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Protein

Pro-resilin

Gene

resilin

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a central role in insect flight by providing low stiffness, high strain and efficient energy storage.Curated

GO - Molecular functioni

  • chitin binding Source: FlyBase
  • extracellular matrix constituent conferring elasticity Source: UniProtKB
  • structural constituent of chitin-based larval cuticle Source: FlyBase
  • structural constituent of cuticle Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-resilin
Gene namesi
Name:resilin
ORF Names:CG15920
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034157. resilin.

Subcellular locationi

GO - Cellular componenti

  • extracellular matrix Source: FlyBase
  • extracellular region Source: UniProtKB
  • protein-carbohydrate complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cuticle

Pathology & Biotechi

Biotechnological usei

Its strong elasticity suggests that it may be used for industrial and pharmaceutical applications. Recombinant protein can be cast into a rubber-like biomaterial by rapid photochemical cross-linking. The resilience (recovery after deformation) of cross-linked recombinant resilin exceeds that of unfilled synthetic polybutadiene, a high resilience rubber.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000004284518 – 620Pro-resilinSequence analysisAdd BLAST603

Proteomic databases

PaxDbiQ9V7U0.
PRIDEiQ9V7U0.

Expressioni

Developmental stagei

Expressed at pupal stage only.1 Publication

Gene expression databases

BgeeiFBgn0034157.
GenevisibleiQ9V7U0. DM.

Interactioni

Protein-protein interaction databases

BioGridi62589. 1 interactor.
MINTiMINT-1724311.
STRINGi7227.FBpp0086175.

Structurei

3D structure databases

ProteinModelPortaliQ9V7U0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati42 – 56Elastic 1Sequence analysisAdd BLAST15
Repeati57 – 77Elastic 2Sequence analysisAdd BLAST21
Repeati78 – 97Elastic 3Sequence analysisAdd BLAST20
Repeati98 – 112Elastic 4Sequence analysisAdd BLAST15
Repeati113 – 127Elastic 5Sequence analysisAdd BLAST15
Repeati128 – 145Elastic 6Sequence analysisAdd BLAST18
Repeati146 – 164Elastic 7Sequence analysisAdd BLAST19
Repeati165 – 179Elastic 8Sequence analysisAdd BLAST15
Repeati180 – 194Elastic 9Sequence analysisAdd BLAST15
Repeati195 – 210Elastic 10Sequence analysisAdd BLAST16
Repeati211 – 225Elastic 11Sequence analysisAdd BLAST15
Repeati226 – 244Elastic 12Sequence analysisAdd BLAST19
Repeati245 – 262Elastic 13Sequence analysisAdd BLAST18
Repeati263 – 276Elastic 14Sequence analysisAdd BLAST14
Repeati277 – 292Elastic 15Sequence analysisAdd BLAST16
Repeati293 – 307Elastic 16Sequence analysisAdd BLAST15
Repeati308 – 324Elastic 17Sequence analysisAdd BLAST17
Domaini342 – 415Chitin-binding type R&RPROSITE-ProRule annotationAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 617Gly-richSequence analysisAdd BLAST584
Compositional biasi168 – 171Poly-SerSequence analysis4

Sequence similaritiesi

Contains 1 chitin-binding type R&R domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J2V1. Eukaryota.
ENOG41128ZS. LUCA.
GeneTreeiENSGT00810000126137.
InParanoidiQ9V7U0.
OMAiGQNGYSS.
OrthoDBiEOG091G14E4.
PhylomeDBiQ9V7U0.

Family and domain databases

InterProiIPR031311. CHIT_BIND_RR_consensus.
IPR000618. Insect_cuticle.
[Graphical view]
PfamiPF00379. Chitin_bind_4. 1 hit.
[Graphical view]
PROSITEiPS00233. CHIT_BIND_RR_1. 1 hit.
PS51155. CHIT_BIND_RR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A1 Publication (identifier: Q9V7U0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFKLLGLTLL MAMVVLGRPE PPVNSYLPPS DSYGAPGQSG PGGRPSDSYG
60 70 80 90 100
APGGGNGGRP SDSYGAPGQG QGQGQGQGGY AGKPSDTYGA PGGGNGNGGR
110 120 130 140 150
PSSSYGAPGG GNGGRPSDTY GAPGGGNGGR PSDTYGAPGG GGNGNGGRPS
160 170 180 190 200
SSYGAPGQGQ GNGNGGRSSS SYGAPGGGNG GRPSDTYGAP GGGNGGRPSD
210 220 230 240 250
TYGAPGGGNN GGRPSSSYGA PGGGNGGRPS DTYGAPGGGN GNGSGGRPSS
260 270 280 290 300
SYGAPGQGQG GFGGRPSDSY GAPGQNQKPS DSYGAPGSGN GNGGRPSSSY
310 320 330 340 350
GAPGSGPGGR PSDSYGPPAS GSGAGGAGGS GPGGADYDND EPAKYEFNYQ
360 370 380 390 400
VEDAPSGLSF GHSEMRDGDF TTGQYNVLLP DGRKQIVEYE ADQQGYRPQI
410 420 430 440 450
RYEGDANDGS GPSGPGGPGG QNLGADGYSS GRPGNGNGNG NGGYSGGRPG
460 470 480 490 500
GQDLGPSGYS GGRPGGQDLG AGGYSNGKPG GQDLGPGGYS GGRPGGQDLG
510 520 530 540 550
RDGYSGGRPG GQDLGASGYS NGRPGGNGNG GSDGGRVIIG GRVIGGQDGG
560 570 580 590 600
DQGYSGGRPG GQDLGRDGYS SGRPGGRPGG NGQDSQDGQG YSSGRPGQGG
610 620
RNGFGPGGQN GDNDGSGYRY
Note: No experimental confirmation available.Curated
Length:620
Mass (Da):58,604
Last modified:May 1, 2000 - v1
Checksum:i432AFA06E54CB6BA
GO
Isoform B1 Publication (identifier: Q9V7U0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     341-385: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:575
Mass (Da):53,526
Checksum:iD234139F8273427D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051872341 – 385Missing in isoform B. 2 PublicationsAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57953.1.
AE013599 Genomic DNA. Translation: AAS64829.1.
BT003322 mRNA. Translation: AAO25082.1.
RefSeqiNP_611157.1. NM_137313.4. [Q9V7U0-1]
NP_995860.1. NM_206138.2. [Q9V7U0-2]
UniGeneiDm.19192.

Genome annotation databases

EnsemblMetazoaiFBtr0087024; FBpp0086175; FBgn0034157. [Q9V7U0-1]
GeneIDi36880.
KEGGidme:Dmel_CG15920.
UCSCiCG15920-RA. d. melanogaster. [Q9V7U0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57953.1.
AE013599 Genomic DNA. Translation: AAS64829.1.
BT003322 mRNA. Translation: AAO25082.1.
RefSeqiNP_611157.1. NM_137313.4. [Q9V7U0-1]
NP_995860.1. NM_206138.2. [Q9V7U0-2]
UniGeneiDm.19192.

3D structure databases

ProteinModelPortaliQ9V7U0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi62589. 1 interactor.
MINTiMINT-1724311.
STRINGi7227.FBpp0086175.

Proteomic databases

PaxDbiQ9V7U0.
PRIDEiQ9V7U0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087024; FBpp0086175; FBgn0034157. [Q9V7U0-1]
GeneIDi36880.
KEGGidme:Dmel_CG15920.
UCSCiCG15920-RA. d. melanogaster. [Q9V7U0-1]

Organism-specific databases

CTDi36880.
FlyBaseiFBgn0034157. resilin.

Phylogenomic databases

eggNOGiENOG410J2V1. Eukaryota.
ENOG41128ZS. LUCA.
GeneTreeiENSGT00810000126137.
InParanoidiQ9V7U0.
OMAiGQNGYSS.
OrthoDBiEOG091G14E4.
PhylomeDBiQ9V7U0.

Miscellaneous databases

ChiTaRSiresilin. fly.
GenomeRNAii36880.
PROiQ9V7U0.

Gene expression databases

BgeeiFBgn0034157.
GenevisibleiQ9V7U0. DM.

Family and domain databases

InterProiIPR031311. CHIT_BIND_RR_consensus.
IPR000618. Insect_cuticle.
[Graphical view]
PfamiPF00379. Chitin_bind_4. 1 hit.
[Graphical view]
PROSITEiPS00233. CHIT_BIND_RR_1. 1 hit.
PS51155. CHIT_BIND_RR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRESIL_DROME
AccessioniPrimary (citable) accession number: Q9V7U0
Secondary accession number(s): Q86P83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.