Reviewed, UniProtKB/Swiss-Prot Q9V589 (OR45B_DROME)

Names and origin

Protein names

Recommended name:
    Putative odorant receptor 45b

Gene names

Name:	Or45b
ORF Names:	CG12931

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Complexes with Or83b to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide By similarity.
Subunit structure	Interacts with Or83b. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Miscellaneous	The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Or83b complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Sequence similarities	Belongs to the odorant-gated ionic channel family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Non-traceable author statement. Source: UniProtKB detection of chemical stimulus involved in sensory perception of smell Inferred from mutant phenotype. Source: FlyBase
Cellular component	integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	odorant binding Inferred from electronic annotation. Source: InterPro olfactory receptor activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Putative odorant receptor 45b		PRO_0000174247
Regions
	Topological domain	1 – 39	39	Cytoplasmic Potential
	Transmembrane	40 – 60	21	1 Potential
	Topological domain	61 – 73	13	Extracellular Potential
	Transmembrane	74 – 94	21	2 Potential
	Topological domain	95 – 135	41	Cytoplasmic Potential
	Transmembrane	136 – 156	21	3 Potential
	Topological domain	157 – 200	44	Extracellular Potential
	Transmembrane	201 – 221	21	4 Potential
	Topological domain	222 – 276	55	Cytoplasmic Potential
	Transmembrane	277 – 297	21	5 Potential
	Topological domain	298 – 301	4	Extracellular Potential
	Transmembrane	302 – 322	21	6 Potential
	Topological domain	323 – 369	47	Cytoplasmic Potential
	Transmembrane	370 – 390	21	7 Potential
	Topological domain	391 – 396	6	Extracellular Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9V589-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 91A87F38F0572A84	FASTA	396	46,324
	10 20 30 40 50 60 MYPRFLSRNY PLAKHLFFVT RYSFGLLGLR FGKEQSWLHL LWLVFNFVNL AHCCQAEFVF 70 80 90 100 110 120 GWSHLRTSPV DAMDAFCPLA CSFTTLFKLG WMWWRRQEVA DLMDRIRLLI GEQEKREDSR 130 140 150 160 170 180 RKVAQRSYYL MVTRCGMLVF TLGSITTGAF VLRSLWEMWV RRHQEFKFDM PFRMLFHDFA 190 200 210 220 230 240 HRMPWFPVFY LYSTWSGQVT VYAFAGTDGF FFGFTLYMAF LLQALRYDIQ DALKPIRDPS 250 260 270 280 290 300 LRESKICCQR LADIVDRHNE IEKIVKEFSG IMAAPTFVHF VSASLVIATS VIDILLYSGY 310 320 330 340 350 360 NIIRYVVYTF TVSSAIFLYC YGGTEMSTES LSLGEAAYSS AWYTWDRETR RRVFLIILRA 370 380 390 QRPITVRVPF FAPSLPVFTS VIKFTGSIVA LAKTIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013599 Genomic DNA. Translation: AAF58928.1.
RefSeq	NP_523667.1.
UniGene	Dm.26889
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q9V589.
Genome annotation databases
Ensembl	FBgn0033422. Drosophila melanogaster. [Contig view]
GeneID	35980.
KEGG	dme:Dmel_CG12931.
NMPDR	fig|7227.3.peg.4092.
Organism-specific databases
FlyBase	FBgn0033422. Or45b.
Phylogenomic databases
HOGENOM	Q9V589.
OMA	Q9V589. AFCPLAC.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-003644-MON.
Gene expression databases
ArrayExpress	Q9V589.
GermOnline	CG12931. Drosophila melanogaster.
Family and domain databases
InterPro	IPR004117. 7tm6_olfct_rcpt. [Graphical view]
PANTHER	PTHR21137. 7tm6_olfct_rcpt. 1 hit.
Pfam	PF02949. 7tm_6. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	796150.

Entry information

Entry name

OR45B_DROME

Accession

Primary (citable) accession number: Q9V589

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project