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Protein

Tankyrase

Gene

Tnks

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates proteasome activity, probably by ADP-ribosylation of PI31. Modulates 26S proteasome assembly.1 Publication

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi1091ZincBy similarity1
Metal bindingi1094ZincBy similarity1
Metal bindingi1099ZincBy similarity1
Metal bindingi1102ZincBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • NAD+ ADP-ribosyltransferase activity Source: FlyBase
  • scaffold protein binding Source: FlyBase

GO - Biological processi

  • canonical Wnt signaling pathway Source: FlyBase
  • chaeta development Source: FlyBase
  • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: FlyBase
  • positive regulation of proteolysis Source: FlyBase
  • protein ADP-ribosylation Source: FlyBase
  • protein poly-ADP-ribosylation Source: FlyBase
  • regulation of proteasome assembly Source: FlyBase
  • wing disc development Source: FlyBase

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-DME-201681. TCF dependent signaling in response to WNT.
R-DME-4641257. Degradation of AXIN.
R-DME-5689880. Ub-specific processing proteases.
R-DME-8948751. Regulation of PTEN stability and activity.

Names & Taxonomyi

Protein namesi
Recommended name:
Tankyrase (EC:2.4.2.301 Publication)
Short name:
dTNKS1 Publication
Alternative name(s):
Poly [ADP-ribose] polymerase
Gene namesi
Name:TnksImported
Synonyms:tankyraseImported
ORF Names:CG4719
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0027508. Tnks.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004248921 – 1181TankyraseAdd BLAST1181

Proteomic databases

PaxDbiQ9VBP3.
PRIDEiQ9VBP3.

Expressioni

Gene expression databases

BgeeiFBgn0027508.
GenevisibleiQ9VBP3. DM.

Interactioni

Subunit structurei

Interacts (via ANK repeats) with PI31.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PI31Q9V6373EBI-124451,EBI-144377

GO - Molecular functioni

  • scaffold protein binding Source: FlyBase

Protein-protein interaction databases

BioGridi68007. 18 interactors.
IntActiQ9VBP3. 6 interactors.
MINTiMINT-1329600.
STRINGi7227.FBpp0303409.

Structurei

3D structure databases

ProteinModelPortaliQ9VBP3.
SMRiQ9VBP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati56 – 85ANK 1Sequence analysisAdd BLAST30
Repeati89 – 118ANK 2Sequence analysisAdd BLAST30
Repeati122 – 151ANK 3Sequence analysisAdd BLAST30
Repeati209 – 238ANK 4Sequence analysisAdd BLAST30
Repeati242 – 271ANK 5Sequence analysisAdd BLAST30
Repeati275 – 304ANK 6Sequence analysisAdd BLAST30
Repeati362 – 394ANK 7Sequence analysisAdd BLAST33
Repeati398 – 427ANK 8Sequence analysisAdd BLAST30
Repeati431 – 458ANK 9Sequence analysisAdd BLAST28
Repeati483 – 513ANK 10Sequence analysisAdd BLAST31
Repeati519 – 548ANK 11Sequence analysisAdd BLAST30
Repeati552 – 581ANK 12Sequence analysisAdd BLAST30
Repeati585 – 614ANK 13Sequence analysisAdd BLAST30
Repeati638 – 668ANK 14Sequence analysisAdd BLAST31
Repeati672 – 701ANK 15Sequence analysisAdd BLAST30
Repeati705 – 734ANK 16Sequence analysisAdd BLAST30
Repeati738 – 767ANK 17Sequence analysisAdd BLAST30
Repeati771 – 799ANK 18Sequence analysisAdd BLAST29
Domaini889 – 952SAMPROSITE-ProRule annotationAdd BLAST64
Domaini969 – 1174PARP catalyticPROSITE-ProRule annotationAdd BLAST206

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
InParanoidiQ9VBP3.
KOiK10799.
OrthoDBiEOG091G00W8.
PhylomeDBiQ9VBP3.

Family and domain databases

CDDicd00204. ANK. 6 hits.
Gene3Di1.25.40.20. 10 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
PfamiView protein in Pfam
PF00023. Ank. 3 hits.
PF12796. Ank_2. 3 hits.
PF00644. PARP. 1 hit.
PF07647. SAM_2. 1 hit.
PRINTSiPR01415. ANKYRIN.
SMARTiView protein in SMART
SM00248. ANK. 17 hits.
SM00454. SAM. 1 hit.
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 3 hits.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 14 hits.
PS51059. PARP_CATALYTIC. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VBP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSSRSRAI LSVNLDAVMA NDPLRELFEA CKTGEIAKVK KLITPQTVNA
60 70 80 90 100
RDTAGRKSTP LHFAAGYGRR EVVEFLLNSG ASIQACDEGG LHPLHNCCSF
110 120 130 140 150
GHAEVVRLLL KAGASPNTTD NWNYTPLHEA ASKGKVDVCL ALLQHGANHT
160 170 180 190 200
IRNSEQKTPL ELADEATRPV LTGEYRKDEL LEAARSGAED RLLALLTPLN
210 220 230 240 250
VNCHASDGRR STPLHLAAGY NRIGIVEILL ANGADVHAKD KGGLVPLHNA
260 270 280 290 300
CSYGHFDVTK LLIQAGANVN ANDLWAFTPL HEAASKSRVE VCSLLLSRGA
310 320 330 340 350
DPTLLNCHSK SAIDAAPTRE LRERIAFEYK GHCLLDACRK CDVSRAKKLV
360 370 380 390 400
CAEIVNFVHP YTGDTPLHLA VVSPDGKRKQ LMELLTRKGS LLNEKNKAFL
410 420 430 440 450
TPLHLAAELL HYDAMEVLLK QGAKVNALDS LGQTPLHRCA RDEQAVRLLL
460 470 480 490 500
SYAADTNIVS LEGLTAAQLA SDSVLKLLKN PPDSETHLLE AAKAGDLDTV
510 520 530 540 550
RRIVLNNPIS VNCRDLDGRH STPLHFAAGF NRVPVVQFLL EHGAEVYAAD
560 570 580 590 600
KGGLVPLHNA CSYGHYEVTE LLVKHGANVN VSDLWKFTPL HEAAAKGKYD
610 620 630 640 650
ICKLLLKHGA DPMKKNRDGA TPADLVKESD HDVAELLRGP SALLDAAKKG
660 670 680 690 700
NLARVQRLVT PESINCRDAQ GRNSTPLHLA AGYNNFECAE YLLENGADVN
710 720 730 740 750
AQDKGGLIPL HNASSYGHLD IAALLIKHKT VVNATDKWGF TPLHEAAQKG
760 770 780 790 800
RTQLCSLLLA HGADAYMKNQ EGQTPIELAT ADDVKCLLQD AMATSLSQQA
810 820 830 840 850
LSASTQSLTS SSPAPDATAA AAPGTSSSSS SAILSPTTET VLLPTGASMI
860 870 880 890 900
LSVPVPLPLS SSTRISPAQG AEANGAEGSS SDDLLPDADT ITNVSGFLSS
910 920 930 940 950
QQLHHLIELF EREQITLDIL AEMGHDDLKQ VGVSAYGFRH KILKGIAQLR
960 970 980 990 1000
STTGIGNNVN LCTLLVDLLP DDKEFVAVEE EMQATIREHR DNGQAGGYFT
1010 1020 1030 1040 1050
RYNIIRVQKV QNRKLWERYA HRRQEIAEEN FLQSNERMLF HGSPFINAIV
1060 1070 1080 1090 1100
QRGFDERHAY IGGMFGAGIY FAEHSSKSNQ YVYGIGGGIG CPSHKDKSCY
1110 1120 1130 1140 1150
VCPRQLLLCR VALGKSFLQY SAMKMAHAPP GHHSVVGRPS AGGLHFAEYV
1160 1170 1180
VYRGEQSYPE YLITYQIVKP DDSSSGTEDT R
Length:1,181
Mass (Da):127,945
Last modified:May 1, 2000 - v1
Checksum:iEB6F0F94E6A3D504
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28F → S in AAD34784 (PubMed:10731138).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56487.1.
AF132196 mRNA. Translation: AAD34784.1.
BT044171 mRNA. Translation: ACH92236.1.
RefSeqiNP_651410.1. NM_143153.3.
UniGeneiDm.3183.

Genome annotation databases

EnsemblMetazoaiFBtr0084890; FBpp0084264; FBgn0027508.
FBtr0330383; FBpp0303409; FBgn0027508.
GeneIDi43095.
KEGGidme:Dmel_CG4719.
UCSCiCG4719-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiTNKS_DROME
AccessioniPrimary (citable) accession number: Q9VBP3
Secondary accession number(s): Q9XZ37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase