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Protein

Calcium-binding mitochondrial carrier protein Aralar1

Gene

aralar1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-dependent mitochondrial solute carrier.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi84 – 95121Add
BLAST
Calcium bindingi118 – 129122Add
BLAST
Calcium bindingi189 – 200123Add
BLAST

GO - Molecular functioni

GO - Biological processi

  • mitochondrial transport Source: FlyBase
  • translation Source: GO_Central
  • transport Source: FlyBase
  • wound healing Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-70263. Gluconeogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein Aralar1
Gene namesi
Name:aralar1
ORF Names:CG2139
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0028646. aralar1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei346 – 36318Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei406 – 42520Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei449 – 46214Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei498 – 51720Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei537 – 55418Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei594 – 61320Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: FlyBase
  • lipid particle Source: FlyBase
  • mitochondrial inner membrane Source: FlyBase
  • mitochondrial membrane Source: FlyBase
  • mitochondrion Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695Calcium-binding mitochondrial carrier protein Aralar1PRO_0000090606Add
BLAST

Proteomic databases

PaxDbiQ9VA73.
PRIDEiQ9VA73.

Expressioni

Gene expression databases

BgeeiQ9VA73.
ExpressionAtlasiQ9VA73. differential.
GenevisibleiQ9VA73. DM.

Interactioni

Protein-protein interaction databases

BioGridi68470. 2 interactions.
DIPiDIP-17130N.
IntActiQ9VA73. 5 interactions.
STRINGi7227.FBpp0297541.

Structurei

3D structure databases

ProteinModelPortaliQ9VA73.
SMRiQ9VA73. Positions 34-601.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 10434EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini105 – 14036EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini142 – 17534EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini176 – 21136EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Repeati340 – 43192Solcar 1Add
BLAST
Repeati439 – 52385Solcar 2Add
BLAST
Repeati531 – 61989Solcar 3Add
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation
Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0751. Eukaryota.
ENOG410XNRM. LUCA.
GeneTreeiENSGT00530000062944.
HOGENOMiHOG000267556.
InParanoidiQ9VA73.
KOiK15105.
OrthoDBiEOG70GMF1.
PhylomeDBiQ9VA73.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13833. EF-hand_8. 2 hits.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9VA73-1) [UniParc]FASTAAdd to basket

Also known as: C

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPMHIPFPFN WIPTLPVARC QESPSLLKRA GTEKLREVFL KYASIQKNGE
60 70 80 90 100
HYMTSEDFVR KFLGLFSESA FNDESVRLLA NIADTSKDGL ISFSEFQAFE
110 120 130 140 150
GLLCTPDALY RTAFQLFDRK GNGTVSYADF ADVVQKTELH SKIPFSLDGP
160 170 180 190 200
FIKRYFGDKK QRLINYAEFT QLLHDFHEEH AMEAFRSKDP AGTGFISPLD
210 220 230 240 250
FQDIIVNVKR HLLTPGVRDN LVSVTEGHKV SFPYFIAFTS LLNNMELIKQ
260 270 280 290 300
VYLHATEGSR TDMITKDQIL LAAQTMSQIT PLEIDILFHL AGAVHQAGRI
310 320 330 340 350
DYSDLSNIAP EHYTKHMTHR LAEIKAVESP ADRSAFIQVL ESSYRFTLGS
360 370 380 390 400
FAGAVGATVV YPIDLVKTRM QNQRAGSYIG EVAYRNSWDC FKKVVRHEGF
410 420 430 440 450
MGLYRGLLPQ LMGVAPEKAI KLTVNDLVRD KLTDKKGNIP TWAEVLAGGC
460 470 480 490 500
AGASQVVFTN PLEIVKIRLQ VAGEIASGSK IRAWSVVREL GLFGLYKGAR
510 520 530 540 550
ACLLRDVPFS AIYFPTYAHT KAMMADKDGY NHPLTLLAAG AIAGVPAASL
560 570 580 590 600
VTPADVIKTR LQVVARSGQT TYTGVWDATK KIMAEEGPRA FWKGTAARVF
610 620 630 640 650
RSSPQFGVTL VTYELLQRLF YVDFGGTQPK GSEAHKITTP LEQAAASVTT
660 670 680 690
ENVDHIGGYR AAVPLLAGVE SKFGLYLPRF GRGVTAASPS TATGS
Note: No experimental confirmation available.
Length:695
Mass (Da):76,754
Last modified:May 1, 2000 - v1
Checksum:i8EC93D92031F5B77
GO
Isoform 2 (identifier: Q9VA73-2) [UniParc]FASTAAdd to basket

Also known as: A, D

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MPMHIPFPFNWIPTLPVARCQE → MPLTKSLPN

Show »
Length:682
Mass (Da):75,129
Checksum:iDF4D6851D4715FC8
GO
Isoform 3 (identifier: Q9VA73-3) [UniParc]FASTAAdd to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MPMHIPFPFNWIPTLPVARCQ → MHDKD

Note: No experimental confirmation available.
Show »
Length:679
Mass (Da):74,903
Checksum:i5F318AC5AFD7B1AA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti356 – 3572GA → AP in CAB62169 (PubMed:10642534).Curated
Sequence conflicti556 – 5561V → A in CAB62169 (PubMed:10642534).Curated
Sequence conflicti653 – 6531V → L in CAB62169 (PubMed:10642534).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2222MPMHI…ARCQE → MPLTKSLPN in isoform 2. 2 PublicationsVSP_003266Add
BLAST
Alternative sequencei1 – 2121MPMHI…VARCQ → MHDKD in isoform 3. CuratedVSP_003265Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18197 mRNA. Translation: CAB62169.1.
AE014297 Genomic DNA. Translation: AAF57048.1.
AE014297 Genomic DNA. Translation: AAF57049.1.
AE014297 Genomic DNA. Translation: AAF57050.3.
AE014297 Genomic DNA. Translation: AAN14230.1.
AY058654 mRNA. Translation: AAL13883.1.
RefSeqiNP_651795.2. NM_143538.3. [Q9VA73-2]
NP_733364.1. NM_170485.2. [Q9VA73-1]
NP_733365.1. NM_170486.2. [Q9VA73-2]
NP_733366.2. NM_170487.3. [Q9VA73-3]
UniGeneiDm.20778.

Genome annotation databases

EnsemblMetazoaiFBtr0085692; FBpp0085054; FBgn0028646. [Q9VA73-1]
GeneIDi43616.
KEGGidme:Dmel_CG2139.
UCSCiCG2139-RA. d. melanogaster. [Q9VA73-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18197 mRNA. Translation: CAB62169.1.
AE014297 Genomic DNA. Translation: AAF57048.1.
AE014297 Genomic DNA. Translation: AAF57049.1.
AE014297 Genomic DNA. Translation: AAF57050.3.
AE014297 Genomic DNA. Translation: AAN14230.1.
AY058654 mRNA. Translation: AAL13883.1.
RefSeqiNP_651795.2. NM_143538.3. [Q9VA73-2]
NP_733364.1. NM_170485.2. [Q9VA73-1]
NP_733365.1. NM_170486.2. [Q9VA73-2]
NP_733366.2. NM_170487.3. [Q9VA73-3]
UniGeneiDm.20778.

3D structure databases

ProteinModelPortaliQ9VA73.
SMRiQ9VA73. Positions 34-601.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68470. 2 interactions.
DIPiDIP-17130N.
IntActiQ9VA73. 5 interactions.
STRINGi7227.FBpp0297541.

Proteomic databases

PaxDbiQ9VA73.
PRIDEiQ9VA73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085692; FBpp0085054; FBgn0028646. [Q9VA73-1]
GeneIDi43616.
KEGGidme:Dmel_CG2139.
UCSCiCG2139-RA. d. melanogaster. [Q9VA73-1]

Organism-specific databases

CTDi43616.
FlyBaseiFBgn0028646. aralar1.

Phylogenomic databases

eggNOGiKOG0751. Eukaryota.
ENOG410XNRM. LUCA.
GeneTreeiENSGT00530000062944.
HOGENOMiHOG000267556.
InParanoidiQ9VA73.
KOiK15105.
OrthoDBiEOG70GMF1.
PhylomeDBiQ9VA73.

Enzyme and pathway databases

ReactomeiR-DME-70263. Gluconeogenesis.

Miscellaneous databases

ChiTaRSiaralar1. fly.
GenomeRNAii43616.
PROiQ9VA73.

Gene expression databases

BgeeiQ9VA73.
ExpressionAtlasiQ9VA73. differential.
GenevisibleiQ9VA73. DM.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13833. EF-hand_8. 2 hits.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a second member of the subfamily of calcium-binding mitochondrial carriers expressed in human non-excitable tissues."
    Del Arco A., Agudo M., Satrustegui J.
    Biochem. J. 345:725-732(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Ovary.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiCMC_DROME
AccessioniPrimary (citable) accession number: Q9VA73
Secondary accession number(s): A4V3N6
, Q95TN5, Q9U5V8, Q9VA72, Q9VA74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.