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Protein
Submitted name:

Beta-4-galactosyltransferase 7

Gene

beta4GalT7

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121UDPCombined sources1
Metal bindingi147ManganeseCombined sources1
Binding sitei177UDPCombined sources1
Binding sitei207UDPCombined sources1
Metal bindingi241Manganese; via tele nitrogenCombined sources1
Metal bindingi243Manganese; via pros nitrogenCombined sources1
Binding sitei250UDPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi82 – 86UDPCombined sources5
Nucleotide bindingi146 – 147UDPCombined sources2
Nucleotide bindingi241 – 243UDPCombined sources3

GO - Molecular functioni

  • galactosyltransferase activity Source: FlyBase
  • metal ion binding Source: FlyBase
  • nucleotide binding Source: UniProtKB-KW
  • xylosylprotein 4-beta-galactosyltransferase activity Source: FlyBase

GO - Biological processi

  • chondroitin sulfate biosynthetic process Source: FlyBase
  • heparan sulfate proteoglycan biosynthetic process Source: FlyBase
  • N-glycan processing Source: FlyBase
  • proteoglycan biosynthetic process Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseImported, Transferase

Keywords - Ligandi

ManganeseCombined sources, Metal-bindingCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

ReactomeiR-DME-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.

Protein family/group databases

CAZyiGT7. Glycosyltransferase Family 7.

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-4-galactosyltransferase 7Imported (EC:2.4.1.-Imported, EC:2.4.1.133Imported)
Submitted name:
FI08434pImported
Gene namesi
Name:beta4GalT7Imported
Synonyms:beta-4GalT7Imported, beta4GalT7-RAImported
ORF Names:CG11780Imported, Dmel_CG11780Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0039258. beta4GalT7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 30HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

  • Golgi apparatus Source: FlyBase
  • integral component of membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi255 ↔ 310Combined sources
Disulfide bondi300 ↔ 308Combined sources

Expressioni

Gene expression databases

BgeeiFBgn0039258.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0084130.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LW6X-ray1.81A71-311[»]
4LW3X-ray2.00A71-311[»]
4LW6X-ray2.40A71-311[»]
4M4KX-ray2.20A71-311[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 158Glyco_transf_7NInterPro annotationAdd BLAST87
Domaini165 – 241Glyco_transf_7CInterPro annotationAdd BLAST77

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3917. Eukaryota.
ENOG410Z0TP. LUCA.
GeneTreeiENSGT00760000119140.
KOiK00733.
OMAiNWLFVCG.
OrthoDBiEOG091G0HCH.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR003859. Galactosyl_T.
IPR027791. Galactosyl_T_C.
IPR027995. Galactosyl_T_N.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR19300. PTHR19300. 1 hit.
PfamiPF02709. Glyco_transf_7C. 1 hit.
PF13733. Glyco_transf_7N. 1 hit.
[Graphical view]
PRINTSiPR02050. B14GALTRFASE.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VBZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNISTINWV FVCGLSFCLG GIAVLSLMPL GSDCVCPLSN PLAKLAGGGE
60 70 80 90 100
GVSVIKKEPA DEKQPQPHDH GASVHKMALL VPFRDRFEEL LQFVPHMTAF
110 120 130 140 150
LKRQGVAHHI FVLNQVDRFR FNRASLINVG FQFASDVYDY IAMHDVDLLP
160 170 180 190 200
LNDNLLYEYP SSLGPLHIAG PKLHPKYHYD NFVGGILLVR REHFKQMNGM
210 220 230 240 250
SNQYWGWGLE DDEFFVRIRD AGLQVTRPQN IKTGTNDTFS HIHNRYHRKR
260 270 280 290 300
DTQKCFNQKE MTRKRDHKTG LDNVKYKILK VHEMLIDQVP VTILNILLDC
310 320
DVNKTPWCDC SGTAAAASAV QT
Length:322
Mass (Da):36,499
Last modified:May 1, 2000 - v1
Checksum:i1F44CF6577ACC0A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56377.1.
BT044519 mRNA. Translation: ACH95293.1.
RefSeqiNP_651319.2. NM_143062.3.
UniGeneiDm.12932.

Genome annotation databases

EnsemblMetazoaiFBtr0084755; FBpp0084130; FBgn0039258.
GeneIDi42991.
KEGGidme:Dmel_CG11780.
UCSCiCG11780-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56377.1.
BT044519 mRNA. Translation: ACH95293.1.
RefSeqiNP_651319.2. NM_143062.3.
UniGeneiDm.12932.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LW6X-ray1.81A71-311[»]
4LW3X-ray2.00A71-311[»]
4LW6X-ray2.40A71-311[»]
4M4KX-ray2.20A71-311[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0084130.

Protein family/group databases

CAZyiGT7. Glycosyltransferase Family 7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0084755; FBpp0084130; FBgn0039258.
GeneIDi42991.
KEGGidme:Dmel_CG11780.
UCSCiCG11780-RA. d. melanogaster.

Organism-specific databases

CTDi42991.
FlyBaseiFBgn0039258. beta4GalT7.

Phylogenomic databases

eggNOGiKOG3917. Eukaryota.
ENOG410Z0TP. LUCA.
GeneTreeiENSGT00760000119140.
KOiK00733.
OMAiNWLFVCG.
OrthoDBiEOG091G0HCH.

Enzyme and pathway databases

ReactomeiR-DME-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.

Miscellaneous databases

ChiTaRSibeta4GalT7. fly.
GenomeRNAii42991.

Gene expression databases

BgeeiFBgn0039258.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR003859. Galactosyl_T.
IPR027791. Galactosyl_T_C.
IPR027995. Galactosyl_T_N.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR19300. PTHR19300. 1 hit.
PfamiPF02709. Glyco_transf_7C. 1 hit.
PF13733. Glyco_transf_7N. 1 hit.
[Graphical view]
PRINTSiPR02050. B14GALTRFASE.
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9VBZ9_DROME
AccessioniPrimary (citable) accession number: Q9VBZ9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 5, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.