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Q9V4X2

- PGSC2_DROME

UniProt

Q9V4X2 - PGSC2_DROME

Protein

Peptidoglycan-recognition protein SC2

Gene

PGRP-SC2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity By similarity.By similarity

    Catalytic activityi

    Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi51 – 511ZincBy similarity
    Metal bindingi85 – 851ZincBy similarity
    Metal bindingi159 – 1591ZincBy similarity
    Metal bindingi167 – 1671ZincBy similarity

    GO - Molecular functioni

    1. N-acetylmuramoyl-L-alanine amidase activity Source: FlyBase
    2. peptidoglycan binding Source: FlyBase
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. immune response Source: FlyBase
    2. innate immune response Source: UniProtKB-KW
    3. negative regulation of innate immune response Source: FlyBase
    4. peptidoglycan catabolic process Source: FlyBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Immunity, Innate immunity

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidoglycan-recognition protein SC2 (EC:3.5.1.28)
    Gene namesi
    Name:PGRP-SC2
    ORF Names:CG14745
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0043575. PGRP-SC2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: FlyBase

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 184164Peptidoglycan-recognition protein SC2PRO_0000023912Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi57 ↔ 63By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ9V4X2.

    Expressioni

    Tissue specificityi

    Constitutively expressed at high level in gut, in addition to the induced expression in fat body.1 Publication

    Inductioni

    Strongly up-regulated by PGN from B.subtilis. Regulated by both imd/Relish and Toll pathways.2 Publications

    Gene expression databases

    BgeeiQ9V4X2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9V4X2.
    SMRiQ9V4X2. Positions 23-184.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5479.
    GeneTreeiENSGT00390000016833.
    InParanoidiQ9V4X2.
    KOiK01446.
    OMAiNSESACK.
    OrthoDBiEOG757CZ5.
    PhylomeDBiQ9V4X2.

    Family and domain databases

    Gene3Di3.40.80.10. 1 hit.
    InterProiIPR002502. Amidase_domain.
    IPR017331. Peptidoglycan_recognition.
    IPR015510. PGRP.
    IPR006619. PGRP_domain_met/bac.
    [Graphical view]
    PANTHERiPTHR11022. PTHR11022. 1 hit.
    PfamiPF01510. Amidase_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037945. PGRPs. 1 hit.
    SMARTiSM00644. Ami_2. 1 hit.
    SM00701. PGRP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55846. SSF55846. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9V4X2-1 [UniParc]FASTAAdd to Basket

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    MANKALILLA VLFCAQAVLG VTIISKSEWG GRSATSKTSL ANYLSYAVIH    50
    HTAGNYCSTK AACITQLQNI QAYHMDSLGW ADIGYNFLIG GDGNVYEGRG 100
    WNVMGAHATN WNSKSIGISF LGNYNTNTLT SAQITAAKGL LSDAVSRGQI 150
    VSGYILYGHR QVGSTECPGT NIWNEIRTWS NWKA 184
    Length:184
    Mass (Da):19,829
    Last modified:May 1, 2000 - v1
    Checksum:i0F99D04914B07238
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71I → V in strain: DI7, Draveil, KY024, KY038, Loua, Monty5, Tahiti and ZW141.
    Natural varianti24 – 241I → V in strain: DI7, Draveil, KY024, KY038, Loua, Monty5 and ZW141.
    Natural varianti72 – 721A → T in strain: KY024, KY038 and ZW141.
    Natural varianti171 – 1711N → H in strain: ZW141.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ556612 Genomic DNA. Translation: CAD89177.1.
    AJ556613 Genomic DNA. Translation: CAD89178.1.
    AJ556614 Genomic DNA. Translation: CAD89179.1.
    AJ556615 Genomic DNA. Translation: CAD89180.1.
    AJ556616 Genomic DNA. Translation: CAD89181.1.
    AJ556617 Genomic DNA. Translation: CAD89182.1.
    AJ556618 Genomic DNA. Translation: CAD89183.1.
    AJ556619 Genomic DNA. Translation: CAD89184.1.
    AJ556620 Genomic DNA. Translation: CAD89185.1.
    AJ556621 Genomic DNA. Translation: CAD89186.1.
    AJ556622 Genomic DNA. Translation: CAD89187.1.
    AE013599 Genomic DNA. Translation: AAF59051.1.
    RefSeqiNP_610410.1. NM_136566.1.
    UniGeneiDm.23629.

    Genome annotation databases

    EnsemblMetazoaiFBtr0088709; FBpp0087788; FBgn0043575.
    GeneIDi35862.
    KEGGidme:Dmel_CG14745.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ556612 Genomic DNA. Translation: CAD89177.1 .
    AJ556613 Genomic DNA. Translation: CAD89178.1 .
    AJ556614 Genomic DNA. Translation: CAD89179.1 .
    AJ556615 Genomic DNA. Translation: CAD89180.1 .
    AJ556616 Genomic DNA. Translation: CAD89181.1 .
    AJ556617 Genomic DNA. Translation: CAD89182.1 .
    AJ556618 Genomic DNA. Translation: CAD89183.1 .
    AJ556619 Genomic DNA. Translation: CAD89184.1 .
    AJ556620 Genomic DNA. Translation: CAD89185.1 .
    AJ556621 Genomic DNA. Translation: CAD89186.1 .
    AJ556622 Genomic DNA. Translation: CAD89187.1 .
    AE013599 Genomic DNA. Translation: AAF59051.1 .
    RefSeqi NP_610410.1. NM_136566.1.
    UniGenei Dm.23629.

    3D structure databases

    ProteinModelPortali Q9V4X2.
    SMRi Q9V4X2. Positions 23-184.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9V4X2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0088709 ; FBpp0087788 ; FBgn0043575 .
    GeneIDi 35862.
    KEGGi dme:Dmel_CG14745.

    Organism-specific databases

    CTDi 35862.
    FlyBasei FBgn0043575. PGRP-SC2.

    Phylogenomic databases

    eggNOGi COG5479.
    GeneTreei ENSGT00390000016833.
    InParanoidi Q9V4X2.
    KOi K01446.
    OMAi NSESACK.
    OrthoDBi EOG757CZ5.
    PhylomeDBi Q9V4X2.

    Miscellaneous databases

    GenomeRNAii 35862.
    NextBioi 795563.

    Gene expression databases

    Bgeei Q9V4X2.

    Family and domain databases

    Gene3Di 3.40.80.10. 1 hit.
    InterProi IPR002502. Amidase_domain.
    IPR017331. Peptidoglycan_recognition.
    IPR015510. PGRP.
    IPR006619. PGRP_domain_met/bac.
    [Graphical view ]
    PANTHERi PTHR11022. PTHR11022. 1 hit.
    Pfami PF01510. Amidase_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037945. PGRPs. 1 hit.
    SMARTi SM00644. Ami_2. 1 hit.
    SM00701. PGRP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55846. SSF55846. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The evolution of parasite recognition genes in the innate immune system: purifying selection on Drosophila melanogaster peptidoglycan recognition proteins."
      Jiggins F.M., Hurst G.D.D.
      J. Mol. Evol. 57:598-605(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DI7, Draveil, KY024, KY038, Loua, Monty5, P.bourg, S30, Tahiti, Texas and ZW141.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. "A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster."
      Werner T., Liu G., Kang D., Ekengren S., Steiner H., Hultmark D.
      Proc. Natl. Acad. Sci. U.S.A. 97:13772-13777(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.
    5. "The Toll and Imd pathways are the major regulators of the immune response in Drosophila."
      De Gregorio E., Spellman P.T., Tzou P., Rubin G.M., Lemaitre B.
      EMBO J. 21:2568-2579(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiPGSC2_DROME
    AccessioniPrimary (citable) accession number: Q9V4X2
    Secondary accession number(s): Q70PT2
    , Q70PT3, Q70PT5, Q70PT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3