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Protein

Ragulator complex protein LAMTOR2 homolog

Gene

CG5189

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular protein localization Source: UniProtKB
  • cellular response to amino acid stimulus Source: FlyBase
  • positive regulation of TOR signaling Source: UniProtKB
  • regulation of cell growth Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-DME-1632852. Macroautophagy.
R-DME-166208. mTORC1-mediated signalling.
R-DME-380972. Energy dependent regulation of mTOR by LKB1-AMPK.
R-DME-5628897. TP53 Regulates Metabolic Genes.
R-DME-5674135. MAP2K and MAPK activation.
R-DME-6798695. Neutrophil degranulation.
R-DME-8943724. Regulation of PTEN gene transcription.

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR2 homolog
Alternative name(s):
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2
Gene namesi
ORF Names:CG5189
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034350. CG5189.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002209631 – 125Ragulator complex protein LAMTOR2 homologAdd BLAST125

Proteomic databases

PaxDbiQ9V8I2.
PRIDEiQ9V8I2.

Expressioni

Gene expression databases

BgeeiFBgn0034350.
GenevisibleiQ9V8I2. DM.

Interactioni

Subunit structurei

Part of the Ragulator complex composed of CG5110, CG5189, CG14184, CG14812, and CG14977.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi62798. 2 interactors.
DIPiDIP-21855N.
IntActiQ9V8I2. 2 interactors.
STRINGi7227.FBpp0289083.

Structurei

3D structure databases

ProteinModelPortaliQ9V8I2.
SMRiQ9V8I2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAMAD family.Curated

Phylogenomic databases

eggNOGiKOG4107. Eukaryota.
ENOG4111GWH. LUCA.
GeneTreeiENSGT00390000006100.
InParanoidiQ9V8I2.
KOiK20398.
OMAiIWSAYEK.
OrthoDBiEOG091G0W0V.
PhylomeDBiQ9V8I2.

Family and domain databases

InterProiView protein in InterPro
IPR037587. LAMTOR2-like.
IPR004942. Roadblock/LAMTOR2_dom.
PANTHERiPTHR13323. PTHR13323. 1 hit.
PfamiView protein in Pfam
PF03259. Robl_LC7. 1 hit.
SMARTiView protein in SMART
SM00960. Robl_LC7. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9V8I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKPKALTQV LSQANTGGVE NTLLLSQEGA LLAYSGYGDK DARITAAIAS
60 70 80 90 100
NIWAAYEKHG RNAFREGRLT FVLIDCENGH VAITQVASVL LCLYAKQTVG
110 120
LGLLKQKAMS LASYLERPLK QISAS
Length:125
Mass (Da):13,439
Last modified:May 1, 2000 - v1
Checksum:i2C1E2A6199225AD1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80H → L in AAR31126 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57685.1.
AE013599 Genomic DNA. Translation: ACL83153.1.
BT011055 mRNA. Translation: AAR31126.1.
BT030774 mRNA. Translation: ABV82156.1.
BT058093 mRNA. Translation: ACM86249.1.
RefSeqiNP_001137699.1. NM_001144227.2.
NP_611334.1. NM_137490.3.
UniGeneiDm.6593.

Genome annotation databases

EnsemblMetazoaiFBtr0086694; FBpp0085873; FBgn0034350.
FBtr0299805; FBpp0289083; FBgn0034350.
GeneIDi37122.
KEGGidme:Dmel_CG5189.
UCSCiCG5189-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiLTOR2_DROME
AccessioniPrimary (citable) accession number: Q9V8I2
Secondary accession number(s): A8E6I2, B7YZK0, Q6NP73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome