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Q9V4X2

- PGSC2_DROME

UniProt

Q9V4X2 - PGSC2_DROME

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Protein

Peptidoglycan-recognition protein SC2

Gene
PGRP-SC2, CG14745
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity By similarity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Cofactori

Zinc By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi51 – 511Zinc By similarity
Metal bindingi85 – 851Zinc By similarity
Metal bindingi159 – 1591Zinc By similarity
Metal bindingi167 – 1671Zinc By similarity

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: FlyBase
  2. peptidoglycan binding Source: FlyBase
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. immune response Source: FlyBase
  2. innate immune response Source: UniProtKB-KW
  3. negative regulation of innate immune response Source: FlyBase
  4. peptidoglycan catabolic process Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan-recognition protein SC2 (EC:3.5.1.28)
Gene namesi
Name:PGRP-SC2
ORF Names:CG14745
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0043575. PGRP-SC2.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 184164Peptidoglycan-recognition protein SC2PRO_0000023912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 63 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9V4X2.

Expressioni

Tissue specificityi

Constitutively expressed at high level in gut, in addition to the induced expression in fat body.1 Publication

Inductioni

Strongly up-regulated by PGN from B.subtilis. Regulated by both imd/Relish and Toll pathways.2 Publications

Gene expression databases

BgeeiQ9V4X2.

Structurei

3D structure databases

ProteinModelPortaliQ9V4X2.
SMRiQ9V4X2. Positions 23-184.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5479.
GeneTreeiENSGT00390000016833.
InParanoidiQ9V4X2.
KOiK01446.
OMAiNSESACK.
OrthoDBiEOG757CZ5.
PhylomeDBiQ9V4X2.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9V4X2-1 [UniParc]FASTAAdd to Basket

« Hide

MANKALILLA VLFCAQAVLG VTIISKSEWG GRSATSKTSL ANYLSYAVIH    50
HTAGNYCSTK AACITQLQNI QAYHMDSLGW ADIGYNFLIG GDGNVYEGRG 100
WNVMGAHATN WNSKSIGISF LGNYNTNTLT SAQITAAKGL LSDAVSRGQI 150
VSGYILYGHR QVGSTECPGT NIWNEIRTWS NWKA 184
Length:184
Mass (Da):19,829
Last modified:May 1, 2000 - v1
Checksum:i0F99D04914B07238
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71I → V in strain: DI7, Draveil, KY024, KY038, Loua, Monty5, Tahiti and ZW141.
Natural varianti24 – 241I → V in strain: DI7, Draveil, KY024, KY038, Loua, Monty5 and ZW141.
Natural varianti72 – 721A → T in strain: KY024, KY038 and ZW141.
Natural varianti171 – 1711N → H in strain: ZW141.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ556612 Genomic DNA. Translation: CAD89177.1.
AJ556613 Genomic DNA. Translation: CAD89178.1.
AJ556614 Genomic DNA. Translation: CAD89179.1.
AJ556615 Genomic DNA. Translation: CAD89180.1.
AJ556616 Genomic DNA. Translation: CAD89181.1.
AJ556617 Genomic DNA. Translation: CAD89182.1.
AJ556618 Genomic DNA. Translation: CAD89183.1.
AJ556619 Genomic DNA. Translation: CAD89184.1.
AJ556620 Genomic DNA. Translation: CAD89185.1.
AJ556621 Genomic DNA. Translation: CAD89186.1.
AJ556622 Genomic DNA. Translation: CAD89187.1.
AE013599 Genomic DNA. Translation: AAF59051.1.
RefSeqiNP_610410.1. NM_136566.1.
UniGeneiDm.23629.

Genome annotation databases

EnsemblMetazoaiFBtr0088709; FBpp0087788; FBgn0043575.
GeneIDi35862.
KEGGidme:Dmel_CG14745.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ556612 Genomic DNA. Translation: CAD89177.1 .
AJ556613 Genomic DNA. Translation: CAD89178.1 .
AJ556614 Genomic DNA. Translation: CAD89179.1 .
AJ556615 Genomic DNA. Translation: CAD89180.1 .
AJ556616 Genomic DNA. Translation: CAD89181.1 .
AJ556617 Genomic DNA. Translation: CAD89182.1 .
AJ556618 Genomic DNA. Translation: CAD89183.1 .
AJ556619 Genomic DNA. Translation: CAD89184.1 .
AJ556620 Genomic DNA. Translation: CAD89185.1 .
AJ556621 Genomic DNA. Translation: CAD89186.1 .
AJ556622 Genomic DNA. Translation: CAD89187.1 .
AE013599 Genomic DNA. Translation: AAF59051.1 .
RefSeqi NP_610410.1. NM_136566.1.
UniGenei Dm.23629.

3D structure databases

ProteinModelPortali Q9V4X2.
SMRi Q9V4X2. Positions 23-184.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9V4X2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0088709 ; FBpp0087788 ; FBgn0043575 .
GeneIDi 35862.
KEGGi dme:Dmel_CG14745.

Organism-specific databases

CTDi 35862.
FlyBasei FBgn0043575. PGRP-SC2.

Phylogenomic databases

eggNOGi COG5479.
GeneTreei ENSGT00390000016833.
InParanoidi Q9V4X2.
KOi K01446.
OMAi NSESACK.
OrthoDBi EOG757CZ5.
PhylomeDBi Q9V4X2.

Miscellaneous databases

GenomeRNAii 35862.
NextBioi 795563.

Gene expression databases

Bgeei Q9V4X2.

Family and domain databases

Gene3Di 3.40.80.10. 1 hit.
InterProi IPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view ]
PANTHERi PTHR11022. PTHR11022. 1 hit.
Pfami PF01510. Amidase_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF037945. PGRPs. 1 hit.
SMARTi SM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view ]
SUPFAMi SSF55846. SSF55846. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The evolution of parasite recognition genes in the innate immune system: purifying selection on Drosophila melanogaster peptidoglycan recognition proteins."
    Jiggins F.M., Hurst G.D.D.
    J. Mol. Evol. 57:598-605(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DI7, Draveil, KY024, KY038, Loua, Monty5, P.bourg, S30, Tahiti, Texas and ZW141.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. "A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster."
    Werner T., Liu G., Kang D., Ekengren S., Steiner H., Hultmark D.
    Proc. Natl. Acad. Sci. U.S.A. 97:13772-13777(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  5. "The Toll and Imd pathways are the major regulators of the immune response in Drosophila."
    De Gregorio E., Spellman P.T., Tzou P., Rubin G.M., Lemaitre B.
    EMBO J. 21:2568-2579(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiPGSC2_DROME
AccessioniPrimary (citable) accession number: Q9V4X2
Secondary accession number(s): Q70PT2
, Q70PT3, Q70PT5, Q70PT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi