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Q9VBV5

- SIL1_DROME

UniProt

Q9VBV5 - SIL1_DROME

Protein

Nucleotide exchange factor SIL1

Gene

CG10420

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for an ER lumenal chaperone of HSP70 family By similarity.By similarity

    GO - Biological processi

    1. SRP-dependent cotranslational protein targeting to membrane, translocation Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleotide exchange factor SIL1
    Gene namesi
    ORF Names:CG10420
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0039296. CG10420.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 429405Nucleotide exchange factor SIL1PRO_0000223358Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9VBV5.
    PRIDEiQ9VBV5.

    Expressioni

    Gene expression databases

    BgeeiQ9VBV5.

    Interactioni

    Protein-protein interaction databases

    BioGridi67953. 13 interactions.
    STRINGi7227.FBpp0084244.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VBV5.
    SMRiQ9VBV5. Positions 187-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili104 – 13532Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi426 – 4294Prevents secretion from ERSequence Analysis

    Sequence similaritiesi

    Belongs to the SIL1 family.Curated

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiNOG310365.
    GeneTreeiENSGT00510000048102.
    InParanoidiQ9VBV5.
    KOiK14001.
    OMAiQGWCEIT.
    OrthoDBiEOG72G176.
    PhylomeDBiQ9VBV5.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9VBV5-1 [UniParc]FASTAAdd to Basket

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    MSGKQVVILL GSVLILGCLQ VAAATETDNK TNDFVATDEW QTIAEGQAIP    50
    RGLHVRINLQ TGLKEAKLLD ESERGTSLQS QPDDQNARES HDDNEPLALD 100
    YKPDIIEESI RRVKEQKKSY AELRKAYKEF QKNFRTDGEL IVQLIDQFRN 150
    FSRTPLESEM RSKLDCLENL EYLLHQIDNA LMFIDNGGLD DVLLPIVVND 200
    TSTSLRVSAM RVLGSLASNN PKAQIKVFEK NFGSHLAQIL TSSGNVGEIS 250
    AALHAFGALL RKFPLAQQRV LSTSGTQALI KVLQSPDVEL RSKAKVVTLI 300
    SDLVLEKRSV LDVSKDDPEA SSTMAQYVLL DFESWLKTPG YCAAVDTVLT 350
    KEFLLLLEQP EVVEQFATAL ETTEDMCTST WSQSSGLRHA LLTVRNRYAN 400
    STDEYRLEVS QILAKLCERL FNKPKHTEL 429
    Length:429
    Mass (Da):47,943
    Last modified:May 1, 2000 - v1
    Checksum:i476349B0C0CD8EE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAF56422.1.
    AY058471 mRNA. Translation: AAL13700.1.
    RefSeqiNP_651356.1. NM_143099.3.
    UniGeneiDm.1330.

    Genome annotation databases

    EnsemblMetazoaiFBtr0084870; FBpp0084244; FBgn0039296.
    GeneIDi43034.
    KEGGidme:Dmel_CG10420.
    UCSCiCG10420-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAF56422.1 .
    AY058471 mRNA. Translation: AAL13700.1 .
    RefSeqi NP_651356.1. NM_143099.3.
    UniGenei Dm.1330.

    3D structure databases

    ProteinModelPortali Q9VBV5.
    SMRi Q9VBV5. Positions 187-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 67953. 13 interactions.
    STRINGi 7227.FBpp0084244.

    Proteomic databases

    PaxDbi Q9VBV5.
    PRIDEi Q9VBV5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0084870 ; FBpp0084244 ; FBgn0039296 .
    GeneIDi 43034.
    KEGGi dme:Dmel_CG10420.
    UCSCi CG10420-RA. d. melanogaster.

    Organism-specific databases

    FlyBasei FBgn0039296. CG10420.

    Phylogenomic databases

    eggNOGi NOG310365.
    GeneTreei ENSGT00510000048102.
    InParanoidi Q9VBV5.
    KOi K14001.
    OMAi QGWCEIT.
    OrthoDBi EOG72G176.
    PhylomeDBi Q9VBV5.

    Miscellaneous databases

    GenomeRNAii 43034.
    NextBioi 831896.
    PROi Q9VBV5.

    Gene expression databases

    Bgeei Q9VBV5.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Head.

    Entry informationi

    Entry nameiSIL1_DROME
    AccessioniPrimary (citable) accession number: Q9VBV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3