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Q9V7U0

- RESIL_DROME

UniProt

Q9V7U0 - RESIL_DROME

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Protein

Pro-resilin

Gene
resilin, CG15920
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a central role in insect flight by providing low stiffness, high strain and efficient energy storage Inferred.

GO - Molecular functioni

  1. chitin binding Source: FlyBase
  2. extracellular matrix constituent conferring elasticity Source: UniProtKB
  3. structural constituent of chitin-based larval cuticle Source: FlyBase
  4. structural constituent of cuticle Source: UniProtKB

GO - Biological processi

  1. chitin-based cuticle development Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-resilin
Gene namesi
Name:resilin
ORF Names:CG15920
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034157. resilin.

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: FlyBase
  2. extracellular region Source: UniProtKB
  3. protein-carbohydrate complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cuticle

Pathology & Biotechi

Biotechnological usei

Its strong elasticity suggests that it may be used for industrial and pharmaceutical applications. Recombinant protein can be cast into a rubber-like biomaterial by rapid photochemical cross-linking. The resilience (recovery after deformation) of cross-linked recombinant resilin exceeds that of unfilled synthetic polybutadiene, a high resilience rubber.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 620603Pro-resilinPRO_0000042845Add
BLAST

Expressioni

Developmental stagei

Expressed at pupal stage only.1 Publication

Gene expression databases

BgeeiQ9V7U0.

Interactioni

Protein-protein interaction databases

BioGridi62589. 1 interaction.
MINTiMINT-1724311.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati42 – 5615Elastic 1Add
BLAST
Repeati57 – 7721Elastic 2Add
BLAST
Repeati78 – 9720Elastic 3Add
BLAST
Repeati98 – 11215Elastic 4Add
BLAST
Repeati113 – 12715Elastic 5Add
BLAST
Repeati128 – 14518Elastic 6Add
BLAST
Repeati146 – 16419Elastic 7Add
BLAST
Repeati165 – 17915Elastic 8Add
BLAST
Repeati180 – 19415Elastic 9Add
BLAST
Repeati195 – 21016Elastic 10Add
BLAST
Repeati211 – 22515Elastic 11Add
BLAST
Repeati226 – 24419Elastic 12Add
BLAST
Repeati245 – 26218Elastic 13Add
BLAST
Repeati263 – 27614Elastic 14Add
BLAST
Repeati277 – 29216Elastic 15Add
BLAST
Repeati293 – 30715Elastic 16Add
BLAST
Repeati308 – 32417Elastic 17Add
BLAST
Domaini342 – 41574Chitin-binding type R&RAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 617584Gly-richAdd
BLAST
Compositional biasi168 – 1714Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000112526.
InParanoidiQ9V7U0.
OMAiDLGQNGY.
OrthoDBiEOG7H4DW0.
PhylomeDBiQ9V7U0.

Family and domain databases

InterProiIPR000618. Insect_cuticle.
[Graphical view]
PROSITEiPS00233. CHIT_BIND_RR_1. 1 hit.
PS51155. CHIT_BIND_RR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A1 Publication (identifier: Q9V7U0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFKLLGLTLL MAMVVLGRPE PPVNSYLPPS DSYGAPGQSG PGGRPSDSYG    50
APGGGNGGRP SDSYGAPGQG QGQGQGQGGY AGKPSDTYGA PGGGNGNGGR 100
PSSSYGAPGG GNGGRPSDTY GAPGGGNGGR PSDTYGAPGG GGNGNGGRPS 150
SSYGAPGQGQ GNGNGGRSSS SYGAPGGGNG GRPSDTYGAP GGGNGGRPSD 200
TYGAPGGGNN GGRPSSSYGA PGGGNGGRPS DTYGAPGGGN GNGSGGRPSS 250
SYGAPGQGQG GFGGRPSDSY GAPGQNQKPS DSYGAPGSGN GNGGRPSSSY 300
GAPGSGPGGR PSDSYGPPAS GSGAGGAGGS GPGGADYDND EPAKYEFNYQ 350
VEDAPSGLSF GHSEMRDGDF TTGQYNVLLP DGRKQIVEYE ADQQGYRPQI 400
RYEGDANDGS GPSGPGGPGG QNLGADGYSS GRPGNGNGNG NGGYSGGRPG 450
GQDLGPSGYS GGRPGGQDLG AGGYSNGKPG GQDLGPGGYS GGRPGGQDLG 500
RDGYSGGRPG GQDLGASGYS NGRPGGNGNG GSDGGRVIIG GRVIGGQDGG 550
DQGYSGGRPG GQDLGRDGYS SGRPGGRPGG NGQDSQDGQG YSSGRPGQGG 600
RNGFGPGGQN GDNDGSGYRY 620

Note: No experimental confirmation available.

Length:620
Mass (Da):58,604
Last modified:May 1, 2000 - v1
Checksum:i432AFA06E54CB6BA
GO
Isoform B1 Publication (identifier: Q9V7U0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     341-385: Missing.

Note: No experimental confirmation available.

Show »
Length:575
Mass (Da):53,526
Checksum:iD234139F8273427D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei341 – 38545Missing in isoform B. 1 PublicationVSP_051872Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013599 Genomic DNA. Translation: AAF57953.1.
AE013599 Genomic DNA. Translation: AAS64829.1.
BT003322 mRNA. Translation: AAO25082.1.
RefSeqiNP_611157.1. NM_137313.3. [Q9V7U0-1]
NP_995860.1. NM_206138.2. [Q9V7U0-2]
UniGeneiDm.19192.

Genome annotation databases

EnsemblMetazoaiFBtr0087024; FBpp0086175; FBgn0034157. [Q9V7U0-1]
GeneIDi36880.
KEGGidme:Dmel_CG15920.
UCSCiCG15920-RA. d. melanogaster. [Q9V7U0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013599 Genomic DNA. Translation: AAF57953.1 .
AE013599 Genomic DNA. Translation: AAS64829.1 .
BT003322 mRNA. Translation: AAO25082.1 .
RefSeqi NP_611157.1. NM_137313.3. [Q9V7U0-1 ]
NP_995860.1. NM_206138.2. [Q9V7U0-2 ]
UniGenei Dm.19192.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 62589. 1 interaction.
MINTi MINT-1724311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0087024 ; FBpp0086175 ; FBgn0034157 . [Q9V7U0-1 ]
GeneIDi 36880.
KEGGi dme:Dmel_CG15920.
UCSCi CG15920-RA. d. melanogaster. [Q9V7U0-1 ]

Organism-specific databases

CTDi 36880.
FlyBasei FBgn0034157. resilin.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00730000112526.
InParanoidi Q9V7U0.
OMAi DLGQNGY.
OrthoDBi EOG7H4DW0.
PhylomeDBi Q9V7U0.

Miscellaneous databases

GenomeRNAii 36880.
NextBioi 800852.

Gene expression databases

Bgeei Q9V7U0.

Family and domain databases

InterProi IPR000618. Insect_cuticle.
[Graphical view ]
PROSITEi PS00233. CHIT_BIND_RR_1. 1 hit.
PS51155. CHIT_BIND_RR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
    Strain: Berkeley.
    Tissue: Testis.
  4. "Tentative identification of a resilin gene in Drosophila melanogaster."
    Ardell D.H., Andersen S.O.
    Insect Biochem. Mol. Biol. 31:965-970(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. Cited for: DEVELOPMENTAL STAGE, BIOTECHNOLOGICAL RELEVANCE.

Entry informationi

Entry nameiRESIL_DROME
AccessioniPrimary (citable) accession number: Q9V7U0
Secondary accession number(s): Q86P83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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