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Q9VAT0

- Q9VAT0_DROME

UniProt

Q9VAT0 - Q9VAT0_DROME

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Protein
Submitted name: RE12101p
Gene
WASp, CG1520, Dmel_CG1520
Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. actin binding Source: FlyBase
  2. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. Arp2/3 complex-mediated actin nucleation Source: FlyBase
  2. apical constriction Source: FlyBase
  3. asymmetric cell division Source: FlyBase
  4. axonal fasciculation Source: FlyBase
  5. axonogenesis Source: FlyBase
  6. cell competition in a multicellular organism Source: FlyBase
  7. cell fate commitment Source: FlyBase
  8. chaeta morphogenesis Source: FlyBase
  9. clathrin-mediated endocytosis Source: FlyBase
  10. cuticle pattern formation Source: FlyBase
  11. epidermal cell differentiation Source: FlyBase
  12. intracellular protein transport Source: FlyBase
  13. membrane budding Source: FlyBase
  14. microtubule bundle formation Source: FlyBase
  15. muscle attachment Source: FlyBase
  16. myoblast fusion Source: FlyBase
  17. negative regulation of synaptic growth at neuromuscular junction Source: FlyBase
  18. regulation of actin filament polymerization Source: FlyBase
  19. regulation of embryonic cell shape Source: FlyBase
  20. regulation of synaptic growth at neuromuscular junction Source: FlyBase
  21. sensory organ development Source: FlyBase
  22. spermatid development Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_181315. Regulation of actin dynamics for phagocytic cup formation.
REACT_222212. DCC mediated attractive signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
RE12101pImported
Submitted name:
WASp, isoform AImported
Submitted name:
WASp, isoform BImported
Gene namesi
Name:WASpImported
ORF Names:CG1520Imported, Dmel_CG1520Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0024273. WASp.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. microvillus Source: FlyBase
  3. nucleus Source: FlyBase
  4. rhabdomere Source: FlyBase
Complete GO annotation...

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
nwkQ9VSU83EBI-132019,EBI-167691

Protein-protein interaction databases

MINTiMINT-742333.

Family & Domainsi

Sequence similaritiesi

Contains CRIB domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00730000110895.
InParanoidiQ9VAT0.
KOiK05747.
OMAiFEGSDGH.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.90.810.10. 1 hit.
InterProiIPR000095. CRIB_dom.
IPR011993. PH_like_dom.
IPR011026. WASP_C.
IPR000697. WH1/EVH1.
IPR003124. WH2_dom.
[Graphical view]
PfamiPF00786. PBD. 1 hit.
PF00568. WH1. 1 hit.
PF02205. WH2. 2 hits.
[Graphical view]
SMARTiSM00246. WH2. 2 hits.
[Graphical view]
SUPFAMiSSF47912. SSF47912. 2 hits.
PROSITEiPS50108. CRIB. 1 hit.
PS50229. WH1. 1 hit.
PS51082. WH2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VAT0-1 [UniParc]FASTAAdd to Basket

« Hide

MSSGMRSQDG PRAKVNAAST LLTQEENEAV FKLLGKKCQT LNTAVVQIYK    50
TEGSAHAHWK KRHTGVVCFV KDSAIRSYFM RAYCLIKNEL IWEHEIYDGM 100
EVVKSRPFLL TFEGSDGHVG LNFVSEEECD SFFRIVDATI ETRNRKRQEK 150
RNRQKSQQAP NAPLPQVQRE PARPPPMQGG LSSTDGVQLR NNKINSVTLT 200
PAPAPAQSKN FLSSSFGLGN NAKDKKRKVT KADISRPTNF VHLSHVGWDA 250
QKGFDLAGNE NDEVLNEFFV KAGVSEVELK DRDTRAFIYD FIQSNNVLAS 300
VKQYSVESPT ETAAPMPPPV PTRHPSNGNQ RTAPPLPPAR QPPPAVPVTV 350
PGAARAPPPP NRPPPISTAP PPPPVSAPVV APPPPPPPPP AAVPPPPPPP 400
MPVGEIPVIT TTHAPTQAAR PAAPAAPDPR NALMDAIRKG TQLKKVDTTA 450
LSTGSGDSRS DLMKDIRQGT VLKPAKEREL GSQRNSDSGA GTDALADALR 500
RALAARGNAI HSDEDETESS DNEGEWD 527
Length:527
Mass (Da):56,974
Last modified:May 1, 2000 - v1
Checksum:i1E02454B47445C2E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAF56819.1.
AY070576 mRNA. Translation: AAL48047.1.
AE014297 Genomic DNA. Translation: AAN14303.1.
RefSeqiNP_001263045.1. NM_001276116.1.
NP_651637.1. NM_143380.4.
NP_733257.1. NM_170378.2.
UniGeneiDm.6373.

Genome annotation databases

EnsemblMetazoaiFBtr0085352; FBpp0084721; FBgn0024273.
FBtr0085353; FBpp0084722; FBgn0024273.
GeneIDi43402.
KEGGidme:Dmel_CG1520.
UCSCiCG1520-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAF56819.1 .
AY070576 mRNA. Translation: AAL48047.1 .
AE014297 Genomic DNA. Translation: AAN14303.1 .
RefSeqi NP_001263045.1. NM_001276116.1.
NP_651637.1. NM_143380.4.
NP_733257.1. NM_170378.2.
UniGenei Dm.6373.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

MINTi MINT-742333.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0085352 ; FBpp0084721 ; FBgn0024273 .
FBtr0085353 ; FBpp0084722 ; FBgn0024273 .
GeneIDi 43402.
KEGGi dme:Dmel_CG1520.
UCSCi CG1520-RA. d. melanogaster.

Organism-specific databases

CTDi 43402.
FlyBasei FBgn0024273. WASp.

Phylogenomic databases

GeneTreei ENSGT00730000110895.
InParanoidi Q9VAT0.
KOi K05747.
OMAi FEGSDGH.

Enzyme and pathway databases

Reactomei REACT_181315. Regulation of actin dynamics for phagocytic cup formation.
REACT_222212. DCC mediated attractive signaling.

Miscellaneous databases

ChiTaRSi WAS. drosophila.
GenomeRNAii 43402.
NextBioi 833747.
PROi Q9VAT0.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
3.90.810.10. 1 hit.
InterProi IPR000095. CRIB_dom.
IPR011993. PH_like_dom.
IPR011026. WASP_C.
IPR000697. WH1/EVH1.
IPR003124. WH2_dom.
[Graphical view ]
Pfami PF00786. PBD. 1 hit.
PF00568. WH1. 1 hit.
PF02205. WH2. 2 hits.
[Graphical view ]
SMARTi SM00246. WH2. 2 hits.
[Graphical view ]
SUPFAMi SSF47912. SSF47912. 2 hits.
PROSITEi PS50108. CRIB. 1 hit.
PS50229. WH1. 1 hit.
PS51082. WH2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  8. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  12. FlyBase
    Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9VAT0_DROME
AccessioniPrimary (citable) accession number: Q9VAT0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3
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