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Protein
Submitted name:

BG1

Gene

Debcl

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: FlyBase
  • apoptotic process involved in morphogenesis Source: FlyBase
  • cellular response to starvation Source: FlyBase
  • developmental programmed cell death Source: FlyBase
  • ectopic germ cell programmed cell death Source: FlyBase
  • extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: FlyBase
  • negative regulation of apoptotic process Source: FlyBase
  • negative regulation of neuron apoptotic process Source: FlyBase
  • neuron cellular homeostasis Source: FlyBase
  • positive regulation of macroautophagy Source: FlyBase
  • regulation of mitochondrial membrane permeability Source: FlyBase
  • regulation of programmed cell death Source: FlyBase
  • response to ionizing radiation Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
BG1Imported
Submitted name:
Bcl-2 ortholog dBorg-1Imported
Submitted name:
Death executioner Bcl-2 homologueImported
Submitted name:
Drob-1Imported
Submitted name:
IP01389pImported
Submitted name:
Proapoptotic Bcl-2 homolog DEBCLImported
Gene namesi
Name:DebclImported
Synonyms:dborg1Imported, debclImported, drob-1Imported
ORF Names:CG33134Imported, Dmel_CG33134Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0029131. Debcl.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei265 – 28420HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial envelope Source: FlyBase
  • mitochondrial outer membrane Source: GO_Central
  • mitochondrion Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-977316.
STRINGi7227.FBpp0085443.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
GeneTreeiENSGT00510000048498.
KOiK02561.
OMAiSNVCRRI.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V9C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTTSPPPK LAKFKSSSLD HEIYTANRRG TIATASSDWK ALRGGVGGGA
60 70 80 90 100
GGPGSVPNPS NGRSLHAGGP MTRAASTSSL ASSTRTMTNY QEYKMDIINQ
110 120 130 140 150
GKCLCGQYIR ARLRRAGVLN RKVTQRLRNI LDPGSSHVVY EVFPALNSMG
160 170 180 190 200
EELERMHPRV YTNISRQLSR APFGELEDSD MAPMLLNLVA KDLFRSSITW
210 220 230 240 250
GKIISIFAVC GGFAIDCVRQ GHFDYLQCLI DGLAEIIEDD LVYWLIDNGG
260 270 280 290 300
WLGLSRHIRP RVGEFTFLGW LTLFVTISAG AYMVSNVCRR IGGQLYSLLF
Length:300
Mass (Da):32,940
Last modified:October 1, 2000 - v2
Checksum:iFF29E0ADCF3D0942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178430 mRNA. Translation: AAF26289.1.
AF222004 mRNA. Translation: AAF44324.1.
AF244352 mRNA. Translation: AAF44714.1.
AE013599 Genomic DNA. Translation: AAF57365.2.
BT022157 mRNA. Translation: AAY51552.1.
AB032430 mRNA. Translation: BAA89603.2.
RefSeqiNP_788278.1. NM_176098.3.
UniGeneiDm.1719.

Genome annotation databases

EnsemblMetazoaiFBtr0086108; FBpp0085443; FBgn0029131.
GeneIDi53585.
KEGGidme:Dmel_CG33134.
UCSCiCG33134-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178430 mRNA. Translation: AAF26289.1.
AF222004 mRNA. Translation: AAF44324.1.
AF244352 mRNA. Translation: AAF44714.1.
AE013599 Genomic DNA. Translation: AAF57365.2.
BT022157 mRNA. Translation: AAY51552.1.
AB032430 mRNA. Translation: BAA89603.2.
RefSeqiNP_788278.1. NM_176098.3.
UniGeneiDm.1719.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-977316.
STRINGi7227.FBpp0085443.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0086108; FBpp0085443; FBgn0029131.
GeneIDi53585.
KEGGidme:Dmel_CG33134.
UCSCiCG33134-RA. d. melanogaster.

Organism-specific databases

CTDi53585.
FlyBaseiFBgn0029131. Debcl.

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
GeneTreeiENSGT00510000048498.
KOiK02561.
OMAiSNVCRRI.

Miscellaneous databases

GenomeRNAii53585.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Drosophila bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation."
    Brachmann C.B., Jassim O.W., Wachsmuth B.D., Cagan R.L.
    Curr. Biol. 10:547-550(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery."
    Colussi P.A., Quinn L.M., Huang D.C., Coombe M., Read S.H., Richardson H., Kumar S.
    J. Cell Biol. 148:703-714(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death."
    Igaki T., Kanuka H., Inohara N., Sawamoto K., Nunez G., Okano H., Miura M.
    Proc. Natl. Acad. Sci. U.S.A. 97:662-667(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Potential Drosophila homologue of Bcl-2-related Ovarian Killer (BOK)."
    Zhou L., Steller H.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  8. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  9. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  10. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J., Park S., Wan K., Yu C., Celniker S.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  13. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  14. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  15. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  16. FlyBase
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9V9C8_DROME
AccessioniPrimary (citable) accession number: Q9V9C8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.