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Protein

Probable dimethyladenosine transferase

Gene

CG11837

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.By similarity

Catalytic activityi

4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei32 – 321S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
Binding sitei57 – 571S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei78 – 781S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei106 – 1061S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei121 – 1211S-adenosyl-L-methioninePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • neurogenesis Source: FlyBase
  • sleep Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dimethyladenosine transferase (EC:2.1.1.183)
Alternative name(s):
Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
Probable 18S rRNA dimethylase
Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
Gene namesi
ORF Names:CG11837
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0039627. CG11837.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Probable dimethyladenosine transferasePRO_0000101469Add
BLAST

Proteomic databases

PaxDbiQ9VAQ5.
PRIDEiQ9VAQ5.

Expressioni

Gene expression databases

BgeeiQ9VAQ5.
GenevisibleiQ9VAQ5. DM.

Interactioni

Protein-protein interaction databases

IntActiQ9VAQ5. 4 interactions.
STRINGi7227.FBpp0084729.

Structurei

3D structure databases

ProteinModelPortaliQ9VAQ5.
SMRiQ9VAQ5. Positions 29-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0820. Eukaryota.
COG0030. LUCA.
GeneTreeiENSGT00530000063389.
InParanoidiQ9VAQ5.
KOiK14191.
OMAiPVEDDFN.
OrthoDBiEOG7RZ5QG.
PhylomeDBiQ9VAQ5.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001737. KsgA/Erm.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11727. PTHR11727. 1 hit.
PfamiPF00398. RrnaAD. 1 hit.
[Graphical view]
SMARTiSM00650. rADc. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00755. ksgA. 1 hit.
PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
PS51689. SAM_RNA_A_N6_MT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VAQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKVTKEKKS RIHNDVQKQG IVFNKDFGQH ILKNPLVITT MLEKAALRAT
60 70 80 90 100
DVVLEIGPGT GNMTVRMLER AKKVIACEID TRLAAELQKR VQATPLQPKL
110 120 130 140 150
QVLIGDFLKA ELPFFDLCIA NVPYQISSPL IFKLLLHRPL FRCAVLMFQR
160 170 180 190 200
EFAERLVAKP GDKLYCRLSI NTQLLARVDM LMKVGKNNFR PPPKVESSVV
210 220 230 240 250
RLEPKNPPPP VNFTEWDGLT RIAFLRKNKT LAATFKVTSV LEMLEKNYKL
260 270 280 290 300
YRSLRNEPIE DDFKMQDKVI SILEEQDMAA KRARSMDIDD FMRLLLAFNS

AGIHFN
Length:306
Mass (Da):35,048
Last modified:May 1, 2000 - v1
Checksum:iCA091714E43A0AFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56847.1.
AY061429 mRNA. Translation: AAL28977.1.
RefSeqiNP_651660.1. NM_143403.4.
UniGeneiDm.1363.

Genome annotation databases

EnsemblMetazoaiFBtr0085360; FBpp0084729; FBgn0039627.
GeneIDi43429.
KEGGidme:Dmel_CG11837.
UCSCiCG11837-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56847.1.
AY061429 mRNA. Translation: AAL28977.1.
RefSeqiNP_651660.1. NM_143403.4.
UniGeneiDm.1363.

3D structure databases

ProteinModelPortaliQ9VAQ5.
SMRiQ9VAQ5. Positions 29-306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9VAQ5. 4 interactions.
STRINGi7227.FBpp0084729.

Proteomic databases

PaxDbiQ9VAQ5.
PRIDEiQ9VAQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085360; FBpp0084729; FBgn0039627.
GeneIDi43429.
KEGGidme:Dmel_CG11837.
UCSCiCG11837-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0039627. CG11837.

Phylogenomic databases

eggNOGiKOG0820. Eukaryota.
COG0030. LUCA.
GeneTreeiENSGT00530000063389.
InParanoidiQ9VAQ5.
KOiK14191.
OMAiPVEDDFN.
OrthoDBiEOG7RZ5QG.
PhylomeDBiQ9VAQ5.

Miscellaneous databases

GenomeRNAii43429.
PROiQ9VAQ5.

Gene expression databases

BgeeiQ9VAQ5.
GenevisibleiQ9VAQ5. DM.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001737. KsgA/Erm.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11727. PTHR11727. 1 hit.
PfamiPF00398. RrnaAD. 1 hit.
[Graphical view]
SMARTiSM00650. rADc. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00755. ksgA. 1 hit.
PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
PS51689. SAM_RNA_A_N6_MT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiDIM1_DROME
AccessioniPrimary (citable) accession number: Q9VAQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.