Q9V4C7 (Q9V4C7_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Plasma membrane calcium ATPase, isoform I EMBL AAF59350.5
EC=3.6.3.8 EMBL AAF59350.5

Submitted name:
Plasma membrane calcium ATPase, isoform L EMBL AAN06528.5
EC=3.6.3.8 EMBL AAN06528.5
Submitted name:
Plasma membrane calcium ATPase, isoform O EMBL ADV37598.1
EC=3.6.3.8 EMBL ADV37598.1

Gene names

Name:	PMCA FlyBase FBgn0259214
ORF Names:	Dmel_CG42314 EMBL AAF59350.5

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the cation transport ATPase (P-type) family. RuleBase RU000653

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS004014
Ligand	ATP-binding SAAS SAAS004014 RuleBase RU000653 Nucleotide-binding
Molecular function	Hydrolase SAAS SAAS006068 RuleBase RU000653 EMBL AAF59350.5
PTM	Phosphoprotein SAAS SAAS004014 RuleBase RU000653
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro cellular calcium ion homeostasis Inferred from mutant phenotype. Source: FlyBase
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9V4C7 [UniParc]. Last modified February 9, 2010. Version 5. Checksum: 76ED7F59F421205D	FASTA	1,206	132,943
	10 20 30 40 50 60 MATIDGRPAQ YGISLKQLRE LMEHRGREGV MKIAENGGIH ELCKKLYTSP NEGLSGSKAD 70 80 90 100 110 120 EEHRRETFGS NVIPPKPPKT FLTLVWEALQ DVTLIILEVA ALVSLGLSFY KPADEDAPVL 130 140 150 160 170 180 QEEEEHHGWI EGLAILISVI VVVIVTAFND YSKERQFRGL QNRIEGEHKF SVIRGGEVCQ 190 200 210 220 230 240 ISVGDILVGD IAQVKYGDLL PADGCLIQSN DLKVDESSLT GESDHVKKGP DVDPMVLSGT 250 260 270 280 290 300 HVMEGSGKMV VTAVGVNSQA GIIFTLLGAA VDEQEAEIKK MKKEAKRANK QKNLTGENDG 310 320 330 340 350 360 RSQIKGSQAP SQRETVTSEI TKSESEGNHL PQSSSSGAAE TGHKKEKSVL QAKLTKLAIQ 370 380 390 400 410 420 IGYAGSTIAV LTVIILIIQF CIKTFVIDEK PWKNTYANNL VKHLIIGVTV LVVAVPEGLP 430 440 450 460 470 480 LAVTLSLAYS VKKMMKDNNL VRHLDACETM GNATAICSDK TGTLTTNRMT VVQSYICEKL 490 500 510 520 530 540 CKVLPTLSDI PQHVGNLITM GISVNSAYTS NIMAGHNPGD LPIQVGNKTE CALLGFVQGL 550 560 570 580 590 600 GVKYQSIRDE ITEDKFTRVY TFNSVRKSMG TVIPRPNGGY RLYTKGASEI IMKKCAFIYG 610 620 630 640 650 660 HEGTLEKFTR DMQERLIREV IEPMACDGLR TISVAYRDFV PGKAAINEVH IDGEPNWDDE 670 680 690 700 710 720 ENIMTNLTCL CVVGIEDPVR PEVPDAIRKC QRAGITVRMV TGDNINTARS IASKCGILRP 730 740 750 760 770 780 NDDFLILEGK EFNRRIRDSN GDIQQHLIDK VWPKLRVLAR SSPTDKYTLV KGIIDSTVSE 790 800 810 820 830 840 NREVVAVTGD GTNDGPALKK ADVGFAMGIA GTDVAKEASD IILTDDNFSS IVKAVMWGRN 850 860 870 880 890 900 VYDSIAKFLQ FQLTVNVVAV IVAFIGACAV QDSPLKAVQM LWVNLIMDTL ASLALATEFP 910 920 930 940 950 960 TPDLLLRKPY GRTKPLISRT MMKNILGQAL YQLIIIFGLL FVGDVILDIE SGRGQELNAG 970 980 990 1000 1010 1020 PTQHFTIIFN TFVMMTLFNE INARKIHGQR NVIEGLLTNP IFYTIWIFTM ISQVLIIQYG 1030 1040 1050 1060 1070 1080 KMAFSTKALT LDQWLWCIFF GIGTLVWGQL ITSVPTRKLP KILSWGRGHP EEYTDGMNLG 1090 1100 1110 1120 1130 1140 EERFDSIDSD KKPRAGQILW IRGLTRLQTQ VIGGELQERL IPVPYSKSNT DQAIRVVNAF 1150 1160 1170 1180 1190 1200 RQGLDARYGD HTNTSLAEVL RKQTSLSKRL SETSSIEYAD NIPDELTIPE IDVERLSSHS HTETAV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Release 5.1 annotation of Drosophila melanogaster heterochromatin." Smith C.D., Shu S., Mungall C.J., Karpen G.H. Science 316:1586-1591(2007) [PubMed: 17569856] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Sequence finishing and mapping of Drosophila melanogaster heterochromatin." Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., Dimitri P., Karpen G.H., Celniker S.E. Science 316:1625-1628(2007) [PubMed: 17569867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Combined evidence annotation of transposable elements in genome sequences." Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D. PLoS Comput. Biol. 1:166-175(2005) [PubMed: 16110336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[5]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[6]	"Heterochromatic sequences in a Drosophila whole-genome shotgun assembly." Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H. Genome Biol. 3:RESEARCH0085.1-RESEARCH0085.16(2002) [PubMed: 12537574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[7]	"The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective." Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J.W., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E. Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed: 12537573] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[8]	"Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence." Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., Pacleb J.M., Park S. , Pfeiffer B.D., Richards S., Sodergren E.J., Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M. Genome Biol. 3 (12), RESEARCH0079 (2002) Cited for: NUCLEOTIDE SEQUENCE.
[9]	Drosophila Heterochromatin Genome Project Smith C.D., Shu S., Mungall C.J., Karpen G.H. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[10]	FlyBase Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[11]	"Drosophila melanogaster release 4 sequence." Berkeley Drosophila Genome Project Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[12]	Celniker S., Carlson J., Kennedy C., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Karpen G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[13]	Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014135 Genomic DNA. Translation: AAF59350.5. AE014135 Genomic DNA. Translation: AAN06528.5. AE014135 Genomic DNA. Translation: ADV37598.1.
RefSeq	NP_001188514.1. NM_001201585.1. NP_726564.5. NM_166754.5. NP_726565.5. NM_166755.5.
UniGene	Dm.3785.
3D structure databases
ProteinModelPortal	Q9V4C7.
SMR	Q9V4C7. Positions 35-1064, 1093-1143.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-788410.
STRING	Q9V4C7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0300554; FBpp0289781; FBgn0259214. FBtr0300557; FBpp0289784; FBgn0259214. FBtr0304046; FBpp0293009; FBgn0259214.
GeneID	43787.
KEGG	dme:Dmel_CG42314.
UCSC	CG42314-RC. d. melanogaster.
Organism-specific databases
CTD	43787.
FlyBase	FBgn0259214. PMCA.
Phylogenomic databases
GeneTree	EMGT00050000001937.
Gene expression databases
Bgee	Q9V4C7.
Family and domain databases
InterPro	IPR022141. ATP_Ca_trans_C. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006408. ATPase_P-typ_Ca-transp_PMCA. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 1 hit.
KO	K05850.
Pfam	PF12424. ATP_Ca_trans_C. 1 hit. PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01517. ATPase-IIB_Ca. 1 hit. TIGR01494. ATPase_P-type. 3 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	835819.

Entry information

Entry name

Q9V4C7_DROME

Accession

Primary (citable) accession number: Q9V4C7

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	February 9, 2010
Last modified:	January 25, 2012
This is version 102 of the entry and version 5 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)