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Protein

Peptidoglycan-recognition protein SC2

Gene

PGRP-SC2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity (By similarity).By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi50Zinc; via pros nitrogenBy similarity1
Sitei85Important for catalytic activity; essential for amidase activity and zinc hydrate coordinationBy similarity1
Metal bindingi159Zinc; via pros nitrogenBy similarity1
Metal bindingi167ZincBy similarity1

GO - Molecular functioni

  • N-acetylmuramoyl-L-alanine amidase activity Source: FlyBase
  • peptidoglycan binding Source: FlyBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • immune response Source: FlyBase
  • innate immune response Source: UniProtKB-KW
  • negative regulation of innate immune response Source: FlyBase
  • peptidoglycan catabolic process Source: FlyBase

Keywordsi

Molecular functionHydrolase
Biological processImmunity, Innate immunity
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-6798695 Neutrophil degranulation
R-DME-6803157 Antimicrobial peptides

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan-recognition protein SC2 (EC:3.5.1.28)
Gene namesi
ORF Names:CG14745
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0043575 PGRP-SC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002391221 – 184Peptidoglycan-recognition protein SC2Add BLAST164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 63By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9V4X2
PRIDEiQ9V4X2

Expressioni

Tissue specificityi

Constitutively expressed at high level in gut, in addition to the induced expression in fat body.1 Publication

Inductioni

Strongly up-regulated by PGN from B.subtilis. Regulated by both imd/Relish and Toll pathways.2 Publications

Gene expression databases

BgeeiFBgn0043575
ExpressionAtlasiQ9V4X2 baseline and differential
GenevisibleiQ9V4X2 DM

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0087788

Structurei

3D structure databases

ProteinModelPortaliQ9V4X2
SMRiQ9V4X2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYTD Eukaryota
ENOG4111PQD LUCA
GeneTreeiENSGT00390000016833
InParanoidiQ9V4X2
KOiK01446
OMAiIISKSQW
OrthoDBiEOG091G0O6Z
PhylomeDBiQ9V4X2

Family and domain databases

CDDicd06583 PGRP, 1 hit
Gene3Di3.40.80.10, 1 hit
InterProiView protein in InterPro
IPR036505 Amidase/PGRP_sf
IPR002502 Amidase_domain
IPR017331 Peptidoglycan_recognition
IPR015510 PGRP
IPR006619 PGRP_domain_met/bac
PANTHERiPTHR11022 PTHR11022, 1 hit
PfamiView protein in Pfam
PF01510 Amidase_2, 1 hit
PIRSFiPIRSF037945 PGRPs, 1 hit
SMARTiView protein in SMART
SM00644 Ami_2, 1 hit
SM00701 PGRP, 1 hit
SUPFAMiSSF55846 SSF55846, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9V4X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKALILLA VLFCAQAVLG VTIISKSEWG GRSATSKTSL ANYLSYAVIH
60 70 80 90 100
HTAGNYCSTK AACITQLQNI QAYHMDSLGW ADIGYNFLIG GDGNVYEGRG
110 120 130 140 150
WNVMGAHATN WNSKSIGISF LGNYNTNTLT SAQITAAKGL LSDAVSRGQI
160 170 180
VSGYILYGHR QVGSTECPGT NIWNEIRTWS NWKA
Length:184
Mass (Da):19,829
Last modified:May 1, 2000 - v1
Checksum:i0F99D04914B07238
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti7I → V in strain: DI7, Draveil, KY024, KY038, Loua, Monty5, Tahiti and ZW141. 1
Natural varianti24I → V in strain: DI7, Draveil, KY024, KY038, Loua, Monty5 and ZW141. 1
Natural varianti72A → T in strain: KY024, KY038 and ZW141. 1
Natural varianti171N → H in strain: ZW141. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ556612 Genomic DNA Translation: CAD89177.1
AJ556613 Genomic DNA Translation: CAD89178.1
AJ556614 Genomic DNA Translation: CAD89179.1
AJ556615 Genomic DNA Translation: CAD89180.1
AJ556616 Genomic DNA Translation: CAD89181.1
AJ556617 Genomic DNA Translation: CAD89182.1
AJ556618 Genomic DNA Translation: CAD89183.1
AJ556619 Genomic DNA Translation: CAD89184.1
AJ556620 Genomic DNA Translation: CAD89185.1
AJ556621 Genomic DNA Translation: CAD89186.1
AJ556622 Genomic DNA Translation: CAD89187.1
AE013599 Genomic DNA Translation: AAF59051.1
RefSeqiNP_610410.1, NM_136566.2

Genome annotation databases

EnsemblMetazoaiFBtr0088709; FBpp0087788; FBgn0043575
GeneIDi35862
KEGGidme:Dmel_CG14745

Similar proteinsi

Entry informationi

Entry nameiPGSC2_DROME
AccessioniPrimary (citable) accession number: Q9V4X2
Secondary accession number(s): Q70PT2
, Q70PT3, Q70PT5, Q70PT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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