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Protein
Submitted name:

RE12101p

Gene

WASp

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • actin binding Source: FlyBase

GO - Biological processi

  • apical constriction Source: FlyBase
  • Arp2/3 complex-mediated actin nucleation Source: FlyBase
  • asymmetric cell division Source: FlyBase
  • axonal fasciculation Source: FlyBase
  • axonogenesis Source: FlyBase
  • cell competition in a multicellular organism Source: FlyBase
  • cell fate commitment Source: FlyBase
  • chaeta morphogenesis Source: FlyBase
  • clathrin-dependent endocytosis Source: FlyBase
  • cuticle pattern formation Source: FlyBase
  • epidermal cell differentiation Source: FlyBase
  • intracellular protein transport Source: FlyBase
  • microtubule bundle formation Source: FlyBase
  • muscle attachment Source: FlyBase
  • myoblast fusion Source: FlyBase
  • negative regulation of synaptic growth at neuromuscular junction Source: FlyBase
  • positive regulation of Arp2/3 complex-mediated actin nucleation Source: InterPro
  • regulation of actin filament polymerization Source: FlyBase
  • regulation of embryonic cell shape Source: FlyBase
  • regulation of synaptic growth at neuromuscular junction Source: FlyBase
  • sensory organ development Source: FlyBase
  • spermatid development Source: FlyBase
  • vesicle budding from membrane Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DME-203641 NOSTRIN mediated eNOS trafficking
R-DME-373753 Nephrin family interactions
R-DME-3928662 EPHB-mediated forward signaling
R-DME-418885 DCC mediated attractive signaling
R-DME-5663213 RHO GTPases Activate WASPs and WAVEs
R-DME-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Submitted name:
RE12101pImported
Submitted name:
WASp, isoform AImported
Submitted name:
WASp, isoform BImported
Submitted name:
WASp, isoform DImported
Gene namesi
Name:WASpImported
Synonyms:D-WASPImported, Dm WASPImported, Dmel\CG1520Imported, DmWASPImported, dWASPImported, WASPImported, WaspImported, waspImported, WSPImported, WspImported, wspImported
ORF Names:CG1520Imported, Dmel_CG1520Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0024273 WASp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ9VAT0

Expressioni

Gene expression databases

BgeeiFBgn0024273
ExpressionAtlasiQ9VAT0 baseline and differential

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
nwkQ9VSU83EBI-132019,EBI-167691

GO - Molecular functioni

  • actin binding Source: FlyBase

Protein-protein interaction databases

IntActiQ9VAT0, 5 interactors
STRINGi7227.FBpp0084721

Structurei

3D structure databases

SMRiQ9VAT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 143WH1InterPro annotationAdd BLAST110
Domaini234 – 247CRIBInterPro annotationAdd BLAST14
Domaini429 – 446WH2InterPro annotationAdd BLAST18
Domaini458 – 475WH2InterPro annotationAdd BLAST18

Phylogenomic databases

eggNOGiKOG3671 Eukaryota
ENOG410ZWK1 LUCA
GeneTreeiENSGT00730000110895
KOiK05747
OMAiKCQTLNT
OrthoDBiEOG091G0VCD

Family and domain databases

CDDicd00132 CRIB, 1 hit
cd01205 EVH1_WASP-like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.90.810.10, 1 hit
InterProiView protein in InterPro
IPR000095 CRIB_dom
IPR036936 CRIB_dom_sf
IPR011993 PH-like_dom_sf
IPR027641 WASP
IPR011026 WASP_C
IPR033927 WASPfam_EVH1
IPR000697 WH1/EVH1_dom
IPR003124 WH2_dom
PANTHERiPTHR23202:SF35 PTHR23202:SF35, 2 hits
PfamiView protein in Pfam
PF00786 PBD, 1 hit
PF00568 WH1, 1 hit
PF02205 WH2, 2 hits
SMARTiView protein in SMART
SM00461 WH1, 1 hit
SM00246 WH2, 2 hits
SUPFAMiSSF47912 SSF47912, 2 hits
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
PS50229 WH1, 1 hit
PS51082 WH2, 2 hits

Sequencei

Sequence statusi: Complete.

Q9VAT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGMRSQDG PRAKVNAAST LLTQEENEAV FKLLGKKCQT LNTAVVQIYK
60 70 80 90 100
TEGSAHAHWK KRHTGVVCFV KDSAIRSYFM RAYCLIKNEL IWEHEIYDGM
110 120 130 140 150
EVVKSRPFLL TFEGSDGHVG LNFVSEEECD SFFRIVDATI ETRNRKRQEK
160 170 180 190 200
RNRQKSQQAP NAPLPQVQRE PARPPPMQGG LSSTDGVQLR NNKINSVTLT
210 220 230 240 250
PAPAPAQSKN FLSSSFGLGN NAKDKKRKVT KADISRPTNF VHLSHVGWDA
260 270 280 290 300
QKGFDLAGNE NDEVLNEFFV KAGVSEVELK DRDTRAFIYD FIQSNNVLAS
310 320 330 340 350
VKQYSVESPT ETAAPMPPPV PTRHPSNGNQ RTAPPLPPAR QPPPAVPVTV
360 370 380 390 400
PGAARAPPPP NRPPPISTAP PPPPVSAPVV APPPPPPPPP AAVPPPPPPP
410 420 430 440 450
MPVGEIPVIT TTHAPTQAAR PAAPAAPDPR NALMDAIRKG TQLKKVDTTA
460 470 480 490 500
LSTGSGDSRS DLMKDIRQGT VLKPAKEREL GSQRNSDSGA GTDALADALR
510 520
RALAARGNAI HSDEDETESS DNEGEWD
Length:527
Mass (Da):56,974
Last modified:May 1, 2000 - v1
Checksum:i1E02454B47445C2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56819.1
AY070576 mRNA Translation: AAL48047.1
AE014297 Genomic DNA Translation: AAN14303.1
AE014297 Genomic DNA Translation: AGB96425.1
RefSeqiNP_001263045.1, NM_001276116.1
NP_651637.1, NM_143380.4
NP_733257.1, NM_170378.2
UniGeneiDm.6373

Genome annotation databases

EnsemblMetazoaiFBtr0085352; FBpp0084721; FBgn0024273
FBtr0085353; FBpp0084722; FBgn0024273
FBtr0085354; FBpp0084723; FBgn0024273
FBtr0336768; FBpp0307744; FBgn0024273
GeneIDi43402
KEGGidme:Dmel_CG1520
UCSCiCG1520-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9VAT0_DROME
AccessioniPrimary (citable) accession number: Q9VAT0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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