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Protein

Probable phosphoserine aminotransferase

Gene

CG11899

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.By similarity

Catalytic activityi

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.
4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.

Cofactori

pyridoxal 5'-phosphateBy similarityNote: Binds 1 pyridoxal phosphate per subunit.By similarity

Pathwayi: L-serine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable phosphoserine aminotransferase (CG11899)
  3. Phosphoserine phosphatase (aay)
This subpathway is part of the pathway L-serine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: pyridoxine 5'-phosphate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Probable phosphoserine aminotransferase (CG11899)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway pyridoxine 5'-phosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40L-glutamateBy similarity1
Binding sitei100Pyridoxal phosphateBy similarity1
Binding sitei149Pyridoxal phosphateBy similarity1
Binding sitei170Pyridoxal phosphateBy similarity1
Binding sitei193Pyridoxal phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Serine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-DME-977347. Serine biosynthesis.
UniPathwayiUPA00135; UER00197.
UPA00244; UER00311.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoserine aminotransferase (EC:2.6.1.52)
Short name:
PSAT
Alternative name(s):
Phosphohydroxythreonine aminotransferase
Gene namesi
ORF Names:CG11899
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0014427. CG11899.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001501391 – 364Probable phosphoserine aminotransferaseAdd BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ9VAN0.
PRIDEiQ9VAN0.

Expressioni

Tissue specificityi

Expressed in ovary and head.1 Publication

Gene expression databases

BgeeiFBgn0014427.
GenevisibleiQ9VAN0. DM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi70214. 8 interactors.
DIPiDIP-17047N.
IntActiQ9VAN0. 7 interactors.
MINTiMINT-334778.
STRINGi7227.FBpp0084759.

Structurei

3D structure databases

ProteinModelPortaliQ9VAN0.
SMRiQ9VAN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni74 – 75Pyridoxal phosphate bindingBy similarity2
Regioni235 – 236Pyridoxal phosphate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2790. Eukaryota.
COG1932. LUCA.
GeneTreeiENSGT00390000015177.
InParanoidiQ9VAN0.
KOiK00831.
OMAiGAQKNMG.
OrthoDBiEOG091G0964.
PhylomeDBiQ9VAN0.

Family and domain databases

CDDicd00611. PSAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00160. SerC_aminotrans_5. 1 hit.
InterProiView protein in InterPro
IPR000192. Aminotrans_V_dom.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR022278. Pser_aminoTfrase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00266. Aminotran_5. 1 hit.
PIRSFiPIRSF000525. SerC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01364. serC_1. 1 hit.
PROSITEiView protein in PROSITE
PS00595. AA_TRANSFER_CLASS_5. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VAN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVINFAAGPA KLPEEVLKEV QENLVNCNGS GISVMEMSHR SSNYAKIHDA
60 70 80 90 100
TISDLRELLN VPSNYKILLM QGGGTGQFAA VALNLIGKTG TADYVITGSW
110 120 130 140 150
SAKAAKEAAQ YGTVNAVLPK LAKYTTVPRQ ETWKLDPNAS YVYYCDNETV
160 170 180 190 200
EGVEFDFVPE VPAGVPLVAD MSSNFLSRPF DVSKFGVIYA GAQKNIGPAG
210 220 230 240 250
TTVIIVRDDL IGKHLKITPS ILNFEQMDKN NSLLNTPPTF GIYVMGLVFK
260 270 280 290 300
WIKRNGGVAG MAKLAAAKSK LIYDTINQSN GFYYCPVDVN VRSRMNVPFR
310 320 330 340 350
IGSASGDDAL EKEFLSKAEA EGMIQLKGHR SVGGIRASLY NAVTLAETQQ
360
LANLMLAFYK NNKN
Length:364
Mass (Da):39,540
Last modified:May 1, 2000 - v1
Checksum:iDAEA4E2F5BD4DB74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ062790 mRNA. Translation: AAY56663.1.
AE014297 Genomic DNA. Translation: AAF56874.1.
AY119560 mRNA. Translation: AAM50214.1.
RefSeqiNP_652046.1. NM_143789.3.
UniGeneiDm.11354.

Genome annotation databases

EnsemblMetazoaiFBtr0085390; FBpp0084759; FBgn0014427.
GeneIDi46391.
KEGGidme:Dmel_CG11899.
UCSCiCG11899-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiSERC_DROME
AccessioniPrimary (citable) accession number: Q9VAN0
Secondary accession number(s): Q3YMT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families