Reviewed, UniProtKB/Swiss-Prot Q9V4Q8 (RU2A_DROME)

Names and origin

Protein names

Recommended name:
    Probable U2 small nuclear ribonucleoprotein A'
      Short name=U2 snRNP-A'

Gene names

Name:	U2A
ORF Names:	CG1406

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA By similarity.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the U2 small nuclear ribonucleoprotein A family. Contains 3 LRR (leucine-rich) repeats.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Leucine-rich repeat Repeat
Ligand	RNA-binding
Molecular function	Ribonucleoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mitotic spindle organization Inferred from mutant phenotype. Source: FlyBase
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell ribonucleoprotein complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Probable U2 small nuclear ribonucleoprotein A'		PRO_0000074177
Regions
	Repeat	41 – 63	23	LRR 1
	Repeat	64 – 87	24	LRR 2
	Repeat	88 – 111	24	LRR 3

Sequences

	Sequence		Length	Mass (Da)
	Q9V4Q8-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: FB09D8D1D96501A5	FASTA	265	29,744
	10 20 30 40 50 60 MVKLTPELIN QSMQYINPCR ERELDLRGYK IPQIENLGAT LDQFDTIDLS DNDLRKLDNL 70 80 90 100 110 120 PHLPRLKCLL LNNNRILRIS EGLEEAVPNL GSIILTGNNL QELSDLEPLV GFTKLETICL 130 140 150 160 170 180 LINPVSTKPN YREYMAYKFP QLRLLDFRKI KQKDRQAAQE FFRTKQGKDV LKEISRKSKM 190 200 210 220 230 240 SAAAAIAAEA GNGKGRGSEG GRLANPQDMQ RIREAIKRAS SLAEVERLSQ ILQSGQLPDK 250 260 FQHEMEAVAQ NGAGHNGSGA VAMEY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013599 Genomic DNA. Translation: AAF59207.1. AY071516 mRNA. Translation: AAL49138.1.
RefSeq	NP_610315.1.
UniGene	Dm.14227
3D structure databases
HSSP	HSSP built from PDB template 1A9N based on UniProtKB P09661.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9V4Q8. 2 interactions.
Proteomic databases
PRIDE	Q9V4Q8.
Genome annotation databases
Ensembl	FBgn0033210. Drosophila melanogaster. [Contig view]
GeneID	35713.
KEGG	dme:Dmel_CG1406.
NMPDR	fig|7227.3.peg.3710.
Organism-specific databases
FlyBase	FBgn0033210. U2A.
Phylogenomic databases
HOGENOM	Q9V4Q8.
OMA	Q9V4Q8. TADLIWK.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-003272-MON.
Gene expression databases
GermOnline	CG1406. Drosophila melanogaster.
Family and domain databases
InterPro	IPR003603. U2A'_phosphoprotein32A_C. [Graphical view]
SMART	SM00446. LRRcap. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	794870.

Entry information

Entry name

RU2A_DROME

Accession

Primary (citable) accession number: Q9V4Q8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project