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Protein

Probable dimethyladenosine transferase

Gene

CG11837

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.By similarity

Catalytic activityi

4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N6-dimethyladenine(1779)/N6-dimethyladenine(1780) in 18S rRNA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei30S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei32S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei57S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei78S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei106S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei121S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dimethyladenosine transferase (EC:2.1.1.183)
Alternative name(s):
Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
Probable 18S rRNA dimethylase
Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
Gene namesi
ORF Names:CG11837
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0039627 CG11837

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001014691 – 306Probable dimethyladenosine transferaseAdd BLAST306

Proteomic databases

PaxDbiQ9VAQ5

Expressioni

Gene expression databases

BgeeiFBgn0039627
GenevisibleiQ9VAQ5 DM

Interactioni

Protein-protein interaction databases

IntActiQ9VAQ5 4 interactors.
STRINGi7227.FBpp0084729

Structurei

3D structure databases

ProteinModelPortaliQ9VAQ5
SMRiQ9VAQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0820 Eukaryota
COG0030 LUCA
GeneTreeiENSGT00530000063389
InParanoidiQ9VAQ5
KOiK14191
OMAiKRFGQHW
OrthoDBiEOG091G0CD4
PhylomeDBiQ9VAQ5

Family and domain databases

InterProiView protein in InterPro
IPR001737 KsgA/Erm
IPR020596 rRNA_Ade_Mease_Trfase_CS
IPR020598 rRNA_Ade_methylase_Trfase_N
IPR011530 rRNA_adenine_dimethylase
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11727 PTHR11727, 1 hit
PfamiView protein in Pfam
PF00398 RrnaAD, 1 hit
SMARTiView protein in SMART
SM00650 rADc, 1 hit
SUPFAMiSSF53335 SSF53335, 2 hits
TIGRFAMsiTIGR00755 ksgA, 1 hit
PROSITEiView protein in PROSITE
PS01131 RRNA_A_DIMETH, 1 hit
PS51689 SAM_RNA_A_N6_MT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VAQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKVTKEKKS RIHNDVQKQG IVFNKDFGQH ILKNPLVITT MLEKAALRAT
60 70 80 90 100
DVVLEIGPGT GNMTVRMLER AKKVIACEID TRLAAELQKR VQATPLQPKL
110 120 130 140 150
QVLIGDFLKA ELPFFDLCIA NVPYQISSPL IFKLLLHRPL FRCAVLMFQR
160 170 180 190 200
EFAERLVAKP GDKLYCRLSI NTQLLARVDM LMKVGKNNFR PPPKVESSVV
210 220 230 240 250
RLEPKNPPPP VNFTEWDGLT RIAFLRKNKT LAATFKVTSV LEMLEKNYKL
260 270 280 290 300
YRSLRNEPIE DDFKMQDKVI SILEEQDMAA KRARSMDIDD FMRLLLAFNS

AGIHFN
Length:306
Mass (Da):35,048
Last modified:May 1, 2000 - v1
Checksum:iCA091714E43A0AFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56847.1
AY061429 mRNA Translation: AAL28977.1
RefSeqiNP_651660.1, NM_143403.4
UniGeneiDm.1363

Genome annotation databases

EnsemblMetazoaiFBtr0085360; FBpp0084729; FBgn0039627
GeneIDi43429
KEGGidme:Dmel_CG11837
UCSCiCG11837-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiDIM1_DROME
AccessioniPrimary (citable) accession number: Q9VAQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome