCT_DROME
AccessioniPrimary (citable) accession number: Q9VCA2
Secondary accession number(s): O01383, O01384
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.