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Protein

Probable cytochrome P450 6g2

Gene

Cyp6g2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.By similarity

Miscellaneous

More highly expressed in DDT-susceptible strains (Canton-S and 91-C) as compared to the DDT-resistant strains (91-R and Wisconsin).

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi460Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • response to insecticide Source: FlyBase

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-211979. Eicosanoids.
R-DME-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome P450 6g2 (EC:1.14.-.-)
Alternative name(s):
CYPVIG2
Gene namesi
Name:Cyp6g2
ORF Names:CG8859
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033696. Cyp6g2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518841 – 519Probable cytochrome P450 6g2Add BLAST519

Proteomic databases

PaxDbiQ9V675.
PRIDEiQ9V675.

Expressioni

Gene expression databases

BgeeiFBgn0033696.
GenevisibleiQ9V675. DM.

Interactioni

Protein-protein interaction databases

BioGridi62095. 1 interactor.
DIPiDIP-19705N.
IntActiQ9V675. 2 interactors.
MINTiMINT-296946.
STRINGi7227.FBpp0087117.

Structurei

3D structure databases

ProteinModelPortaliQ9V675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
InParanoidiQ9V675.
KOiK14999.
OMAiERTPHRM.
OrthoDBiEOG091G0JNC.
PhylomeDBiQ9V675.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9V675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELVLLILVA SLIGIAFLAL QQHYSYWRRM GVREIRPKWI VGNLMGLLNM
60 70 80 90 100
RMSPAEFISQ LYNHPDAENE PFVGIHVFHK PALLLRDPEM VRNILVKDFA
110 120 130 140 150
GFSNRYSSSD PKGDPLGSQN IFFLKNPAWK EVRLKLSPFF TGNRLKQMFP
160 170 180 190 200
LIEEVGASLD AHLRQQPLHN ERMRCFDLEA KELCALYTTD VIATVAYGVS
210 220 230 240 250
ANSFTDPKCE FRRHGRSVFE FNLLRAAEFT LVFFLPHLVP FVRFKVVPAE
260 270 280 290 300
ATRFLRKTIN YVMSEREKSG QKRNDLIDIL IEFRRSTQLA KASGIKDQFV
310 320 330 340 350
FEGDILVAQA VLFFTAGFES SSSTMAFAMY ELAKDTDVQQ RLREEIKDAL
360 370 380 390 400
VESGGQVTLK MIESLEFMQM ILLEVLRMYP PLPFLDRECT SGRDYSLAPF
410 420 430 440 450
HKKFVVPKGM PVYIPCYALH MDPQYFPQPR KFLPERFSPE NRKLHTPYTY
460 470 480 490 500
MPFGLGPHGC IGERFGYLQA KVGLVNLLRN HMITTSERTP HRMQLDPKAI
510
ITQAKGGIHL RLVRDALGV
Length:519
Mass (Da):59,608
Last modified:May 1, 2000 - v1
Checksum:i8C1770B4264CF8FB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti442R → H in AAR88134 (PubMed:15663776).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY459353 mRNA. Translation: AAR88134.1.
AE013599 Genomic DNA. Translation: AAF58556.1.
BT031097 mRNA. Translation: ABX00719.1.
RefSeqiNP_610744.1. NM_136900.2.
UniGeneiDm.18513.

Genome annotation databases

EnsemblMetazoaiFBtr0088009; FBpp0087117; FBgn0033696.
GeneIDi36317.
KEGGidme:Dmel_CG8859.
UCSCiCG8859-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiCP6G2_DROME
AccessioniPrimary (citable) accession number: Q9V675
Secondary accession number(s): A8WHF1, Q6SEI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families