Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protocadherin-like wing polarity protein stan

Gene

stan

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the fz signaling pathway that controls wing tissue polarity. Also mediates homophilic cell adhesion. May play a role in initiating prehair morphogenesis. May play a critical role in tissue polarity and in formation of normal dendrite fields.2 Publications

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • cell adhesion molecule binding Source: FlyBase
  • G-protein coupled receptor activity Source: UniProtKB-KW
  • receptor activity Source: FlyBase
  • signal transducer activity, downstream of receptor Source: UniProtKB
  • transmembrane signaling receptor activity Source: FlyBase

GO - Biological processi

  • axon guidance Source: FlyBase
  • axonogenesis Source: FlyBase
  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • dendrite development Source: UniProtKB
  • dendrite morphogenesis Source: FlyBase
  • dendrite self-avoidance Source: FlyBase
  • establishment of ommatidial planar polarity Source: FlyBase
  • establishment of planar polarity Source: FlyBase
  • establishment of tissue polarity Source: FlyBase
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
  • morphogenesis of a polarized epithelium Source: FlyBase
  • mushroom body development Source: FlyBase
  • negative regulation of Notch signaling pathway Source: FlyBase
  • negative regulation of Wnt signaling pathway Source: FlyBase
  • ommatidial rotation Source: FlyBase
  • positive regulation of axon extension Source: FlyBase
  • positive regulation of axon guidance Source: FlyBase
  • positive regulation of Wnt signaling pathway Source: FlyBase
  • R3/R4 cell fate commitment Source: FlyBase
  • R3/R4 development Source: FlyBase
  • regulation of axonogenesis Source: FlyBase
  • regulation of establishment of planar polarity Source: FlyBase
  • regulation of synapse assembly Source: FlyBase
  • regulation of tube length, open tracheal system Source: FlyBase
  • segment polarity determination Source: UniProtKB
  • sensory perception of pain Source: FlyBase
  • signal transduction Source: FlyBase
  • Wnt signaling pathway Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-like wing polarity protein stan
Alternative name(s):
Protein flamingo
Protein starry night
Gene namesi
Name:stan
Synonyms:fmi
ORF Names:CG11895
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0024836. stan.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 2816ExtracellularSequence analysisAdd BLAST2787
Transmembranei2817 – 2837Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini2838 – 2845CytoplasmicSequence analysis8
Transmembranei2846 – 2866Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini2867 – 2883ExtracellularSequence analysisAdd BLAST17
Transmembranei2884 – 2904Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini2905 – 2919CytoplasmicSequence analysisAdd BLAST15
Transmembranei2920 – 2940Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini2941 – 2959ExtracellularSequence analysisAdd BLAST19
Transmembranei2960 – 2980Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini2981 – 3000CytoplasmicSequence analysisAdd BLAST20
Transmembranei3001 – 3021Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini3022 – 3031ExtracellularSequence analysis10
Transmembranei3032 – 3052Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini3053 – 3579CytoplasmicSequence analysisAdd BLAST527

GO - Cellular componenti

  • cell-cell junction Source: FlyBase
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001292130 – 3579Protocadherin-like wing polarity protein stanAdd BLAST3550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Glycosylationi340N-linked (GlcNAc...)Sequence analysis1
Glycosylationi671N-linked (GlcNAc...)Sequence analysis1
Glycosylationi886N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1269N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1374N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1441N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1486 ↔ 1497Sequence analysis
Disulfide bondi1491 ↔ 1506Sequence analysis
Disulfide bondi1508 ↔ 1517Sequence analysis
Glycosylationi1650N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1678N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1727 ↔ 1753By similarity
Glycosylationi1747N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1760 ↔ 1771Sequence analysis
Disulfide bondi1765 ↔ 1780Sequence analysis
Disulfide bondi1782 ↔ 1791Sequence analysis
Glycosylationi1843N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1937 ↔ 1963By similarity
Disulfide bondi1969 ↔ 1979Sequence analysis
Disulfide bondi1973 ↔ 1988Sequence analysis
Glycosylationi1975N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1990 ↔ 1999Sequence analysis
Glycosylationi2016N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2028N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2071N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2088N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2092 ↔ 2095Sequence analysis
Disulfide bondi2097 ↔ 2114Sequence analysis
Disulfide bondi2116 ↔ 2125Sequence analysis
Disulfide bondi2128 ↔ 2140By similarity
Glycosylationi2196N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2320N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2784N-linked (GlcNAc...)Sequence analysis1
Modified residuei3199Phosphoserine1 Publication1
Modified residuei3200Phosphoserine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9V5N8.
PRIDEiQ9V5N8.

