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Q9V7U0

- RESIL_DROME

UniProt

Q9V7U0 - RESIL_DROME

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Protein

Pro-resilin

Gene

resilin

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Plays a central role in insect flight by providing low stiffness, high strain and efficient energy storage.Curated

GO - Molecular functioni

  1. chitin binding Source: FlyBase
  2. extracellular matrix constituent conferring elasticity Source: UniProtKB
  3. structural constituent of chitin-based larval cuticle Source: FlyBase
  4. structural constituent of cuticle Source: UniProtKB

GO - Biological processi

  1. chitin-based cuticle development Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-resilin
Gene namesi
Name:resilin
ORF Names:CG15920
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034157. resilin.

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: FlyBase
  2. extracellular region Source: UniProtKB
  3. protein-carbohydrate complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cuticle

Pathology & Biotechi

Biotechnological usei

Its strong elasticity suggests that it may be used for industrial and pharmaceutical applications. Recombinant protein can be cast into a rubber-like biomaterial by rapid photochemical cross-linking. The resilience (recovery after deformation) of cross-linked recombinant resilin exceeds that of unfilled synthetic polybutadiene, a high resilience rubber.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 620603Pro-resilinSequence AnalysisPRO_0000042845Add
BLAST

Expressioni

Developmental stagei

Expressed at pupal stage only.1 Publication

Gene expression databases

BgeeiQ9V7U0.

Interactioni

Protein-protein interaction databases

BioGridi62589. 1 interaction.
MINTiMINT-1724311.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati42 – 5615Elastic 1Sequence AnalysisAdd
BLAST
Repeati57 – 7721Elastic 2Sequence AnalysisAdd
BLAST
Repeati78 – 9720Elastic 3Sequence AnalysisAdd
BLAST
Repeati98 – 11215Elastic 4Sequence AnalysisAdd
BLAST
Repeati113 – 12715Elastic 5Sequence AnalysisAdd
BLAST
Repeati128 – 14518Elastic 6Sequence AnalysisAdd
BLAST
Repeati146 – 16419Elastic 7Sequence AnalysisAdd
BLAST
Repeati165 – 17915Elastic 8Sequence AnalysisAdd
BLAST
Repeati180 – 19415Elastic 9Sequence AnalysisAdd
BLAST
Repeati195 – 21016Elastic 10Sequence AnalysisAdd
BLAST
Repeati211 – 22515Elastic 11Sequence AnalysisAdd
BLAST
Repeati226 – 24419Elastic 12Sequence AnalysisAdd
BLAST
Repeati245 – 26218Elastic 13Sequence AnalysisAdd
BLAST
Repeati263 – 27614Elastic 14Sequence AnalysisAdd
BLAST
Repeati277 – 29216Elastic 15Sequence AnalysisAdd
BLAST
Repeati293 – 30715Elastic 16Sequence AnalysisAdd
BLAST
Repeati308 – 32417Elastic 17Sequence AnalysisAdd
BLAST
Domaini342 – 41574Chitin-binding type R&RPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 617584Gly-richSequence AnalysisAdd
BLAST
Compositional biasi168 – 1714Poly-SerSequence Analysis

Sequence similaritiesi

Contains 1 chitin-binding type R&R domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000112526.
InParanoidiQ9V7U0.
OMAiDLGQNGY.
OrthoDBiEOG7H4DW0.
PhylomeDBiQ9V7U0.

Family and domain databases

InterProiIPR000618. Insect_cuticle.
[Graphical view]
PROSITEiPS00233. CHIT_BIND_RR_1. 1 hit.
PS51155. CHIT_BIND_RR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A1 Publication (identifier: Q9V7U0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFKLLGLTLL MAMVVLGRPE PPVNSYLPPS DSYGAPGQSG PGGRPSDSYG
60 70 80 90 100
APGGGNGGRP SDSYGAPGQG QGQGQGQGGY AGKPSDTYGA PGGGNGNGGR
110 120 130 140 150
PSSSYGAPGG GNGGRPSDTY GAPGGGNGGR PSDTYGAPGG GGNGNGGRPS
160 170 180 190 200
SSYGAPGQGQ GNGNGGRSSS SYGAPGGGNG GRPSDTYGAP GGGNGGRPSD
210 220 230 240 250
TYGAPGGGNN GGRPSSSYGA PGGGNGGRPS DTYGAPGGGN GNGSGGRPSS
260 270 280 290 300
SYGAPGQGQG GFGGRPSDSY GAPGQNQKPS DSYGAPGSGN GNGGRPSSSY
310 320 330 340 350
GAPGSGPGGR PSDSYGPPAS GSGAGGAGGS GPGGADYDND EPAKYEFNYQ
360 370 380 390 400
VEDAPSGLSF GHSEMRDGDF TTGQYNVLLP DGRKQIVEYE ADQQGYRPQI
410 420 430 440 450
RYEGDANDGS GPSGPGGPGG QNLGADGYSS GRPGNGNGNG NGGYSGGRPG
460 470 480 490 500
GQDLGPSGYS GGRPGGQDLG AGGYSNGKPG GQDLGPGGYS GGRPGGQDLG
510 520 530 540 550
RDGYSGGRPG GQDLGASGYS NGRPGGNGNG GSDGGRVIIG GRVIGGQDGG
560 570 580 590 600
DQGYSGGRPG GQDLGRDGYS SGRPGGRPGG NGQDSQDGQG YSSGRPGQGG
610 620
RNGFGPGGQN GDNDGSGYRY

Note: No experimental confirmation available.Curated

Length:620
Mass (Da):58,604
Last modified:May 1, 2000 - v1
Checksum:i432AFA06E54CB6BA
GO
Isoform B1 Publication (identifier: Q9V7U0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     341-385: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:575
Mass (Da):53,526
Checksum:iD234139F8273427D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei341 – 38545Missing in isoform B. 2 PublicationsVSP_051872Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57953.1.
AE013599 Genomic DNA. Translation: AAS64829.1.
BT003322 mRNA. Translation: AAO25082.1.
RefSeqiNP_611157.1. NM_137313.4. [Q9V7U0-1]
NP_995860.1. NM_206138.2. [Q9V7U0-2]
UniGeneiDm.19192.

Genome annotation databases

EnsemblMetazoaiFBtr0087024; FBpp0086175; FBgn0034157. [Q9V7U0-1]
GeneIDi36880.
KEGGidme:Dmel_CG15920.
UCSCiCG15920-RA. d. melanogaster. [Q9V7U0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57953.1 .
AE013599 Genomic DNA. Translation: AAS64829.1 .
BT003322 mRNA. Translation: AAO25082.1 .
RefSeqi NP_611157.1. NM_137313.4. [Q9V7U0-1 ]
NP_995860.1. NM_206138.2. [Q9V7U0-2 ]
UniGenei Dm.19192.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 62589. 1 interaction.
MINTi MINT-1724311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0087024 ; FBpp0086175 ; FBgn0034157 . [Q9V7U0-1 ]
GeneIDi 36880.
KEGGi dme:Dmel_CG15920.
UCSCi CG15920-RA. d. melanogaster. [Q9V7U0-1 ]

Organism-specific databases

CTDi 36880.
FlyBasei FBgn0034157. resilin.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00730000112526.
InParanoidi Q9V7U0.
OMAi DLGQNGY.
OrthoDBi EOG7H4DW0.
PhylomeDBi Q9V7U0.

Miscellaneous databases

ChiTaRSi resilin. fly.
GenomeRNAii 36880.
NextBioi 800852.

Gene expression databases

Bgeei Q9V7U0.

Family and domain databases

InterProi IPR000618. Insect_cuticle.
[Graphical view ]
PROSITEi PS00233. CHIT_BIND_RR_1. 1 hit.
PS51155. CHIT_BIND_RR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley1 Publication.
  2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
    Strain: Berkeley.
    Tissue: Testis.
  4. "Tentative identification of a resilin gene in Drosophila melanogaster."
    Ardell D.H., Andersen S.O.
    Insect Biochem. Mol. Biol. 31:965-970(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. Cited for: DEVELOPMENTAL STAGE, BIOTECHNOLOGICAL RELEVANCE.

Entry informationi

Entry nameiRESIL_DROME
AccessioniPrimary (citable) accession number: Q9V7U0
Secondary accession number(s): Q86P83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3