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Protein

Probable cytochrome P450 6g2

Gene

Cyp6g2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi460 – 4601Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

  • response to insecticide Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome P450 6g2 (EC:1.14.-.-)
Alternative name(s):
CYPVIG2
Gene namesi
Name:Cyp6g2
ORF Names:CG8859
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033696. Cyp6g2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Probable cytochrome P450 6g2PRO_0000051884Add
BLAST

Proteomic databases

PaxDbiQ9V675.
PRIDEiQ9V675.

Expressioni

Gene expression databases

BgeeiQ9V675.
GenevisibleiQ9V675. DM.

Interactioni

Protein-protein interaction databases

BioGridi62095. 1 interaction.
DIPiDIP-19705N.
IntActiQ9V675. 1 interaction.
MINTiMINT-296946.
STRINGi7227.FBpp0087117.

Structurei

3D structure databases

ProteinModelPortaliQ9V675.
SMRiQ9V675. Positions 74-505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
InParanoidiQ9V675.
KOiK14999.
OMAiQPRKFLP.
OrthoDBiEOG7W6WKQ.
PhylomeDBiQ9V675.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELVLLILVA SLIGIAFLAL QQHYSYWRRM GVREIRPKWI VGNLMGLLNM
60 70 80 90 100
RMSPAEFISQ LYNHPDAENE PFVGIHVFHK PALLLRDPEM VRNILVKDFA
110 120 130 140 150
GFSNRYSSSD PKGDPLGSQN IFFLKNPAWK EVRLKLSPFF TGNRLKQMFP
160 170 180 190 200
LIEEVGASLD AHLRQQPLHN ERMRCFDLEA KELCALYTTD VIATVAYGVS
210 220 230 240 250
ANSFTDPKCE FRRHGRSVFE FNLLRAAEFT LVFFLPHLVP FVRFKVVPAE
260 270 280 290 300
ATRFLRKTIN YVMSEREKSG QKRNDLIDIL IEFRRSTQLA KASGIKDQFV
310 320 330 340 350
FEGDILVAQA VLFFTAGFES SSSTMAFAMY ELAKDTDVQQ RLREEIKDAL
360 370 380 390 400
VESGGQVTLK MIESLEFMQM ILLEVLRMYP PLPFLDRECT SGRDYSLAPF
410 420 430 440 450
HKKFVVPKGM PVYIPCYALH MDPQYFPQPR KFLPERFSPE NRKLHTPYTY
460 470 480 490 500
MPFGLGPHGC IGERFGYLQA KVGLVNLLRN HMITTSERTP HRMQLDPKAI
510
ITQAKGGIHL RLVRDALGV
Length:519
Mass (Da):59,608
Last modified:May 1, 2000 - v1
Checksum:i8C1770B4264CF8FB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti442 – 4421R → H in AAR88134 (PubMed:15663776).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY459353 mRNA. Translation: AAR88134.1.
AE013599 Genomic DNA. Translation: AAF58556.1.
BT031097 mRNA. Translation: ABX00719.1.
RefSeqiNP_610744.1. NM_136900.2.
UniGeneiDm.18513.

Genome annotation databases

EnsemblMetazoaiFBtr0088009; FBpp0087117; FBgn0033696.
GeneIDi36317.
KEGGidme:Dmel_CG8859.
UCSCiCG8859-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY459353 mRNA. Translation: AAR88134.1.
AE013599 Genomic DNA. Translation: AAF58556.1.
BT031097 mRNA. Translation: ABX00719.1.
RefSeqiNP_610744.1. NM_136900.2.
UniGeneiDm.18513.

3D structure databases

ProteinModelPortaliQ9V675.
SMRiQ9V675. Positions 74-505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi62095. 1 interaction.
DIPiDIP-19705N.
IntActiQ9V675. 1 interaction.
MINTiMINT-296946.
STRINGi7227.FBpp0087117.

Proteomic databases

PaxDbiQ9V675.
PRIDEiQ9V675.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088009; FBpp0087117; FBgn0033696.
GeneIDi36317.
KEGGidme:Dmel_CG8859.
UCSCiCG8859-RA. d. melanogaster.

Organism-specific databases

CTDi36317.
FlyBaseiFBgn0033696. Cyp6g2.

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
InParanoidiQ9V675.
KOiK14999.
OMAiQPRKFLP.
OrthoDBiEOG7W6WKQ.
PhylomeDBiQ9V675.

Miscellaneous databases

GenomeRNAii36317.
NextBioi797883.
PROiQ9V675.

Gene expression databases

BgeeiQ9V675.
GenevisibleiQ9V675. DM.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of Cyp6g1 and Cyp12d1 in DDT resistant and susceptible strains of Drosophila melanogaster."
    Festucci-Buselli R.A., Carvalho-Dias A.S., de Oliveira-Andrade M., Caixeta-Nunes C., Li H.-M., Stuart J.J., Muir W., Scharf M.E., Pittendrigh B.R.
    Insect Mol. Biol. 14:69-77(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.

Entry informationi

Entry nameiCP6G2_DROME
AccessioniPrimary (citable) accession number: Q9V675
Secondary accession number(s): A8WHF1, Q6SEI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

More highly expressed in DDT-susceptible strains (Canton-S and 91-C) as compared to the DDT-resistant strains (91-R and Wisconsin).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.