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Protein

Probable glucosamine 6-phosphate N-acetyltransferase

Gene

CG1969

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate.By similarity

Pathwayi: UDP-N-acetyl-alpha-D-glucosamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable glucosamine 6-phosphate N-acetyltransferase (CG1969)
  2. no protein annotated in this organism
This subpathway is part of the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I), the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641SubstrateBy similarity
Binding sitei186 – 1861SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-DME-446210. Synthesis of UDP-N-acetyl-glucosamine.
UniPathwayiUPA00113; UER00529.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucosamine 6-phosphate N-acetyltransferase (EC:2.3.1.4By similarity)
Alternative name(s):
Phosphoglucosamine acetylase
Phosphoglucosamine transacetylase
Gene namesi
ORF Names:CG1969
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0039690. CG1969.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Probable glucosamine 6-phosphate N-acetyltransferasePRO_0000074557Add
BLAST

Proteomic databases

PaxDbiQ9VAI0.
PRIDEiQ9VAI0.

Expressioni

Gene expression databases

BgeeiQ9VAI0.
ExpressionAtlasiQ9VAI0. differential.
GenevisibleiQ9VAI0. DM.

Interactioni

Protein-protein interaction databases

BioGridi68368. 1 interaction.
DIPiDIP-22984N.
STRINGi7227.FBpp0303328.

Structurei

3D structure databases

ProteinModelPortaliQ9VAI0.
SMRiQ9VAI0. Positions 6-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 198157N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni111 – 1144Substrate bindingBy similarity
Regioni123 – 1253Substrate bindingBy similarity
Regioni133 – 1386Acetyl-CoA bindingBy similarity
Regioni154 – 1552Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3396. Eukaryota.
COG0454. LUCA.
GeneTreeiENSGT00390000008666.
InParanoidiQ9VAI0.
KOiK00621.
OrthoDBiEOG77T165.
PhylomeDBiQ9VAI0.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VAI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQLTEETYL YDPNLLLKLD FHRSPANFKP FISAANPGEP WMKVRPLKDT
60 70 80 90 100
DYDRGFLQLL SQLTHVGNVN RTQFLTRFSQ MKASGDYFVT VIEDTRKNEI
110 120 130 140 150
IGAASLVIER KFIHNCAVRG RLEDVVVNDT YRGKQLGKLI VVTVSLLAEE
160 170 180 190 200
LGCYKMSLDC KDKLIKFYES LGYVAIPGNS NSMTIRYDEG PTLKRNATSA
210
GSSGTVGDSC QTVSLDFAS
Length:219
Mass (Da):24,492
Last modified:May 1, 2000 - v1
Checksum:iB08592F34D557A0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56929.1.
AY058687 mRNA. Translation: AAL13916.1.
RefSeqiNP_651719.1. NM_143462.4.
UniGeneiDm.1369.

Genome annotation databases

EnsemblMetazoaiFBtr0085475; FBpp0084841; FBgn0039690.
GeneIDi43504.
KEGGidme:Dmel_CG1969.
UCSCiCG1969-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56929.1.
AY058687 mRNA. Translation: AAL13916.1.
RefSeqiNP_651719.1. NM_143462.4.
UniGeneiDm.1369.

3D structure databases

ProteinModelPortaliQ9VAI0.
SMRiQ9VAI0. Positions 6-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68368. 1 interaction.
DIPiDIP-22984N.
STRINGi7227.FBpp0303328.

Proteomic databases

PaxDbiQ9VAI0.
PRIDEiQ9VAI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085475; FBpp0084841; FBgn0039690.
GeneIDi43504.
KEGGidme:Dmel_CG1969.
UCSCiCG1969-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0039690. CG1969.

Phylogenomic databases

eggNOGiKOG3396. Eukaryota.
COG0454. LUCA.
GeneTreeiENSGT00390000008666.
InParanoidiQ9VAI0.
KOiK00621.
OrthoDBiEOG77T165.
PhylomeDBiQ9VAI0.

Enzyme and pathway databases

UniPathwayiUPA00113; UER00529.
ReactomeiR-DME-446210. Synthesis of UDP-N-acetyl-glucosamine.

Miscellaneous databases

GenomeRNAii43504.
PROiQ9VAI0.

Gene expression databases

BgeeiQ9VAI0.
ExpressionAtlasiQ9VAI0. differential.
GenevisibleiQ9VAI0. DM.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiGNA1_DROME
AccessioniPrimary (citable) accession number: Q9VAI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.