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Q9VA02

- DHTK1_DROME

UniProt

Q9VA02 - DHTK1_DROME

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Protein
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial
Gene
CG1544
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. generation of precursor metabolites and energy Source: UniProtKB
  2. glycolytic process Source: UniProtKB-KW
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial (EC:1.2.4.2)
Gene namesi
ORF Names:CG1544
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0039827. CG1544.

Subcellular locationi

Mitochondrion Reviewed prediction

GO - Cellular componenti

  1. mitochondrial membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 919Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrialPRO_0000307943
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

PaxDbiQ9VA02.

Expressioni

Gene expression databases

BgeeiQ9VA02.

Interactioni

Protein-protein interaction databases

BioGridi68534. 4 interactions.
IntActiQ9VA02. 1 interaction.
MINTiMINT-940711.

Structurei

3D structure databases

ProteinModelPortaliQ9VA02.
SMRiQ9VA02. Positions 54-917.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0567.
GeneTreeiENSGT00530000063092.
InParanoidiQ9VA02.
KOiK15791.
OMAiLCSGKHY.
OrthoDBiEOG7CZK4Z.
PhylomeDBiQ9VA02.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VA02-1 [UniParc]FASTAAdd to Basket

« Hide

MLRYLALSEA GIAKLPRPQS RCYHSEKGVW GYKPIAQREF QVAEDVRASR    50
NSQANVYRFV EAFRQHGHKL AAVNPISIRT SQQELQELSP AFYGLQTQEP 100
VRTDGLLSGP QVAHNVAQLE QLLKDIYCGR STSAEFSYVE DIEEREWLAR 150
NFETLDQQQL GKSERCEIAE LLIKSQAWDN FMALKFPTVK RYGGEGAESM 200
LAFFWQLLRD SVQANIEHVV LAMPHRGRTP LQAALLNMRP AKVFRKLSGA 250
SEFSEDIEAM SDVISHFHVS EQLKILGKKL SFSMVRNPSH LEAANPVAMG 300
KTRSKQQARG EGAFGDGSQP FGEHVLNVIL HGDAAFAGQG INQECLNMAY 350
VPHFEVGGSL HLIVNNQVGF TTPGDRGRST AYTSDLAKSI QAPVFHVNGD 400
DPEALARVTS LAFRYQREFR KDIFIDLNCF RRWGHNELDD PTFTNPLVYK 450
IVHQRESVPD LYAQQLAKEQ VLSESKAKEM RDEYMKYLGE ELALAPAYQP 500
PPSYFEKQWT NFQLAPSKEL TYWDTGLDYS LLHYIGQQSV TFPEDFNIHP 550
HLLKTHVNAR LKKLENGVKI DWSTAEALAI GSLMYQGHNV RISGEDVGRG 600
TFSHRHAMLV DQQTNEMFIP LNSMEGGNGG KLELAHSILS EEAVLGFEYG 650
MAIDNPNNLI IWEAQFGDFA NGAQIIIDTF IVSGETKWME SNALVMLLPH 700
GYDGAASEHS SCRIERFLQL CDSKETSADG DSVNVHIVNP TTPAQYYHVL 750
RRQLARNFRK PLVVVAPKTL LRLPAATSTH EDFQPGTLFH NVLGDTIAKP 800
EQVRKVILCS GKHYYTLAEE REKRQAYDTA ILRLESLCPF PIQELQAQLA 850
QYGNVQSFVW SQEEHRNMGA WTFVRPRFEN LIGQQLHYCG RCEAPTPATG 900
IGKVHKREVD EIVAAPFEL 919
Length:919
Mass (Da):103,635
Last modified:March 1, 2003 - v2
Checksum:i064A1E1034DE5E0E
GO

Sequence cautioni

The sequence AAM48330.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti248 – 2481S → G in AAN71328. 1 Publication
Sequence conflicti913 – 9131V → D in AAN71328. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAF57126.2.
AY118301 mRNA. Translation: AAM48330.1. Different initiation.
BT001573 mRNA. Translation: AAN71328.1.
RefSeqiNP_651849.1. NM_143592.2.
UniGeneiDm.10912.

Genome annotation databases

EnsemblMetazoaiFBtr0085755; FBpp0085117; FBgn0039827.
GeneIDi43689.
KEGGidme:Dmel_CG1544.
UCSCiCG1544-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAF57126.2 .
AY118301 mRNA. Translation: AAM48330.1 . Different initiation.
BT001573 mRNA. Translation: AAN71328.1 .
RefSeqi NP_651849.1. NM_143592.2.
UniGenei Dm.10912.

3D structure databases

ProteinModelPortali Q9VA02.
SMRi Q9VA02. Positions 54-917.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 68534. 4 interactions.
IntActi Q9VA02. 1 interaction.
MINTi MINT-940711.

Proteomic databases

PaxDbi Q9VA02.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0085755 ; FBpp0085117 ; FBgn0039827 .
GeneIDi 43689.
KEGGi dme:Dmel_CG1544.
UCSCi CG1544-RA. d. melanogaster.

Organism-specific databases

FlyBasei FBgn0039827. CG1544.

Phylogenomic databases

eggNOGi COG0567.
GeneTreei ENSGT00530000063092.
InParanoidi Q9VA02.
KOi K15791.
OMAi LCSGKHY.
OrthoDBi EOG7CZK4Z.
PhylomeDBi Q9VA02.

Miscellaneous databases

GenomeRNAii 43689.
NextBioi 835260.
PROi Q9VA02.

Gene expression databases

Bgeei Q9VA02.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo and Head.

Entry informationi

Entry nameiDHTK1_DROME
AccessioniPrimary (citable) accession number: Q9VA02
Secondary accession number(s): Q8IGV6, Q8MT95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi