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Protein
Submitted name:

Bub3, isoform A

Gene

Bub3

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • mitotic spindle assembly checkpoint Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-DME-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DME-179409. APC-Cdc20 mediated degradation of Nek2A.

Names & Taxonomyi

Protein namesi
Submitted name:
Bub3, isoform AImported
Submitted name:
Bub3, isoform BImported
Submitted name:
FI07632pImported
Gene namesi
Name:Bub3Imported
Synonyms:Bub3-RAImported
ORF Names:CG7581Imported, Dmel_CG7581Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0025457. Bub3.

Subcellular locationi

GO - Cellular componenti

  • kinetochore Source: FlyBase
  • microtubule associated complex Source: FlyBase
  • nucleoplasm Source: FlyBase

Expressioni

Gene expression databases

BgeeiFBgn0025457.

Interactioni

Protein-protein interaction databases

MINTiMINT-898078.
STRINGi7227.FBpp0084831.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 294WD_REPEATS_REGIONInterPro annotationAdd BLAST204
Repeati91 – 132WDPROSITE-ProRule annotationAdd BLAST42
Repeati237 – 262WDPROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1036. Eukaryota.
ENOG410XRBG. LUCA.
GeneTreeiENSGT00530000063440.
KOiK02180.
OMAiEGEKSHE.
OrthoDBiEOG091G0AB8.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 3 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 5 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VAJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPPEFKLNN PPEDLISAVK FGPKSNQYMA ASSWDGTLRF YDVPANQLRQ
60 70 80 90 100
KFVQDAPLLD CAFMDIVHVV SGSLDNQLRL FDVNTQAESI IGAHEEPIRC
110 120 130 140 150
VEHAEYVNGI LTGSWDNTVK LWDMREKRCV GTFEQNNGKV YSMSVIDEKI
160 170 180 190 200
VVATSDRKVL IWDLRKMDSY IMKRESSLKY QTRCIRLFPN KEGYVMSSIE
210 220 230 240 250
GRVAVEYLDH DPEVQRRKFA FKCHRNREQN IEQIYPVNAL SFHNVYQTFA
260 270 280 290 300
TGGSDGIVNI WDGFNKKRLC QFHEYDTSIS TLNFSSDGSA LAIGCSYLDQ
310 320
LPETPATVPH PAIYIRYPTD QETKQK
Length:326
Mass (Da):37,415
Last modified:May 1, 2000 - v1
Checksum:i89EC16E18E5A9E9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56914.1.
BT083437 mRNA. Translation: ACQ99842.1.
AE014297 Genomic DNA. Translation: AHN57586.1.
RefSeqiNP_001287587.1. NM_001300658.1.
NP_477381.1. NM_058033.4.
UniGeneiDm.7050.

Genome annotation databases

EnsemblMetazoaiFBtr0085465; FBpp0084831; FBgn0025457.
FBtr0339148; FBpp0308293; FBgn0025457.
GeneIDi43490.
KEGGidme:Dmel_CG7581.
UCSCiCG7581-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56914.1.
BT083437 mRNA. Translation: ACQ99842.1.
AE014297 Genomic DNA. Translation: AHN57586.1.
RefSeqiNP_001287587.1. NM_001300658.1.
NP_477381.1. NM_058033.4.
UniGeneiDm.7050.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-898078.
STRINGi7227.FBpp0084831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085465; FBpp0084831; FBgn0025457.
FBtr0339148; FBpp0308293; FBgn0025457.
GeneIDi43490.
KEGGidme:Dmel_CG7581.
UCSCiCG7581-RA. d. melanogaster.

Organism-specific databases

CTDi9184.
FlyBaseiFBgn0025457. Bub3.

Phylogenomic databases

eggNOGiKOG1036. Eukaryota.
ENOG410XRBG. LUCA.
GeneTreeiENSGT00530000063440.
KOiK02180.
OMAiEGEKSHE.
OrthoDBiEOG091G0AB8.

Enzyme and pathway databases

ReactomeiR-DME-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-DME-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DME-179409. APC-Cdc20 mediated degradation of Nek2A.

Miscellaneous databases

GenomeRNAii43490.

Gene expression databases

BgeeiFBgn0025457.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 3 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 5 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9VAJ2_DROME
AccessioniPrimary (citable) accession number: Q9VAJ2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: March 15, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.