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Q9V9R2

- Q9V9R2_DROME

UniProt

Q9V9R2 - Q9V9R2_DROME

Protein
Submitted name:

Cullin-2, isoform A

Gene

Cul2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. growth of a germarium-derived egg chamber Source: FlyBase
    2. neurogenesis Source: FlyBase
    3. regulation of synaptic growth at neuromuscular junction Source: FlyBase
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cullin-2, isoform AImported
    Submitted name:
    Cullin-2, isoform BImported
    Submitted name:
    LD36177pImported
    Gene namesi
    Name:Cul2Imported
    Synonyms:Cul-2Imported, cul-2Imported
    ORF Names:CG1512Imported, Dmel_CG1512Imported
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0032956. Cul2.

    Subcellular locationi

    GO - Cellular componenti

    1. cullin-RING ubiquitin ligase complex Source: InterPro

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-904022.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cullin family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG5647.
    GeneTreeiENSGT00730000110820.
    InParanoidiQ9V9R2.
    KOiK03870.
    OMAiVMLDYVE.
    OrthoDBiEOG7X3QQG.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    InterProiIPR016157. Cullin_CS.
    IPR016158. Cullin_homology.
    IPR001373. Cullin_N.
    IPR019559. Cullin_neddylation_domain.
    IPR016159. Cullin_repeat-like_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00888. Cullin. 1 hit.
    PF10557. Cullin_Nedd8. 1 hit.
    [Graphical view]
    SMARTiSM00182. CULLIN. 1 hit.
    SM00884. Cullin_Nedd8. 1 hit.
    [Graphical view]
    SUPFAMiSSF74788. SSF74788. 1 hit.
    SSF75632. SSF75632. 1 hit.
    PROSITEiPS01256. CULLIN_1. 1 hit.
    PS50069. CULLIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9V9R2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLKPKIVEF VDVWPRLRCI AESVITLTKV ERSVWNTSFS DVYTLCVAQP    50
    EPMADRLYGE TKHFLEQHVQ EMLAKKVLIE GECSHSNGGP DLLQRYYITW 100
    MEYSQGIKYL HQLYIYLNQQ HIKKQKITDT ESFYGNLSSD AAEQMEIGEL 150
    GLDIWRLYMI EYLSSELVRH ILEGIAADRA SNGTLDHHRV QIINGVIHSF 200
    VEVQDYKKTG SLKLYQELFE GPMLEASGAY YTDEANKLLH RCSVSEYMQE 250
    VIRILEYESR RAQKFLHVSS LPKLRKECEE KFINDRLGFI YSECREMVSE 300
    ERRQDLRNMY VVLKPIPDNL KSELITTFLD HIKSEGLQTV SALKGENIHI 350
    AFVENMLKVH HKYQELIADV FENDSLFLSA LDKACASVIN RRPTERQPCR 400
    SAEYVAKYCD TLLKKSKTCE AEIDQKLTNN ITIFKYIEDK DVYQKFYSRL 450
    LAKRLIHEQS QSMDAEEGMI NRLKQACGYE FTNKLHRMFT DISVSVDLNN 500
    KFNTHLKDSN VDLGINLAIK VLQAGAWPLG STQVIPFAVP QEFEKSIKMF 550
    EDYYHKLFSG RKLTWLHHMC HGELKLSHLK KSYIVTMQTY QMAIILLFET 600
    CDSLSCREIQ NTLQLNDETF QKHMQPIIES KLLNASSENL AGETRIELNL 650
    DYTNKRTKFK ISSALQKETP QEVEHTINSV DEDRKLFLQA AIVRIMKARK 700
    VLKHNALIQE VLSLSKVSFT PNIAMIKKCV ESLIDKQYIE RTANSGDEYS 750
    YMA 753
    Length:753
    Mass (Da):87,373
    Last modified:October 1, 2002 - v3
    Checksum:i001F5ED9046DA04C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF57224.3.
    AE014134 Genomic DNA. Translation: AAG22124.2.
    AY061434 mRNA. Translation: AAL28982.1.
    RefSeqiNP_610117.1. NM_136273.3.
    NP_724352.1. NM_165390.2.
    UniGeneiDm.6467.

    Genome annotation databases

    EnsemblMetazoaiFBtr0085899; FBpp0085254; FBgn0032956.
    FBtr0085900; FBpp0085255; FBgn0032956.
    GeneIDi35420.
    KEGGidme:Dmel_CG1512.
    UCSCiCG1512-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF57224.3 .
    AE014134 Genomic DNA. Translation: AAG22124.2 .
    AY061434 mRNA. Translation: AAL28982.1 .
    RefSeqi NP_610117.1. NM_136273.3.
    NP_724352.1. NM_165390.2.
    UniGenei Dm.6467.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-904022.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0085899 ; FBpp0085254 ; FBgn0032956 .
    FBtr0085900 ; FBpp0085255 ; FBgn0032956 .
    GeneIDi 35420.
    KEGGi dme:Dmel_CG1512.
    UCSCi CG1512-RA. d. melanogaster.

    Organism-specific databases

    CTDi 35420.
    FlyBasei FBgn0032956. Cul2.

    Phylogenomic databases

    eggNOGi COG5647.
    GeneTreei ENSGT00730000110820.
    InParanoidi Q9V9R2.
    KOi K03870.
    OMAi VMLDYVE.
    OrthoDBi EOG7X3QQG.

    Miscellaneous databases

    GenomeRNAii 35420.
    NextBioi 793437.
    PROi Q9V9R2.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    InterProi IPR016157. Cullin_CS.
    IPR016158. Cullin_homology.
    IPR001373. Cullin_N.
    IPR019559. Cullin_neddylation_domain.
    IPR016159. Cullin_repeat-like_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00888. Cullin. 1 hit.
    PF10557. Cullin_Nedd8. 1 hit.
    [Graphical view ]
    SMARTi SM00182. CULLIN. 1 hit.
    SM00884. Cullin_Nedd8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF74788. SSF74788. 1 hit.
    SSF75632. SSF75632. 1 hit.
    PROSITEi PS01256. CULLIN_1. 1 hit.
    PS50069. CULLIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BerkeleyImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    4. Cited for: GENOME REANNOTATION.
      Strain: BerkeleyImported.
    5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
      Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
      Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
      Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
      Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    7. "Combined evidence annotation of transposable elements in genome sequences."
      Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
      PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    9. "Drosophila melanogaster release 4 sequence."
      Berkeley Drosophila Genome Project
      Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
      Smith C.D., Shu S., Mungall C.J., Karpen G.H.
      Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    12. FlyBase
      Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9V9R2_DROME
    AccessioniPrimary (citable) accession number: Q9V9R2
    Secondary accession number(s): Q95RE8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3