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Q9V813

- MTAP_DROME

UniProt

Q9V813 - MTAP_DROME

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Protein
S-methyl-5'-thioadenosine phosphorylase
Gene
Mtap, CG4802
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei24 – 241Phosphate By similarity
Sitei184 – 1841Important for substrate specificity By similarity
Binding sitei202 – 2021Substrate; via amide nitrogen By similarity
Binding sitei203 – 2031Phosphate By similarity
Sitei239 – 2391Important for substrate specificity By similarity

GO - Molecular functioni

  1. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP
  2. phosphorylase activity Source: InterPro

GO - Biological processi

  1. L-methionine salvage from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

ReactomeiREACT_180809. Methionine salvage pathway.
SignaLinkiQ9V813.
UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylase (EC:2.4.2.28)
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name:
MTA phosphorylase
Short name:
MTAP
Short name:
MTAPase
Gene namesi
Name:Mtap
ORF Names:CG4802
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034215. Mtap.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible auditory phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289S-methyl-5'-thioadenosine phosphorylaseUniRule annotation
PRO_0000184548Add
BLAST

Proteomic databases

PaxDbiQ9V813.
PRIDEiQ9V813.

Expressioni

Tissue specificityi

In embryos, expressed in the fat body and visceral mesoderm.1 Publication

Gene expression databases

BgeeiQ9V813.

Interactioni

Subunit structurei

Homotrimer By similarity.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
Klp59CQ9W1U41EBI-124076,EBI-99880

Protein-protein interaction databases

BioGridi62649. 5 interactions.
DIPiDIP-20687N.
IntActiQ9V813. 14 interactions.
MINTiMINT-287272.
STRINGi7227.FBpp0086072.

Structurei

3D structure databases

ProteinModelPortaliQ9V813.
SMRiQ9V813. Positions 16-277.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 672Phosphate binding By similarity
Regioni99 – 1002Phosphate binding By similarity
Regioni226 – 2283Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0005.
GeneTreeiENSGT00550000074874.
InParanoidiQ9V813.
KOiK00772.
OrthoDBiEOG771270.
PhylomeDBiQ9V813.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.
PROSITEiPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V813-1 [UniParc]FASTAAdd to Basket

« Hide

MITIKCKDTN LDPLPVKIGI IGGSGLDDPD ILEQRQERVV ETPYGEPSDA    50
LIEGEINGVQ CVLLARHGRK HDIMPSNVNY RANIWALRDV GCTHLIVSTA 100
CGSLREEIKP GNLVVPHDFI DRTTKRLQTF YDGKAQSPRG VCHLPMFPAF 150
SERTRNILLQ AAKELEIPAH DKATIVTIEG PRFSSRSESH MFRQWGGDLI 200
NMTTCPEVVL AKEAGLLYGS VAIATDYDCW RMGCEGVNVQ DVLRTFAENV 250
IKVKKILVNA VGRIAKEDWS EDILNAKQCV CNNTMSGAM 289
Length:289
Mass (Da):32,018
Last modified:May 1, 2000 - v1
Checksum:i387328BCAFD5E6D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013599 Genomic DNA. Translation: AAF57869.1.
BT004912 mRNA. Translation: AAO49165.1.
RefSeqiNP_611208.1. NM_137364.3.
UniGeneiDm.11469.

Genome annotation databases

EnsemblMetazoaiFBtr0086916; FBpp0086072; FBgn0034215.
GeneIDi36955.
KEGGidme:Dmel_CG4802.
UCSCiCG4802-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013599 Genomic DNA. Translation: AAF57869.1 .
BT004912 mRNA. Translation: AAO49165.1 .
RefSeqi NP_611208.1. NM_137364.3.
UniGenei Dm.11469.

3D structure databases

ProteinModelPortali Q9V813.
SMRi Q9V813. Positions 16-277.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 62649. 5 interactions.
DIPi DIP-20687N.
IntActi Q9V813. 14 interactions.
MINTi MINT-287272.
STRINGi 7227.FBpp0086072.

Proteomic databases

PaxDbi Q9V813.
PRIDEi Q9V813.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0086916 ; FBpp0086072 ; FBgn0034215 .
GeneIDi 36955.
KEGGi dme:Dmel_CG4802.
UCSCi CG4802-RA. d. melanogaster.

Organism-specific databases

FlyBasei FBgn0034215. Mtap.

Phylogenomic databases

eggNOGi COG0005.
GeneTreei ENSGT00550000074874.
InParanoidi Q9V813.
KOi K00772.
OrthoDBi EOG771270.
PhylomeDBi Q9V813.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .
Reactomei REACT_180809. Methionine salvage pathway.
SignaLinki Q9V813.

Miscellaneous databases

GenomeRNAii 36955.
NextBioi 801212.
PROi Q9V813.

Gene expression databases

Bgeei Q9V813.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
PROSITEi PS01240. PNP_MTAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Ovary.
  4. "Methylthioadenosine phosphorylase (MTAP) in hearing: gene disruption by chromosomal rearrangement in a hearing impaired individual and model organism analysis."
    Williamson R.E., Darrow K.N., Michaud S., Jacobs J.S., Jones M.C., Eberl D.F., Maas R.L., Liberman M.C., Morton C.C.
    Am. J. Med. Genet. A 143:1630-1639(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiMTAP_DROME
AccessioniPrimary (citable) accession number: Q9V813
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 24, 2002
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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