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Q9VAH4

- PTC71_DROME

UniProt

Q9VAH4 - PTC71_DROME

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Protein
Protein phosphatase PTC7 homolog fig
Gene
fig, CG7615
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Magnesium or manganese Reviewed prediction.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Manganese 1 By similarityBy similarity
Metal bindingi87 – 871Manganese 2 By similarityBy similarity
Metal bindingi88 – 881Manganese 1; via carbonyl oxygen By similarityBy similarity
Metal bindingi232 – 2321Manganese 2 By similarityBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase PTC7 homolog fig
Alternative name(s):
Fos intronic gene protein (EC:3.1.3.16)
Gene namesi
Name:fig
ORF Names:CG7615
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0039694. fig.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Protein phosphatase PTC7 homolog fig
PRO_0000377398Add
BLAST

Proteomic databases

PaxDbiQ9VAH4.
PRIDEiQ9VAH4.

Expressioni

Developmental stagei

Isoform alpha and isoform beta are expressed both maternally and zygotically. Zygotic expression is present throughout embryogenesis and fades by first larval instar. Expression levels at all stages are low.1 Publication

Gene expression databases

BgeeiQ9VAH4.

Interactioni

Protein-protein interaction databases

BioGridi68375. 1 interaction.
MINTiMINT-1029422.
STRINGi7227.FBpp0084904.

Structurei

3D structure databases

ProteinModelPortaliQ9VAH4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 307256PP2C-like
Add
BLAST

Sequence similaritiesi

Belongs to the PP2C family.
Contains 1 PP2C-like domain.

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00390000011937.
InParanoidiQ9VAH4.
KOiK17508.
OMAiGPNDENE.
OrthoDBiEOG7DRJ3F.
PhylomeDBiQ9VAH4.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
[Graphical view]
PfamiPF07228. SpoIIE. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. Align

Isoform alpha1 Publication (identifier: Q9VAH4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MITCLRNWPL LLKRFSVHQI HQFTQLSGRF ERPPQSGKSS RDPYLVTVVQ    50
GRSKKPRFPG ERSNQRFGED SWFVSSTPLA EVMGVADGVG GWRDLGVDAG 100
RFAKELMSCC SGQTQLSDFD GRSPRNMLIA GFQELSHREH PVVGSSTACL 150
ATMHRKDCTL YTANLGDSGF LVVRNGRVLH RSVEQTHDFN TPYQLTVPPE 200
DRKESYYCDK PEMAVSTRHS LLPGDLVLLA TDGLFDNMPE SMLLSILNGL 250
KERGEHDLLV GASRVVEKAR ELSMNASFQS PFAIKARQHN VSYSGGGKPD 300
DITLILSSVE VPNA 314
Length:314
Mass (Da):34,838
Last modified:May 1, 2000 - v1
Checksum:iF6D2A3360D4AD8A4
GO
Isoform beta1 Publication (identifier: Q9VAH4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: Missing.

Show »
Length:162
Mass (Da):17,957
Checksum:i73B5489F6FBCFA18
GO

Sequence cautioni

The sequence AAM11295.1 differs from that shown. Reason: Frameshift at position 143.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 152152Missing in isoform beta. 1 Publication
VSP_053111Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ858472 mRNA. Translation: ABI74754.1.
DQ858473 mRNA. Translation: ABI74755.1.
AE014297 Genomic DNA. Translation: AAF56936.1.
AY094942 mRNA. Translation: AAM11295.1. Frameshift.
BT044569 mRNA. Translation: ACI16531.1.
RefSeqiNP_651724.1. NM_143467.3. [Q9VAH4-1]
UniGeneiDm.29813.

Genome annotation databases

EnsemblMetazoaiFBtr0085538; FBpp0084904; FBgn0039694. [Q9VAH4-1]
GeneIDi43511.
KEGGidme:Dmel_CG7615.
UCSCiCG7615-RA. d. melanogaster. [Q9VAH4-1]

Keywords - Coding sequence diversityi

Alternative promoter usage

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ858472 mRNA. Translation: ABI74754.1 .
DQ858473 mRNA. Translation: ABI74755.1 .
AE014297 Genomic DNA. Translation: AAF56936.1 .
AY094942 mRNA. Translation: AAM11295.1 . Frameshift.
BT044569 mRNA. Translation: ACI16531.1 .
RefSeqi NP_651724.1. NM_143467.3. [Q9VAH4-1 ]
UniGenei Dm.29813.

3D structure databases

ProteinModelPortali Q9VAH4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 68375. 1 interaction.
MINTi MINT-1029422.
STRINGi 7227.FBpp0084904.

Proteomic databases

PaxDbi Q9VAH4.
PRIDEi Q9VAH4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0085538 ; FBpp0084904 ; FBgn0039694 . [Q9VAH4-1 ]
GeneIDi 43511.
KEGGi dme:Dmel_CG7615.
UCSCi CG7615-RA. d. melanogaster. [Q9VAH4-1 ]

Organism-specific databases

CTDi 43511.
FlyBasei FBgn0039694. fig.

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00390000011937.
InParanoidi Q9VAH4.
KOi K17508.
OMAi GPNDENE.
OrthoDBi EOG7DRJ3F.
PhylomeDBi Q9VAH4.

Miscellaneous databases

GenomeRNAii 43511.
NextBioi 834314.

Gene expression databases

Bgeei Q9VAH4.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
[Graphical view ]
Pfami PF07228. SpoIIE. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The gene structure of the Drosophila melanogaster proto-oncogene, kayak, and its nested gene, fos-intronic gene."
    Hudson S.G., Goldstein E.S.
    Gene 420:76-81(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), ALTERNATIVE PROMOTER USAGE, DEVELOPMENTAL STAGE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
    Strain: Berkeley.
    Tissue: Head.
  5. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
    Strain: Berkeley.

Entry informationi

Entry nameiPTC71_DROME
AccessioniPrimary (citable) accession number: Q9VAH4
Secondary accession number(s): A8MPH7, Q8SWZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi