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Q9V9R2

- Q9V9R2_DROME

UniProt

Q9V9R2 - Q9V9R2_DROME

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Protein
Submitted name:

Cullin 2, isoform A

Gene

Cul2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. growth of a germarium-derived egg chamber Source: FlyBase
  2. neurogenesis Source: FlyBase
  3. regulation of synaptic growth at neuromuscular junction Source: FlyBase
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cullin 2, isoform AImported
Submitted name:
Cullin 2, isoform BImported
Submitted name:
LD36177pImported
Gene namesi
Name:Cul2Imported
Synonyms:Cul-2Imported, cul-2Imported
ORF Names:CG1512Imported, Dmel_CG1512Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0032956. Cul2.

Subcellular locationi

GO - Cellular componenti

  1. cullin-RING ubiquitin ligase complex Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

MINTiMINT-904022.

Family & Domainsi

Sequence similaritiesi

Belongs to the cullin family.UniRule annotation

Phylogenomic databases

eggNOGiCOG5647.
GeneTreeiENSGT00760000119212.
KOiK03870.
OMAiVMLDYVE.
OrthoDBiEOG7X3QQG.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR016157. Cullin_CS.
IPR016158. Cullin_homology.
IPR001373. Cullin_N.
IPR019559. Cullin_neddylation_domain.
IPR016159. Cullin_repeat-like_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00888. Cullin. 1 hit.
PF10557. Cullin_Nedd8. 1 hit.
[Graphical view]
SMARTiSM00182. CULLIN. 1 hit.
SM00884. Cullin_Nedd8. 1 hit.
[Graphical view]
SUPFAMiSSF74788. SSF74788. 1 hit.
SSF75632. SSF75632. 1 hit.
PROSITEiPS01256. CULLIN_1. 1 hit.
PS50069. CULLIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V9R2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLKPKIVEF VDVWPRLRCI AESVITLTKV ERSVWNTSFS DVYTLCVAQP
60 70 80 90 100
EPMADRLYGE TKHFLEQHVQ EMLAKKVLIE GECSHSNGGP DLLQRYYITW
110 120 130 140 150
MEYSQGIKYL HQLYIYLNQQ HIKKQKITDT ESFYGNLSSD AAEQMEIGEL
160 170 180 190 200
GLDIWRLYMI EYLSSELVRH ILEGIAADRA SNGTLDHHRV QIINGVIHSF
210 220 230 240 250
VEVQDYKKTG SLKLYQELFE GPMLEASGAY YTDEANKLLH RCSVSEYMQE
260 270 280 290 300
VIRILEYESR RAQKFLHVSS LPKLRKECEE KFINDRLGFI YSECREMVSE
310 320 330 340 350
ERRQDLRNMY VVLKPIPDNL KSELITTFLD HIKSEGLQTV SALKGENIHI
360 370 380 390 400
AFVENMLKVH HKYQELIADV FENDSLFLSA LDKACASVIN RRPTERQPCR
410 420 430 440 450
SAEYVAKYCD TLLKKSKTCE AEIDQKLTNN ITIFKYIEDK DVYQKFYSRL
460 470 480 490 500
LAKRLIHEQS QSMDAEEGMI NRLKQACGYE FTNKLHRMFT DISVSVDLNN
510 520 530 540 550
KFNTHLKDSN VDLGINLAIK VLQAGAWPLG STQVIPFAVP QEFEKSIKMF
560 570 580 590 600
EDYYHKLFSG RKLTWLHHMC HGELKLSHLK KSYIVTMQTY QMAIILLFET
610 620 630 640 650
CDSLSCREIQ NTLQLNDETF QKHMQPIIES KLLNASSENL AGETRIELNL
660 670 680 690 700
DYTNKRTKFK ISSALQKETP QEVEHTINSV DEDRKLFLQA AIVRIMKARK
710 720 730 740 750
VLKHNALIQE VLSLSKVSFT PNIAMIKKCV ESLIDKQYIE RTANSGDEYS

YMA
Length:753
Mass (Da):87,373
Last modified:October 1, 2002 - v3
Checksum:i001F5ED9046DA04C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014134 Genomic DNA. Translation: AAF57224.3.
AE014134 Genomic DNA. Translation: AAG22124.2.
AY061434 mRNA. Translation: AAL28982.1.
RefSeqiNP_610117.1. NM_136273.3.
NP_724352.1. NM_165390.2.
UniGeneiDm.6467.

Genome annotation databases

EnsemblMetazoaiFBtr0085899; FBpp0085254; FBgn0032956.
FBtr0085900; FBpp0085255; FBgn0032956.
GeneIDi35420.
KEGGidme:Dmel_CG1512.
UCSCiCG1512-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014134 Genomic DNA. Translation: AAF57224.3 .
AE014134 Genomic DNA. Translation: AAG22124.2 .
AY061434 mRNA. Translation: AAL28982.1 .
RefSeqi NP_610117.1. NM_136273.3.
NP_724352.1. NM_165390.2.
UniGenei Dm.6467.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-904022.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0085899 ; FBpp0085254 ; FBgn0032956 .
FBtr0085900 ; FBpp0085255 ; FBgn0032956 .
GeneIDi 35420.
KEGGi dme:Dmel_CG1512.
UCSCi CG1512-RA. d. melanogaster.

Organism-specific databases

CTDi 8453.
FlyBasei FBgn0032956. Cul2.

Phylogenomic databases

eggNOGi COG5647.
GeneTreei ENSGT00760000119212.
KOi K03870.
OMAi VMLDYVE.
OrthoDBi EOG7X3QQG.

Miscellaneous databases

GenomeRNAii 35420.
NextBioi 793437.
PROi Q9V9R2.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
InterProi IPR016157. Cullin_CS.
IPR016158. Cullin_homology.
IPR001373. Cullin_N.
IPR019559. Cullin_neddylation_domain.
IPR016159. Cullin_repeat-like_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00888. Cullin. 1 hit.
PF10557. Cullin_Nedd8. 1 hit.
[Graphical view ]
SMARTi SM00182. CULLIN. 1 hit.
SM00884. Cullin_Nedd8. 1 hit.
[Graphical view ]
SUPFAMi SSF74788. SSF74788. 1 hit.
SSF75632. SSF75632. 1 hit.
PROSITEi PS01256. CULLIN_1. 1 hit.
PS50069. CULLIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  4. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. FlyBase
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9V9R2_DROME
AccessioniPrimary (citable) accession number: Q9V9R2
Secondary accession number(s): Q95RE8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3