Reviewed, UniProtKB/Swiss-Prot Q9VAW0 (OR98B_DROME)

Names and origin

Protein names

Recommended name:
    Putative odorant receptor 98b

Gene names

Name:	Or98b
ORF Names:	CG1867

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Complexes with Or83b to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide By similarity.
Subunit structure	Interacts with Or83b. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Miscellaneous	The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Or83b complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Sequence similarities	Belongs to the odorant-gated ionic channel family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of smell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	odorant binding Inferred from electronic annotation. Source: InterPro olfactory receptor activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q8T3Y1	1	EBI-157182,EBI-166306
	Q9VHX9	1	EBI-157182,EBI-149978
Ady43A	Q9V4J1	1	EBI-157182,EBI-117175
CG9699	Q9VXD0	1	EBI-157182,EBI-118172

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Putative odorant receptor 98b		PRO_0000174285
Regions
	Topological domain	1 – 34	34	Cytoplasmic Potential
	Transmembrane	35 – 55	21	1 Potential
	Topological domain	56 – 66	11	Extracellular Potential
	Transmembrane	67 – 87	21	2 Potential
	Topological domain	88 – 128	41	Cytoplasmic Potential
	Transmembrane	129 – 149	21	3 Potential
	Topological domain	150 – 177	28	Extracellular Potential
	Transmembrane	178 – 198	21	4 Potential
	Topological domain	199 – 258	60	Cytoplasmic Potential
	Transmembrane	259 – 279	21	5 Potential
	Topological domain	280 – 284	5	Extracellular Potential
	Transmembrane	285 – 305	21	6 Potential
	Topological domain	306 – 329	24	Cytoplasmic Potential
	Transmembrane	330 – 350	21	7 Potential
	Topological domain	351 – 384	34	Extracellular Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9VAW0-1 [UniParc]. Last modified April 4, 2006. Version 3. Checksum: B6C33492578994F0	FASTA	384	43,644
	10 20 30 40 50 60 MLTDKFLRLQ SALFRLLGLE LLHEQDVGHR YPWRSICCIL SVASFMPLTI AFGLQNVQNV 70 80 90 100 110 120 EQLTDSLCSV LVDLLALCKI GLFLWLYKDF KFLIGQFYCV LQTETHTAVA EMIVTRESRR 130 140 150 160 170 180 DQFISAMYAY CFITAGLSAC LMSPLSMLIS YQRTGELQPK FPFPSVYPWD NMKLSNYIIS 190 200 210 220 230 240 YFWNVCAALG VALPTVCVDT LFCSLSHNLC ALFQIARHKM MHFEGRNTKE THENLKHVFQ 250 260 270 280 290 300 LYALCLNLGH FLNEYFRPLI CQFVAASLHL CVLCYQLSAN ILQPALLFYA AFTAAVVGQV 310 320 330 340 350 360 SIYCFCGSSI HSECQLFGQA IYESSWPHLL QENLQLVSSL KIAMMRSSLG CPIDGYFFEA 370 380 NRETLITVSK AFIKVSKKTP QVND

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014297 Genomic DNA. Translation: AAF56788.3.
RefSeq	NP_524540.3.
UniGene	Dm.31287
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:22652N.
IntAct	Q9VAW0. 5 interactions.
Genome annotation databases
Ensembl	FBgn0039582. Drosophila melanogaster. [Contig view]
GeneID	43375.
KEGG	dme:Dmel_CG1867.
Organism-specific databases
FlyBase	FBgn0039582. Or98b.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-013823-MON.
Family and domain databases
InterPro	IPR004117. 7tm6_olfct_rcpt. [Graphical view]
PANTHER	PTHR21137. 7tm6_olfct_rcpt. 1 hit.
Pfam	PF02949. 7tm_6. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	833609.

Entry information

Entry name

OR98B_DROME

Accession

Primary (citable) accession number: Q9VAW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	April 4, 2006
Last modified:	June 16, 2009
This is version 63 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project