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Protein

Calcium-binding mitochondrial carrier protein Aralar1

Gene

aralar1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-dependent mitochondrial solute carrier.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi84 – 951Add BLAST12
Calcium bindingi118 – 1292Add BLAST12
Calcium bindingi189 – 2003Add BLAST12

GO - Molecular functioni

GO - Biological processi

  • aspartate transport Source: GO_Central
  • L-glutamate transmembrane transport Source: GO_Central
  • malate-aspartate shuttle Source: GO_Central
  • mitochondrial transport Source: FlyBase
  • wound healing Source: FlyBase

Keywordsi

Biological processTransport
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-70263. Gluconeogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein Aralar1
Gene namesi
Name:aralar1
ORF Names:CG2139
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0028646. aralar1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei346 – 363Helical; Name=1Sequence analysisAdd BLAST18
Transmembranei406 – 425Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei449 – 462Helical; Name=3Sequence analysisAdd BLAST14
Transmembranei498 – 517Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei537 – 554Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei594 – 613Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906061 – 695Calcium-binding mitochondrial carrier protein Aralar1Add BLAST695

Proteomic databases

PaxDbiQ9VA73.
PRIDEiQ9VA73.

Expressioni

Gene expression databases

BgeeiFBgn0028646.
ExpressionAtlasiQ9VA73. differential.
GenevisibleiQ9VA73. DM.

Interactioni

Protein-protein interaction databases

BioGridi68470. 2 interactors.
DIPiDIP-17130N.
IntActiQ9VA73. 5 interactors.
STRINGi7227.FBpp0297541.

Structurei

3D structure databases

ProteinModelPortaliQ9VA73.
SMRiQ9VA73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 104EF-hand 1PROSITE-ProRule annotationAdd BLAST34
Domaini105 – 140EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini142 – 175EF-hand 3PROSITE-ProRule annotationAdd BLAST34
Domaini176 – 211EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Repeati340 – 431Solcar 1Add BLAST92
Repeati439 – 523Solcar 2Add BLAST85
Repeati531 – 619Solcar 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0751. Eukaryota.
ENOG410XNRM. LUCA.
GeneTreeiENSGT00530000062944.
HOGENOMiHOG000267556.
InParanoidiQ9VA73.
KOiK15105.
OrthoDBiEOG091G08GT.
PhylomeDBiQ9VA73.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom_sf.
PfamiView protein in Pfam
PF13833. EF-hand_8. 2 hits.
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SMARTiView protein in SMART
SM00054. EFh. 3 hits.
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 2 hits.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9VA73-1) [UniParc]FASTAAdd to basket
Also known as: C

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPMHIPFPFN WIPTLPVARC QESPSLLKRA GTEKLREVFL KYASIQKNGE
60 70 80 90 100
HYMTSEDFVR KFLGLFSESA FNDESVRLLA NIADTSKDGL ISFSEFQAFE
110 120 130 140 150
GLLCTPDALY RTAFQLFDRK GNGTVSYADF ADVVQKTELH SKIPFSLDGP
160 170 180 190 200
FIKRYFGDKK QRLINYAEFT QLLHDFHEEH AMEAFRSKDP AGTGFISPLD
210 220 230 240 250
FQDIIVNVKR HLLTPGVRDN LVSVTEGHKV SFPYFIAFTS LLNNMELIKQ
260 270 280 290 300
VYLHATEGSR TDMITKDQIL LAAQTMSQIT PLEIDILFHL AGAVHQAGRI
310 320 330 340 350
DYSDLSNIAP EHYTKHMTHR LAEIKAVESP ADRSAFIQVL ESSYRFTLGS
360 370 380 390 400
FAGAVGATVV YPIDLVKTRM QNQRAGSYIG EVAYRNSWDC FKKVVRHEGF
410 420 430 440 450
MGLYRGLLPQ LMGVAPEKAI KLTVNDLVRD KLTDKKGNIP TWAEVLAGGC
460 470 480 490 500
AGASQVVFTN PLEIVKIRLQ VAGEIASGSK IRAWSVVREL GLFGLYKGAR
510 520 530 540 550
ACLLRDVPFS AIYFPTYAHT KAMMADKDGY NHPLTLLAAG AIAGVPAASL
560 570 580 590 600
VTPADVIKTR LQVVARSGQT TYTGVWDATK KIMAEEGPRA FWKGTAARVF
610 620 630 640 650
RSSPQFGVTL VTYELLQRLF YVDFGGTQPK GSEAHKITTP LEQAAASVTT
660 670 680 690
ENVDHIGGYR AAVPLLAGVE SKFGLYLPRF GRGVTAASPS TATGS
Note: No experimental confirmation available.
Length:695
Mass (Da):76,754
Last modified:May 1, 2000 - v1
Checksum:i8EC93D92031F5B77
GO
Isoform 2 (identifier: Q9VA73-2) [UniParc]FASTAAdd to basket
Also known as: A, D

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MPMHIPFPFNWIPTLPVARCQE → MPLTKSLPN

Show »
Length:682
Mass (Da):75,129
Checksum:iDF4D6851D4715FC8
GO
Isoform 3 (identifier: Q9VA73-3) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MPMHIPFPFNWIPTLPVARCQ → MHDKD

Note: No experimental confirmation available.
Show »
Length:679
Mass (Da):74,903
Checksum:i5F318AC5AFD7B1AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti356 – 357GA → AP in CAB62169 (PubMed:10642534).Curated2
Sequence conflicti556V → A in CAB62169 (PubMed:10642534).Curated1
Sequence conflicti653V → L in CAB62169 (PubMed:10642534).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0032661 – 22MPMHI…ARCQE → MPLTKSLPN in isoform 2. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_0032651 – 21MPMHI…VARCQ → MHDKD in isoform 3. CuratedAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18197 mRNA. Translation: CAB62169.1.
AE014297 Genomic DNA. Translation: AAF57048.1.
AE014297 Genomic DNA. Translation: AAF57049.1.
AE014297 Genomic DNA. Translation: AAF57050.3.
AE014297 Genomic DNA. Translation: AAN14230.1.
AY058654 mRNA. Translation: AAL13883.1.
RefSeqiNP_651795.2. NM_143538.3. [Q9VA73-2]
NP_733364.1. NM_170485.2. [Q9VA73-1]
NP_733365.1. NM_170486.2. [Q9VA73-2]
NP_733366.2. NM_170487.3. [Q9VA73-3]
UniGeneiDm.20778.

Genome annotation databases

EnsemblMetazoaiFBtr0085692; FBpp0085054; FBgn0028646. [Q9VA73-1]
FBtr0085693; FBpp0085055; FBgn0028646. [Q9VA73-3]
FBtr0085694; FBpp0085056; FBgn0028646. [Q9VA73-2]
FBtr0085695; FBpp0085057; FBgn0028646. [Q9VA73-2]
GeneIDi43616.
KEGGidme:Dmel_CG2139.
UCSCiCG2139-RA. d. melanogaster.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCMC_DROME
AccessioniPrimary (citable) accession number: Q9VA73
Secondary accession number(s): A4V3N6
, Q95TN5, Q9U5V8, Q9VA72, Q9VA74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families