Q9VAH4 (PTC71_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein phosphatase PTC7 homolog fig

Alternative name(s):
Fos intronic gene protein
EC=3.1.3.16

Gene names

Name:	fig
ORF Names:	CG7615

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate. UniProtKB P35813
Cofactor	Magnesium or manganese Potential. UniProtKB P35813
Developmental stage	Isoform alpha and isoform beta are expressed both maternally and zygotically. Zygotic expresson is present throughout embryogenesis and fades by first larval instar. Expression levels at all stages are low. Ref.1
Sequence similarities	Belongs to the PP2C family. Contains 1 PP2C-like domain.
Sequence caution	The sequence AAM11295.1 differs from that shown. Reason: Frameshift at position 143.

Ontologies

Keywords
Coding sequence diversity	Alternative promoter usage
Ligand	Magnesium Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative promoter usage. [Align] [Select]

Isoform alpha Ref.1 (identifier: Q9VAH4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform beta Ref.1 (identifier: Q9VAH4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Protein phosphatase PTC7 homolog fig		PRO_0000377398
Regions
	Domain	52 – 307	256	PP2C-like
Sites
	Metal binding	87	1	Manganese 1 By similarity UniProtKB P35813
	Metal binding	87	1	Manganese 2 By similarity UniProtKB P35813
	Metal binding	88	1	Manganese 1; via carbonyl oxygen By similarity UniProtKB P35813
	Metal binding	232	1	Manganese 2 By similarity UniProtKB P35813
Natural variations
	Alternative sequence	1 – 152	152	Missing in isoform beta. Ref.1		VSP_053111

Sequences

	Sequence		Length	Mass (Da)
	Isoform alpha [UniParc]. Last modified May 1, 2000. Version 1. Checksum: F6D2A3360D4AD8A4	FASTA	314	34,838
	10 20 30 40 50 60 MITCLRNWPL LLKRFSVHQI HQFTQLSGRF ERPPQSGKSS RDPYLVTVVQ GRSKKPRFPG 70 80 90 100 110 120 ERSNQRFGED SWFVSSTPLA EVMGVADGVG GWRDLGVDAG RFAKELMSCC SGQTQLSDFD 130 140 150 160 170 180 GRSPRNMLIA GFQELSHREH PVVGSSTACL ATMHRKDCTL YTANLGDSGF LVVRNGRVLH 190 200 210 220 230 240 RSVEQTHDFN TPYQLTVPPE DRKESYYCDK PEMAVSTRHS LLPGDLVLLA TDGLFDNMPE 250 260 270 280 290 300 SMLLSILNGL KERGEHDLLV GASRVVEKAR ELSMNASFQS PFAIKARQHN VSYSGGGKPD 310 DITLILSSVE VPNA
	Isoform beta [UniParc]. Checksum: 73B5489F6FBCFA18	FASTA	162	17,957
	10 20 30 40 50 60 MHRKDCTLYT ANLGDSGFLV VRNGRVLHRS VEQTHDFNTP YQLTVPPEDR KESYYCDKPE 70 80 90 100 110 120 MAVSTRHSLL PGDLVLLATD GLFDNMPESM LLSILNGLKE RGEHDLLVGA SRVVEKAREL 130 140 150 160 SMNASFQSPF AIKARQHNVS YSGGGKPDDI TLILSSVEVP NA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The gene structure of the Drosophila melanogaster proto-oncogene, kayak, and its nested gene, fos-intronic gene." Hudson S.G., Goldstein E.S. Gene 420:76-81(2008) [PubMed: 18571877] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), ALTERNATIVE PROMOTER USAGE, DEVELOPMENTAL STAGE.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA). Strain: Berkeley. Tissue: Head.
[5]	Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA). Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ858472 mRNA. Translation: ABI74754.1. DQ858473 mRNA. Translation: ABI74755.1. AE014297 Genomic DNA. Translation: AAF56936.1. AY094942 mRNA. Translation: AAM11295.1. Frameshift. BT044569 mRNA. Translation: ACI16531.1.
RefSeq	NP_651724.1. NM_143467.2.
UniGene	Dm.29813.
3D structure databases
ProteinModelPortal	Q9VAH4.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1029422.
STRING	Q9VAH4.
Proteomic databases
PRIDE	Q9VAH4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0085538; FBpp0084904; FBgn0039694.
GeneID	43511.
KEGG	dme:Dmel_CG7615.
NMPDR	fig|7227.3.peg.15287.
UCSC	CG7615-RA. d. melanogaster.
Organism-specific databases
CTD	43511.
FlyBase	FBgn0039694. fig.
Phylogenomic databases
eggNOG	inNOG06459.
GeneTree	EMGT00050000014031.
InParanoid	Q9VAH4.
OMA	GEDSWFV.
OrthoDB	EOG4ZKH2X.
PhylomeDB	Q9VAH4.
Gene expression databases
Bgee	Q9VAH4.
Family and domain databases
InterPro	IPR001932. PP2C-like. [Graphical view]
Gene3D	G3DSA:3.60.40.10. PP2C-related. 1 hit.
Pfam	PF07228. SpoIIE. 1 hit. [Graphical view]
SMART	SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view]
SUPFAM	SSF81606. PP2C-related. 1 hit.
ProtoNet	Search...
Other
NextBio	834314.

Entry information

Entry name

PTC71_DROME

Accession

Primary (citable) accession number: Q9VAH4
Secondary accession number(s): A8MPH7, Q8SWZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project