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Q9V719

- SIN1_DROME

UniProt

Q9V719 - SIN1_DROME

Protein

Stress-activated map kinase-interacting protein 1

Gene

Sin1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Component of a multiprotein complex that phosphorylates Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes.1 Publication

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. dendrite morphogenesis Source: FlyBase
    3. regulation of protein phosphorylation Source: FlyBase
    4. synaptic growth at neuromuscular junction Source: FlyBase

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    ReactomeiREACT_184384. Constitutive PI3K/AKT Signaling in Cancer.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Stress-activated map kinase-interacting protein 1
    Short name:
    SAPK-interacting protein 1
    Short name:
    dSin1
    Gene namesi
    Name:Sin1
    ORF Names:CG10105
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0033935. Sin1.

    Subcellular locationi

    GO - Cellular componenti

    1. TORC2 complex Source: FlyBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 569569Stress-activated map kinase-interacting protein 1PRO_0000218772Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei333 – 3331Phosphoserine1 Publication
    Modified residuei355 – 3551Phosphoserine1 Publication
    Modified residuei372 – 3721Phosphoserine1 Publication
    Modified residuei504 – 5041Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9V719.
    PRIDEiQ9V719.

    Expressioni

    Gene expression databases

    BgeeiQ9V719.

    Interactioni

    Protein-protein interaction databases

    BioGridi62354. 1 interaction.
    IntActiQ9V719. 12 interactions.
    MINTiMINT-7555994.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9V719.
    SMRiQ9V719. Positions 389-547.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SIN1 family.Curated

    Phylogenomic databases

    eggNOGiNOG281916.
    GeneTreeiENSGT00390000000642.
    InParanoidiQ9V719.
    OMAiERIEIDQ.
    OrthoDBiEOG7GXPBF.
    PhylomeDBiQ9V719.

    Family and domain databases

    InterProiIPR008828. SIN1.
    [Graphical view]
    PANTHERiPTHR13335. PTHR13335. 1 hit.
    PfamiPF05422. SIN1. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9V719-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATYSNQHWL LSHIRNSFIS TDDTGMCETV MLSDDMPKHY LRKFGNSGAG    50
    GDHYHWRRAH KTPPTGGGTT PERNTRHPDA PLQEVDFICY PGLDLSDDEE 100
    DMSTHSFDIQ MYPEVGAHRF RSNTAQKLEK LDIAKRRAAR IKSVNYQEEV 150
    QPPESDDFFK RKELPLSKAE RVKNEPKAND DDLSDEGVQS QLTEQLAKSP 200
    KQAQNRFIEF ARFDGTSQVG MQTKRINVFL NMLPEPDRNY PLKICVVATA 250
    KIQEVIGFVC YRTSLQYPDV PLKSLQHYAL YMTEDNDDME DFPPLDNREP 300
    CSKFGFSQLT LAERRPLAPV TRVDYHSQLG SKSMTSVEDK TALSDAAVKA 350
    LQNISLNGGT SDPGGGGGGG DSPHDNVKEY EKRLLNHNDM LEAPMHRTFR 400
    LNIIDKRFFK SDVTLGISGE RIEIDQCKNA KFWPQKKPVS TPIDFVAHCE 450
    ILERRHLKAL LRIWLKSNSS SPSFSTGCTS APINASVTTL NAGSGSGGIA 500
    HSPSSPGHSS GLFSSSNIRF KHYDFDTDTH TAEQIHNKLN CILEMRSSDL 550
    RREFLLQRDR KQEKRQLKL 569
    Length:569
    Mass (Da):64,239
    Last modified:May 1, 2000 - v1
    Checksum:iBD18DC6186C4E665
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013599 Genomic DNA. Translation: AAF58247.1.
    BT003261 mRNA. Translation: AAO25018.1.
    RefSeqiNP_610963.1. NM_137119.3.
    UniGeneiDm.10957.

    Genome annotation databases

    EnsemblMetazoaiFBtr0087487; FBpp0086616; FBgn0033935.
    GeneIDi36604.
    KEGGidme:Dmel_CG10105.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013599 Genomic DNA. Translation: AAF58247.1 .
    BT003261 mRNA. Translation: AAO25018.1 .
    RefSeqi NP_610963.1. NM_137119.3.
    UniGenei Dm.10957.

    3D structure databases

    ProteinModelPortali Q9V719.
    SMRi Q9V719. Positions 389-547.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 62354. 1 interaction.
    IntActi Q9V719. 12 interactions.
    MINTi MINT-7555994.

    Proteomic databases

    PaxDbi Q9V719.
    PRIDEi Q9V719.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0087487 ; FBpp0086616 ; FBgn0033935 .
    GeneIDi 36604.
    KEGGi dme:Dmel_CG10105.

    Organism-specific databases

    CTDi 36604.
    FlyBasei FBgn0033935. Sin1.

    Phylogenomic databases

    eggNOGi NOG281916.
    GeneTreei ENSGT00390000000642.
    InParanoidi Q9V719.
    OMAi ERIEIDQ.
    OrthoDBi EOG7GXPBF.
    PhylomeDBi Q9V719.

    Enzyme and pathway databases

    Reactomei REACT_184384. Constitutive PI3K/AKT Signaling in Cancer.

    Miscellaneous databases

    GenomeRNAii 36604.
    NextBioi 799458.
    PROi Q9V719.

    Gene expression databases

    Bgeei Q9V719.

    Family and domain databases

    InterProi IPR008828. SIN1.
    [Graphical view ]
    PANTHERi PTHR13335. PTHR13335. 1 hit.
    Pfami PF05422. SIN1. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.
    4. "mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s."
      Frias M.A., Thoreen C.C., Jaffe J.D., Schroder W., Sculley T., Carr S.A., Sabatini D.M.
      Curr. Biol. 16:1865-1870(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333; SER-355; SER-372 AND SER-504, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiSIN1_DROME
    AccessioniPrimary (citable) accession number: Q9V719
    Secondary accession number(s): Q53YG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3