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Protein

Palmitoyltransferase

Gene

CG4956

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.UniRule annotation

GO - Molecular functioni

  • protein-cysteine S-palmitoyltransferase activity Source: FlyBase

GO - Biological processi

  • protein palmitoylation Source: FlyBase

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
PalmitoyltransferaseUniRule annotation (EC:2.3.1.225UniRule annotation)
Gene namesi
ORF Names:CG4956Imported, Dmel_CG4956Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0039370. CG4956.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 59HelicalUniRule annotationAdd BLAST23
Transmembranei74 – 96HelicalUniRule annotationAdd BLAST23
Transmembranei167 – 188HelicalUniRule annotationAdd BLAST22
Transmembranei227 – 247HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0039370.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0084294.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 256DHHCInterPro annotationAdd BLAST134

Domaini

The DHHC domain is required for palmitoyltransferase activity.UniRule annotation

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00850000132405.
KOiK18932.
OMAiRRFWIFF.
OrthoDBiEOG091G0RWR.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VBM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRFRVLLRS TCGWSRRMCF RAEEGFHRHF QLHRIKVMGL LHPFCAIFLL
60 70 80 90 100
CLIGLLFVYE LCYVLPQITD PHGIWHKLCW FMGIYTVINI LGNWWLGCMT
110 120 130 140 150
NTSVDSLVLE RQYPVAGEAH LWHYCSTCQK LVPPRSWHCS LCNICILKRD
160 170 180 190 200
HHCTFFASCI GHKNQRYFLA FLFHLSFGSG QALVYNGILN WTNKAFLVVD
210 220 230 240 250
PLLLMFQDTT QDADFKWKYT IANLFKLNLF LFGVPLFMFV FQMIMVYRNS
260 270 280 290 300
TCYKMLDRSY DVGWRRNFDM VLGKRRFWIF FSPTISSPLP TDGTQWFQKQ

TV
Length:302
Mass (Da):35,790
Last modified:February 7, 2006 - v2
Checksum:iF721FC523F91CF48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56506.2.
BT022146 mRNA. Translation: AAY51541.1.
RefSeqiNP_651428.2. NM_143171.2.
UniGeneiDm.25012.

Genome annotation databases

EnsemblMetazoaiFBtr0084920; FBpp0084294; FBgn0039370.
GeneIDi43114.
KEGGidme:Dmel_CG4956.
UCSCiCG4956-RA. d. melanogaster.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ9VBM4_DROME
AccessioniPrimary (citable) accession number: Q9VBM4
Secondary accession number(s): Q4V710
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: February 7, 2006
Last modified: July 5, 2017
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported