ID   PICO_DROME              Reviewed;         529 AA.
AC   Q9V7S5; O61364; Q8T077; Q9V7S6;
DT   28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   27-MAR-2024, entry version 153.
DE   RecName: Full=Putative inorganic phosphate cotransporter;
GN   Name=Picot; ORFNames=CG8098;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE OF 449-529.
RC   STRAIN=Canton-S;
RA   Da Lage J.-L.;
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be an inorganic phosphate cotransporter.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=B;
CC         IsoId=Q9V7S5-1; Sequence=Displayed;
CC       Name=A;
CC         IsoId=Q9V7S5-2; Sequence=VSP_007009;
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion
CC       cotransporter family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE013599; AAF57968.1; -; Genomic_DNA.
DR   EMBL; AE013599; AAF57969.1; -; Genomic_DNA.
DR   EMBL; AY069501; AAL39646.1; -; mRNA.
DR   EMBL; AF022713; AAD09148.1; -; Genomic_DNA.
DR   RefSeq; NP_001286496.1; NM_001299567.1. [Q9V7S5-2]
DR   RefSeq; NP_001286497.1; NM_001299568.1. [Q9V7S5-2]
DR   RefSeq; NP_611146.1; NM_137302.3. [Q9V7S5-2]
DR   RefSeq; NP_725600.1; NM_166187.2. [Q9V7S5-1]
DR   AlphaFoldDB; Q9V7S5; -.
DR   SMR; Q9V7S5; -.
DR   BioGRID; 62577; 6.
DR   DIP; DIP-22400N; -.
DR   STRING; 7227.FBpp0086261; -.
DR   TCDB; 2.A.1.14.34; the major facilitator superfamily (mfs).
DR   SwissPalm; Q9V7S5; -.
DR   PaxDb; 7227-FBpp0086261; -.
DR   DNASU; 36865; -.
DR   EnsemblMetazoa; FBtr0087114; FBpp0086260; FBgn0024315. [Q9V7S5-2]
DR   EnsemblMetazoa; FBtr0087115; FBpp0086261; FBgn0024315. [Q9V7S5-1]
DR   EnsemblMetazoa; FBtr0340067; FBpp0309073; FBgn0024315. [Q9V7S5-2]
DR   EnsemblMetazoa; FBtr0340068; FBpp0309074; FBgn0024315. [Q9V7S5-2]
DR   GeneID; 36865; -.
DR   KEGG; dme:Dmel_CG8098; -.
DR   UCSC; CG8098-RA; d. melanogaster. [Q9V7S5-1]
DR   AGR; FB:FBgn0024315; -.
DR   CTD; 36865; -.
DR   FlyBase; FBgn0024315; Picot.
DR   VEuPathDB; VectorBase:FBgn0024315; -.
DR   eggNOG; KOG2532; Eukaryota.
DR   GeneTree; ENSGT00940000173740; -.
DR   InParanoid; Q9V7S5; -.
DR   OMA; MRGTWAF; -.
DR   OrthoDB; 2685946at2759; -.
DR   PhylomeDB; Q9V7S5; -.
DR   BioGRID-ORCS; 36865; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 36865; -.
DR   PRO; PR:Q9V7S5; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   Bgee; FBgn0024315; Expressed in adult hindgut (Drosophila) and 35 other cell types or tissues.
DR   ExpressionAtlas; Q9V7S5; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015114; F:phosphate ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006820; P:monoatomic anion transport; IBA:GO_Central.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   CDD; cd17318; MFS_SLC17; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR004745; Pi_cotranspt.
DR   NCBIfam; TIGR00894; 2A0114euk; 1.
DR   PANTHER; PTHR11662:SF459; MFS DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR11662; SOLUTE CARRIER FAMILY 17; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   Genevisible; Q9V7S5; DM.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Ion transport; Membrane; Reference proteome; Sodium;
KW   Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..529
FT                   /note="Putative inorganic phosphate cotransporter"
FT                   /id="PRO_0000220946"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        466..486
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          495..529
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        502..529
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..35
FT                   /note="MPFRRSSLNHRHRDGHVLVWNQRNLHESLEQQPQR -> MSASKEAICGSTE
FT                   KDLEKPALG (in isoform A)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_007009"
SQ   SEQUENCE   529 AA;  58372 MW;  07B89A52D5081EFB CRC64;
     MPFRRSSLNH RHRDGHVLVW NQRNLHESLE QQPQRCFATR YFVTFMLFLG MANAYVMRTN
     MSVAIVAMVN HTAIKSGEAE EYDDECGDRD IPIDDSQDGE FAWSSALQGY ILSSFFYGYV
     ITQIPFGILA KKYGSLRFLG YGMLINSVFA FLVPVAARGG GVWGLCAVRF IQGLGEGPIV
     PCTHAMLAKW IPPNERSRMG AAVYAGAQFG TIISMPLSGL LAEYGFDGGW PSIFYVFGIV
     GTVWSIAFLI FVHEDPSSHP TIDEREKKYI NDSLWGTDVV KSPPIPFKAI IKSLPFYAIL
     FAHMGHNYGY ETLMTELPTY MKQVLRFSLK SNGLLSSLPY LAMWLFSMFI SVVADWMISS
     KRFSHTATRK LINSIGQYGP GVALIAASYT GCDRALTLAI LTIGVGLNGG IYSGFKINHL
     DLTPRFAGFL MSITNCSANL AGLLAPIAAG HLISDPSKPM MGQWQIVFFI AAFVYIICGT
     FYNIFGSGER QYWDNPEDDE QKPALQTTVT TSPARLSNGS TAPAAISSS
//