Q9V574 (L2K1_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein lethal(2)k10201

Alternative name(s):
Wunen region B protein

Gene names

Name:	l(2)k10201
ORF Names:	CG13951

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Vital for development. Ref.1
Sequence similarities	Contains 2 C2H2-type zinc fingers.
Sequence caution	The sequence AAC47450.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from mutant phenotype Ref.1. Source: UniProtKB
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Protein lethal(2)k10201		PRO_0000046927
Regions
	Zinc finger	74 – 97	24	C2H2-type 1
	Zinc finger	113 – 138	26	C2H2-type 2

Sequences

	Sequence		Length	Mass (Da)
	Q9V574 [UniParc]. Last modified June 1, 2003. Version 2. Checksum: CC906EC62398DAD9	FASTA	221	24,962
	10 20 30 40 50 60 MDSEAAGVAL LSREQIIRIL SEVPAGFIKP TDPPAPSLAP FKKLGVLVDI DDILGEQDAA 70 80 90 100 110 120 AARIRDNIDK EQSYSCVECR KMLPTAHLLD LHITEQHDCY FAASVERGDK PMFSCFLEEC 130 140 150 160 170 180 TIKFHTARQR KDHCIITHKL PANYRFDHSK NRGKQKHQGK SKPNSMEVDE VIEETKSLPY 190 200 210 220 VKAFSFGHQT QRSFYTGKDQ RSGKTLDDVQ AMKEAINDIL D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Drosophila protein Wunen repels migrating germ cells." Zhang N., Zhang J.P., Purcell K.J., Chen Y., Howard K. Nature 385:64-67(1997) [PubMed: 8985246] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U73823 Genomic DNA. Translation: AAC47450.1. Sequence problems. AE013599 Genomic DNA. Translation: AAF58944.2.
RefSeq	NP_788296.1. NM_176116.2.
UniGene	Dm.27473.
3D structure databases
ProteinModelPortal	Q9V574.
SMR	Q9V574. Positions 69-139.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-19602N.
IntAct	Q9V574. 2 interactions.
MINT	MINT-752655.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0088505; FBpp0087589; FBgn0016970.
GeneID	48373.
KEGG	dme:Dmel_CG13951.
NMPDR	fig|7227.3.peg.4072.
Organism-specific databases
FlyBase	FBgn0016970. l(2)k10201.
Phylogenomic databases
eggNOG	inNOG11231.
GeneTree	EMGT00050000016613.
InParanoid	Q9V574.
OMA	YFAASVE.
OrthoDB	EOG42Z36M.
PhylomeDB	Q9V574.
Gene expression databases
Bgee	Q9V574.
GermOnline	CG13951. Drosophila melanogaster.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. [Graphical view]
SMART	SM00355. ZnF_C2H2. 2 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 2 hits. PS50157. ZINC_FINGER_C2H2_2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	839365.

Entry information

Entry name

L2K1_DROME

Accession

Primary (citable) accession number: Q9V574
Secondary accession number(s): P91662

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project