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Protein
Submitted name:

RE12101p

Gene

WASp

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • actin binding Source: FlyBase

GO - Biological processi

  • apical constriction Source: FlyBase
  • Arp2/3 complex-mediated actin nucleation Source: FlyBase
  • asymmetric cell division Source: FlyBase
  • axonal fasciculation Source: FlyBase
  • axonogenesis Source: FlyBase
  • cell competition in a multicellular organism Source: FlyBase
  • cell fate commitment Source: FlyBase
  • chaeta morphogenesis Source: FlyBase
  • clathrin-dependent endocytosis Source: FlyBase
  • cuticle pattern formation Source: FlyBase
  • epidermal cell differentiation Source: FlyBase
  • intracellular protein transport Source: FlyBase
  • membrane budding Source: FlyBase
  • microtubule bundle formation Source: FlyBase
  • muscle attachment Source: FlyBase
  • myoblast fusion Source: FlyBase
  • negative regulation of synaptic growth at neuromuscular junction Source: FlyBase
  • positive regulation of Arp2/3 complex-mediated actin nucleation Source: InterPro
  • regulation of actin filament polymerization Source: FlyBase
  • regulation of embryonic cell shape Source: FlyBase
  • regulation of synaptic growth at neuromuscular junction Source: FlyBase
  • sensory organ development Source: FlyBase
  • spermatid development Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DME-203641. NOSTRIN mediated eNOS trafficking.
R-DME-373753. Nephrin interactions.
R-DME-3928662. EPHB-mediated forward signaling.
R-DME-418885. DCC mediated attractive signaling.
R-DME-5663213. RHO GTPases Activate WASPs and WAVEs.
R-DME-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Submitted name:
RE12101pImported
Submitted name:
WASp, isoform AImported
Submitted name:
WASp, isoform BImported
Submitted name:
WASp, isoform DImported
Gene namesi
Name:WASpImported
ORF Names:CG1520Imported, Dmel_CG1520Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0024273. WASp.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • microvillus Source: FlyBase
  • neuromuscular junction Source: FlyBase
  • nucleus Source: FlyBase
  • rhabdomere Source: FlyBase
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiFBgn0024273.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
nwkQ9VSU83EBI-132019,EBI-167691

GO - Molecular functioni

  • actin binding Source: FlyBase

Protein-protein interaction databases

MINTiMINT-742333.
STRINGi7227.FBpp0084721.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 143WH1InterPro annotationAdd BLAST110
Domaini234 – 247CRIBInterPro annotationAdd BLAST14
Domaini429 – 446WH2InterPro annotationAdd BLAST18
Domaini458 – 475WH2InterPro annotationAdd BLAST18

Phylogenomic databases

eggNOGiKOG3671. Eukaryota.
ENOG410ZWK1. LUCA.
GeneTreeiENSGT00730000110895.
KOiK05747.
OMAiWSKKCCG.
OrthoDBiEOG091G0VCD.

Family and domain databases

CDDicd01205. EVH1_WASP-like. 1 hit.
Gene3Di2.30.29.30. 1 hit.
3.90.810.10. 1 hit.
InterProiIPR000095. CRIB_dom.
IPR011993. PH_dom-like.
IPR011026. WASP_C.
IPR033927. WASPfam_EVH1.
IPR000697. WH1/EVH1_dom.
IPR003124. WH2_dom.
IPR028297. Wsp1/Las17.
[Graphical view]
PANTHERiPTHR23202:SF34. PTHR23202:SF34. 1 hit.
PfamiPF00786. PBD. 1 hit.
PF00568. WH1. 1 hit.
PF02205. WH2. 2 hits.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
SM00246. WH2. 2 hits.
[Graphical view]
SUPFAMiSSF47912. SSF47912. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50108. CRIB. 1 hit.
PS50229. WH1. 1 hit.
PS51082. WH2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VAT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGMRSQDG PRAKVNAAST LLTQEENEAV FKLLGKKCQT LNTAVVQIYK
60 70 80 90 100
TEGSAHAHWK KRHTGVVCFV KDSAIRSYFM RAYCLIKNEL IWEHEIYDGM
110 120 130 140 150
EVVKSRPFLL TFEGSDGHVG LNFVSEEECD SFFRIVDATI ETRNRKRQEK
160 170 180 190 200
RNRQKSQQAP NAPLPQVQRE PARPPPMQGG LSSTDGVQLR NNKINSVTLT
210 220 230 240 250
PAPAPAQSKN FLSSSFGLGN NAKDKKRKVT KADISRPTNF VHLSHVGWDA
260 270 280 290 300
QKGFDLAGNE NDEVLNEFFV KAGVSEVELK DRDTRAFIYD FIQSNNVLAS
310 320 330 340 350
VKQYSVESPT ETAAPMPPPV PTRHPSNGNQ RTAPPLPPAR QPPPAVPVTV
360 370 380 390 400
PGAARAPPPP NRPPPISTAP PPPPVSAPVV APPPPPPPPP AAVPPPPPPP
410 420 430 440 450
MPVGEIPVIT TTHAPTQAAR PAAPAAPDPR NALMDAIRKG TQLKKVDTTA
460 470 480 490 500
LSTGSGDSRS DLMKDIRQGT VLKPAKEREL GSQRNSDSGA GTDALADALR
510 520
RALAARGNAI HSDEDETESS DNEGEWD
Length:527
Mass (Da):56,974
Last modified:May 1, 2000 - v1
Checksum:i1E02454B47445C2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56819.1.
AY070576 mRNA. Translation: AAL48047.1.
AE014297 Genomic DNA. Translation: AAN14303.1.
AE014297 Genomic DNA. Translation: AGB96425.1.
RefSeqiNP_001263045.1. NM_001276116.1.
NP_651637.1. NM_143380.4.
NP_733257.1. NM_170378.2.
UniGeneiDm.6373.

Genome annotation databases

EnsemblMetazoaiFBtr0085352; FBpp0084721; FBgn0024273.
FBtr0085353; FBpp0084722; FBgn0024273.
FBtr0336768; FBpp0307744; FBgn0024273.
GeneIDi43402.
KEGGidme:Dmel_CG1520.
UCSCiCG1520-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56819.1.
AY070576 mRNA. Translation: AAL48047.1.
AE014297 Genomic DNA. Translation: AAN14303.1.
AE014297 Genomic DNA. Translation: AGB96425.1.
RefSeqiNP_001263045.1. NM_001276116.1.
NP_651637.1. NM_143380.4.
NP_733257.1. NM_170378.2.
UniGeneiDm.6373.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-742333.
STRINGi7227.FBpp0084721.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085352; FBpp0084721; FBgn0024273.
FBtr0085353; FBpp0084722; FBgn0024273.
FBtr0336768; FBpp0307744; FBgn0024273.
GeneIDi43402.
KEGGidme:Dmel_CG1520.
UCSCiCG1520-RA. d. melanogaster.

Organism-specific databases

CTDi43402.
FlyBaseiFBgn0024273. WASp.

Phylogenomic databases

eggNOGiKOG3671. Eukaryota.
ENOG410ZWK1. LUCA.
GeneTreeiENSGT00730000110895.
KOiK05747.
OMAiWSKKCCG.
OrthoDBiEOG091G0VCD.

Enzyme and pathway databases

ReactomeiR-DME-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DME-203641. NOSTRIN mediated eNOS trafficking.
R-DME-373753. Nephrin interactions.
R-DME-3928662. EPHB-mediated forward signaling.
R-DME-418885. DCC mediated attractive signaling.
R-DME-5663213. RHO GTPases Activate WASPs and WAVEs.
R-DME-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

GenomeRNAii43402.

Gene expression databases

BgeeiFBgn0024273.

Family and domain databases

CDDicd01205. EVH1_WASP-like. 1 hit.
Gene3Di2.30.29.30. 1 hit.
3.90.810.10. 1 hit.
InterProiIPR000095. CRIB_dom.
IPR011993. PH_dom-like.
IPR011026. WASP_C.
IPR033927. WASPfam_EVH1.
IPR000697. WH1/EVH1_dom.
IPR003124. WH2_dom.
IPR028297. Wsp1/Las17.
[Graphical view]
PANTHERiPTHR23202:SF34. PTHR23202:SF34. 1 hit.
PfamiPF00786. PBD. 1 hit.
PF00568. WH1. 1 hit.
PF02205. WH2. 2 hits.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
SM00246. WH2. 2 hits.
[Graphical view]
SUPFAMiSSF47912. SSF47912. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50108. CRIB. 1 hit.
PS50229. WH1. 1 hit.
PS51082. WH2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9VAT0_DROME
AccessioniPrimary (citable) accession number: Q9VAT0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.