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Protein

Enoyl-[acyl-carrier-protein] reductase, mitochondrial

Gene

CG16935

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro.By similarity

Catalytic activityi

An acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74Proton donorBy similarity1
Binding sitei147NADPBy similarity1
Binding sitei349NADPBy similarity1
Binding sitei350NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi173 – 176NADPBy similarity4
Nucleotide bindingi196 – 198NADPBy similarity3
Nucleotide bindingi264 – 267NADPBy similarity4
Nucleotide bindingi289 – 291NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Enzyme and pathway databases

ReactomeiR-DME-77346. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC:1.3.1.104)
Alternative name(s):
2-enoyl thioester reductase
Gene namesi
ORF Names:CG16935
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033883. CG16935.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 19MitochondrionSequence analysisAdd BLAST19
ChainiPRO_000000089420 – 357Enoyl-[acyl-carrier-protein] reductase, mitochondrialAdd BLAST338

Proteomic databases

PaxDbiQ9V6U9.
PRIDEiQ9V6U9.

Expressioni

Gene expression databases

BgeeiFBgn0033883.
ExpressionAtlasiQ9V6U9. differential.
GenevisibleiQ9V6U9. DM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi62294. 2 interactors.
IntActiQ9V6U9. 2 interactors.
MINTiMINT-286445.
STRINGi7227.FBpp0086748.

Structurei

3D structure databases

ProteinModelPortaliQ9V6U9.
SMRiQ9V6U9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0025. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00550000074483.
InParanoidiQ9V6U9.
KOiK07512.
OMAiAFRGFWM.
OrthoDBiEOG091G0BAE.
PhylomeDBiQ9V6U9.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9V6U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRGFLSRI NAAQWSRQMS VVAKSLKYTQ HGEPQEVLQL VEDKLPDPKD
60 70 80 90 100
NQVLVKILAA PINPADINTI QGKYPVKPKF PAVGGNECVA EVICVGDKVK
110 120 130 140 150
GFEAGQHVIP LASGLGTWTT HAVYKEDQLL IVSKKVGLAE AATSTVNPTT
160 170 180 190 200
AYRMLKDFVQ LCPGDTVIQN GANSAVGQAV HQLCRAWGIN SVGIVRDRPE
210 220 230 240 250
IAELKQMLQC LGATEVLTEA EIRTSDIFKS GKLKKPRLAF NCVGGKSATE
260 270 280 290 300
VSRHLDNGGV LVTYGGMSRE PVTVATGPLI FKDIAFRGFW MTRWSKENYS
310 320 330 340 350
SPERSKMFKE IFELMEQGKF VAPNHEMVPL AKFKDAAAAA LSFKGFTGKK

YILDMSI
Length:357
Mass (Da):39,111
Last modified:July 5, 2004 - v2
Checksum:i7E5F0D1EF9C70693
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58322.2.
RefSeqiNP_001286396.1. NM_001299467.1.
NP_610914.2. NM_137070.2.
UniGeneiDm.30974.

Genome annotation databases

EnsemblMetazoaiFBtr0087622; FBpp0086748; FBgn0033883.
FBtr0339954; FBpp0308976; FBgn0033883.
GeneIDi36540.
KEGGidme:Dmel_CG16935.
UCSCiCG16935-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiMECR_DROME
AccessioniPrimary (citable) accession number: Q9V6U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families