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Protein

Calcium-transporting ATPase

Gene

PMCA

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • cellular calcium ion homeostasis Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotationImported

Keywords - Biological processi

Calcium transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-418359. Reduction of cytosolic Ca++ levels.
R-DME-5578775. Ion homeostasis.
R-DME-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:PMCAImported
ORF Names:CG42314Imported, Dmel_CG42314Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 4

Organism-specific databases

FlyBaseiFBgn0259214. PMCA.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei361 – 385HelicalUniRule annotationAdd BLAST25
Transmembranei405 – 429HelicalUniRule annotationAdd BLAST25
Transmembranei848 – 867HelicalUniRule annotationAdd BLAST20
Transmembranei921 – 942HelicalUniRule annotationAdd BLAST22
Transmembranei962 – 981HelicalUniRule annotationAdd BLAST20
Transmembranei1001 – 1021HelicalUniRule annotationAdd BLAST21
Transmembranei1033 – 1051HelicalUniRule annotationAdd BLAST19

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0259214.

Interactioni

Protein-protein interaction databases

MINTiMINT-788410.
STRINGi7227.FBpp0289782.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 109Cation_ATPase_NInterPro annotationAdd BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili271 – 298Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0204. Eukaryota.
ENOG410XNNC. LUCA.
GeneTreeiENSGT00510000046331.
OrthoDBiEOG091G057D.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR030319. ATP2B1/4.
IPR022141. ATP_Ca_trans_C.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF276. PTHR24093:SF276. 3 hits.
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 2 hits.
PF08282. Hydrolase_3. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V4C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIDGRPAQ YGISLKQLRE LMEHRGREGV MKIAENGGIH ELCKKLYTSP
60 70 80 90 100
NEGLSGSKAD EEHRRETFGS NVIPPKPPKT FLTLVWEALQ DVTLIILEVA
110 120 130 140 150
ALVSLGLSFY KPADEDAPVL QEEEEHHGWI EGLAILISVI VVVIVTAFND
160 170 180 190 200
YSKERQFRGL QNRIEGEHKF SVIRGGEVCQ ISVGDILVGD IAQVKYGDLL
210 220 230 240 250
PADGCLIQSN DLKVDESSLT GESDHVKKGP DVDPMVLSGT HVMEGSGKMV
260 270 280 290 300
VTAVGVNSQA GIIFTLLGAA VDEQEAEIKK MKKEAKRANK QKNLTGENDG
310 320 330 340 350
RSQIKGSQAP SQRETVTSEI TKSESEGNHL PQSSSSGAAE TGHKKEKSVL
360 370 380 390 400
QAKLTKLAIQ IGYAGSTIAV LTVIILIIQF CIKTFVIDEK PWKNTYANNL
410 420 430 440 450
VKHLIIGVTV LVVAVPEGLP LAVTLSLAYS VKKMMKDNNL VRHLDACETM
460 470 480 490 500
GNATAICSDK TGTLTTNRMT VVQSYICEKL CKVLPTLSDI PQHVGNLITM
510 520 530 540 550
GISVNSAYTS NIMAGHNPGD LPIQVGNKTE CALLGFVQGL GVKYQSIRDE
560 570 580 590 600
ITEDKFTRVY TFNSVRKSMG TVIPRPNGGY RLYTKGASEI IMKKCAFIYG
610 620 630 640 650
HEGTLEKFTR DMQERLIREV IEPMACDGLR TISVAYRDFV PGKAAINEVH
660 670 680 690 700
IDGEPNWDDE ENIMTNLTCL CVVGIEDPVR PEVPDAIRKC QRAGITVRMV
710 720 730 740 750
TGDNINTARS IASKCGILRP NDDFLILEGK EFNRRIRDSN GDIQQHLIDK
760 770 780 790 800
VWPKLRVLAR SSPTDKYTLV KGIIDSTVSE NREVVAVTGD GTNDGPALKK
810 820 830 840 850
ADVGFAMGIA GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSIAKFLQ
860 870 880 890 900
FQLTVNVVAV IVAFIGACAV QDSPLKAVQM LWVNLIMDTL ASLALATEFP
910 920 930 940 950
TPDLLLRKPY GRTKPLISRT MMKNILGQAL YQLIIIFGLL FVGDVILDIE
960 970 980 990 1000
SGRGQELNAG PTQHFTIIFN TFVMMTLFNE INARKIHGQR NVIEGLLTNP
1010 1020 1030 1040 1050
IFYTIWIFTM ISQVLIIQYG KMAFSTKALT LDQWLWCIFF GIGTLVWGQL
1060 1070 1080 1090 1100
ITSVPTRKLP KILSWGRGHP EEYTDGMNLG EERFDSIDSD KKPRAGQILW
1110 1120 1130 1140 1150
IRGLTRLQTQ VIGGELQERL IPVPYSKSNT DQAIRVVNAF RQGLDARYGD
1160 1170 1180 1190 1200
HTNTSLAEVL RKQTSLSKRL SETSSIEYAD NIPDELTIPE IDVERLSSHS

HTETAV
Length:1,206
Mass (Da):132,943
Last modified:February 9, 2010 - v5
Checksum:i76ED7F59F421205D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014135 Genomic DNA. Translation: AAF59350.5.
AE014135 Genomic DNA. Translation: AAN06528.5.
AE014135 Genomic DNA. Translation: ADV37598.1.
RefSeqiNP_001188514.1. NM_001201585.2.
NP_726564.5. NM_166754.6.
NP_726565.5. NM_166755.6.
UniGeneiDm.3785.

Genome annotation databases

EnsemblMetazoaiFBtr0300554; FBpp0289781; FBgn0259214.
FBtr0300557; FBpp0289784; FBgn0259214.
FBtr0304046; FBpp0293009; FBgn0259214.
GeneIDi43787.
UCSCiCG42314-RC. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014135 Genomic DNA. Translation: AAF59350.5.
AE014135 Genomic DNA. Translation: AAN06528.5.
AE014135 Genomic DNA. Translation: ADV37598.1.
RefSeqiNP_001188514.1. NM_001201585.2.
NP_726564.5. NM_166754.6.
NP_726565.5. NM_166755.6.
UniGeneiDm.3785.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-788410.
STRINGi7227.FBpp0289782.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0300554; FBpp0289781; FBgn0259214.
FBtr0300557; FBpp0289784; FBgn0259214.
FBtr0304046; FBpp0293009; FBgn0259214.
GeneIDi43787.
UCSCiCG42314-RC. d. melanogaster.

Organism-specific databases

CTDi43787.
FlyBaseiFBgn0259214. PMCA.

Phylogenomic databases

eggNOGiKOG0204. Eukaryota.
ENOG410XNNC. LUCA.
GeneTreeiENSGT00510000046331.
OrthoDBiEOG091G057D.

Enzyme and pathway databases

ReactomeiR-DME-418359. Reduction of cytosolic Ca++ levels.
R-DME-5578775. Ion homeostasis.
R-DME-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiPMCA. fly.
GenomeRNAii43787.

Gene expression databases

BgeeiFBgn0259214.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR030319. ATP2B1/4.
IPR022141. ATP_Ca_trans_C.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF276. PTHR24093:SF276. 3 hits.
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 2 hits.
PF08282. Hydrolase_3. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9V4C7_DROME
AccessioniPrimary (citable) accession number: Q9V4C7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: February 9, 2010
Last modified: October 5, 2016
This is version 149 of the entry and version 5 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.