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Protein

Enoyl-[acyl-carrier-protein] reductase, mitochondrial

Gene

CG16935

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro.By similarity

Catalytic activityi

An acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74Proton donorBy similarity1
Binding sitei147NADPBy similarity1
Binding sitei349NADPBy similarity1
Binding sitei350NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi173 – 176NADPBy similarity4
Nucleotide bindingi196 – 198NADPBy similarity3
Nucleotide bindingi264 – 267NADPBy similarity4
Nucleotide bindingi289 – 291NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Enzyme and pathway databases

ReactomeiR-DME-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC:1.3.1.104)
Alternative name(s):
2-enoyl thioester reductase
Gene namesi
ORF Names:CG16935
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033883 CG16935

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 19MitochondrionSequence analysisAdd BLAST19
ChainiPRO_000000089420 – 357Enoyl-[acyl-carrier-protein] reductase, mitochondrialAdd BLAST338

Proteomic databases

PaxDbiQ9V6U9
PRIDEiQ9V6U9

Expressioni

Gene expression databases

BgeeiFBgn0033883
ExpressionAtlasiQ9V6U9 baseline and differential
GenevisibleiQ9V6U9 DM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi62294, 3 interactors
IntActiQ9V6U9, 2 interactors
STRINGi7227.FBpp0086748

Structurei

3D structure databases

ProteinModelPortaliQ9V6U9
SMRiQ9V6U9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0025 Eukaryota
COG0604 LUCA
GeneTreeiENSGT00550000074483
InParanoidiQ9V6U9
KOiK07512
OMAiAFRGFWM
OrthoDBiEOG091G0BAE
PhylomeDBiQ9V6U9

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9V6U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRGFLSRI NAAQWSRQMS VVAKSLKYTQ HGEPQEVLQL VEDKLPDPKD
60 70 80 90 100
NQVLVKILAA PINPADINTI QGKYPVKPKF PAVGGNECVA EVICVGDKVK
110 120 130 140 150
GFEAGQHVIP LASGLGTWTT HAVYKEDQLL IVSKKVGLAE AATSTVNPTT
160 170 180 190 200
AYRMLKDFVQ LCPGDTVIQN GANSAVGQAV HQLCRAWGIN SVGIVRDRPE
210 220 230 240 250
IAELKQMLQC LGATEVLTEA EIRTSDIFKS GKLKKPRLAF NCVGGKSATE
260 270 280 290 300
VSRHLDNGGV LVTYGGMSRE PVTVATGPLI FKDIAFRGFW MTRWSKENYS
310 320 330 340 350
SPERSKMFKE IFELMEQGKF VAPNHEMVPL AKFKDAAAAA LSFKGFTGKK

YILDMSI
Length:357
Mass (Da):39,111
Last modified:July 5, 2004 - v2
Checksum:i7E5F0D1EF9C70693
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58322.2
RefSeqiNP_001286396.1, NM_001299467.1
NP_610914.2, NM_137070.2
UniGeneiDm.30974

Genome annotation databases

EnsemblMetazoaiFBtr0087622; FBpp0086748; FBgn0033883
FBtr0339954; FBpp0308976; FBgn0033883
GeneIDi36540
KEGGidme:Dmel_CG16935
UCSCiCG16935-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiMECR_DROME
AccessioniPrimary (citable) accession number: Q9V6U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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