PTM databases

iPTMnetiQ9V5N8.

Expressioni

Tissue specificityi

In the pupal wing, expressed at relatively even levels in all regions. Abundant in 6-9 hours embryos. Expressed at higher levels in pupae than larvae.1 Publication

Developmental stagei

At 12 hours after puparium formation (apf), expressed evenly at cell boundaries. By 30 hours apf, expression is concentrated at proximal and distal cell boundaries with little or no expression at anterior and posterior boundaries. When prehairs emerge at 30-36 hours apf, expression becomes evenly distributed again along the whole cell boundary.1 Publication

Gene expression databases

BgeeiFBgn0024836.
ExpressionAtlasiQ9V5N8. baseline.
GenevisibleiQ9V5N8. DM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
fzP185373EBI-119250,EBI-251576

GO - Molecular functioni

  • cell adhesion molecule binding Source: FlyBase

Protein-protein interaction databases

BioGridi61934. 5 interactors.
IntActiQ9V5N8. 3 interactors.
STRINGi7227.FBpp0303451.

Structurei

3D structure databases

ProteinModelPortaliQ9V5N8.
SMRiQ9V5N8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini360 – 464Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini465 – 581Cadherin 2PROSITE-ProRule annotationAdd BLAST117
Domaini582 – 689Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini690 – 794Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini795 – 897Cadherin 5PROSITE-ProRule annotationAdd BLAST103
Domaini898 – 1007Cadherin 6PROSITE-ProRule annotationAdd BLAST110
Domaini1008 – 1113Cadherin 7PROSITE-ProRule annotationAdd BLAST106
Domaini1114 – 1220Cadherin 8PROSITE-ProRule annotationAdd BLAST107
Domaini1482 – 1518EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1556 – 1753Laminin G-like 1PROSITE-ProRule annotationAdd BLAST198
Domaini1756 – 1792EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1796 – 1963Laminin G-like 2PROSITE-ProRule annotationAdd BLAST168
Domaini1965 – 2000EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini2095 – 2142Laminin EGF-likePROSITE-ProRule annotationAdd BLAST48
Domaini2744 – 2802GPSPROSITE-ProRule annotationAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 143Poly-His4
Compositional biasi155 – 159Poly-Arg5
Compositional biasi2567 – 2579Poly-SerAdd BLAST13
Compositional biasi3460 – 3467Poly-Gln8

Sequence similaritiesi

Contains 8 cadherin domains.PROSITE-ProRule annotation
Contains 3 EGF-like domains.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 laminin EGF-like domain.PROSITE-ProRule annotation
Contains 2 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4289. Eukaryota.
ENOG410XTGH. LUCA.
GeneTreeiENSGT00760000118805.
InParanoidiQ9V5N8.
KOiK04600.
OrthoDBiEOG091G0039.
PhylomeDBiQ9V5N8.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR002049. Laminin_EGF.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF00008. EGF. 2 hits.
PF16489. GAIN. 1 hit.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTiSM00112. CA. 8 hits.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 2 hits.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
PROSITEiPS00232. CADHERIN_1. 6 hits.
PS50268. CADHERIN_2. 8 hits.
PS00022. EGF_1. 4 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 3 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q9V5N8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQTREFPQRP LGLLLVLLVV LLQSSLIKSY LIIVHEDTPP GTVIFNASVY
60 70 80 90 100
KLGSERHYKI NAHKSANFVH HLVSVNHKDG QIQLRKALKC DGIYYPNLFT
110 120 130 140 150
FYVDSTSNRL RSIDYYSLPV RIFVSGHSCN EDRRIEQELH HHHYEEEDNT
160 170 180 190 200
GYSKRRRRRS TQEMIQLNGN QLEEVFRQNS TEFRAGDLIF GDSFDNEMRH
210 220 230 240 250
RILSRKRRAV GSPDPLHLQP ALHRRISDAK QWISETYASY AIHTTDKWNQ
260 270 280 290 300
ICLRRSQFIN SLNAFLPRSV CQHCKVSFLD VNDERFAIEH QSRDLVASRD
310 320 330 340 350
VCIAESMWKV SITFNIRCDR RDIVDSDHRL KIVYHHQEFN DTDIARRVRR
360 370 380 390 400
ELRNQSPYFE QALYVASVLE EQPAGAAVTT VRARDPEDSP VVYSMVSLLD
410 420 430 440 450
SRSQSLFKVD SRTGVVTTSA SLDRELMDVH YFRVVATDDS FPPRSGTTTL
460 470 480 490 500
QVNVLDCNDH SPTFEAEQFE ASIREGATVG STVITLRATD QDIGKNAEIE
510 520 530 540 550
YGIEAVTDGA GLAQDQEMPI FRIDSRSGVI STRSSLDRET SDSYHLLVTA
560 570 580 590 600
ADLASAQSER RTATASVQVK VLDDNDNYPQ FSERTYTVQV PEDQWGGTED
610 620 630 640 650
NTVAHIRATD ADQGNNAAIR YAIIGGNTQS QFSIDSMSGD VSLVKPLDYE
660 670 680 690 700
SVRSYRLVIR AQDGGSPSRS NTTQLLVNVI DANDNAPRFY TSQFQESVLE
710 720 730 740 750
NVPVGYNIIR VQAYDSDEGA NAEITYSISE RDDNFPLAVD PRTGWVQTIK
760 770 780 790 800
PLDREEQGRF AFQVVAKDGG VPPKSASSSV VITVQDVNDN DPAFNPKYYE
810 820 830 840 850
ANVGEDQPPG TPVTTVTATD PDEDSRLHYE ITTGNTRGRF AITSQNGRGL
860 870 880 890 900
ITIAQSLDYK QEKRFLLTVA ATDSGGRSDT ATVHINITDA NNFAPIFENA
910 920 930 940 950
PYSASVFEDA PVGTTVLVVS ATDSDVGVNA QITYSLNEES INGLGSPDPF
960 970 980 990 1000
SINPQTGAIV TNAPLDRETT SGYLLTVTAK DGGNPSLSDT TDVEIGVTDV
1010 1020 1030 1040 1050
NDNAPAFKSP LYQASILEDA LVGTSVIQVA ASDPDVGLNG RIKYLLSDRD
1060 1070 1080 1090 1100
IEDGSFVIDP TSGTIRTNKG LDRESVAVFH LTAIAVDKGS PPLSSTVEVQ
1110 1120 1130 1140 1150
IRLEDVNDSP PTFASDKITL YVPENSPVGS VVGEIHAHDP DEGVNAVVHY
1160 1170 1180 1190 1200
SIIGGDDSNA FSLVTRPGSE RAQLLTMTEL DYESTRKRFE LVVRAASPPL
1210 1220 1230 1240 1250
RNDAHIEILV TDVNDNAPVL RDFQVIFNNF RDHFPSGEIG RIPAFDADVS
1260 1270 1280 1290 1300
DKLHYRILSG NNANLLRLNS SSGGLVLSPQ LNTNVPKFAT MEVSVSDGIN
1310 1320 1330 1340 1350
EAKAIMQLSV RLITEDMLFN SVTVRLNEMT EEAFLSPLLN FFLDGLAAII
1360 1370 1380 1390 1400
PCPKEHIFVF SIQDDTDVSS RILNVSFSAR RPDVSHEEFY TPQYLQERVY
1410 1420 1430 1440 1450
LNRAILARLA TVEVLPFDDN LCVREPCLNF EECLTVLKFG NASEFIHSDT
1460 1470 1480 1490 1500
VLFRPIYPVN TFACSCPEGF TGSKEHYLCD TEVDLCYSDP CQNGGTCVRR
1510 1520 1530 1540 1550
EGGYTCVCPS THTGQNCETG VGHLRPCPSE TCEGGLSCLS NYPSSQPPPY
1560 1570 1580 1590 1600
TATCELRARA FGRNSFLTFE SLKQRHRFNL KLRFATVQEN GLLLYNGRYN
1610 1620 1630 1640 1650
ELHDFIALEI HEGHVSFSFS LGDHSERISV IQEAKVSDGK WHQVEVVYLN
1660 1670 1680 1690 1700
RSVTLVLDNC DTAIALSGQL GDRWSCANRT TLKLDKRCSL LTETCHRFLD
1710 1720 1730 1740 1750
LTGPLQVGGL PRIPAHFPVT NRDFVGCISD LRIDDRFVDL NSYVADNGTL
1760 1770 1780 1790 1800
AGCPQKAPLC QSEPCFNGGT CREGWGTYSC ECPEGYAGNS CQDNIPAPWR
1810 1820 1830 1840 1850
FSGDGSLSFN PLLRPIQLPW TTSFSLRTRQ KEAFLLQIQI GQNSSAAVCL
1860 1870 1880 1890 1900
RQGVLYYIFD GEPMYLAGAF LSDGEWHRVE IRWQQGSEIH FSVDYGQRSG
1910 1920 1930 1940 1950
SVPMSQKVQG LYVGKIVMGS PDGSIGAVPE ASPFEGCIQD VRIGAGQSVL
1960 1970 1980 1990 2000
SRPTIRENVE DGCESRAQCP DHCPNHSSCQ SSWDLSTCEC DSGYVGTDCA
2010 2020 2030 2040 2050
PICTVRPCAS GVCRANTSLP RGYDCECNSS SRHGDYCEKE LQQPCPGGWW
2060 2070 2080 2090 2100
GERVCGPCRC DLAQGYHPDC NKTTGQCYCK TNHYQPPNET ACLSCDCYSI
2110 2120 2130 2140 2150
GSFSGACNPL TGQCECREGV IGRRCDSCSN PYAEVTLSGC EVVYDACPRS
2160 2170 2180 2190 2200
FAGGVWWPRT PLGGVAIEGC PPPARGKGQR SCDVQSGSWN TPDMYNCTSE
2210 2220 2230 2240 2250
PFVELRRQLS QLEKLELELN SFVAIKMAEQ LRKACEAVDR RGASKDQKIS
2260 2270 2280 2290 2300
GNGRPNRRYK MESSFLLSNG GNVWSHELEM DYLSDELKFT HDRLYGADLL
2310 2320 2330 2340 2350
VTEGLLQELI NYELMQSGLN LSHSQDKYFI KNLVDAASVI LDRKYEAEWR
2360 2370 2380 2390 2400
RATELIQRGP DDLVDAFNKY LVVLARSQHD TYTSPFEIVQ PNMALGLDIV
2410 2420 2430 2440 2450
TTESLFGYEP EQLSEYHRSK YLKPNAFTTE SVVLPDTSGF LQHSARQRPV
2460 2470 2480 2490 2500
ISFPKYNNYI LDRRKFDQHT KVLVPLEMLG ITPPESDEIS QSGRRGSSHD
2510 2520 2530 2540 2550
HRAIVAYAQY KDVGQLLPDL YDETITRRWG VDVELATPIL SLQILVPSME
2560 2570 2580 2590 2600
REQETQRLEI PSRKIFSSSS PSSSSSSGST EQQFVEVFDV PKAPTSSSEQ
2610 2620 2630 2640 2650
QIEDIRITAH EIPPPVSSVE QQEASSDEDG EEREPHIRLN LDDIEFHGNS
2660 2670 2680 2690 2700
GEEVISPDSP EMLNPNYEGV SSTGSDEQPK GENEAVYRDR RLVKRQVEIT
2710 2720 2730 2740 2750
YPSEQMQQTE QVVYRSLGSP HLAQPIKLQM WLDVDSARFG PRSNPQCVRW
2760 2770 2780 2790 2800
NSFTNQWTRL GCQTEIPDFD GDFNPAAQQA ILVNCSCTHI SSYAVIVDVI
2810 2820 2830 2840 2850
DPEDIPEPSL LVQITSYSAF LVSLPLLLGV LLALALLRGQ QTNSNTIHQN
2860 2870 2880 2890 2900
IVLCVFCAEL LFFVGMQSRR QLLESEFPCK LTAICLHYFW LAAFAWTTVD
2910 2920 2930 2940 2950
CVHLYRMLTE MRDINHGPMG FYFAMGYGAP AIVVGLSVGV RAHEYGNSLF
2960 2970 2980 2990 3000
CWLSVYEPVV WWLVGPIAGM SVVNLLILFV SVKAAFTLKD HVLGFGNLRT
3010 3020 3030 3040 3050
LLWLSVVSLP LMGVMWVLAV LAASEHSQLL SLLLSGVVLL HALFCLIGYC
3060 3070 3080 3090 3100
IINKRVRENL QRTCLRCMGR KVPLLDSSMV VSNSSHNVNA AARPSNFLAS
3110 3120 3130 3140 3150
GYDTTTRRNI GISASSTTSR STAKTSSSPY SDGQLRQTST STSNYNSASD
3160 3170 3180 3190 3200
APSFLRGFES STTGRSRGGE EKPSRRQRKD SDSGSETDGR SLELASSHSS
3210 3220 3230 3240 3250
DDDESRTARS SGTHRSTAVS STPAYLPNIT EHVQATTPPE LNVVQSPQLF
3260 3270 3280 3290 3300
PSVNKPVYAP RWSSQLPDAY LQSPPNIGRW SQDTGSDNEH VHGQAKMTIS
3310 3320 3330 3340 3350
PNPLPNPDLT DTSYLQQHHN KINMPPSILE NIRDAREGYE DSLYGRRGEY
3360 3370 3380 3390 3400
PDKYGSYKPP SHYGSEKDYP GGGSGSQTIG HMRSFHPDAA YLSDNIYDKQ
3410 3420 3430 3440 3450
RTLGSGYLGA KSESPYLSKD RITPDIYGSR DGHYSLKRQP AYATDSLHSV
3460 3470 3480 3490 3500
HSLLKNDYHQ QQQQQQQHHL QDRLSEGSDK NGYHFPYTAE EDHLPARKLS
3510 3520 3530 3540 3550
HTQPPSLHGS QLMQPPGVGL VNDVNNPGLM GRHTLNGGSR HSSRASSPPS
3560 3570
TMVAPMQPLG PLTSITDTER NIDDDETTV
Length:3,579
Mass (Da):397,143
Last modified:April 14, 2009 - v4
Checksum:i4E801C493031FB19
GO
Isoform B (identifier: Q9V5N8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3569-3579: ERNIDDDETTV → DSEAEY

