Reviewed, UniProtKB/Swiss-Prot Q9VBW3 (CAD96_DROME)

Names and origin

Protein names

Recommended name:
    Tyrosine kinase receptor Cad96Ca
    EC=2.7.10.1
Alternative name(s):
    Cadherin-96Ca
    Tyrosine kinase receptor HD-14

Gene names

Name:	Cad96Ca
Synonyms:	HD-14
ORF Names:	CG10244

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	773 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. Contains 1 cadherin domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro protein amino acid phosphorylation Ref.4 Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium ion binding Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 48	48	Potential
	Chain	49 – 773	725	Tyrosine kinase receptor Cad96Ca		PRO_0000016797
Regions
	Topological domain	49 – 315	267	Extracellular Potential
	Transmembrane	316 – 336	21	Potential
	Topological domain	337 – 773	437	Cytoplasmic Potential
	Domain	58 – 172	115	Cadherin
	Domain	470 – 749	280	Protein kinase
	Nucleotide binding	476 – 484	9	ATP By similarity
	Compositional bias	202 – 236	35	Pro-rich
Sites
	Active site	610	1	Proton acceptor By similarity
	Binding site	504	1	ATP By similarity
Amino acid modifications
	Glycosylation	126	1	N-linked (GlcNAc...) Potential
	Glycosylation	164	1	N-linked (GlcNAc...) Potential
	Glycosylation	180	1	N-linked (GlcNAc...) Potential
	Glycosylation	278	1	N-linked (GlcNAc...) Potential
	Glycosylation	279	1	N-linked (GlcNAc...) Potential
	Glycosylation	300	1	N-linked (GlcNAc...) Potential
	Glycosylation	301	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9VBW3-1 [UniParc]. Last modified January 27, 2003. Version 2. Checksum: CFD6B8F27EAC46E4	FASTA	773	86,220
	10 20 30 40 50 60 MVYHHHNHES RIIHCRKQLT SWRRRSLLLT IIVVTATVVS LISQEAEAHN QNAPPILYVR 70 80 90 100 110 120 ERNWRISETE KVGQIIDRVR AEDPDGDDLI FGIEPRFSLP GGENDASPPE KIPFQIDRET 130 140 150 160 170 180 GVVTLNESLA GRAGQNFLIY ITVTDGSYTA KNEVFINILG ERENSSGYRP QTSISNVVHN 190 200 210 220 230 240 ISQFLPRFDQ LPGVQSIRNG LPNSRPGGWY PPVPQNNIFG PPPFGNNYPP PPPNIPGVRG 250 260 270 280 290 300 EQSGEEEQPD EEVTPTTPVR ISSTTPKSRT KLTPITANNS TRVESAIPAE TTTPSGGHHN 310 320 330 340 350 360 NSSSPITIFS LKSGTIPIVV TVGGFFVAIA VLLAYLCRRR LCAISRTLKK TKEKEELAKK 370 380 390 400 410 420 SNQSQLSSTL TDDSRNSMVM QQWQGPVAFA NRYVPWERDQ QMGIATSQLS TGVTNGGVSS 430 440 450 460 470 480 PGVPSPGTGE PGSNLGPGCL TGGAGSSGAP ENAFAGEANC DRWEFPRYRL KFFNILGEGA 490 500 510 520 530 540 FGQVWRCEAT NINGNEGITT VAVKTLKESA TEVDRKDLLS ELEVMKSLEP HINVVHLLGC 550 560 570 580 590 600 CTDKDPTFVI LEYVNRGKLQ TYLRSSRAER HYGNTHGKSN VLTSCDLTSF MYQVAKGMDY 610 620 630 640 650 660 LTSRGIIHRD LAARNILITD DHTCKVADFG FARDVITSKI YERKSEGKLP IRWMATESLY 670 680 690 700 710 720 DNIFSVKSDI WSFGILMWEI VTLGSTPYPG ISAADVMRKV RDGYRLEKPE HCRRELYNIM 730 740 750 760 770 YYCWSHDPQE RPLFAEIIQM LDKLLHTEMD YIELERFPDH NYYNIVSLSG EKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[4]	"Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA." Oates A.C., Wollberg P., Achen M.G., Wilks A.F. Biochem. Biophys. Res. Commun. 249:660-667(1998) [PubMed: 9731193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 616-668. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014297 Genomic DNA. Translation: AAF56414.2. AY070958 mRNA. Translation: AAL48580.1. BT001586 mRNA. Translation: AAN71341.1. BT001657 mRNA. Translation: AAN71412.1. AJ002910 Genomic DNA. Translation: CAA05745.1.
RefSeq	NP_651349.1.
UniGene	Dm.6193
3D structure databases
HSSP	HSSP built from PDB template 1FGK based on UniProtKB P11362.
ModBase	Search...
Genome annotation databases
Ensembl	FBgn0022800. Drosophila melanogaster. [Contig view]
GeneID	43026.
KEGG	dme:Dmel_CG10244.
NMPDR	fig|7227.3.peg.14608.
Organism-specific databases
FlyBase	FBgn0022800. Cad96Ca.
Phylogenomic databases
HOGENOM	Q9VBW3.
OMA	Q9VBW3. RELYNIM.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-013345-MON.
BRENDA	2.7.10.1. 48.
Gene expression databases
ArrayExpress	Q9VBW3.
GermOnline	CG10244. Drosophila melanogaster.
Family and domain databases
InterPro	IPR002126. Cadherin. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. [Graphical view]
Gene3D	G3DSA:2.60.40.60. Cadherin. 1 hit.
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00112. CA. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS00232. CADHERIN_1. False negative. PS50268. CADHERIN_2. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	831866.

Entry information

Entry name

CAD96_DROME

Accession

Primary (citable) accession number: Q9VBW3
Secondary accession number(s): O18368, Q8SZC9, Q9VBW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	January 27, 2003
Last modified:	June 16, 2009
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project