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Q9VAH4 (PTC71_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase PTC7 homolog fig
Alternative name(s):
Fos intronic gene protein
EC=3.1.3.16
Gene names
Name:fig
ORF Names:CG7615
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Magnesium or manganese Potential. UniProtKB P35813

Developmental stage

Isoform alpha and isoform beta are expressed both maternally and zygotically. Zygotic expression is present throughout embryogenesis and fades by first larval instar. Expression levels at all stages are low. Ref.1

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Sequence caution

The sequence AAM11295.1 differs from that shown. Reason: Frameshift at position 143.

Alternative products

This entry describes 2 isoforms produced by alternative promoter usage. [Align] [Select]
Isoform alpha Ref.1 (identifier: Q9VAH4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform beta Ref.1 (identifier: Q9VAH4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Protein phosphatase PTC7 homolog fig
PRO_0000377398

Regions

Domain52 – 307256PP2C-like

Sites

Metal binding871Manganese 1 By similarity UniProtKB P35813
Metal binding871Manganese 2 By similarity UniProtKB P35813
Metal binding881Manganese 1; via carbonyl oxygen By similarity UniProtKB P35813
Metal binding2321Manganese 2 By similarity UniProtKB P35813

Natural variations

Alternative sequence1 – 152152Missing in isoform beta. Ref.1
VSP_053111

Sequences

Sequence LengthMass (Da)Tools
Isoform alpha [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: F6D2A3360D4AD8A4

FASTA31434,838
        10         20         30         40         50         60 
MITCLRNWPL LLKRFSVHQI HQFTQLSGRF ERPPQSGKSS RDPYLVTVVQ GRSKKPRFPG 

        70         80         90        100        110        120 
ERSNQRFGED SWFVSSTPLA EVMGVADGVG GWRDLGVDAG RFAKELMSCC SGQTQLSDFD 

       130        140        150        160        170        180 
GRSPRNMLIA GFQELSHREH PVVGSSTACL ATMHRKDCTL YTANLGDSGF LVVRNGRVLH 

       190        200        210        220        230        240 
RSVEQTHDFN TPYQLTVPPE DRKESYYCDK PEMAVSTRHS LLPGDLVLLA TDGLFDNMPE 

       250        260        270        280        290        300 
SMLLSILNGL KERGEHDLLV GASRVVEKAR ELSMNASFQS PFAIKARQHN VSYSGGGKPD 

       310 
DITLILSSVE VPNA 

« Hide

Isoform beta [UniParc].

Checksum: 73B5489F6FBCFA18
Show »

FASTA16217,957

References

« Hide 'large scale' references
[1]"The gene structure of the Drosophila melanogaster proto-oncogene, kayak, and its nested gene, fos-intronic gene."
Hudson S.G., Goldstein E.S.
Gene 420:76-81(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), ALTERNATIVE PROMOTER USAGE, DEVELOPMENTAL STAGE.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
Strain: Berkeley.
Tissue: Head.
[5]Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
Strain: Berkeley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ858472 mRNA. Translation: ABI74754.1.
DQ858473 mRNA. Translation: ABI74755.1.
AE014297 Genomic DNA. Translation: AAF56936.1.
AY094942 mRNA. Translation: AAM11295.1. Frameshift.
BT044569 mRNA. Translation: ACI16531.1.
RefSeqNP_651724.1. NM_143467.3.
UniGeneDm.29813.

3D structure databases

ProteinModelPortalQ9VAH4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid68375. 1 interaction.
MINTMINT-1029422.
STRING7227.FBpp0084904.

Proteomic databases

PaxDbQ9VAH4.
PRIDEQ9VAH4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0085538; FBpp0084904; FBgn0039694. [Q9VAH4-1]
GeneID43511.
KEGGdme:Dmel_CG7615.
UCSCCG7615-RA. d. melanogaster. [Q9VAH4-1]

Organism-specific databases

CTD43511.
FlyBaseFBgn0039694. fig.

Phylogenomic databases

eggNOGCOG0631.
GeneTreeENSGT00390000011937.
InParanoidQ9VAH4.
KOK17508.
OMADSWFVSS.
OrthoDBEOG7DRJ3F.
PhylomeDBQ9VAH4.

Gene expression databases

BgeeQ9VAH4.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
[Graphical view]
PfamPF07228. SpoIIE. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi43511.
NextBio834314.

Entry information

Entry namePTC71_DROME
AccessionPrimary (citable) accession number: Q9VAH4
Secondary accession number(s): A8MPH7, Q8SWZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase