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Protein
Submitted name:

Bub3, isoform A

Gene

Bub3

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • mitotic spindle assembly checkpoint Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-DME-179409 APC-Cdc20 mediated degradation of Nek2A

Names & Taxonomyi

Protein namesi
Submitted name:
Bub3, isoform AImported
Submitted name:
Bub3, isoform BImported
Submitted name:
FI07632pImported
Gene namesi
Name:Bub3Imported
Synonyms:BUB3Imported, bub3Imported, Bub3-RAImported, dBUB3Imported, Dmbub3Imported, Dmel\CG7581Imported
ORF Names:CG7581Imported, Dmel_CG7581Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0025457 Bub3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ9VAJ2

Expressioni

Gene expression databases

BgeeiFBgn0025457
ExpressionAtlasiQ9VAJ2 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9VAJ2, 4 interactors
STRINGi7227.FBpp0084831

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 294WD_REPEATS_REGIONInterPro annotationAdd BLAST204
Repeati91 – 132WDPROSITE-ProRule annotationAdd BLAST42
Repeati237 – 262WDPROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1036 Eukaryota
ENOG410XRBG LUCA
GeneTreeiENSGT00530000063440
KOiK02180
OMAiCMPNDAG
OrthoDBiEOG091G0AB8

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VAJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPPEFKLNN PPEDLISAVK FGPKSNQYMA ASSWDGTLRF YDVPANQLRQ
60 70 80 90 100
KFVQDAPLLD CAFMDIVHVV SGSLDNQLRL FDVNTQAESI IGAHEEPIRC
110 120 130 140 150
VEHAEYVNGI LTGSWDNTVK LWDMREKRCV GTFEQNNGKV YSMSVIDEKI
160 170 180 190 200
VVATSDRKVL IWDLRKMDSY IMKRESSLKY QTRCIRLFPN KEGYVMSSIE
210 220 230 240 250
GRVAVEYLDH DPEVQRRKFA FKCHRNREQN IEQIYPVNAL SFHNVYQTFA
260 270 280 290 300
TGGSDGIVNI WDGFNKKRLC QFHEYDTSIS TLNFSSDGSA LAIGCSYLDQ
310 320
LPETPATVPH PAIYIRYPTD QETKQK
Length:326
Mass (Da):37,415
Last modified:May 1, 2000 - v1
Checksum:i89EC16E18E5A9E9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56914.1
BT083437 mRNA Translation: ACQ99842.1
AE014297 Genomic DNA Translation: AHN57586.1
RefSeqiNP_001287587.1, NM_001300658.1
NP_477381.1, NM_058033.4
UniGeneiDm.7050

Genome annotation databases

EnsemblMetazoaiFBtr0085465; FBpp0084831; FBgn0025457
FBtr0339148; FBpp0308293; FBgn0025457
GeneIDi43490
KEGGidme:Dmel_CG7581
UCSCiCG7581-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9VAJ2_DROME
AccessioniPrimary (citable) accession number: Q9VAJ2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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