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Protein
Submitted name:

Cadherin 99C, isoform A

Gene

Cad99C

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • calcium ion binding Source: FlyBase
  • myosin binding Source: FlyBase

GO - Biological processi

  • apical protein localization Source: FlyBase
  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • calcium-mediated signaling Source: FlyBase
  • cell-cell adhesion mediated by cadherin Source: FlyBase
  • chorion-containing eggshell formation Source: FlyBase
  • follicle cell microvillus organization Source: FlyBase
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • mucosal immune response Source: FlyBase
  • positive regulation of clathrin-dependent endocytosis Source: FlyBase
  • regulation of follicle cell microvillus length Source: FlyBase
  • smoothened signaling pathway Source: FlyBase
  • tube morphogenesis Source: FlyBase
  • vitelline membrane formation involved in chorion-containing eggshell formation Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

CalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Cadherin 99C, isoform AImported
Submitted name:
Cadherin 99C, isoform BImported
Gene namesi
Name:Cad99CImported
ORF Names:CG31009Imported, Dmel_CG31009Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0039709. Cad99C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1391 – 1419HelicalSequence analysisAdd BLAST29

GO - Cellular componenti

  • apical plasma membrane Source: FlyBase
  • integral component of plasma membrane Source: UniProtKB
  • intracellular Source: GOC
  • microvillus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500818059829 – 1706Sequence analysisAdd BLAST1678

Expressioni

Gene expression databases

BgeeiFBgn0039709.

Interactioni

GO - Molecular functioni

  • myosin binding Source: FlyBase

Protein-protein interaction databases

IntActiQ9VAF5. 2 interactors.
MINTiMINT-321696.
STRINGi7227.FBpp0292214.

Structurei

3D structure databases

ProteinModelPortaliQ9VAF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 142CadherinInterPro annotationAdd BLAST75
Domaini143 – 264CadherinInterPro annotationAdd BLAST122
Domaini277 – 387CadherinInterPro annotationAdd BLAST111
Domaini388 – 500CadherinInterPro annotationAdd BLAST113
Domaini519 – 604CadherinInterPro annotationAdd BLAST86
Domaini605 – 704CadherinInterPro annotationAdd BLAST100
Domaini707 – 807CadherinInterPro annotationAdd BLAST101
Domaini808 – 908CadherinInterPro annotationAdd BLAST101
Domaini909 – 1005CadherinInterPro annotationAdd BLAST97
Domaini1038 – 1148CadherinInterPro annotationAdd BLAST111
Domaini1156 – 1270CadherinInterPro annotationAdd BLAST115

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132356.
KOiK16500.
OMAiDPTGPNN.
OrthoDBiEOG091G0MMW.

