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Q9VAT0

- Q9VAT0_DROME

UniProt

Q9VAT0 - Q9VAT0_DROME

Protein
Submitted name:

RE12101p

Gene

WASp

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. actin binding Source: FlyBase
    2. protein binding Source: IntAct

    GO - Biological processi

    1. apical constriction Source: FlyBase
    2. Arp2/3 complex-mediated actin nucleation Source: FlyBase
    3. asymmetric cell division Source: FlyBase
    4. axonal fasciculation Source: FlyBase
    5. axonogenesis Source: FlyBase
    6. cell competition in a multicellular organism Source: FlyBase
    7. cell fate commitment Source: FlyBase
    8. chaeta morphogenesis Source: FlyBase
    9. clathrin-mediated endocytosis Source: FlyBase
    10. cuticle pattern formation Source: FlyBase
    11. epidermal cell differentiation Source: FlyBase
    12. intracellular protein transport Source: FlyBase
    13. membrane budding Source: FlyBase
    14. microtubule bundle formation Source: FlyBase
    15. muscle attachment Source: FlyBase
    16. myoblast fusion Source: FlyBase
    17. negative regulation of synaptic growth at neuromuscular junction Source: FlyBase
    18. regulation of actin filament polymerization Source: FlyBase
    19. regulation of embryonic cell shape Source: FlyBase
    20. regulation of synaptic growth at neuromuscular junction Source: FlyBase
    21. sensory organ development Source: FlyBase
    22. spermatid development Source: FlyBase

    Enzyme and pathway databases

    ReactomeiREACT_181315. Regulation of actin dynamics for phagocytic cup formation.
    REACT_222212. DCC mediated attractive signaling.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    RE12101pImported
    Submitted name:
    WASp, isoform AImported
    Submitted name:
    WASp, isoform BImported
    Gene namesi
    Name:WASpImported
    ORF Names:CG1520Imported, Dmel_CG1520Imported
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0024273. WASp.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: FlyBase
    2. microvillus Source: FlyBase
    3. nucleus Source: FlyBase
    4. rhabdomere Source: FlyBase

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    nwkQ9VSU83EBI-132019,EBI-167691

    Protein-protein interaction databases

    MINTiMINT-742333.

    Family & Domainsi

    Sequence similaritiesi

    Contains CRIB domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110895.
    InParanoidiQ9VAT0.
    KOiK05747.
    OMAiFEGSDGH.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.90.810.10. 1 hit.
    InterProiIPR000095. CRIB_dom.
    IPR011993. PH_like_dom.
    IPR011026. WASP_C.
    IPR000697. WH1/EVH1.
    IPR003124. WH2_dom.
    [Graphical view]
    PfamiPF00786. PBD. 1 hit.
    PF00568. WH1. 1 hit.
    PF02205. WH2. 2 hits.
    [Graphical view]
    SMARTiSM00246. WH2. 2 hits.
    [Graphical view]
    SUPFAMiSSF47912. SSF47912. 2 hits.
    PROSITEiPS50108. CRIB. 1 hit.
    PS50229. WH1. 1 hit.
    PS51082. WH2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9VAT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSGMRSQDG PRAKVNAAST LLTQEENEAV FKLLGKKCQT LNTAVVQIYK    50
    TEGSAHAHWK KRHTGVVCFV KDSAIRSYFM RAYCLIKNEL IWEHEIYDGM 100
    EVVKSRPFLL TFEGSDGHVG LNFVSEEECD SFFRIVDATI ETRNRKRQEK 150
    RNRQKSQQAP NAPLPQVQRE PARPPPMQGG LSSTDGVQLR NNKINSVTLT 200
    PAPAPAQSKN FLSSSFGLGN NAKDKKRKVT KADISRPTNF VHLSHVGWDA 250
    QKGFDLAGNE NDEVLNEFFV KAGVSEVELK DRDTRAFIYD FIQSNNVLAS 300
    VKQYSVESPT ETAAPMPPPV PTRHPSNGNQ RTAPPLPPAR QPPPAVPVTV 350
    PGAARAPPPP NRPPPISTAP PPPPVSAPVV APPPPPPPPP AAVPPPPPPP 400
    MPVGEIPVIT TTHAPTQAAR PAAPAAPDPR NALMDAIRKG TQLKKVDTTA 450
    LSTGSGDSRS DLMKDIRQGT VLKPAKEREL GSQRNSDSGA GTDALADALR 500
    RALAARGNAI HSDEDETESS DNEGEWD 527
    Length:527
    Mass (Da):56,974
    Last modified:May 1, 2000 - v1
    Checksum:i1E02454B47445C2E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAF56819.1.
    AY070576 mRNA. Translation: AAL48047.1.
    AE014297 Genomic DNA. Translation: AAN14303.1.
    RefSeqiNP_001263045.1. NM_001276116.1.
    NP_651637.1. NM_143380.4.
    NP_733257.1. NM_170378.2.
    UniGeneiDm.6373.

