Unreviewed, UniProtKB/TrEMBL Q9VAF5 (Q9VAF5_DROME)

Names and origin

Protein names

Submitted name:
    Cad99C EMBL AAF56955.2

Gene names

Name:	Cad99C EMBL AAF56955.2
ORF Names:	Dmel_CG31009 EMBL AAF56955.2

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1706 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Spearmint SPM002126
Ligand	Calcium RuleBase RU000484V3
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	calcium-dependent cell-cell adhesion Non-traceable author statement. Source: UniProtKB homophilic cell adhesion Inferred from electronic annotation. Source: InterPro smoothened signaling pathway Inferred from mutant phenotype. Source: FlyBase
Cellular component	integral to plasma membrane Non-traceable author statement. Source: UniProtKB
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9VUV8	1	EBI-187019,EBI-161029
pcl	Q9W5G3	1	EBI-187019,EBI-139248

Sequences

	Sequence		Length	Mass (Da)
	Q9VAF5-1 [UniParc]. Last modified June 1, 2003. Version 2. Checksum: 2A2CB6F3D5561D8B	FASTA	1,706	186,874
	10 20 30 40 50 60 MAARNSLTPQ QGLGFFGLLI LLCSAVLGKS QMCEVETGQT NIILDIEESR ESFIGQPTTP 70 80 90 100 110 120 PELPIFGDPD TEIALNLVFP KGQPIFQLNG KKLQLLQPLD RDEENLSHIV FQVSCTTRST 130 140 150 160 170 180 GKKRTIPIIV RVSDINDNAP RFMNTPYEVT VPESTPVGTT IFRNIQALDK DAGVNGLVEY 190 200 210 220 230 240 FIAEGSPNST NVEKYSADGY GTFAISFPHQ GQVTVAKTLD FEKIQTYYLT IVASDRARNT 250 260 270 280 290 300 ADRLSSTTTL TVNIADSNDL DPSFIYSGCV SLDGACINPE YSASVPAGSL LGVLTVLPER 310 320 330 340 350 360 IQAVDLDTIN SPIRYSFASG MPGNYADYFQ IDESTGVLKQ TKAVDTSTAK KYDIIVKAEE 370 380 390 400 410 420 VSPGPQRFTT AKLEIFVKPV DANPPVISSS QAEGYVDENS PIGTRVLDAH GNPISFMTTD 430 440 450 460 470 480 ADLSDSDPKP DYIYELTTPS FNVTGDGILV VNEENLDRDP PAPGRFKFQV VAREPRTNAA 490 500 510 520 530 540 SAPLSLTVHL RDVNDNAPKL AMVAPISITA GDQSESRLVT QVTATDNDEG PNAVVTYSIY 550 560 570 580 590 600 HVSNNGIQKF TINATTGEIR TQGRLLAGEQ YSITVQATDI GGLSSQAIVE VSVTPGPNTK 610 620 630 640 650 660 PPRFQKPIYE VQVSEGAEIN STVTVVHAED PENDAVVYSI ISGNDLRQFA VGQESGVIIV 670 680 690 700 710 720 IRKLDRESLT RYQLILKAED TGGLSSSATV NIKVTDINDK NPEFEASTLP YVFQVEEGKA 730 740 750 760 770 780 QASVGVVHAT DADEGINAEI TYSIPTDIPF TINATSGEIL TAKELDYEQL NEYKFVVTAK 790 800 810 820 830 840 DGAPDARLGT ASVTVMVLDL PDEVPKFSDA RIDVHIPENE ENFLVATVQA FDPDSMPEIT 850 860 870 880 890 900 YVLRKGNAEL FKVSEKSGEV RTIKGLDYES QKQHQLTIGT IENDGNGPGD TILLVVDVED 910 920 930 940 950 960 RNDLPPRFIT VPDPVTVNDD QGIGTIIATL PAIDGDGTSP GNVVRYEIVG RGKAPKYFQV 970 980 990 1000 1010 1020 DPDTGAVRIR DELRKEEDTE YQVDIRAYDL GEPQLSSVAP LRVDVHHLLS SGNNEIKLDN 1030 1040 1050 1060 1070 1080 KLESGTGMSS ESIGLAFSDD SYTTSVPESM EANSTLKLIQ IVNSKTSGDG PPAFRCEFVS 1090 1100 1110 1120 1130 1140 GNGGGIFNLS SADHGCNLLL IQPLDFENKS SYSLQLRLTS HRYFVNPLKD TTSVEIIVQD 1150 1160 1170 1180 1190 1200 ENDNAPEFEF NRLRGQQDTF YTVVTEEMDV DTTILQVRAT DRDSGKFGTV RYTLYDDDEN 1210 1220 1230 1240 1250 1260 RVNMPTSFFM MSEDTGVLRT AKHFKNENDF PLTFLVEARD SDGQEQGSHR TRARIVVNKL 1270 1280 1290 1300 1310 1320 ADINRMALSF PNAAPSDLRN YYTELEELLD KKTGLVSGIE RMSSQKYLAK NGSVIENPAA 1330 1340 1350 1360 1370 1380 TDIWFYLIDP KTEQLVSRKD SIVETTLLEP AARSELNIAL PRATAENISF PLERKEHVHK 1390 1400 1410 1420 1430 1440 VKAAVAIDNE VFPFTLIAIS LVILILGTIG IIYICISWSK YKNFKQRMRQ YSSTNPPRYD 1450 1460 1470 1480 1490 1500 PVIVNQQASS ASETIANMKE YETQMLAMAV PPDVDDDLQL DFSAKNHAFS LDNVSYITHK 1510 1520 1530 1540 1550 1560 ENTNGGGQSS PSHSDATTAT IATLRRHKNL NNASMNNNLA INNRQNTFNR TLEMNTRNNA 1570 1580 1590 1600 1610 1620 NPLASPPNGA LSGTLTLGRI KHQNSNHYQN GAYNIDPTGP NNMAHAKNNA YSTMGRRGNT 1630 1640 1650 1660 1670 1680 FGDVGLLNGN GELMNATLGR NGQLNNRLYG GEVPITNPLF QRSNSDHNHL SSTNENVSFG 1690 1700 KRDYGQIGFS YLNDLDRSEV ETTTEL

