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Q9VAH4

- PTC71_DROME

UniProt

Q9VAH4 - PTC71_DROME

Protein

Protein phosphatase PTC7 homolog fig

Gene

fig

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Magnesium or manganese.By similarityCurated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi87 – 871Manganese 1By similarity
    Metal bindingi87 – 871Manganese 2By similarity
    Metal bindingi88 – 881Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi232 – 2321Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. dephosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase PTC7 homolog fig
    Alternative name(s):
    Fos intronic gene protein (EC:3.1.3.16)
    Gene namesi
    Name:figImported
    ORF Names:CG7615
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0039694. fig.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Protein phosphatase PTC7 homolog figPRO_0000377398Add
    BLAST

    Proteomic databases

    PaxDbiQ9VAH4.
    PRIDEiQ9VAH4.

    Expressioni

    Developmental stagei

    Isoform alpha and isoform beta are expressed both maternally and zygotically. Zygotic expression is present throughout embryogenesis and fades by first larval instar. Expression levels at all stages are low.1 Publication

    Gene expression databases

    BgeeiQ9VAH4.

    Interactioni

    Protein-protein interaction databases

    BioGridi68375. 1 interaction.
    MINTiMINT-1029422.
    STRINGi7227.FBpp0084904.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VAH4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 307256PP2C-likeSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Sequence Analysis
    Contains 1 PP2C-like domain.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00390000011937.
    InParanoidiQ9VAH4.
    KOiK17508.
    OMAiGPNDENE.
    OrthoDBiEOG7DRJ3F.
    PhylomeDBiQ9VAH4.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    [Graphical view]
    PfamiPF07228. SpoIIE. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative promoter usage. Align

    Isoform alpha1 Publication (identifier: Q9VAH4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MITCLRNWPL LLKRFSVHQI HQFTQLSGRF ERPPQSGKSS RDPYLVTVVQ    50
    GRSKKPRFPG ERSNQRFGED SWFVSSTPLA EVMGVADGVG GWRDLGVDAG 100
    RFAKELMSCC SGQTQLSDFD GRSPRNMLIA GFQELSHREH PVVGSSTACL 150
    ATMHRKDCTL YTANLGDSGF LVVRNGRVLH RSVEQTHDFN TPYQLTVPPE 200
    DRKESYYCDK PEMAVSTRHS LLPGDLVLLA TDGLFDNMPE SMLLSILNGL 250
    KERGEHDLLV GASRVVEKAR ELSMNASFQS PFAIKARQHN VSYSGGGKPD 300
    DITLILSSVE VPNA 314
    Length:314
    Mass (Da):34,838
    Last modified:May 1, 2000 - v1
    Checksum:iF6D2A3360D4AD8A4
    GO
    Isoform beta1 Publication (identifier: Q9VAH4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-152: Missing.

    Show »
    Length:162
    Mass (Da):17,957
    Checksum:i73B5489F6FBCFA18
    GO

    Sequence cautioni

    The sequence AAM11295.1 differs from that shown. Reason: Frameshift at position 143.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 152152Missing in isoform beta. 1 PublicationVSP_053111Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ858472 mRNA. Translation: ABI74754.1.
    DQ858473 mRNA. Translation: ABI74755.1.
    AE014297 Genomic DNA. Translation: AAF56936.1.
    AY094942 mRNA. Translation: AAM11295.1. Frameshift.
    BT044569 mRNA. Translation: ACI16531.1.
    RefSeqiNP_651724.1. NM_143467.3. [Q9VAH4-1]
    UniGeneiDm.29813.

    Genome annotation databases

    EnsemblMetazoaiFBtr0085538; FBpp0084904; FBgn0039694. [Q9VAH4-1]
    GeneIDi43511.
    KEGGidme:Dmel_CG7615.
    UCSCiCG7615-RA. d. melanogaster. [Q9VAH4-1]

    Keywords - Coding sequence diversityi

    Alternative promoter usage

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ858472 mRNA. Translation: ABI74754.1 .
    DQ858473 mRNA. Translation: ABI74755.1 .
    AE014297 Genomic DNA. Translation: AAF56936.1 .
    AY094942 mRNA. Translation: AAM11295.1 . Frameshift.
    BT044569 mRNA. Translation: ACI16531.1 .
    RefSeqi NP_651724.1. NM_143467.3. [Q9VAH4-1 ]
    UniGenei Dm.29813.

    3D structure databases

    ProteinModelPortali Q9VAH4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 68375. 1 interaction.
    MINTi MINT-1029422.
    STRINGi 7227.FBpp0084904.

    Proteomic databases

    PaxDbi Q9VAH4.
    PRIDEi Q9VAH4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0085538 ; FBpp0084904 ; FBgn0039694 . [Q9VAH4-1 ]
    GeneIDi 43511.
    KEGGi dme:Dmel_CG7615.
    UCSCi CG7615-RA. d. melanogaster. [Q9VAH4-1 ]

    Organism-specific databases

    CTDi 43511.
    FlyBasei FBgn0039694. fig.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00390000011937.
    InParanoidi Q9VAH4.
    KOi K17508.
    OMAi GPNDENE.
    OrthoDBi EOG7DRJ3F.
    PhylomeDBi Q9VAH4.

    Miscellaneous databases

    GenomeRNAii 43511.
    NextBioi 834314.

    Gene expression databases

    Bgeei Q9VAH4.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    [Graphical view ]
    Pfami PF07228. SpoIIE. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The gene structure of the Drosophila melanogaster proto-oncogene, kayak, and its nested gene, fos-intronic gene."
      Hudson S.G., Goldstein E.S.
      Gene 420:76-81(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), ALTERNATIVE PROMOTER USAGE, DEVELOPMENTAL STAGE.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
      Strain: BerkeleyImported.
      Tissue: Head1 Publication.
    5. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
      Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
      Strain: Berkeley.

    Entry informationi

    Entry nameiPTC71_DROME
    AccessioniPrimary (citable) accession number: Q9VAH4
    Secondary accession number(s): A8MPH7, Q8SWZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3