    Genome annotation databases

    EnsemblMetazoaiFBtr0085352; FBpp0084721; FBgn0024273.
    FBtr0085353; FBpp0084722; FBgn0024273.
    GeneIDi43402.
    KEGGidme:Dmel_CG1520.
    UCSCiCG1520-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAF56819.1 .
    AY070576 mRNA. Translation: AAL48047.1 .
    AE014297 Genomic DNA. Translation: AAN14303.1 .
    RefSeqi NP_001263045.1. NM_001276116.1.
    NP_651637.1. NM_143380.4.
    NP_733257.1. NM_170378.2.
    UniGenei Dm.6373.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-742333.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0085352 ; FBpp0084721 ; FBgn0024273 .
    FBtr0085353 ; FBpp0084722 ; FBgn0024273 .
    GeneIDi 43402.
    KEGGi dme:Dmel_CG1520.
    UCSCi CG1520-RA. d. melanogaster.

    Organism-specific databases

    CTDi 43402.
    FlyBasei FBgn0024273. WASp.

    Phylogenomic databases

    GeneTreei ENSGT00730000110895.
    InParanoidi Q9VAT0.
    KOi K05747.
    OMAi FEGSDGH.

    Enzyme and pathway databases

    Reactomei REACT_181315. Regulation of actin dynamics for phagocytic cup formation.
    REACT_222212. DCC mediated attractive signaling.

    Miscellaneous databases

    ChiTaRSi WAS. drosophila.
    GenomeRNAii 43402.
    NextBioi 833747.
    PROi Q9VAT0.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.90.810.10. 1 hit.
    InterProi IPR000095. CRIB_dom.
    IPR011993. PH_like_dom.
    IPR011026. WASP_C.
    IPR000697. WH1/EVH1.
    IPR003124. WH2_dom.
    [Graphical view ]
    Pfami PF00786. PBD. 1 hit.
    PF00568. WH1. 1 hit.
    PF02205. WH2. 2 hits.
    [Graphical view ]
    SMARTi SM00246. WH2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47912. SSF47912. 2 hits.
    PROSITEi PS50108. CRIB. 1 hit.
    PS50229. WH1. 1 hit.
    PS51082. WH2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BerkeleyImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    4. Cited for: GENOME REANNOTATION.
      Strain: BerkeleyImported.
    5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
      Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
      Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
      Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
      Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    7. "Combined evidence annotation of transposable elements in genome sequences."
      Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
      PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    8. "Drosophila melanogaster release 4 sequence."
      Berkeley Drosophila Genome Project
      Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    9. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
      Smith C.D., Shu S., Mungall C.J., Karpen G.H.
      Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    12. FlyBase
      Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9VAT0_DROME
    AccessioniPrimary (citable) accession number: Q9VAT0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3