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Q9V719 (SIN1_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Stress-activated map kinase-interacting protein 1

Short name=SAPK-interacting protein 1
Short name=dSin1
Gene names
Name:Sin1
ORF Names:CG10105
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length569 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of a multiprotein complex that phosphorylates Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Ref.4

Sequence similarities

Belongs to the SIN1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 569569Stress-activated map kinase-interacting protein 1
PRO_0000218772

Amino acid modifications

Modified residue3331Phosphoserine Ref.5
Modified residue3551Phosphoserine Ref.5
Modified residue3721Phosphoserine Ref.5
Modified residue5041Phosphoserine Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q9V719 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: BD18DC6186C4E665

FASTA56964,239
        10         20         30         40         50         60 
MATYSNQHWL LSHIRNSFIS TDDTGMCETV MLSDDMPKHY LRKFGNSGAG GDHYHWRRAH 

        70         80         90        100        110        120 
KTPPTGGGTT PERNTRHPDA PLQEVDFICY PGLDLSDDEE DMSTHSFDIQ MYPEVGAHRF 

       130        140        150        160        170        180 
RSNTAQKLEK LDIAKRRAAR IKSVNYQEEV QPPESDDFFK RKELPLSKAE RVKNEPKAND 

       190        200        210        220        230        240 
DDLSDEGVQS QLTEQLAKSP KQAQNRFIEF ARFDGTSQVG MQTKRINVFL NMLPEPDRNY 

       250        260        270        280        290        300 
PLKICVVATA KIQEVIGFVC YRTSLQYPDV PLKSLQHYAL YMTEDNDDME DFPPLDNREP 

       310        320        330        340        350        360 
CSKFGFSQLT LAERRPLAPV TRVDYHSQLG SKSMTSVEDK TALSDAAVKA LQNISLNGGT 

       370        380        390        400        410        420 
SDPGGGGGGG DSPHDNVKEY EKRLLNHNDM LEAPMHRTFR LNIIDKRFFK SDVTLGISGE 

       430        440        450        460        470        480 
RIEIDQCKNA KFWPQKKPVS TPIDFVAHCE ILERRHLKAL LRIWLKSNSS SPSFSTGCTS 

       490        500        510        520        530        540 
APINASVTTL NAGSGSGGIA HSPSSPGHSS GLFSSSNIRF KHYDFDTDTH TAEQIHNKLN 

       550        560 
CILEMRSSDL RREFLLQRDR KQEKRQLKL 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[4]"mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s."
Frias M.A., Thoreen C.C., Jaffe J.D., Schroder W., Sculley T., Carr S.A., Sabatini D.M.
Curr. Biol. 16:1865-1870(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333; SER-355; SER-372 AND SER-504, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013599 Genomic DNA. Translation: AAF58247.1.
BT003261 mRNA. Translation: AAO25018.1.
RefSeqNP_610963.1. NM_137119.3.
UniGeneDm.10957.

3D structure databases

ProteinModelPortalQ9V719.
SMRQ9V719. Positions 389-547.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid62354. 1 interaction.
IntActQ9V719. 12 interactions.
MINTMINT-7555994.

Proteomic databases

PaxDbQ9V719.
PRIDEQ9V719.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0087487; FBpp0086616; FBgn0033935.
GeneID36604.
KEGGdme:Dmel_CG10105.

Organism-specific databases

CTD36604.
FlyBaseFBgn0033935. Sin1.

Phylogenomic databases

eggNOGNOG281916.
GeneTreeENSGT00390000000642.
InParanoidQ9V719.
OMAERIEIDQ.
OrthoDBEOG7GXPBF.
PhylomeDBQ9V719.

Gene expression databases

BgeeQ9V719.

Family and domain databases

InterProIPR008828. SIN1.
[Graphical view]
PANTHERPTHR13335. PTHR13335. 1 hit.
PfamPF05422. SIN1. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi36604.
NextBio799458.
PROQ9V719.

Entry information

Entry nameSIN1_DROME
AccessionPrimary (citable) accession number: Q9V719
Secondary accession number(s): Q53YG4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase