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Q9V7U0

- RESIL_DROME

UniProt

Q9V7U0 - RESIL_DROME

Protein

Pro-resilin

Gene

resilin

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Plays a central role in insect flight by providing low stiffness, high strain and efficient energy storage.Curated

    GO - Molecular functioni

    1. chitin binding Source: FlyBase
    2. extracellular matrix constituent conferring elasticity Source: UniProtKB
    3. structural constituent of chitin-based larval cuticle Source: FlyBase
    4. structural constituent of cuticle Source: UniProtKB

    GO - Biological processi

    1. chitin-based cuticle development Source: FlyBase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pro-resilin
    Gene namesi
    Name:resilin
    ORF Names:CG15920
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0034157. resilin.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular matrix Source: FlyBase
    2. extracellular region Source: UniProtKB
    3. protein-carbohydrate complex Source: FlyBase

    Keywords - Cellular componenti

    Cuticle

    Pathology & Biotechi

    Biotechnological usei

    Its strong elasticity suggests that it may be used for industrial and pharmaceutical applications. Recombinant protein can be cast into a rubber-like biomaterial by rapid photochemical cross-linking. The resilience (recovery after deformation) of cross-linked recombinant resilin exceeds that of unfilled synthetic polybutadiene, a high resilience rubber.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 620603Pro-resilinSequence AnalysisPRO_0000042845Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed at pupal stage only.1 Publication

    Gene expression databases

    BgeeiQ9V7U0.

    Interactioni

    Protein-protein interaction databases

    BioGridi62589. 1 interaction.
    MINTiMINT-1724311.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati42 – 5615Elastic 1Sequence AnalysisAdd
    BLAST
    Repeati57 – 7721Elastic 2Sequence AnalysisAdd
    BLAST
    Repeati78 – 9720Elastic 3Sequence AnalysisAdd
    BLAST
    Repeati98 – 11215Elastic 4Sequence AnalysisAdd
    BLAST
    Repeati113 – 12715Elastic 5Sequence AnalysisAdd
    BLAST
    Repeati128 – 14518Elastic 6Sequence AnalysisAdd
    BLAST
    Repeati146 – 16419Elastic 7Sequence AnalysisAdd
    BLAST
    Repeati165 – 17915Elastic 8Sequence AnalysisAdd
    BLAST
    Repeati180 – 19415Elastic 9Sequence AnalysisAdd
    BLAST
    Repeati195 – 21016Elastic 10Sequence AnalysisAdd
    BLAST
    Repeati211 – 22515Elastic 11Sequence AnalysisAdd
    BLAST
    Repeati226 – 24419Elastic 12Sequence AnalysisAdd
    BLAST
    Repeati245 – 26218Elastic 13Sequence AnalysisAdd
    BLAST
    Repeati263 – 27614Elastic 14Sequence AnalysisAdd
    BLAST
    Repeati277 – 29216Elastic 15Sequence AnalysisAdd
    BLAST
    Repeati293 – 30715Elastic 16Sequence AnalysisAdd
    BLAST
    Repeati308 – 32417Elastic 17Sequence AnalysisAdd
    BLAST
    Domaini342 – 41574Chitin-binding type R&RPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi34 – 617584Gly-richSequence AnalysisAdd
    BLAST
    Compositional biasi168 – 1714Poly-SerSequence Analysis

    Sequence similaritiesi

    Contains 1 chitin-binding type R&R domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00730000112526.
    InParanoidiQ9V7U0.
    OMAiDLGQNGY.
    OrthoDBiEOG7H4DW0.
    PhylomeDBiQ9V7U0.

    Family and domain databases

    InterProiIPR000618. Insect_cuticle.
    [Graphical view]
    PROSITEiPS00233. CHIT_BIND_RR_1. 1 hit.
    PS51155. CHIT_BIND_RR_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform A1 Publication (identifier: Q9V7U0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFKLLGLTLL MAMVVLGRPE PPVNSYLPPS DSYGAPGQSG PGGRPSDSYG    50
    APGGGNGGRP SDSYGAPGQG QGQGQGQGGY AGKPSDTYGA PGGGNGNGGR 100
    PSSSYGAPGG GNGGRPSDTY GAPGGGNGGR PSDTYGAPGG GGNGNGGRPS 150
    SSYGAPGQGQ GNGNGGRSSS SYGAPGGGNG GRPSDTYGAP GGGNGGRPSD 200
    TYGAPGGGNN GGRPSSSYGA PGGGNGGRPS DTYGAPGGGN GNGSGGRPSS 250
    SYGAPGQGQG GFGGRPSDSY GAPGQNQKPS DSYGAPGSGN GNGGRPSSSY 300
    GAPGSGPGGR PSDSYGPPAS GSGAGGAGGS GPGGADYDND EPAKYEFNYQ 350
    VEDAPSGLSF GHSEMRDGDF TTGQYNVLLP DGRKQIVEYE ADQQGYRPQI 400
    RYEGDANDGS GPSGPGGPGG QNLGADGYSS GRPGNGNGNG NGGYSGGRPG 450
    GQDLGPSGYS GGRPGGQDLG AGGYSNGKPG GQDLGPGGYS GGRPGGQDLG 500
    RDGYSGGRPG GQDLGASGYS NGRPGGNGNG GSDGGRVIIG GRVIGGQDGG 550
    DQGYSGGRPG GQDLGRDGYS SGRPGGRPGG NGQDSQDGQG YSSGRPGQGG 600
    RNGFGPGGQN GDNDGSGYRY 620

    Note: No experimental confirmation available.Curated

    Length:620
    Mass (Da):58,604
    Last modified:May 1, 2000 - v1
    Checksum:i432AFA06E54CB6BA
    GO
    Isoform B1 Publication (identifier: Q9V7U0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         341-385: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:575
    Mass (Da):53,526
    Checksum:iD234139F8273427D
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei341 – 38545Missing in isoform B. 2 PublicationsVSP_051872Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013599 Genomic DNA. Translation: AAF57953.1.
    AE013599 Genomic DNA. Translation: AAS64829.1.
    BT003322 mRNA. Translation: AAO25082.1.
    RefSeqiNP_611157.1. NM_137313.3. [Q9V7U0-1]
    NP_995860.1. NM_206138.2. [Q9V7U0-2]
    UniGeneiDm.19192.

    Genome annotation databases

    EnsemblMetazoaiFBtr0087024; FBpp0086175; FBgn0034157. [Q9V7U0-1]
    GeneIDi36880.
    KEGGidme:Dmel_CG15920.
    UCSCiCG15920-RA. d. melanogaster. [Q9V7U0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013599 Genomic DNA. Translation: AAF57953.1 .
    AE013599 Genomic DNA. Translation: AAS64829.1 .
    BT003322 mRNA. Translation: AAO25082.1 .
    RefSeqi NP_611157.1. NM_137313.3. [Q9V7U0-1 ]
    NP_995860.1. NM_206138.2. [Q9V7U0-2 ]
    UniGenei Dm.19192.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 62589. 1 interaction.
    MINTi MINT-1724311.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0087024 ; FBpp0086175 ; FBgn0034157 . [Q9V7U0-1 ]
    GeneIDi 36880.
    KEGGi dme:Dmel_CG15920.
    UCSCi CG15920-RA. d. melanogaster. [Q9V7U0-1 ]

    Organism-specific databases

    CTDi 36880.
    FlyBasei FBgn0034157. resilin.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00730000112526.
    InParanoidi Q9V7U0.
    OMAi DLGQNGY.
    OrthoDBi EOG7H4DW0.
    PhylomeDBi Q9V7U0.

    Miscellaneous databases

    GenomeRNAii 36880.
    NextBioi 800852.

    Gene expression databases

    Bgeei Q9V7U0.

    Family and domain databases

    InterProi IPR000618. Insect_cuticle.
    [Graphical view ]
    PROSITEi PS00233. CHIT_BIND_RR_1. 1 hit.
    PS51155. CHIT_BIND_RR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley1 Publication.
    2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
      Strain: Berkeley.
      Tissue: Testis.
    4. "Tentative identification of a resilin gene in Drosophila melanogaster."
      Ardell D.H., Andersen S.O.
      Insect Biochem. Mol. Biol. 31:965-970(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    5. Cited for: DEVELOPMENTAL STAGE, BIOTECHNOLOGICAL RELEVANCE.

    Entry informationi

    Entry nameiRESIL_DROME
    AccessioniPrimary (citable) accession number: Q9V7U0
    Secondary accession number(s): Q86P83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3