Family and domain databases

Gene3Di2.60.40.60. 11 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 8 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 11 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 10 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VAF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARNSLTPQ QGLGFFGLLI LLCSAVLGKS QMCEVETGQT NIILDIEESR
60 70 80 90 100
ESFIGQPTTP PELPIFGDPD TEIALNLVFP KGQPIFQLNG KKLQLLQPLD
110 120 130 140 150
RDEENLSHIV FQVSCTTRST GKKRTIPIIV RVSDINDNAP RFMNTPYEVT
160 170 180 190 200
VPESTPVGTT IFRNIQALDK DAGVNGLVEY FIAEGSPNST NVEKYSADGY
210 220 230 240 250
GTFAISFPHQ GQVTVAKTLD FEKIQTYYLT IVASDRARNT ADRLSSTTTL
260 270 280 290 300
TVNIADSNDL DPSFIYSGCV SLDGACINPE YSASVPAGSL LGVLTVLPER
310 320 330 340 350
IQAVDLDTIN SPIRYSFASG MPGNYADYFQ IDESTGVLKQ TKAVDTSTAK
360 370 380 390 400
KYDIIVKAEE VSPGPQRFTT AKLEIFVKPV DANPPVISSS QAEGYVDENS
410 420 430 440 450
PIGTRVLDAH GNPISFMTTD ADLSDSDPKP DYIYELTTPS FNVTGDGILV
460 470 480 490 500
VNEENLDRDP PAPGRFKFQV VAREPRTNAA SAPLSLTVHL RDVNDNAPKL
510 520 530 540 550
AMVAPISITA GDQSESRLVT QVTATDNDEG PNAVVTYSIY HVSNNGIQKF
560 570 580 590 600
TINATTGEIR TQGRLLAGEQ YSITVQATDI GGLSSQAIVE VSVTPGPNTK
610 620 630 640 650
PPRFQKPIYE VQVSEGAEIN STVTVVHAED PENDAVVYSI ISGNDLRQFA
660 670 680 690 700
VGQESGVIIV IRKLDRESLT RYQLILKAED TGGLSSSATV NIKVTDINDK
710 720 730 740 750
NPEFEASTLP YVFQVEEGKA QASVGVVHAT DADEGINAEI TYSIPTDIPF
760 770 780 790 800
TINATSGEIL TAKELDYEQL NEYKFVVTAK DGAPDARLGT ASVTVMVLDL
810 820 830 840 850
PDEVPKFSDA RIDVHIPENE ENFLVATVQA FDPDSMPEIT YVLRKGNAEL
860 870 880 890 900
FKVSEKSGEV RTIKGLDYES QKQHQLTIGT IENDGNGPGD TILLVVDVED
910 920 930 940 950
RNDLPPRFIT VPDPVTVNDD QGIGTIIATL PAIDGDGTSP GNVVRYEIVG
960 970 980 990 1000
RGKAPKYFQV DPDTGAVRIR DELRKEEDTE YQVDIRAYDL GEPQLSSVAP
1010 1020 1030 1040 1050
LRVDVHHLLS SGNNEIKLDN KLESGTGMSS ESIGLAFSDD SYTTSVPESM
1060 1070 1080 1090 1100
EANSTLKLIQ IVNSKTSGDG PPAFRCEFVS GNGGGIFNLS SADHGCNLLL
1110 1120 1130 1140 1150
IQPLDFENKS SYSLQLRLTS HRYFVNPLKD TTSVEIIVQD ENDNAPEFEF
1160 1170 1180 1190 1200
NRLRGQQDTF YTVVTEEMDV DTTILQVRAT DRDSGKFGTV RYTLYDDDEN
1210 1220 1230 1240 1250
RVNMPTSFFM MSEDTGVLRT AKHFKNENDF PLTFLVEARD SDGQEQGSHR
1260 1270 1280 1290 1300
TRARIVVNKL ADINRMALSF PNAAPSDLRN YYTELEELLD KKTGLVSGIE
1310 1320 1330 1340 1350
RMSSQKYLAK NGSVIENPAA TDIWFYLIDP KTEQLVSRKD SIVETTLLEP
1360 1370 1380 1390 1400
AARSELNIAL PRATAENISF PLERKEHVHK VKAAVAIDNE VFPFTLIAIS
1410 1420 1430 1440 1450
LVILILGTIG IIYICISWSK YKNFKQRMRQ YSSTNPPRYD PVIVNQQASS
1460 1470 1480 1490 1500
ASETIANMKE YETQMLAMAV PPDVDDDLQL DFSAKNHAFS LDNVSYITHK
1510 1520 1530 1540 1550
ENTNGGGQSS PSHSDATTAT IATLRRHKNL NNASMNNNLA INNRQNTFNR
1560 1570 1580 1590 1600
TLEMNTRNNA NPLASPPNGA LSGTLTLGRI KHQNSNHYQN GAYNIDPTGP
1610 1620 1630 1640 1650
NNMAHAKNNA YSTMGRRGNT FGDVGLLNGN GELMNATLGR NGQLNNRLYG
1660 1670 1680 1690 1700
GEVPITNPLF QRSNSDHNHL SSTNENVSFG KRDYGQIGFS YLNDLDRSEV

ETTTEL
Length:1,706
Mass (Da):186,874
Last modified:June 1, 2003 - v2
Checksum:i2A2CB6F3D5561D8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56955.2.
AE014297 Genomic DNA. Translation: ADV37401.1.
RefSeqiNP_001189311.1. NM_001202382.1.
NP_733314.1. NM_170435.2.
UniGeneiDm.4517.

Genome annotation databases

EnsemblMetazoaiFBtr0085488; FBpp0084854; FBgn0039709.
FBtr0303095; FBpp0292214; FBgn0039709.
GeneIDi43528.
KEGGidme:Dmel_CG31009.
UCSCiCG31009-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56955.2.
AE014297 Genomic DNA. Translation: ADV37401.1.
RefSeqiNP_001189311.1. NM_001202382.1.
NP_733314.1. NM_170435.2.
UniGeneiDm.4517.

3D structure databases

ProteinModelPortaliQ9VAF5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9VAF5. 2 interactors.
MINTiMINT-321696.
STRINGi7227.FBpp0292214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085488; FBpp0084854; FBgn0039709.
FBtr0303095; FBpp0292214; FBgn0039709.
GeneIDi43528.
KEGGidme:Dmel_CG31009.
UCSCiCG31009-RA. d. melanogaster.

Organism-specific databases

CTDi43528.
FlyBaseiFBgn0039709. Cad99C.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132356.
KOiK16500.
OMAiDPTGPNN.
OrthoDBiEOG091G0MMW.

Miscellaneous databases

GenomeRNAii43528.

Gene expression databases

BgeeiFBgn0039709.

Family and domain databases

Gene3Di2.60.40.60. 11 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 8 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 11 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 10 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9VAF5_DROME
AccessioniPrimary (citable) accession number: Q9VAF5
Secondary accession number(s): Q961C6, Q9VAF6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.