Unreviewed, UniProtKB/TrEMBL Q9VAX7 (Q9VAX7_DROME)

Names and origin

Protein names

Submitted name:
    Beta-Tubulin at 97EF EMBL AAF56770.2

Gene names

Name:	betaTub97EF FlyBase FBgn0003890
Synonyms:	beta-Tub97EF FlyBase FBgn0003890
ORF Names:	Dmel_CG4869 EMBL AAF56770.2

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	522 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain By similarity. RuleBase RU003505V0 Spearmint SPM003008
Subunit structure	Dimer of alpha and beta chains By similarity. RuleBase RU003505V0 Spearmint SPM003008
Sequence similarities	Belongs to the tubulin family. RuleBase RU000352V1

Ontologies

Keywords
Cellular component	Microtubule RuleBase RU000352V1 Spearmint SPM003008
Ligand	GTP-binding RuleBase RU000351V1 Spearmint SPM013838 Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	microtubule-based movement Inferred from electronic annotation. Source: InterPro protein polymerization Inferred from electronic annotation. Source: InterPro
Cellular component	microtubule Inferred from electronic annotation. Source: InterPro protein complex Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: InterPro GTPase activity Inferred from electronic annotation. Source: InterPro structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VAX7-1 [UniParc]. Last modified October 1, 2002. Version 2. Checksum: 9299E94B66A8F704	FASTA	522	58,571
	10 20 30 40 50 60 MREIVHLQAG QCGNQIGSKF WEIISDEHGI DPNGYYHGES ALQHERIDVY YNEASSGKYV 70 80 90 100 110 120 PRAVLIDLEP GTMDSVRQSP VGQLFRPDNF VYGQSGAGNN WAKGHYTEGA ELIDSVLEVL 130 140 150 160 170 180 RKESEGCDCL QGFQLAHSLG GGTGSGLGTL LISKIREEYP DRIMNSFSVV PSPKVSDTVV 190 200 210 220 230 240 EPYNATLSIH QLVENTDETF CIDNEALYDI CFRTLKLSSP TYGDLNHLVS VSEVVVEPYN 250 260 270 280 290 300 ATLSLHQLIV DTDETFCIDN EALYDICYQS LRICSPTYQD LNHLVSVSSQ DISINVTMSG 310 320 330 340 350 360 VTTCLRFPGQ LNADLRKLAV NMVPFPRLHF FMPGFAPLTA KGSQQYRALT VAELTQQMFD 370 380 390 400 410 420 AKNMMTACDP RHGRYLTVAC IFRGPMSMKE VDTQMYNVQS KNSSYFVEWI PNNVKVAVCD 430 440 450 460 470 480 IPPRGLKMSA TFIGNSTAIQ EIFKRISEQF TAMFRRKAFL HWYTGEGMDE MEFTEAESNM 490 500 510 520 NDLISEYQQY QEATADDEVE FDDEQAEQEG YESEVLQNGN GE

References

[1]

"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.

[2]

"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014297 Genomic DNA. Translation: AAF56770.2.
RefSeq	NP_651606.1.
UniGene	Dm.13754
3D structure databases
HSSP	HSSP built from PDB template 1FFX based on UniProtKB P02554.
ModBase	Search...
Genome annotation databases
Ensembl	FBgn0003890. Drosophila melanogaster. [Contig view]
GeneID	43359.
KEGG	dme:Dmel_CG4869.
NMPDR	fig|7227.3.peg.15069.
Organism-specific databases
FlyBase	FBgn0003890. betaTub97EF.
Phylogenomic databases
HOGENOM	Q9VAX7.
OMA	Q9VAX7. IRKETES.
Gene expression databases
ArrayExpress	Q9VAX7.
Family and domain databases
InterPro	IPR013838. Beta-tubulin_BS. IPR002453. Beta_tubulin. IPR000217. Tubulin. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR017975. Tubulin_CS. IPR003008. Tubulin_FtsZ_GTPase. [Graphical view]
Gene3D	G3DSA:3.30.1330.20. Tubulin/FtsZ_2-layer-sand-dom. 1 hit. G3DSA:3.40.50.1440. Tubulin_FtsZ. 2 hits.
PANTHER	PTHR11588:SF9. Beta_tubulin. 1 hit. PTHR11588. Tubulin. 1 hit.
Pfam	PF00091. Tubulin. 2 hits. PF03953. Tubulin_C. 1 hit. [Graphical view]
PRINTS	PR01163. BETATUBULIN. PR01161. TUBULIN.
PROSITE	PS00227. TUBULIN. 1 hit. PS00228. TUBULIN_B_AUTOREG. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	833537.

Entry information

Entry name

Q9VAX7_DROME

Accession

Primary (citable) accession number: Q9VAX7

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)