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Q9V7U0 (RESIL_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pro-resilin
Gene names
Name:resilin
ORF Names:CG15920
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length620 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a central role in insect flight by providing low stiffness, high strain and efficient energy storage Probable.

Developmental stage

Expressed at pupal stage only. Ref.5

Biotechnological use

Its strong elasticity suggests that it may be used for industrial and pharmaceutical applications. Recombinant protein can be cast into a rubber-like biomaterial by rapid photochemical cross-linking. The resilience (recovery after deformation) of cross-linked recombinant resilin exceeds that of unfilled synthetic polybutadiene, a high resilience rubber. Ref.5

Sequence similarities

Contains 1 chitin-binding type R&R domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A Ref.1 (identifier: Q9V7U0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform B Ref.1 (identifier: Q9V7U0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     341-385: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 620603Pro-resilin
PRO_0000042845

Regions

Repeat42 – 5615Elastic 1
Repeat57 – 7721Elastic 2
Repeat78 – 9720Elastic 3
Repeat98 – 11215Elastic 4
Repeat113 – 12715Elastic 5
Repeat128 – 14518Elastic 6
Repeat146 – 16419Elastic 7
Repeat165 – 17915Elastic 8
Repeat180 – 19415Elastic 9
Repeat195 – 21016Elastic 10
Repeat211 – 22515Elastic 11
Repeat226 – 24419Elastic 12
Repeat245 – 26218Elastic 13
Repeat263 – 27614Elastic 14
Repeat277 – 29216Elastic 15
Repeat293 – 30715Elastic 16
Repeat308 – 32417Elastic 17
Domain342 – 41574Chitin-binding type R&R
Compositional bias34 – 617584Gly-rich
Compositional bias168 – 1714Poly-Ser

Natural variations

Alternative sequence341 – 38545Missing in isoform B. Ref.1
VSP_051872

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 432AFA06E54CB6BA

FASTA62058,604
        10         20         30         40         50         60 
MFKLLGLTLL MAMVVLGRPE PPVNSYLPPS DSYGAPGQSG PGGRPSDSYG APGGGNGGRP 

        70         80         90        100        110        120 
SDSYGAPGQG QGQGQGQGGY AGKPSDTYGA PGGGNGNGGR PSSSYGAPGG GNGGRPSDTY 

       130        140        150        160        170        180 
GAPGGGNGGR PSDTYGAPGG GGNGNGGRPS SSYGAPGQGQ GNGNGGRSSS SYGAPGGGNG 

       190        200        210        220        230        240 
GRPSDTYGAP GGGNGGRPSD TYGAPGGGNN GGRPSSSYGA PGGGNGGRPS DTYGAPGGGN 

       250        260        270        280        290        300 
GNGSGGRPSS SYGAPGQGQG GFGGRPSDSY GAPGQNQKPS DSYGAPGSGN GNGGRPSSSY 

       310        320        330        340        350        360 
GAPGSGPGGR PSDSYGPPAS GSGAGGAGGS GPGGADYDND EPAKYEFNYQ VEDAPSGLSF 

       370        380        390        400        410        420 
GHSEMRDGDF TTGQYNVLLP DGRKQIVEYE ADQQGYRPQI RYEGDANDGS GPSGPGGPGG 

       430        440        450        460        470        480 
QNLGADGYSS GRPGNGNGNG NGGYSGGRPG GQDLGPSGYS GGRPGGQDLG AGGYSNGKPG 

       490        500        510        520        530        540 
GQDLGPGGYS GGRPGGQDLG RDGYSGGRPG GQDLGASGYS NGRPGGNGNG GSDGGRVIIG 

       550        560        570        580        590        600 
GRVIGGQDGG DQGYSGGRPG GQDLGRDGYS SGRPGGRPGG NGQDSQDGQG YSSGRPGQGG 

       610        620 
RNGFGPGGQN GDNDGSGYRY 

« Hide

Isoform B [UniParc].

Checksum: D234139F8273427D
Show »

FASTA57553,526

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
Strain: Berkeley.
[3]Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A. expand/collapse author list , Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
Strain: Berkeley.
Tissue: Testis.
[4]"Tentative identification of a resilin gene in Drosophila melanogaster."
Ardell D.H., Andersen S.O.
Insect Biochem. Mol. Biol. 31:965-970(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]"Synthesis and properties of crosslinked recombinant pro-resilin."
Elvin C.M., Carr A.G., Huson M.G., Maxwell J.M., Pearson R.D., Vuocolo T., Liyou N.E., Wong D.C.C., Merritt D.J., Dixon N.E.
Nature 437:999-1002(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE, BIOTECHNOLOGICAL RELEVANCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013599 Genomic DNA. Translation: AAF57953.1.
AE013599 Genomic DNA. Translation: AAS64829.1.
BT003322 mRNA. Translation: AAO25082.1.
RefSeqNP_611157.1. NM_137313.3. [Q9V7U0-1]
NP_995860.1. NM_206138.2. [Q9V7U0-2]
UniGeneDm.19192.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid62589. 1 interaction.
MINTMINT-1724311.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0087024; FBpp0086175; FBgn0034157. [Q9V7U0-1]
GeneID36880.
KEGGdme:Dmel_CG15920.
UCSCCG15920-RA. d. melanogaster. [Q9V7U0-1]

Organism-specific databases

CTD36880.
FlyBaseFBgn0034157. resilin.

Phylogenomic databases

eggNOGNOG12793.
GeneTreeENSGT00730000112526.
InParanoidQ9V7U0.
OMADLGQNGY.
OrthoDBEOG7H4DW0.
PhylomeDBQ9V7U0.

Gene expression databases

BgeeQ9V7U0.

Family and domain databases

InterProIPR000618. Insect_cuticle.
[Graphical view]
PROSITEPS00233. CHIT_BIND_RR_1. 1 hit.
PS51155. CHIT_BIND_RR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi36880.
NextBio800852.

Entry information

Entry nameRESIL_DROME
AccessionPrimary (citable) accession number: Q9V7U0
Secondary accession number(s): Q86P83
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase