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Protein

Alkyldihydroxyacetonephosphate synthase

Gene

CG10253

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.By similarity

Catalytic activityi

1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion.

Cofactori

FADBy similarity

Pathwayi: ether lipid biosynthesis

This protein is involved in the pathway ether lipid biosynthesis, which is part of Glycerolipid metabolism.
View all proteins of this organism that are known to be involved in the pathway ether lipid biosynthesis and in Glycerolipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei372 – 3721Important for enzyme activityBy similarity
Binding sitei467 – 4671SubstrateBy similarity
Active sitei529 – 5291Proton donor/acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi187 – 1937FADBy similarity
Nucleotide bindingi256 – 2627FADBy similarity
Nucleotide bindingi269 – 2724FADBy similarity
Nucleotide bindingi321 – 3277FADBy similarity

GO - Molecular functioni

GO - Biological processi

  • ether lipid biosynthetic process Source: UniProtKB
  • lipid biosynthetic process Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-DME-75896. Plasmalogen biosynthesis.
UniPathwayiUPA00781.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkyldihydroxyacetonephosphate synthase (EC:2.5.1.26)
Short name:
Alkyl-DHAP synthase
Alternative name(s):
Alkylglycerone-phosphate synthase
Gene namesi
ORF Names:CG10253
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033983. CG10253.

Subcellular locationi

GO - Cellular componenti

  • peroxisome Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631Alkyldihydroxyacetonephosphate synthasePRO_0000128179Add
BLAST

Proteomic databases

PaxDbiQ9V778.
PRIDEiQ9V778.

Expressioni

Gene expression databases

BgeeiQ9V778.
ExpressionAtlasiQ9V778. differential.
GenevisibleiQ9V778. DM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi7227.FBpp0292773.

Structurei

3D structure databases

ProteinModelPortaliQ9V778.
SMRiQ9V778. Positions 37-609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini155 – 337183FAD-binding PCMH-typePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni566 – 5683Important for enzyme activityBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi629 – 6313Microbody targeting signalSequence analysis

Sequence similaritiesi

Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1233. Eukaryota.
COG0277. LUCA.
GeneTreeiENSGT00530000063515.
InParanoidiQ9V778.
KOiK00803.
OMAiEIMKWNG.
OrthoDBiEOG7DRJ2W.
PhylomeDBiQ9V778.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR025650. Alkyl-DHAP_Synthase.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR016164. FAD-linked_Oxase-like_C.
IPR004113. FAD-linked_oxidase_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR11748:SF3. PTHR11748:SF3. 1 hit.
PfamiPF02913. FAD-oxidase_C. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
SUPFAMiSSF55103. SSF55103. 2 hits.
SSF56176. SSF56176. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKRNAVTT EAPESSAPGE GTALALDSRL SKRVESVIPK KRHEALKWFG
60 70 80 90 100
WGYNDSQFYG KDGIICFRGE KYPLGGCELP SFTKWVEKKF DLRVDTTKQY
110 120 130 140 150
PQLPRTYPRP VENAPFLHEL KGTTQVDYSA EGIDRLVRCH GQTLNDIYSL
160 170 180 190 200
WHHKFRRIPD LVVWPRCHDE VVQLVRLANK HNVMLVPFGG GTSVSGAITC
210 220 230 240 250
PQNESRMICA LDTSQMNRLL WLNRENLTVC FESGIVGQDL ERVLRSEGLT
260 270 280 290 300
VGHEPDSYEF STLGGWVATR ASGMKKNVYG NIEDLVVRVR MVTPSGTLER
310 320 330 340 350
ECSAPRVSCG PDFNHVILGS EGTLGVITEV VLKVRPLPSL RRYGSLAFPN
360 370 380 390 400
FEQGVLFMRE VARRRCQPAS VRLMDNEQFM FGQALKPEKS WWASVVDAMK
410 420 430 440 450
QRYVTSWKGI DLNQICAATL LFEGDLKDVQ RQEALIYEIA EKFQGFPAGG
460 470 480 490 500
QNGERGYILT FVIAYIRDFG LHQGIVAESF ETSVPWDRCS LLCRSVKQRV
510 520 530 540 550
VSECSKRSIN YYTISCRVTQ TYDAGACIYF YFGFRSTDVA DPVELFEAIE
560 570 580 590 600
HSARDEILSC GGSLSHHHGV GKIRSHWYRN AVTETGSSLY SAAKRHLDPK
610 620 630
NIFALGNLLP LEEAQASPPP PTSSTPPKAK L
Length:631
Mass (Da):70,822
Last modified:May 1, 2000 - v1
Checksum:iAEDD6FDDA6BFB862
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58181.1.
AY094917 mRNA. Translation: AAM11270.1.
RefSeqiNP_001188935.1. NM_001202006.1.
NP_001188936.1. NM_001202007.2.
NP_001188937.1. NM_001202008.1.
NP_611006.1. NM_137162.3.
UniGeneiDm.12883.

Genome annotation databases

EnsemblMetazoaiFBtr0087428; FBpp0086558; FBgn0033983.
FBtr0303760; FBpp0292772; FBgn0033983.
FBtr0303761; FBpp0292773; FBgn0033983.
FBtr0303762; FBpp0292774; FBgn0033983.
GeneIDi36669.
KEGGidme:Dmel_CG10253.
UCSCiCG10253-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58181.1.
AY094917 mRNA. Translation: AAM11270.1.
RefSeqiNP_001188935.1. NM_001202006.1.
NP_001188936.1. NM_001202007.2.
NP_001188937.1. NM_001202008.1.
NP_611006.1. NM_137162.3.
UniGeneiDm.12883.

3D structure databases

ProteinModelPortaliQ9V778.
SMRiQ9V778. Positions 37-609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0292773.

Proteomic databases

PaxDbiQ9V778.
PRIDEiQ9V778.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087428; FBpp0086558; FBgn0033983.
FBtr0303760; FBpp0292772; FBgn0033983.
FBtr0303761; FBpp0292773; FBgn0033983.
FBtr0303762; FBpp0292774; FBgn0033983.
GeneIDi36669.
KEGGidme:Dmel_CG10253.
UCSCiCG10253-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0033983. CG10253.

Phylogenomic databases

eggNOGiKOG1233. Eukaryota.
COG0277. LUCA.
GeneTreeiENSGT00530000063515.
InParanoidiQ9V778.
KOiK00803.
OMAiEIMKWNG.
OrthoDBiEOG7DRJ2W.
PhylomeDBiQ9V778.

Enzyme and pathway databases

UniPathwayiUPA00781.
ReactomeiR-DME-75896. Plasmalogen biosynthesis.

Miscellaneous databases

GenomeRNAii36669.
NextBioi799777.
PROiQ9V778.

Gene expression databases

BgeeiQ9V778.
ExpressionAtlasiQ9V778. differential.
GenevisibleiQ9V778. DM.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR025650. Alkyl-DHAP_Synthase.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR016164. FAD-linked_Oxase-like_C.
IPR004113. FAD-linked_oxidase_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR11748:SF3. PTHR11748:SF3. 1 hit.
PfamiPF02913. FAD-oxidase_C. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
SUPFAMiSSF55103. SSF55103. 2 hits.
SSF56176. SSF56176. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.

Entry informationi

Entry nameiADAS_DROME
AccessioniPrimary (citable) accession number: Q9V778
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: December 9, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.