Show »
Length:3,574
Mass (Da):396,549
Checksum:i300AA4A28BC83D83
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181T → S in AAF02618 (PubMed:10556066).Curated1
Sequence conflicti361Q → L in AAF02618 (PubMed:10556066).Curated1
Sequence conflicti395 – 401MVSLLDS → NGLTVGLP in BAA84069 (PubMed:10490098).Curated7
Sequence conflicti1968Q → H in AAF02618 (PubMed:10556066).Curated1
Sequence conflicti2271G → E in AAF02618 (PubMed:10556066).Curated1
Sequence conflicti2502R → C in BAA84069 (PubMed:10490098).Curated1
Sequence conflicti2627D → G in BAA84069 (PubMed:10490098).Curated1
Sequence conflicti2709T → S in BAA84069 (PubMed:10490098).Curated1
Sequence conflicti2756Q → R in BAA84069 (PubMed:10490098).Curated1
Sequence conflicti2901C → Y in AAF02618 (PubMed:10556066).Curated1
Sequence conflicti3098L → P in AAF02618 (PubMed:10556066).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0369113569 – 3579ERNIDDDETTV → DSEAEY in isoform B. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172329 mRNA. Translation: AAF02618.1.
AB028498 mRNA. Translation: BAA84069.1.
AE013599 Genomic DNA. Translation: AAF58763.5.
RefSeqiNP_001188903.1. NM_001201974.2. [Q9V5N8-1]
NP_724962.3. NM_165794.4. [Q9V5N8-1]
UniGeneiDm.4360.

Genome annotation databases

EnsemblMetazoaiFBtr0088214; FBpp0087309; FBgn0024836. [Q9V5N8-1]
FBtr0303223; FBpp0292315; FBgn0024836. [Q9V5N8-1]
GeneIDi36125.
KEGGidme:Dmel_CG11895.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172329 mRNA. Translation: AAF02618.1.
AB028498 mRNA. Translation: BAA84069.1.
AE013599 Genomic DNA. Translation: AAF58763.5.
RefSeqiNP_001188903.1. NM_001201974.2. [Q9V5N8-1]
NP_724962.3. NM_165794.4. [Q9V5N8-1]
UniGeneiDm.4360.

3D structure databases

ProteinModelPortaliQ9V5N8.
SMRiQ9V5N8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61934. 5 interactors.
IntActiQ9V5N8. 3 interactors.
STRINGi7227.FBpp0303451.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9V5N8.

Proteomic databases

PaxDbiQ9V5N8.
PRIDEiQ9V5N8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088214; FBpp0087309; FBgn0024836. [Q9V5N8-1]
FBtr0303223; FBpp0292315; FBgn0024836. [Q9V5N8-1]
GeneIDi36125.
KEGGidme:Dmel_CG11895.

Organism-specific databases

CTDi36125.
FlyBaseiFBgn0024836. stan.

Phylogenomic databases

eggNOGiKOG4289. Eukaryota.
ENOG410XTGH. LUCA.
GeneTreeiENSGT00760000118805.
InParanoidiQ9V5N8.
KOiK04600.
OrthoDBiEOG091G0039.
PhylomeDBiQ9V5N8.

Miscellaneous databases

GenomeRNAii36125.
PROiQ9V5N8.

Gene expression databases

BgeeiFBgn0024836.
ExpressionAtlasiQ9V5N8. baseline.
GenevisibleiQ9V5N8. DM.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR002049. Laminin_EGF.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF00008. EGF. 2 hits.
PF16489. GAIN. 1 hit.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTiSM00112. CA. 8 hits.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 2 hits.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
PROSITEiPS00232. CADHERIN_1. 6 hits.
PS50268. CADHERIN_2. 8 hits.
PS00022. EGF_1. 4 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 3 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTAN_DROME
AccessioniPrimary (citable) accession number: Q9V5N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: April 14, 2009
Last modified: November 30, 2016
This is version 160 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.