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Protein
Submitted name:

Calnexin 99A, isoform A

Gene

Cnx99A

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • protein folding Source: FlyBase
  • regulation of calcium ion transport into cytosol Source: FlyBase
  • retina homeostasis Source: FlyBase
  • rhodopsin biosynthetic process Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

ChaperoneUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DME-901042. Calnexin/calreticulin cycle.

Names & Taxonomyi

Protein namesi
Submitted name:
Calnexin 99A, isoform AImported
Submitted name:
Calnexin 99A, isoform BImported
Submitted name:
Calnexin 99A, isoform DImported
Submitted name:
FI03837pImported
Gene namesi
Name:Cnx99AImported
Synonyms:Cnx99A-RDImported
ORF Names:CG11958Imported, Dmel_CG11958Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0015622. Cnx99A.

Subcellular locationi

  • Endoplasmic reticulum SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei489 – 50820HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  • endomembrane system Source: FlyBase
  • endoplasmic reticulum Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW
  • perinuclear endoplasmic reticulum Source: FlyBase
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929UniRule annotationAdd
BLAST
Chaini30 – 605576UniRule annotationPRO_5006993947Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiQ9VAL7. differential.

Interactioni

Protein-protein interaction databases

IntActiQ9VAL7. 1 interaction.
MINTiMINT-870024.

Structurei

3D structure databases

SMRiQ9VAL7. Positions 62-464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calreticulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00430000030841.

Family and domain databases

Gene3Di2.10.250.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VAL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWKMGGNRA ATLALLFASS LLLLSAANAA DLDTESDDFE DGYVEDVQEE
60 70 80 90 100
PAVIGGDEKL AYESPVIDAK KFHFADHFDD VEESRKRWVL SQAKKDDIAE
110 120 130 140 150
EISKYDGIWN WESPQRIVWA NDLGLVLKSK AKHAAIAAPL RKPFEFKSDK
160 170 180 190 200
PLVVQYEVTL QEGQECGGSY LKLLSAGKDT EQLKAFNDKT PYTIMFGPDK
210 220 230 240 250
CGNDVKMHFI FRHVNPINGT ITEKHCNKPK NRLEEPFKDK LPHLYQLVVR
260 270 280 290 300
PDNSFEIRVD HKIINEGSLL TDFKPPVNPP AEIDDPNDHK PESWDEREKI
310 320 330 340 350
PDPTAHKPED WDEDAPPQLP DTDAVMPNGW LEDEPDMIFD PTATKPEDWD
360 370 380 390 400
AEIDGEWEAP LVDNPVCEKA PGCGKWKAPL IPNPNYKGKW RAPMIENPNY
410 420 430 440 450
QGKWAPRKIP NPDFFEDLKP FQMTPISAVG LELWSMSSDI LFDNLIITDD
460 470 480 490 500
VEVARDFAAN SFDIKRRYID RESDSFVNKV VELAKANPSI WGIGLVAIVA
510 520 530 540 550
LVALTIYCRF GTAKSQDSAA KKAAAEAKKS DDPQPDDEPE AEEESDERAA
560 570 580 590 600
GDTSKESTPL SASPKKNQKS DLDDNEEESK AAESREPAQT EESNTKTRKR

QARKE
Length:605
Mass (Da):68,019
Last modified:October 1, 2002 - v2
Checksum:i21662F9C3831E9E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56887.2.
AE014297 Genomic DNA. Translation: AAN14170.1.
AE014297 Genomic DNA. Translation: ABI31216.1.
BT044173 mRNA. Translation: ACH92238.1.
RefSeqiNP_001036767.1. NM_001043302.2.
NP_477157.1. NM_057809.5.
NP_733286.1. NM_170407.3.
UniGeneiDm.8009.

Genome annotation databases

EnsemblMetazoaiFBtr0085437; FBpp0084803; FBgn0015622.
FBtr0085438; FBpp0084804; FBgn0015622.
FBtr0110909; FBpp0110209; FBgn0015622.
GeneIDi44643.
UCSCiCG11958-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56887.2.
AE014297 Genomic DNA. Translation: AAN14170.1.
AE014297 Genomic DNA. Translation: ABI31216.1.
BT044173 mRNA. Translation: ACH92238.1.
RefSeqiNP_001036767.1. NM_001043302.2.
NP_477157.1. NM_057809.5.
NP_733286.1. NM_170407.3.
UniGeneiDm.8009.

3D structure databases

SMRiQ9VAL7. Positions 62-464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9VAL7. 1 interaction.
MINTiMINT-870024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085437; FBpp0084803; FBgn0015622.
FBtr0085438; FBpp0084804; FBgn0015622.
FBtr0110909; FBpp0110209; FBgn0015622.
GeneIDi44643.
UCSCiCG11958-RA. d. melanogaster.

Organism-specific databases

CTDi44643.
FlyBaseiFBgn0015622. Cnx99A.

Phylogenomic databases

GeneTreeiENSGT00430000030841.

Enzyme and pathway databases

ReactomeiR-DME-901042. Calnexin/calreticulin cycle.

Miscellaneous databases

ChiTaRSiCnx99A. fly.
GenomeRNAii44643.

Gene expression databases

ExpressionAtlasiQ9VAL7. differential.

Family and domain databases

Gene3Di2.10.250.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.
    Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. FlyBase
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9VAL7_DROME
AccessioniPrimary (citable) accession number: Q9VAL7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.