UniProtKB - Q9V6L0 (KDM4B_DROME)
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Protein
Probable lysine-specific demethylase 4B
Gene
Kdm4B
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate (By similarity).By similarity
Cofactori
Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 130 | 2-oxoglutarateBy similarity | 1 | |
Metal bindingi | 186 | Iron; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 188 | Iron; catalyticPROSITE-ProRule annotation | 1 | |
Binding sitei | 196 | 2-oxoglutarateBy similarity | 1 | |
Binding sitei | 204 | 2-oxoglutarateBy similarity | 1 | |
Metal bindingi | 232 | ZincBy similarity | 1 | |
Metal bindingi | 238 | ZincBy similarity | 1 | |
Binding sitei | 239 | 2-oxoglutarateBy similarity | 1 | |
Metal bindingi | 274 | Iron; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 304 | ZincBy similarity | 1 | |
Metal bindingi | 306 | ZincBy similarity | 1 |
GO - Molecular functioni
- histone demethylase activity (H3-K36 specific) Source: FlyBase
- histone demethylase activity (H3-K9 specific) Source: FlyBase
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- histone demethylation Source: UniProtKB
- histone H3-K36 demethylation Source: FlyBase
- histone H3-K9 demethylation Source: FlyBase
- negative regulation of transcription, DNA-templated Source: UniProtKB
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | Chromatin regulator, Dioxygenase, Oxidoreductase |
Biological process | Transcription, Transcription regulation |
Ligand | Iron, Metal-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 1.14.11.27. 1994. 1.14.11.B1. 1994. |
Reactomei | R-DME-3214842. HDMs demethylate histones. R-DME-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks. |
Names & Taxonomyi
Protein namesi | Recommended name: Probable lysine-specific demethylase 4B (EC:1.14.11.-)Alternative name(s): Probable JmjC domain-containing histone demethylation protein 3B |
Gene namesi | Name:Kdm4B ORF Names:CG33182 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0053182. Kdm4B. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000234380 | 1 – 590 | Probable lysine-specific demethylase 4BAdd BLAST | 590 |
Proteomic databases
PaxDbi | Q9V6L0. |
PRIDEi | Q9V6L0. |
Interactioni
Protein-protein interaction databases
BioGridi | 77204. 4 interactors. |
STRINGi | 7227.FBpp0302636. |
Structurei
3D structure databases
ProteinModelPortali | Q9V6L0. |
SMRi | Q9V6L0. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 51 | JmjNPROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 140 – 306 | JmjCPROSITE-ProRule annotationAdd BLAST | 167 |
Sequence similaritiesi
Belongs to the JHDM3 histone demethylase family.Curated
Phylogenomic databases
eggNOGi | KOG0958. Eukaryota. ENOG410XP0T. LUCA. |
GeneTreei | ENSGT00530000063342. |
InParanoidi | Q9V6L0. |
KOi | K06709. |
OMAi | QESGEIM. |
OrthoDBi | EOG091G01FR. |
PhylomeDBi | Q9V6L0. |
Family and domain databases
InterProi | View protein in InterPro IPR003347. JmjC_dom. IPR003349. JmjN. |
Pfami | View protein in Pfam PF02373. JmjC. 1 hit. PF02375. JmjN. 1 hit. |
SMARTi | View protein in SMART SM00558. JmjC. 1 hit. SM00545. JmjN. 1 hit. |
PROSITEi | View protein in PROSITE PS51184. JMJC. 1 hit. PS51183. JMJN. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9V6L0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKMSEVPRIK VFRPTWEEFK DFPKYVAYME SQGAHKAGLA KVVPPPEWVP
60 70 80 90 100
RRSGYADLDA LNVTIPAPIC QVVTGKQGYY QQINIQKKPL TVKQFSELAS
110 120 130 140 150
TERYATPKHF DFEDLERKYW KNITYVAPIY GADVSGSITD TDQDSWNINR
160 170 180 190 200
LGTILDYVNK DYNIQIDGVN TAYLYFGMWK TTFAWHTEDM DLYSINYLHF
210 220 230 240 250
GAPKTWYVVP PECGRKLEKV ANQYFPASYK NCNAYLRHKM TLISPQILKQ
260 270 280 290 300
HDVPVSKITQ EAGEIMITFP FGYHAGFNHG FNCAESTNFA MERWIEYGKR
310 320 330 340 350
AVQCTCSNDM VKISMDTFVK RFQSDRYDLW MEGRDVGRHP EDPPNAVLSA
360 370 380 390 400
APLPPHLDVL LCDKKMKKQC NPTKAKSFKE RNPDLDLDEI QQNPNVPDDV
410 420 430 440 450
KAMLKESVLT LDTGDLATDE ADFPNEDAMS LQSPANLKTK QELLEYIDDG
460 470 480 490 500
TEDDDEEEDF KRRKQKRRYD ADYDDDWLAS KRKTNSRNNR GRSPRTKDDR
510 520 530 540 550
SISPASSTSS TSRGARRGKA SGTPRKTPAR RKKDSITTSP AVSSAATAVK
560 570 580 590
TPTSAVVAGT TSIATTTTPP ADGGGGESSS LGSHCTTASP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA. Translation: AAF58413.3. |
RefSeqi | NP_001163137.1. NM_001169666.2. NP_001163138.1. NM_001169667.2. NP_001163139.1. NM_001169668.2. NP_788344.2. NM_176164.4. |
UniGenei | Dm.6975. |
Genome annotation databases
EnsemblMetazoai | FBtr0087770; FBpp0086883; FBgn0053182. FBtr0302052; FBpp0291262; FBgn0053182. FBtr0302053; FBpp0291263; FBgn0053182. FBtr0302054; FBpp0291264; FBgn0053182. FBtr0310498; FBpp0302636; FBgn0053182. |
GeneIDi | 318918. |
KEGGi | dme:Dmel_CG33182. |
UCSCi | CG33182-RA. d. melanogaster. |
Similar proteinsi
Entry informationi
Entry namei | KDM4B_DROME | |
Accessioni | Q9V6L0Primary (citable) accession number: Q9V6L0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | January 15, 2008 | |
Last modified: | March 28, 2018 | |
This is version 117 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |