Reviewed, UniProtKB/Swiss-Prot Q9V574 (L2K1_DROME)

Names and origin

Protein names

Recommended name:
    Protein lethal(2)k10201
Alternative name(s):
    Wunen region B protein

Gene names

Name:	l(2)k10201
ORF Names:	CG13951

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Vital for development. Ref.1
Sequence similarities	Contains 2 C2H2-type zinc fingers.
Sequence caution	The sequence AAC47450.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Ref.1 Inferred from mutant phenotype. Source: UniProtKB
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9VR04	1	EBI-154227,EBI-155749
	Q9W1K5-1	1	EBI-154227,EBI-212772

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Protein lethal(2)k10201		PRO_0000046927
Regions
	Zinc finger	74 – 97	24	C2H2-type 1
	Zinc finger	113 – 138	26	C2H2-type 2

Sequences

	Sequence		Length	Mass (Da)
	Q9V574-1 [UniParc]. Last modified June 1, 2003. Version 2. Checksum: CC906EC62398DAD9	FASTA	221	24,962
	10 20 30 40 50 60 MDSEAAGVAL LSREQIIRIL SEVPAGFIKP TDPPAPSLAP FKKLGVLVDI DDILGEQDAA 70 80 90 100 110 120 AARIRDNIDK EQSYSCVECR KMLPTAHLLD LHITEQHDCY FAASVERGDK PMFSCFLEEC 130 140 150 160 170 180 TIKFHTARQR KDHCIITHKL PANYRFDHSK NRGKQKHQGK SKPNSMEVDE VIEETKSLPY 190 200 210 220 VKAFSFGHQT QRSFYTGKDQ RSGKTLDDVQ AMKEAINDIL D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Drosophila protein Wunen repels migrating germ cells." Zhang N., Zhang J.P., Purcell K.J., Chen Y., Howard K. Nature 385:64-67(1997) [PubMed: 8985246] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U73823 Genomic DNA. Translation: AAC47450.1. Sequence problems. AE013599 Genomic DNA. Translation: AAF58944.2.
RefSeq	NP_788296.1.
UniGene	Dm.27473
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:19602N.
IntAct	Q9V574. 2 interactions.
Genome annotation databases
Ensembl	FBgn0016970. Drosophila melanogaster. [Contig view]
GeneID	48373.
KEGG	dme:Dmel_CG13951.
NMPDR	fig|7227.3.peg.4072.
Organism-specific databases
FlyBase	FBgn0016970. l(2)k10201.
Phylogenomic databases
HOGENOM	Q9V574.
OMA	Q9V574. HITEQHD.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-003625-MON.
Gene expression databases
ArrayExpress	Q9V574.
GermOnline	CG13951. Drosophila melanogaster.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. [Graphical view]
SMART	SM00355. ZnF_C2H2. 2 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 2 hits. PS50157. ZINC_FINGER_C2H2_2. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	839365.

Entry information

Entry name

L2K1_DROME

Accession

Primary (citable) accession number: Q9V574
Secondary accession number(s): P91662

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project