References

[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014297 Genomic DNA. Translation: AAF56955.2.
RefSeq	NP_733314.1.
UniGene	Dm.4517
3D structure databases
HSSP	HSSP built from PDB template 1NCJ based on UniProtKB P15116.
SMR	Q9VAF5. Positions 131-258, 622-799, 815-1004.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VAF5. 2 interactions.
STRING	Q9VAF5.
Genome annotation databases
Ensembl	FBtr0085488; FBpp0084854; FBgn0039709; Drosophila melanogaster. [Genome view]
GeneID	43528.
KEGG	dme:Dmel_CG31009.
NMPDR	fig|7227.3.peg.15305.
UCSC	CG31009-RA. d. melanogaster.
Organism-specific databases
CTD	43528.
FlyBase	FBgn0039709. Cad99C.
Phylogenomic databases
InParanoid	Q9VAF5.
OMA	NSIVEEL.
OrthoDB	EOG9D7ZCQ.
PhylomeDB	Q9VAF5.
Gene expression databases
ArrayExpress	Q9VAF5.
Family and domain databases
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR003961. FN_III. [Graphical view]
Gene3D	G3DSA:2.60.40.60. Cadherin. 10 hits.
Pfam	PF00028. Cadherin. 8 hits. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 11 hits. [Graphical view]
PROSITE	PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 11 hits. PS50853. FN3. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	834380.

Entry information

Entry name

Q9VAF5_DROME

Accession

Primary (citable) accession number: Q9VAF5
Secondary accession number(s): Q961C6, Q9VAF6

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	June 1, 2003
Last modified:	February 9, 2010
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)