Reviewed,
UniProtKB/Swiss-Prot Q9V9A7 (MCCB_DROME)
Last modified
January 19, 2010.
Version 67.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial Short name=MCCase subunit beta EC=6.4.1.4 Alternative name(s): 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit 3-methylcrotonyl-CoA carboxylase 2 | ||||
| Gene names |
| ||||
| Organism | Drosophila melanogaster (Fruit fly) [Complete proteome] | ||||
| Taxonomic identifier | 7227 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 578 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Vital for adult survival. Ref.3 |
| Catalytic activity | ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA. |
| Pathway | |
| Subcellular location | Mitochondrion matrix By similarity UniProtKB P07633. |
| Tissue specificity | Expressed in third instar larval ring gland (lateral and medial secretory cells and corpus cardiacum cells) and CNS. Ref.3 |
| Sequence similarities | Contains 1 carboxyltransferase domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – ? | Mitochondrion By similarity UniProtKB P07633 | |||||||
| Chain | ? – 578 | Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial | PRO_0000000297 | ||||||
Regions | |||||||||
| Domain | 54 – 572 | 519 | Carboxyltransferase | ||||||
| Region | 355 – 388 | 34 | Acyl-CoA binding Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 50 | 1 | S → R Ref.3 | ||||||
| Sequence conflict | 96 | 1 | F → G Ref.3 | ||||||
| Sequence conflict | 277 | 1 | L → V Ref.3 | ||||||
| Sequence conflict | 330 | 1 | E → R Ref.3 | ||||||
| Sequence conflict | 376 – 377 | 2 | KL → NV Ref.3 | ||||||
| Sequence conflict | 422 | 1 | Missing Ref.3 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE013599 Genomic DNA. Translation: AAM70824.1. AF006654 mRNA. Translation: AAB62570.1. |
| RefSeq | NP_652724.1. |
| UniGene | Dm.5216 |
3D structure databases | |
| SMR | Q9V9A7. Positions 45-576. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9V9A7. |
Proteomic databases | |
| PRIDE | Q9V9A7. |
Genome annotation databases | |
| Ensembl | FBtr0086126; FBpp0085460; FBgn0042083; Drosophila melanogaster. [Genome view] |
| GeneID | 59261. |
| KEGG | dme:Dmel_CG3267. |
| NMPDR | fig|7227.3.peg.3506. |
| UCSC | CG3267-RA. d. melanogaster. |
Organism-specific databases | |
| FlyBase | FBgn0042083. CG3267. |
Phylogenomic databases | |
| InParanoid | Q9V9A7. |
| OMA | AYHGDSV. |
| OrthoDB | EOG9B2T3K. |
| PhylomeDB | Q9V9A7. |
Enzyme and pathway databases | |
| BioCyc | DMEL-XXX-02:DMEL-XXX-02-003088-MONOMER. |
| BRENDA | 6.4.1.4. 48. |
Gene expression databases | |
| ArrayExpress | Q9V9A7. |
| GermOnline | CG3267. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR000022. Carboxyl_trans. IPR011763. COA_CT_C. IPR011762. COA_CT_N. [Graphical view] |
| Pfam | PF01039. Carboxyl_trans. 1 hit. [Graphical view] |
| PROSITE | PS50989. COA_CT_CTER. 1 hit. PS50980. COA_CT_NTER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 841761. |
Entry information
| Entry name | MCCB_DROME | ||||||||
| Accession | Primary (citable) accession number: Q9V9A7 Secondary accession number(s): O18364 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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