Q9VAN0 (SERC_DROME) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 95.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Probable phosphoserine aminotransferase Short name=PSAT EC=2.6.1.52 Alternative name(s): Phosphohydroxythreonine aminotransferase | ||
| Gene names |
| ||
| Organism | Drosophila melanogaster (Fruit fly) | ||
| Taxonomic identifier | 7227 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 364 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine By similarity. |
| Catalytic activity | O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. 4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate. |
| Cofactor | Binds 1 pyridoxal phosphate per subunit By similarity. |
| Pathway | Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. |
| Subunit structure | Homodimer By similarity. |
| Tissue specificity | Expressed in ovary and head. Ref.1 |
| Sequence similarities | Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Serine biosynthesis |
| Ligand | Pyridoxal phosphate |
| Molecular function | Aminotransferase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | L-serine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | O-phospho-L-serine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 364 | 364 | Probable phosphoserine aminotransferase | PRO_0000150139 | |||||
Regions | |||||||||
| Region | 74 – 75 | 2 | Pyridoxal phosphate binding By similarity | ||||||
| Region | 235 – 236 | 2 | Pyridoxal phosphate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 40 | 1 | L-glutamate By similarity | ||||||
| Binding site | 100 | 1 | Pyridoxal phosphate By similarity | ||||||
| Binding site | 149 | 1 | Pyridoxal phosphate By similarity | ||||||
| Binding site | 170 | 1 | Pyridoxal phosphate By similarity | ||||||
| Binding site | 193 | 1 | Pyridoxal phosphate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 194 | 1 | N6-(pyridoxal phosphate)lysine By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | DQ062790 mRNA. Translation: AAY56663.1. AE014297 Genomic DNA. Translation: AAF56874.1. AY119560 mRNA. Translation: AAM50214.1. |
| RefSeq | NP_652046.1. NM_143789.2. |
| UniGene | Dm.11354. |
3D structure databases | |
| ProteinModelPortal | Q9VAN0. |
| SMR | Q9VAN0. Positions 12-358. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-17047N. |
| IntAct | Q9VAN0. 2 interactions. |
| MINT | MINT-334778. |
| STRING | Q9VAN0. |
Proteomic databases | |
| PRIDE | Q9VAN0. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | FBtr0085390; FBpp0084759; FBgn0014427. |
| GeneID | 46391. |
| KEGG | dme:Dmel_CG11899. |
| NMPDR | fig|7227.3.peg.15201. |
| UCSC | CG11899-RA. d. melanogaster. |
Organism-specific databases | |
| FlyBase | FBgn0014427. CG11899. |
Phylogenomic databases | |
| eggNOG | inNOG04441. |
| GeneTree | EMGT00050000017895. |
| InParanoid | Q9VAN0. |
| OMA | YEVLFLQ. |
| OrthoDB | EOG4B2RCS. |
| PhylomeDB | Q9VAN0. |
Gene expression databases | |
| Bgee | Q9VAN0. |
| GermOnline | CG11899. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR000192. Aminotrans_V/Cys_dSase. IPR020578. Aminotrans_V_PyrdxlP_BS. IPR022278. Pser_aminoTfrase. IPR003248. Pser_aminoTfrase_subgr. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view] |
| Gene3D | G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit. |
| KO | K00831. |
| PANTHER | PTHR21152:SF1. PTHR21152:SF1. 1 hit. |
| Pfam | PF00266. Aminotran_5. 1 hit. [Graphical view] |
| PIRSF | PIRSF000525. SerC. 1 hit. |
| SUPFAM | SSF53383. PyrdxlP-dep_Trfase_major. 1 hit. |
| TIGRFAMs | TIGR01364. SerC_1. 1 hit. |
| PROSITE | PS00595. AA_TRANSFER_CLASS_5. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 838831. |
Entry information
| Entry name | SERC_DROME | ||||||||
| Accession | Primary (citable) accession number: Q9VAN0 Secondary accession number(s): Q3YMT6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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