Reviewed, UniProtKB/Swiss-Prot Q9V5N8 (STAN_DROME)

Names and origin

Protein names

Recommended name:
    Protocadherin-like wing polarity protein stan
Alternative name(s):
    Protein starry night
    Protein flamingo

Gene names

Name:	stan
Synonyms:	fmi
ORF Names:	CG11895

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	3579 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the fz signaling pathway that controls wing tissue polarity. Also mediates homophilic cell adhesion. May play a role in initiating prehair morphogenesis. May play a critical role in tissue polarity and in formation of normal dendrite fields. Ref.1 Ref.2
Subcellular location	Cell membrane; Multi-pass membrane protein. Ref.2
Tissue specificity	In the pupal wing, expressed at relatively even levels in all regions. Abundant in 6-9 hours embryos. Expressed at higher levels in pupae than larvae. Ref.1
Developmental stage	At 12 hours after puparium formation (apf), expressed evenly at cell boundaries. By 30 hours apf, expression is concentrated at proximal and distal cell boundaries with little or no expression at anterior and posterior boundaries. When prehairs emerge at 30-36 hours apf, expression becomes evenly distributed again along the whole cell boundary. Ref.1
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. Contains 8 cadherin domains. Contains 4 EGF-like domains. Contains 1 GPS domain. Contains 1 laminin EGF-like domain. Contains 2 laminin G-like domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	EGF-like domain Laminin EGF-like domain Repeat Signal Transmembrane
Ligand	Calcium
Molecular function	Developmental protein G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	R3/R4 cell fate commitment Non-traceable author statement. Source: FlyBase R3/R4 development Inferred from mutant phenotype. Source: FlyBase Wnt receptor signaling pathway Ref.1 Ref.2 Inferred from mutant phenotype. Source: FlyBase axon guidance Inferred from mutant phenotype. Source: FlyBase calcium-dependent cell-cell adhesion Ref.1 Inferred from mutant phenotype. Source: UniProtKB dendrite morphogenesis Inferred from mutant phenotype. Source: FlyBase homophilic cell adhesion Traceable author statement. Source: FlyBase mushroom body development Inferred from mutant phenotype. Source: FlyBase negative regulation of Wnt receptor signaling pathway Traceable author statement. Source: FlyBase neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro positive regulation of Wnt receptor signaling pathway Non-traceable author statement. Source: FlyBase segment polarity determination Ref.1 Ref.2 Inferred from mutant phenotype. Source: UniProtKB
