Q9V9C8 (Q9V9C8_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
BG1 EMBL AAF44324.1

Submitted name:
Bcl-2 ortholog dBorg-1 EMBL AAF44714.1
Submitted name:
Death executioner Bcl-2 homologue EMBL AAF57365.2
Submitted name:
Drob-1 EMBL BAA89603.2
Submitted name:
IP01389p EMBL AAY51552.1
Submitted name:
Proapoptotic Bcl-2 homolog DEBCL EMBL AAF26289.1

Gene names

Name:	debcl FlyBase FBgn0029131 EMBL AAF26289.1
Synonyms:	dborg1 EMBL AAF44714.1, drob-1 EMBL BAA89603.2
ORF Names:	CG33134 FlyBase FBgn0029131, Dmel_CG33134 EMBL AAF57365.2

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome] EMBL BAA89603.2

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	induction of apoptosis Inferred from mutant phenotype Ref.2. Source: FlyBase intrinsic apoptotic signaling pathway in response to DNA damage Inferred from mutant phenotype Ref.1. Source: FlyBase negative regulation of neuron apoptotic process Inferred from mutant phenotype PubMed 16001086. Source: FlyBase neuron homeostasis Inferred from genetic interaction PubMed 22153373. Source: FlyBase
Cellular_component	mitochondrial envelope Inferred from direct assay PubMed 10639136. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9V9C8 [UniParc]. Last modified October 1, 2000. Version 2. Checksum: FF29E0ADCF3D0942	FASTA	300	32,940
	10 20 30 40 50 60 MAPTTSPPPK LAKFKSSSLD HEIYTANRRG TIATASSDWK ALRGGVGGGA GGPGSVPNPS 70 80 90 100 110 120 NGRSLHAGGP MTRAASTSSL ASSTRTMTNY QEYKMDIINQ GKCLCGQYIR ARLRRAGVLN 130 140 150 160 170 180 RKVTQRLRNI LDPGSSHVVY EVFPALNSMG EELERMHPRV YTNISRQLSR APFGELEDSD 190 200 210 220 230 240 MAPMLLNLVA KDLFRSSITW GKIISIFAVC GGFAIDCVRQ GHFDYLQCLI DGLAEIIEDD 250 260 270 280 290 300 LVYWLIDNGG WLGLSRHIRP RVGEFTFLGW LTLFVTISAG AYMVSNVCRR IGGQLYSLLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Drosophila bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation." Brachmann C.B., Jassim O.W., Wachsmuth B.D., Cagan R.L. Curr. Biol. 10:547-550(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery." Colussi P.A., Quinn L.M., Huang D.C., Coombe M., Read S.H., Richardson H., Kumar S. J. Cell Biol. 148:703-714(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death." Igaki T., Kanuka H., Inohara N., Sawamoto K., Nunez G., Okano H., Miura M. Proc. Natl. Acad. Sci. U.S.A. 97:662-667(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[4]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[5]	"Potential Drosophila homologue of Bcl-2-related Ovarian Killer (BOK)." Zhou L., Steller H. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[6]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[7]	Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J., Park S., Wan K., Yu C., Celniker S. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF178430 mRNA. Translation: AAF26289.1. AF222004 mRNA. Translation: AAF44324.1. AF244352 mRNA. Translation: AAF44714.1. AE013599 Genomic DNA. Translation: AAF57365.2. BT022157 mRNA. Translation: AAY51552.1. AB032430 mRNA. Translation: BAA89603.2.
RefSeq	NP_788278.1. NM_176098.3.
UniGene	Dm.1719.
3D structure databases
SMR	Q9V9C8. Positions 101-261.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-977316.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0086108; FBpp0085443; FBgn0029131.
GeneID	53585.
KEGG	dme:Dmel_CG33134.
UCSC	CG33134-RA. d. melanogaster.
Organism-specific databases
CTD	53585.
FlyBase	FBgn0029131. debcl.
Phylogenomic databases
GeneTree	ENSGT00510000048498.
InParanoid	Q9V9C8.
OMA	FRSSITW.
Family and domain databases
InterPro	IPR002475. Bcl2-like. IPR026298. Blc2_fam. [Graphical view]
PANTHER	PTHR11256. PTHR11256. 1 hit.
Pfam	PF00452. Bcl-2. 1 hit. [Graphical view]
PRINTS	PR01862. BCL2FAMILY.
PROSITE	PS50062. BCL2_FAMILY. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	53585.
NextBio	841482.

Entry information

Entry name

Q9V9C8_DROME

Accession

Primary (citable) accession number: Q9V9C8

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)