Q9VAT0 (Q9VAT0_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
RE12101p EMBL AAL48047.1

Submitted name:
WASp, isoform A EMBL AAF56819.1
Submitted name:
WASp, isoform B EMBL AAN14303.1

Gene names

Name:	WASp FlyBase FBgn0024273 EMBL AAL48047.1
ORF Names:	CG1520 FlyBase FBgn0024273, Dmel_CG1520 EMBL AAF56819.1

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	527 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 CRIB domain. SAAS SAAS000095

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Arp2/3 complex-mediated actin nucleation Inferred from direct assay PubMed 19633175. Source: FlyBase actin polymerization or depolymerization Inferred from electronic annotation. Source: InterPro apical constriction Inferred from mutant phenotype PubMed 19934015. Source: FlyBase asymmetric cell division Traceable author statement PubMed 15196561. Source: FlyBase axonal fasciculation Inferred from genetic interaction PubMed 11854309. Source: FlyBase cell competition in a multicellular organism Inferred from mutant phenotype PubMed 17574031. Source: FlyBase cell fate commitment Traceable author statement PubMed 15196561. Source: FlyBase chaeta morphogenesis Inferred from mutant phenotype PubMed 11854309. Source: FlyBase cuticle pattern formation Inferred from mutant phenotype PubMed 16933974. Source: FlyBase epidermal cell differentiation Inferred from mutant phenotype PubMed 16933974. Source: FlyBase intracellular protein transport Inferred from mutant phenotype PubMed 19543274. Source: FlyBase microtubule bundle formation Inferred from direct assay PubMed 19633175. Source: FlyBase muscle attachment Inferred from mutant phenotype PubMed 17306790. Source: FlyBase myoblast fusion Inferred from mutant phenotype PubMed 17306790PubMed 17419994PubMed 21098115. Source: FlyBase negative regulation of synaptic growth at neuromuscular junction Inferred from mutant phenotype PubMed 14980202PubMed 21041451. Source: FlyBase protein complex assembly Inferred from electronic annotation. Source: InterPro regulation of embryonic cell shape Inferred from mutant phenotype PubMed 19934015. Source: FlyBase spermatid development Inferred from mutant phenotype PubMed 21652648. Source: FlyBase
Cellular_component	actin cytoskeleton Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from direct assay PubMed 22275148. Source: FlyBase microvillus Inferred from mutant phenotype PubMed 14744998. Source: FlyBase nucleus Inferred from direct assay PubMed 22275148. Source: FlyBase rhabdomere Inferred from mutant phenotype PubMed 14744998. Source: FlyBase
Molecular_function	actin binding Inferred from sequence or structural similarity PubMed 10908588. Source: FlyBase small GTPase regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
nwk	Q9VSU8	3	EBI-132019,EBI-167691

Sequences

	Sequence		Length	Mass (Da)
	Q9VAT0 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 1E02454B47445C2E	FASTA	527	56,974
	10 20 30 40 50 60 MSSGMRSQDG PRAKVNAAST LLTQEENEAV FKLLGKKCQT LNTAVVQIYK TEGSAHAHWK 70 80 90 100 110 120 KRHTGVVCFV KDSAIRSYFM RAYCLIKNEL IWEHEIYDGM EVVKSRPFLL TFEGSDGHVG 130 140 150 160 170 180 LNFVSEEECD SFFRIVDATI ETRNRKRQEK RNRQKSQQAP NAPLPQVQRE PARPPPMQGG 190 200 210 220 230 240 LSSTDGVQLR NNKINSVTLT PAPAPAQSKN FLSSSFGLGN NAKDKKRKVT KADISRPTNF 250 260 270 280 290 300 VHLSHVGWDA QKGFDLAGNE NDEVLNEFFV KAGVSEVELK DRDTRAFIYD FIQSNNVLAS 310 320 330 340 350 360 VKQYSVESPT ETAAPMPPPV PTRHPSNGNQ RTAPPLPPAR QPPPAVPVTV PGAARAPPPP 370 380 390 400 410 420 NRPPPISTAP PPPPVSAPVV APPPPPPPPP AAVPPPPPPP MPVGEIPVIT TTHAPTQAAR 430 440 450 460 470 480 PAAPAAPDPR NALMDAIRKG TQLKKVDTTA LSTGSGDSRS DLMKDIRQGT VLKPAKEREL 490 500 510 520 GSQRNSDSGA GTDALADALR RALAARGNAI HSDEDETESS DNEGEWD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. , Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAL48047.1.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014297 Genomic DNA. Translation: AAF56819.1. AY070576 mRNA. Translation: AAL48047.1. AE014297 Genomic DNA. Translation: AAN14303.1.
RefSeq	NP_001263045.1. NM_001276116.1. NP_651637.1. NM_143380.4. NP_733257.1. NM_170378.2.
UniGene	Dm.6373.
3D structure databases
HSSP	HSSP built from PDB template 1MKE based on UniProtKB O08816.
SMR	Q9VAT0. Positions 29-136, 226-284.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VAT0. 5 interactions.
MINT	MINT-742333.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0085352; FBpp0084721; FBgn0024273. FBtr0085353; FBpp0084722; FBgn0024273.
GeneID	43402.
KEGG	dme:Dmel_CG1520.
UCSC	CG1520-RA. d. melanogaster.
Organism-specific databases
CTD	43402.
FlyBase	FBgn0024273. WASp.
Phylogenomic databases
GeneTree	ENSGT00550000074443.
InParanoid	Q9VAT0.
KO	K05747.
OMA	DTCQIGL.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR000697. EVH1. IPR000095. PAK_box_Rho-bd. IPR011993. PH_like_dom. IPR011026. WASP_C. IPR003124. WH2_dom. [Graphical view]
Pfam	PF00786. PBD. 1 hit. PF00568. WH1. 1 hit. PF02205. WH2. 2 hits. [Graphical view]
SMART	SM00246. WH2. 2 hits. [Graphical view]
SUPFAM	SSF47912. WASP_C. 1 hit.
PROSITE	PS50108. CRIB. 1 hit. PS50229. WH1. 1 hit. PS51082. WH2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	WAS. drosophila.
GenomeRNAi	43402.
NextBio	833747.

Entry information

Entry name

Q9VAT0_DROME

Accession

Primary (citable) accession number: Q9VAT0

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)