Cellular component	integral to membrane Ref.1 Ref.2 Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct receptor signaling protein activity Ref.1 Ref.2 Inferred from mutant phenotype. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
fz	P18537	3	EBI-119250,EBI-251576

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q9V5N8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q9V5N8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     3569-3579: ERNIDDDETTV → DSEAEY

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 3579	3550	Protocadherin-like wing polarity protein stan		PRO_0000012921
Regions
	Topological domain	30 – 2816	2787	Extracellular Potential
	Transmembrane	2817 – 2837	21	1 Potential
	Topological domain	2838 – 2845	8	Cytoplasmic Potential
	Transmembrane	2846 – 2866	21	2 Potential
	Topological domain	2867 – 2883	17	Extracellular Potential
	Transmembrane	2884 – 2904	21	3 Potential
	Topological domain	2905 – 2919	15	Cytoplasmic Potential
	Transmembrane	2920 – 2940	21	4 Potential
	Topological domain	2941 – 2959	19	Extracellular Potential
	Transmembrane	2960 – 2980	21	5 Potential
	Topological domain	2981 – 3000	20	Cytoplasmic Potential
	Transmembrane	3001 – 3021	21	6 Potential
	Topological domain	3022 – 3031	10	Extracellular Potential
	Transmembrane	3032 – 3052	21	7 Potential
	Topological domain	3053 – 3579	527	Cytoplasmic Potential
	Domain	360 – 464	105	Cadherin 1
	Domain	465 – 581	117	Cadherin 2
	Domain	582 – 689	108	Cadherin 3
	Domain	690 – 794	105	Cadherin 4
	Domain	795 – 897	103	Cadherin 5
	Domain	898 – 1007	110	Cadherin 6
	Domain	1008 – 1113	106	Cadherin 7
	Domain	1114 – 1220	107	Cadherin 8
	Domain	1482 – 1518	37	EGF-like 1; calcium-binding
	Domain	1556 – 1753	198	Laminin G-like 1
	Domain	1756 – 1792	37	EGF-like 2; calcium-binding
	Domain	1796 – 1963	168	Laminin G-like 2
	Domain	1965 – 2000	36	EGF-like 3; calcium-binding
	Domain	2095 – 2142	48	Laminin EGF-like
	Domain	2744 – 2802	59	GPS
	Compositional bias	140 – 143	4	Poly-His
	Compositional bias	155 – 159	5	Poly-Arg
	Compositional bias	2567 – 2579	13	Poly-Ser
	Compositional bias	3460 – 3467	8	Poly-Gln
Amino acid modifications
	Modified residue	3199	1	Phosphoserine Ref.5
	Modified residue	3200	1	Phosphoserine Ref.5
	Glycosylation	46	1	N-linked (GlcNAc...) Potential
	Glycosylation	179	1	N-linked (GlcNAc...) Potential
	Glycosylation	340	1	N-linked (GlcNAc...) Potential
	Glycosylation	671	1	N-linked (GlcNAc...) Potential
	Glycosylation	886	1	N-linked (GlcNAc...) Potential
	Glycosylation	1269	1	N-linked (GlcNAc...) Potential
	Glycosylation	1374	1	N-linked (GlcNAc...) Potential
	Glycosylation	1441	1	N-linked (GlcNAc...) Potential
	Glycosylation	1650	1	N-linked (GlcNAc...) Potential
	Glycosylation	1678	1	N-linked (GlcNAc...) Potential
	Glycosylation	1747	1	N-linked (GlcNAc...) Potential
	Glycosylation	1843	1	N-linked (GlcNAc...) Potential
	Glycosylation	1975	1	N-linked (GlcNAc...) Potential
	Glycosylation	2016	1	N-linked (GlcNAc...) Potential
	Glycosylation	2028	1	N-linked (GlcNAc...) Potential
	Glycosylation	2071	1	N-linked (GlcNAc...) Potential
	Glycosylation	2088	1	N-linked (GlcNAc...) Potential
	Glycosylation	2196	1	N-linked (GlcNAc...) Potential
	Glycosylation	2320	1	N-linked (GlcNAc...) Potential
	Glycosylation	2784	1	N-linked (GlcNAc...) Potential
	Disulfide bond	1486 ↔ 1497		Potential
	Disulfide bond	1491 ↔ 1506		Potential
	Disulfide bond	1508 ↔ 1517		Potential
	Disulfide bond	1727 ↔ 1753		By similarity
	Disulfide bond	1760 ↔ 1771		Potential
	Disulfide bond	1765 ↔ 1780		Potential
	Disulfide bond	1782 ↔ 1791		Potential
	Disulfide bond	1937 ↔ 1963		By similarity
	Disulfide bond	1969 ↔ 1979		Potential
	Disulfide bond	1973 ↔ 1988		Potential
	Disulfide bond	1990 ↔ 1999		Potential
	Disulfide bond	2092 ↔ 2095		Potential
	Disulfide bond	2097 ↔ 2114		Potential
	Disulfide bond	2116 ↔ 2125		Potential
	Disulfide bond	2128 ↔ 2140		By similarity
Natural variations
	Alternative sequence	3569 – 3579	11	ERNIDDDETTV → DSEAEY in isoform B.		VSP_036911
Experimental info
	Sequence conflict	181	1	T → S in AAF02618. Ref.1
	Sequence conflict	361	1	Q → L in AAF02618. Ref.1
	Sequence conflict	395 – 401	7	MVSLLDS → NGLTVGLP in BAA84069. Ref.2
	Sequence conflict	1968	1	Q → H in AAF02618. Ref.1
	Sequence conflict	2271	1	G → E in AAF02618. Ref.1
	Sequence conflict	2502	1	R → C in BAA84069. Ref.2
	Sequence conflict	2627	1	D → G in BAA84069. Ref.2
	Sequence conflict	2709	1	T → S in BAA84069. Ref.2
	Sequence conflict	2756	1	Q → R in BAA84069. Ref.2
	Sequence conflict	2901	1	C → Y in AAF02618. Ref.1
	Sequence conflict	3098	1	L → P in AAF02618. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified April 14, 2009. Version 4. Checksum: 4E801C493031FB19	FASTA	3,579	397,143
	10 20 30 40 50 60 MQTREFPQRP LGLLLVLLVV LLQSSLIKSY LIIVHEDTPP GTVIFNASVY KLGSERHYKI 70 80 90 100 110 120 NAHKSANFVH HLVSVNHKDG QIQLRKALKC DGIYYPNLFT FYVDSTSNRL RSIDYYSLPV 130 140 150 160 170 180 RIFVSGHSCN EDRRIEQELH HHHYEEEDNT GYSKRRRRRS TQEMIQLNGN QLEEVFRQNS 190 200 210 220 230 240 TEFRAGDLIF GDSFDNEMRH RILSRKRRAV GSPDPLHLQP ALHRRISDAK QWISETYASY 250 260 270 280 290 300 AIHTTDKWNQ ICLRRSQFIN SLNAFLPRSV CQHCKVSFLD VNDERFAIEH QSRDLVASRD 310 320 330 340 350 360 VCIAESMWKV SITFNIRCDR RDIVDSDHRL KIVYHHQEFN DTDIARRVRR ELRNQSPYFE 370 380 390 400 410 420 QALYVASVLE EQPAGAAVTT VRARDPEDSP VVYSMVSLLD SRSQSLFKVD SRTGVVTTSA 430 440 450 460 470 480 SLDRELMDVH YFRVVATDDS FPPRSGTTTL QVNVLDCNDH SPTFEAEQFE ASIREGATVG 490 500 510 520 530 540 STVITLRATD QDIGKNAEIE YGIEAVTDGA GLAQDQEMPI FRIDSRSGVI STRSSLDRET 550 560 570 580 590 600 SDSYHLLVTA ADLASAQSER RTATASVQVK VLDDNDNYPQ FSERTYTVQV PEDQWGGTED 610 620 630 640 650 660 NTVAHIRATD ADQGNNAAIR YAIIGGNTQS QFSIDSMSGD VSLVKPLDYE SVRSYRLVIR 670 680 690 700 710 720 AQDGGSPSRS NTTQLLVNVI DANDNAPRFY TSQFQESVLE NVPVGYNIIR VQAYDSDEGA 730 740 750 760 770 780 NAEITYSISE RDDNFPLAVD PRTGWVQTIK PLDREEQGRF AFQVVAKDGG VPPKSASSSV 790 800 810 820 830 840 VITVQDVNDN DPAFNPKYYE ANVGEDQPPG TPVTTVTATD PDEDSRLHYE ITTGNTRGRF 850 860 870 880 890 900 AITSQNGRGL ITIAQSLDYK QEKRFLLTVA ATDSGGRSDT ATVHINITDA NNFAPIFENA 910 920 930 940 950 960 PYSASVFEDA PVGTTVLVVS ATDSDVGVNA QITYSLNEES INGLGSPDPF SINPQTGAIV 970 980 990 1000 1010 1020 TNAPLDRETT SGYLLTVTAK DGGNPSLSDT TDVEIGVTDV NDNAPAFKSP LYQASILEDA 1030 1040 1050 1060 1070 1080 LVGTSVIQVA ASDPDVGLNG RIKYLLSDRD IEDGSFVIDP TSGTIRTNKG LDRESVAVFH 1090 1100 1110 1120 1130 1140 LTAIAVDKGS PPLSSTVEVQ IRLEDVNDSP PTFASDKITL YVPENSPVGS VVGEIHAHDP 1150 1160 1170 1180 1190 1200 DEGVNAVVHY SIIGGDDSNA FSLVTRPGSE RAQLLTMTEL DYESTRKRFE LVVRAASPPL 1210 1220 1230 1240 1250 1260 RNDAHIEILV TDVNDNAPVL RDFQVIFNNF RDHFPSGEIG RIPAFDADVS DKLHYRILSG 1270 1280 1290 1300 1310 1320 NNANLLRLNS SSGGLVLSPQ LNTNVPKFAT MEVSVSDGIN EAKAIMQLSV RLITEDMLFN 1330 1340 1350 1360 1370 1380 SVTVRLNEMT EEAFLSPLLN FFLDGLAAII PCPKEHIFVF SIQDDTDVSS RILNVSFSAR 1390 1400 1410 1420 1430 1440 RPDVSHEEFY TPQYLQERVY LNRAILARLA TVEVLPFDDN LCVREPCLNF EECLTVLKFG 1450 1460 1470 1480 1490 1500 NASEFIHSDT VLFRPIYPVN TFACSCPEGF TGSKEHYLCD TEVDLCYSDP CQNGGTCVRR 1510 1520 1530 1540 1550 1560 EGGYTCVCPS THTGQNCETG VGHLRPCPSE TCEGGLSCLS NYPSSQPPPY TATCELRARA 1570 1580 1590 1600 1610 1620 FGRNSFLTFE SLKQRHRFNL KLRFATVQEN GLLLYNGRYN ELHDFIALEI HEGHVSFSFS 1630 1640 1650 1660 1670 1680 LGDHSERISV IQEAKVSDGK WHQVEVVYLN RSVTLVLDNC DTAIALSGQL GDRWSCANRT 1690 1700 1710 1720 1730 1740 TLKLDKRCSL LTETCHRFLD LTGPLQVGGL PRIPAHFPVT NRDFVGCISD LRIDDRFVDL 1750 1760 1770 1780 1790 1800 NSYVADNGTL AGCPQKAPLC QSEPCFNGGT CREGWGTYSC ECPEGYAGNS CQDNIPAPWR 1810 1820 1830 1840 1850 1860 FSGDGSLSFN PLLRPIQLPW TTSFSLRTRQ KEAFLLQIQI GQNSSAAVCL RQGVLYYIFD 1870 1880 1890 1900 1910 1920 GEPMYLAGAF LSDGEWHRVE IRWQQGSEIH FSVDYGQRSG SVPMSQKVQG LYVGKIVMGS 1930 1940 1950 1960 1970 1980 PDGSIGAVPE ASPFEGCIQD VRIGAGQSVL SRPTIRENVE DGCESRAQCP DHCPNHSSCQ 1990 2000 2010 2020 2030 2040 SSWDLSTCEC DSGYVGTDCA PICTVRPCAS GVCRANTSLP RGYDCECNSS SRHGDYCEKE 2050 2060 2070 2080 2090 2100 LQQPCPGGWW GERVCGPCRC DLAQGYHPDC NKTTGQCYCK TNHYQPPNET ACLSCDCYSI 2110 2120 2130 2140 2150 2160 GSFSGACNPL TGQCECREGV IGRRCDSCSN PYAEVTLSGC EVVYDACPRS FAGGVWWPRT 2170 2180 2190 2200 2210 2220 PLGGVAIEGC PPPARGKGQR SCDVQSGSWN TPDMYNCTSE PFVELRRQLS QLEKLELELN 2230 2240 2250 2260 2270 2280 SFVAIKMAEQ LRKACEAVDR RGASKDQKIS GNGRPNRRYK MESSFLLSNG GNVWSHELEM 2290 2300 2310 2320 2330 2340 DYLSDELKFT HDRLYGADLL VTEGLLQELI NYELMQSGLN LSHSQDKYFI KNLVDAASVI 2350 2360 2370 2380 2390 2400 LDRKYEAEWR RATELIQRGP DDLVDAFNKY LVVLARSQHD TYTSPFEIVQ PNMALGLDIV 2410 2420 2430 2440 2450 2460 TTESLFGYEP EQLSEYHRSK YLKPNAFTTE SVVLPDTSGF LQHSARQRPV ISFPKYNNYI 2470 2480 2490 2500 2510 2520 LDRRKFDQHT KVLVPLEMLG ITPPESDEIS QSGRRGSSHD HRAIVAYAQY KDVGQLLPDL 2530 2540 2550 2560 2570 2580 YDETITRRWG VDVELATPIL SLQILVPSME REQETQRLEI PSRKIFSSSS PSSSSSSGST 2590 2600 2610 2620 2630 2640 EQQFVEVFDV PKAPTSSSEQ QIEDIRITAH EIPPPVSSVE QQEASSDEDG EEREPHIRLN 2650 2660 2670 2680 2690 2700 LDDIEFHGNS GEEVISPDSP EMLNPNYEGV SSTGSDEQPK GENEAVYRDR RLVKRQVEIT 2710 2720 2730 2740 2750 2760 YPSEQMQQTE QVVYRSLGSP HLAQPIKLQM WLDVDSARFG PRSNPQCVRW NSFTNQWTRL 2770 2780 2790 2800 2810 2820 GCQTEIPDFD GDFNPAAQQA ILVNCSCTHI SSYAVIVDVI DPEDIPEPSL LVQITSYSAF 2830 2840 2850 2860 2870 2880 LVSLPLLLGV LLALALLRGQ QTNSNTIHQN IVLCVFCAEL LFFVGMQSRR QLLESEFPCK 2890 2900 2910 2920 2930 2940 LTAICLHYFW LAAFAWTTVD CVHLYRMLTE MRDINHGPMG FYFAMGYGAP AIVVGLSVGV 2950 2960 2970 2980 2990 3000 RAHEYGNSLF CWLSVYEPVV WWLVGPIAGM SVVNLLILFV SVKAAFTLKD HVLGFGNLRT 3010 3020 3030 3040 3050 3060 LLWLSVVSLP LMGVMWVLAV LAASEHSQLL SLLLSGVVLL HALFCLIGYC IINKRVRENL 3070 3080 3090 3100 3110 3120 QRTCLRCMGR KVPLLDSSMV VSNSSHNVNA AARPSNFLAS GYDTTTRRNI GISASSTTSR 3130 3140 3150 3160 3170 3180 STAKTSSSPY SDGQLRQTST STSNYNSASD APSFLRGFES STTGRSRGGE EKPSRRQRKD 3190 3200 3210 3220 3230 3240 SDSGSETDGR SLELASSHSS DDDESRTARS SGTHRSTAVS STPAYLPNIT EHVQATTPPE 3250 3260 3270 3280 3290 3300 LNVVQSPQLF PSVNKPVYAP RWSSQLPDAY LQSPPNIGRW SQDTGSDNEH VHGQAKMTIS 3310 3320 3330 3340 3350 3360 PNPLPNPDLT DTSYLQQHHN KINMPPSILE NIRDAREGYE DSLYGRRGEY PDKYGSYKPP 3370 3380 3390 3400 3410 3420 SHYGSEKDYP GGGSGSQTIG HMRSFHPDAA YLSDNIYDKQ RTLGSGYLGA KSESPYLSKD 3430 3440 3450 3460 3470 3480 RITPDIYGSR DGHYSLKRQP AYATDSLHSV HSLLKNDYHQ QQQQQQQHHL QDRLSEGSDK 3490 3500 3510 3520 3530 3540 NGYHFPYTAE EDHLPARKLS HTQPPSLHGS QLMQPPGVGL VNDVNNPGLM GRHTLNGGSR 3550 3560 3570 HSSRASSPPS TMVAPMQPLG PLTSITDTER NIDDDETTV
	Isoform B. Checksum: 300AA4A28BC83D83	FASTA	3,574	396,549
	10 20 30 40 50 60 MQTREFPQRP LGLLLVLLVV LLQSSLIKSY LIIVHEDTPP GTVIFNASVY KLGSERHYKI 70 80 90 100 110 120 NAHKSANFVH HLVSVNHKDG QIQLRKALKC DGIYYPNLFT FYVDSTSNRL RSIDYYSLPV 130 140 150 160 170 180 RIFVSGHSCN EDRRIEQELH HHHYEEEDNT GYSKRRRRRS TQEMIQLNGN QLEEVFRQNS 190 200 210 220 230 240 TEFRAGDLIF GDSFDNEMRH RILSRKRRAV GSPDPLHLQP ALHRRISDAK QWISETYASY 250 260 270 280 290 300 AIHTTDKWNQ ICLRRSQFIN SLNAFLPRSV CQHCKVSFLD VNDERFAIEH QSRDLVASRD 310 320 330 340 350 360 VCIAESMWKV SITFNIRCDR RDIVDSDHRL KIVYHHQEFN DTDIARRVRR ELRNQSPYFE 370 380 390 400 410 420 QALYVASVLE EQPAGAAVTT VRARDPEDSP VVYSMVSLLD SRSQSLFKVD SRTGVVTTSA 430 440 450 460 470 480 SLDRELMDVH YFRVVATDDS FPPRSGTTTL QVNVLDCNDH SPTFEAEQFE ASIREGATVG 490 500 510 520 530 540 STVITLRATD QDIGKNAEIE YGIEAVTDGA GLAQDQEMPI FRIDSRSGVI STRSSLDRET 550 560 570 580 590 600 SDSYHLLVTA ADLASAQSER RTATASVQVK VLDDNDNYPQ FSERTYTVQV PEDQWGGTED 610 620 630 640 650 660 NTVAHIRATD ADQGNNAAIR YAIIGGNTQS QFSIDSMSGD VSLVKPLDYE SVRSYRLVIR 670 680 690 700 710 720 AQDGGSPSRS NTTQLLVNVI DANDNAPRFY TSQFQESVLE NVPVGYNIIR VQAYDSDEGA 730 740 750 760 770 780 NAEITYSISE RDDNFPLAVD PRTGWVQTIK PLDREEQGRF AFQVVAKDGG VPPKSASSSV 790 800 810 820 830 840 VITVQDVNDN DPAFNPKYYE ANVGEDQPPG TPVTTVTATD PDEDSRLHYE ITTGNTRGRF 850 860 870 880 890 900 AITSQNGRGL ITIAQSLDYK QEKRFLLTVA ATDSGGRSDT ATVHINITDA NNFAPIFENA 910 920 930 940 950 960 PYSASVFEDA PVGTTVLVVS ATDSDVGVNA QITYSLNEES INGLGSPDPF SINPQTGAIV 970 980 990 1000 1010 1020 TNAPLDRETT SGYLLTVTAK DGGNPSLSDT TDVEIGVTDV NDNAPAFKSP LYQASILEDA 1030 1040 1050 1060 1070 1080 LVGTSVIQVA ASDPDVGLNG RIKYLLSDRD IEDGSFVIDP TSGTIRTNKG LDRESVAVFH 1090 1100 1110 1120 1130 1140 LTAIAVDKGS PPLSSTVEVQ IRLEDVNDSP PTFASDKITL YVPENSPVGS VVGEIHAHDP 1150 1160 1170 1180 1190 1200 DEGVNAVVHY SIIGGDDSNA FSLVTRPGSE RAQLLTMTEL DYESTRKRFE LVVRAASPPL 1210 1220 1230 1240 1250 1260 RNDAHIEILV TDVNDNAPVL RDFQVIFNNF RDHFPSGEIG RIPAFDADVS DKLHYRILSG 1270 1280 1290 1300 1310 1320 NNANLLRLNS SSGGLVLSPQ LNTNVPKFAT MEVSVSDGIN EAKAIMQLSV RLITEDMLFN 1330 1340 1350 1360 1370 1380 SVTVRLNEMT EEAFLSPLLN FFLDGLAAII PCPKEHIFVF SIQDDTDVSS RILNVSFSAR 1390 1400 1410 1420 1430 1440 RPDVSHEEFY TPQYLQERVY LNRAILARLA TVEVLPFDDN LCVREPCLNF EECLTVLKFG 1450 1460 1470 1480 1490 1500 NASEFIHSDT VLFRPIYPVN TFACSCPEGF TGSKEHYLCD TEVDLCYSDP CQNGGTCVRR 1510 1520 1530 1540 1550 1560 EGGYTCVCPS THTGQNCETG VGHLRPCPSE TCEGGLSCLS NYPSSQPPPY TATCELRARA 1570 1580 1590 1600 1610 1620 FGRNSFLTFE SLKQRHRFNL KLRFATVQEN GLLLYNGRYN ELHDFIALEI HEGHVSFSFS 1630 1640 1650 1660 1670 1680 LGDHSERISV IQEAKVSDGK WHQVEVVYLN RSVTLVLDNC DTAIALSGQL GDRWSCANRT 1690 1700 1710 1720 1730 1740 TLKLDKRCSL LTETCHRFLD LTGPLQVGGL PRIPAHFPVT NRDFVGCISD LRIDDRFVDL 1750 1760 1770 1780 1790 1800 NSYVADNGTL AGCPQKAPLC QSEPCFNGGT CREGWGTYSC ECPEGYAGNS CQDNIPAPWR 1810 1820 1830 1840 1850 1860 FSGDGSLSFN PLLRPIQLPW TTSFSLRTRQ KEAFLLQIQI GQNSSAAVCL RQGVLYYIFD 1870 1880 1890 1900 1910 1920 GEPMYLAGAF LSDGEWHRVE IRWQQGSEIH FSVDYGQRSG SVPMSQKVQG LYVGKIVMGS 1930 1940 1950 1960 1970 1980 PDGSIGAVPE ASPFEGCIQD VRIGAGQSVL SRPTIRENVE DGCESRAQCP DHCPNHSSCQ 1990 2000 2010 2020 2030 2040 SSWDLSTCEC DSGYVGTDCA PICTVRPCAS GVCRANTSLP RGYDCECNSS SRHGDYCEKE 2050 2060 2070 2080 2090 2100 LQQPCPGGWW GERVCGPCRC DLAQGYHPDC NKTTGQCYCK TNHYQPPNET ACLSCDCYSI 2110 2120 2130 2140 2150 2160 GSFSGACNPL TGQCECREGV IGRRCDSCSN PYAEVTLSGC EVVYDACPRS FAGGVWWPRT 2170 2180 2190 2200 2210 2220 PLGGVAIEGC PPPARGKGQR SCDVQSGSWN TPDMYNCTSE PFVELRRQLS QLEKLELELN 2230 2240 2250 2260 2270 2280 SFVAIKMAEQ LRKACEAVDR RGASKDQKIS GNGRPNRRYK MESSFLLSNG GNVWSHELEM 2290 2300 2310 2320 2330 2340 DYLSDELKFT HDRLYGADLL VTEGLLQELI NYELMQSGLN LSHSQDKYFI KNLVDAASVI 2350 2360 2370 2380 2390 2400 LDRKYEAEWR RATELIQRGP DDLVDAFNKY LVVLARSQHD TYTSPFEIVQ PNMALGLDIV 2410 2420 2430 2440 2450 2460 TTESLFGYEP EQLSEYHRSK YLKPNAFTTE SVVLPDTSGF LQHSARQRPV ISFPKYNNYI 2470 2480 2490 2500 2510 2520 LDRRKFDQHT KVLVPLEMLG ITPPESDEIS QSGRRGSSHD HRAIVAYAQY KDVGQLLPDL 2530 2540 2550 2560 2570 2580 YDETITRRWG VDVELATPIL SLQILVPSME REQETQRLEI PSRKIFSSSS PSSSSSSGST 2590 2600 2610 2620 2630 2640 EQQFVEVFDV PKAPTSSSEQ QIEDIRITAH EIPPPVSSVE QQEASSDEDG EEREPHIRLN 2650 2660 2670 2680 2690 2700 LDDIEFHGNS GEEVISPDSP EMLNPNYEGV SSTGSDEQPK GENEAVYRDR RLVKRQVEIT 2710 2720 2730 2740 2750 2760 YPSEQMQQTE QVVYRSLGSP HLAQPIKLQM WLDVDSARFG PRSNPQCVRW NSFTNQWTRL 2770 2780 2790 2800 2810 2820 GCQTEIPDFD GDFNPAAQQA ILVNCSCTHI SSYAVIVDVI DPEDIPEPSL LVQITSYSAF 2830 2840 2850 2860 2870 2880 LVSLPLLLGV LLALALLRGQ QTNSNTIHQN IVLCVFCAEL LFFVGMQSRR QLLESEFPCK 2890 2900 2910 2920 2930 2940 LTAICLHYFW LAAFAWTTVD CVHLYRMLTE MRDINHGPMG FYFAMGYGAP AIVVGLSVGV 2950 2960 2970 2980 2990 3000 RAHEYGNSLF CWLSVYEPVV WWLVGPIAGM SVVNLLILFV SVKAAFTLKD HVLGFGNLRT 3010 3020 3030 3040 3050 3060 LLWLSVVSLP LMGVMWVLAV LAASEHSQLL SLLLSGVVLL HALFCLIGYC IINKRVRENL 3070 3080 3090 3100 3110 3120 QRTCLRCMGR KVPLLDSSMV VSNSSHNVNA AARPSNFLAS GYDTTTRRNI GISASSTTSR 3130 3140 3150 3160 3170 3180 STAKTSSSPY SDGQLRQTST STSNYNSASD APSFLRGFES STTGRSRGGE EKPSRRQRKD 3190 3200 3210 3220 3230 3240 SDSGSETDGR SLELASSHSS DDDESRTARS SGTHRSTAVS STPAYLPNIT EHVQATTPPE 3250 3260 3270 3280 3290 3300 LNVVQSPQLF PSVNKPVYAP RWSSQLPDAY LQSPPNIGRW SQDTGSDNEH VHGQAKMTIS 3310 3320 3330 3340 3350 3360 PNPLPNPDLT DTSYLQQHHN KINMPPSILE NIRDAREGYE DSLYGRRGEY PDKYGSYKPP 3370 3380 3390 3400 3410 3420 SHYGSEKDYP GGGSGSQTIG HMRSFHPDAA YLSDNIYDKQ RTLGSGYLGA KSESPYLSKD 3430 3440 3450 3460 3470 3480 RITPDIYGSR DGHYSLKRQP AYATDSLHSV HSLLKNDYHQ QQQQQQQHHL QDRLSEGSDK 3490 3500 3510 3520 3530 3540 NGYHFPYTAE EDHLPARKLS HTQPPSLHGS QLMQPPGVGL VNDVNNPGLM GRHTLNGGSR 3550 3560 3570 HSSRASSPPS TMVAPMQPLG PLTSITDTDS EAEY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Drosophila tissue polarity gene starry night encodes a member of the protocadherin family." Chae J.W., Kim M.-J., Goo J.H., Collier S., Gubb D., Charlton J., Adler P.N., Park W.J. Development 126:5421-5429(1999) [PubMed: 10556066] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Embryo.
[2]	"Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of frizzled." Usui T., Shima Y., Shimada Y., Hirano S., Burgess R.W., Schwarz T.L., Takeichi M., Uemura T. Cell 98:585-595(1999) [PubMed: 10490098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), FUNCTION, SUBCELLULAR LOCATION.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[5]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3199 AND SER-3200, MASS SPECTROMETRY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF172329 mRNA. Translation: AAF02618.1. AB028498 mRNA. Translation: BAA84069.1. AE013599 Genomic DNA. Translation: AAF58763.5.
RefSeq	NP_724962.3.
UniGene	Dm.4360
3D structure databases
HSSP	HSSP built from PDB template 1BF9 based on UniProtKB P08709.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9V5N8. 1 interaction.
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	FBgn0024836. Drosophila melanogaster. [Contig view]
GeneID	36125.
KEGG	dme:Dmel_CG11895.
Organism-specific databases
FlyBase	FBgn0024836. stan.
Phylogenomic databases
HOGENOM	Q9V5N8.
OMA	Q9V5N8. YILRAYA.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-003906-MON.
Gene expression databases
ArrayExpress	Q9V5N8.
GermOnline	CG11895. Drosophila melanogaster.
Family and domain databases
InterPro	IPR002126. Cadherin. IPR013320. ConA-like_subgrp. IPR006209. EGF. IPR006210. EGF-like. IPR013032. EGF-like_reg_CS. IPR000742. EGF_3. IPR001881. EGF_Ca_bd. IPR002049. EGF_laminin. IPR017981. GPCR_2-like. IPR001879. GPCR_2_extracellular. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. IPR001791. Laminin_G. IPR012680. Laminin_G_2. IPR000203. PKD_cys_rich. [Graphical view]
Gene3D	G3DSA:2.60.40.60. Cadherin. 9 hits. G3DSA:2.60.120.200. ConA_like_subgrp. 2 hits.
Pfam	PF00002. 7tm_2. 1 hit. PF00028. Cadherin. 8 hits. PF00008. EGF. 2 hits. PF01825. GPS. 1 hit. PF02793. HRM. 1 hit. PF00053. Laminin_EGF. 1 hit. PF02210. Laminin_G_2. 2 hits. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 8 hits. SM00181. EGF. 3 hits. SM00179. EGF_CA. 1 hit. SM00180. EGF_Lam. 1 hit. SM00303. GPS. 1 hit. SM00282. LamG. 2 hits. [Graphical view]
PROSITE	PS00232. CADHERIN_1. 6 hits. PS50268. CADHERIN_2. 8 hits. PS00022. EGF_1. 4 hits. PS01186. EGF_2. 3 hits. PS50026. EGF_3. 3 hits. PS01248. EGF_LAM_1. 1 hit. PS50027. EGF_LAM_2. 1 hit. PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. False negative. PS50227. G_PROTEIN_RECEP_F2_3. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. PS50025. LAM_G_DOMAIN. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	796977.

Entry information

Entry name

STAN_DROME

Accession

Primary (citable) accession number: Q9V5N8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
Last sequence update:	April 14, 2009
Last modified:	June 16, 2009
This is version 92 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project