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Q9V5L3 (C49A1_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome P450 49a1
EC=1.14.-.-
Alternative name(s):
CYPXLIXA1
Gene names
Name:Cyp49a1
ORF Names:CG18377
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length589 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides By similarity.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein Potential. Microsome membrane; Peripheral membrane protein Potential.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence caution

The sequence AAM27517.1 differs from that shown. Reason: Intron retention.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: Q9V5L3-1)

Also known as: D;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform C (identifier: Q9V5L3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-174: Missing.
     175-177: MPH → MEL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 589589Probable cytochrome P450 49a1
PRO_0000051996

Sites

Metal binding5361Iron (heme axial ligand) By similarity

Natural variations

Alternative sequence1 – 174174Missing in isoform C.
VSP_000616
Alternative sequence175 – 1773MPH → MEL in isoform C.
VSP_000617

Experimental info

Sequence conflict4611S → N in AAL68266. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform A (D) [UniParc].

Last modified August 2, 2002. Version 3.
Checksum: A0DE2D1118807817

FASTA58965,902
        10         20         30         40         50         60 
MSGLRKTSIA LMRRSTSSTT ILPHSGGVGG AVSPPSSGVG VATEIEKSIA MQRLRTGESS 

        70         80         90        100        110        120 
NPKKLNVSQQ PVTSVATTRT TASSLPAETT SSPAAAVRPY SEVPGPYPLP LIGNSWRFAP 

       130        140        150        160        170        180 
LIGTYKISDL DKVMNELHVN YGKMAKVGGL IGHPDLLFVF DGDEIRNIFK KEEAMPHRPS 

       190        200        210        220        230        240 
MPSLRHYKGD LRRDFFGDVA GLIGVHGPKW EAFRQEVQHI LLQPQTAKKY IPPLNDIASE 

       250        260        270        280        290        300 
FMGRIELMRD EKDELPANFL HELYKWALES VGRVSLDTRL GCLSPEGSEE AQQIIEAINT 

       310        320        330        340        350        360 
FFWAVPELEL RMPLWRIYPT KAYRSFVKAL DQFTAICMKN IGKTMDKADA DEARGLSKSE 

       370        380        390        400        410        420 
ADISIVERIV RKTGNRKLAA ILALDLFLVG VDTTSVAASS TIYQLAKNPD KQKKLFDELQ 

       430        440        450        460        470        480 
KVFPHREADI NQNVLEQMPY LRACVKETLR MRPVVIANGR SLQSDAVING YHVPKGTHVI 

       490        500        510        520        530        540 
FPHLVVSNDP AYFPEPKRFL PERWLKQSTD AAGCPHANQK IHPFVSLPFG FGRRMCVGRR 

       550        560        570        580 
FAEIELHTLL AKIFRKYKVS YNSGEFVYRV NSTYIPQSPL NFKLTLRDE

« Hide

Isoform C [UniParc].

Checksum: AB12EB38715FD0D5
Show »

FASTA41547,476

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
Strain: Berkeley.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND C).
Strain: Berkeley.
Tissue: Embryo.
[4]Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
Strain: Berkeley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE013599 Genomic DNA. Translation: AAF58791.3.
AE013599 Genomic DNA. Translation: AAF58793.2.
AE013599 Genomic DNA. Translation: AAM68760.2.
AY075453 mRNA. Translation: AAL68266.1.
AY102688 mRNA. Translation: AAM27517.1. Sequence problems.
BT056244 mRNA. Translation: ACL68691.1.
RefSeqNP_610588.2. NM_136744.2.
NP_724937.1. NM_165774.1.
NP_995803.1. NM_206081.1.
UniGeneDm.5498.

3D structure databases

ProteinModelPortalQ9V5L3.
SMRQ9V5L3. Positions 96-587.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-22876N.
MINTMINT-836087.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0088311; FBpp0087403; FBgn0033524.
FBtr0088313; FBpp0089308; FBgn0033524.
FBtr0304592; FBpp0293134; FBgn0033524.
GeneID36105.
KEGGdme:Dmel_CG18377.
UCSCCG18377-RA. d. melanogaster.

Organism-specific databases

CTD36105.
FlyBaseFBgn0033524. Cyp49a1.

Phylogenomic databases

eggNOGinNOG06359.
GeneTreeEMGT00050000001200.
InParanoidQ9V5L3.
OMAHINIAME.
OrthoDBEOG4S7H58.
PhylomeDBQ9V5L3.

Gene expression databases

ArrayExpressQ9V5L3.
BgeeQ9V5L3.
GermOnlineCG18377. Drosophila melanogaster.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. Cytochrome_P450. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio796892.

Entry information

Entry nameC49A1_DROME
AccessionPrimary (citable) accession number: Q9V5L3
Secondary accession number(s): A4UZC2 expand/collapse secondary AC list , B8A3V2, Q8MZH1, Q8SY18
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 2, 2002
Last modified: January 25, 2012
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents